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PubMed code 27890378

Compile data set for download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205604
PNG
(CHEMBL3907401)
Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(F)cc2)C(=O)CCC1 |t:11|
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n/an/a 170n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205613
PNG
(CHEMBL3934464)
Show SMILES CCCN1N=C(CCCC1=O)c1ccc(OC)c(OC)c1 |c:4|
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n/an/a 260n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205599
PNG
(CHEMBL3933197)
Show SMILES COc1ccc(cc1OC)C1=NN(Cc2cccnc2)C(=O)CCC1 |t:11|
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n/an/a 290n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205619
PNG
(CHEMBL3965269)
Show SMILES COc1ccc(cc1OC)C1=NN(CC2CCC2)C(=O)CCC1 |t:11|
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n/an/a 320n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205603
PNG
(CHEMBL3937306)
Show SMILES COc1ccc(cc1OC)C1=NN(CC(C)C)C(=O)CCC1 |t:11|
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n/an/a 340n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205600
PNG
(CHEMBL3897315)
Show SMILES COc1ccc(cc1OC)C1=NN(CC=C)C(=O)CCC1 |t:11|
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n/an/a 1.13E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205602
PNG
(CHEMBL3919202)
Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(F)cc2)C(=O)CC(C)(C)C1 |t:11|
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n/an/a 1.22E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205610
PNG
(CHEMBL3926566)
Show SMILES COc1ccc(cc1OC)C1=NN(CCCO)C(=O)CCC1 |t:11|
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n/an/a 1.22E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205614
PNG
(CHEMBL3892849)
Show SMILES CCN(CC)CCN1N=C(CCCC1=O)c1ccc(OC)c(OC)c1 |c:8|
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n/an/a 1.22E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205611
PNG
(CHEMBL3969575)
Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(cc2)S(C)(=O)=O)C(=O)CCC1 |t:11|
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n/an/a 1.29E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205608
PNG
(CHEMBL3898376)
Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccncc2)C(=O)CCC1 |t:11|
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n/an/a 1.41E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM14769
PNG
(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Show SMILES COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1
Show InChI InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
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n/an/a 1.41E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205617
PNG
(CHEMBL3916376)
Show SMILES CCOCCN1N=C(CCCC1=O)c1ccc(OC)c(OC)c1 |c:6|
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n/an/a 2.27E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205609
PNG
(CHEMBL3938207)
Show SMILES COc1ccc(cc1OC)C1=NN(CCCO)C(=O)CC(C)(C)C1 |t:11|
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n/an/a 2.69E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205618
PNG
(CHEMBL3929714)
Show SMILES COc1ccc(cc1)C(=O)CCCC(O)=O
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n/an/a 3.53E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205605
PNG
(CHEMBL3932749)
Show SMILES COc1ccc(cc1OC)C1=NNC(=O)CC(C)(C)C1 |t:11|
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n/an/a 3.53E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205601
PNG
(CHEMBL3892468)
Show SMILES COc1ccc(cc1OC)C1=NNC(=O)CCC1 |t:11|
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n/an/a 4.17E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205607
PNG
(CHEMBL3925358)
Show SMILES COc1ccc(cc1OC)C1=NN(CC(N)=O)C(=O)CCC1 |t:11|
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n/an/a 7.55E+3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205612
PNG
(CHEMBL3910284)
Show SMILES COc1ccc(cc1OC)C1=NN(CC(O)=O)C(=O)CC(C)(C)C1 |t:11|
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n/an/a 1.31E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50205606
PNG
(CHEMBL3945980)
Show SMILES COc1ccc(cc1)C1=NNC(=O)CCC1 |t:9|
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay


Bioorg Med Chem Lett 27: 24-29 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.040
BindingDB Entry DOI: 10.7270/Q21N8333
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%