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PubMed code 27908761

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>1.79E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in CHO cells after 120 mins by scintillation counting method


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>2.40E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1D receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>2.97E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1F receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>3.02E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1A receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>3.30E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5T2B receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>3.58E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1B receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>3.98E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells after 120 mins by scintillation counting method


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>5.37E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT1E receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>6.31E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of human recombinant 5HT4E receptor expressed in CHO cells after 60 mins by scintillation counting method


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>6.90E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of human 5HT5A receptor expressed in HEK293 cells after 120 mins by scintillation counting method


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>7.47E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5HT2A receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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>7.87E+6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Activity at human 5T2C receptor


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/a 24n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207410
PNG
(CHEMBL3909995)
Show SMILES CCCc1c(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
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n/an/a 62n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207406
PNG
(CHEMBL3890848)
Show SMILES CCCc1c(OCc2cccc(Oc3cc(ccn3)C(O)=O)c2)ccc(C(C)=O)c1O
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n/an/a 74n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207398
PNG
(CHEMBL3965244)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)c(c1O)C(F)(F)F
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n/an/a 112n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207404
PNG
(CHEMBL3935529)
Show SMILES CCCc1c(OCc2ccc(Oc3ccc(cn3)C(O)=O)cc2)ccc(C(C)=O)c1O
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n/an/a 132n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207411
PNG
(CHEMBL3973048)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(c1O)C(F)(F)F
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n/an/a 144n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207399
PNG
(CHEMBL3913281)
Show SMILES CCCc1c(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
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n/an/a 200n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207405
PNG
(CHEMBL3918914)
Show SMILES CCCc1c(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
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n/an/a 203n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207413
PNG
(CHEMBL3945882)
Show SMILES CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
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n/an/a 330n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207397
PNG
(CHEMBL3927834)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)c(Cl)c1O
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n/an/a 342n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207403
PNG
(CHEMBL3911282)
Show SMILES CCCc1c(OCc2ccc(Oc3ccc(cn3)-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
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n/an/a 346n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207402
PNG
(CHEMBL3980125)
Show SMILES CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
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n/an/a 390n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207407
PNG
(CHEMBL3936830)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(Cl)c1O
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n/an/a 475n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207412
PNG
(CHEMBL3920609)
Show SMILES CCCc1c(OCc2ccc(Oc3cccc(c3)-c3nn[nH]n3)nc2)ccc(C(C)=O)c1O
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n/an/a 484n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207409
PNG
(CHEMBL3892611)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cccc(c3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/a 1.43E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor


(Homo sapiens (Human))
BDBM50207408
PNG
(CHEMBL3943547)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(F)c1O
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n/an/a 1.50E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/a>8.00E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu1 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as inhibition of glutamate-induced ...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/a>1.25E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu5 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as inhibition of glutamate-induced ...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/a>1.25E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as inhibition of glutamate-induced ...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/a>1.25E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as inhibition of glutamate-induced ...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207402
PNG
(CHEMBL3980125)
Show SMILES CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
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n/an/an/an/a 227n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207397
PNG
(CHEMBL3927834)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)c(Cl)c1O
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n/an/an/an/a 87n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207410
PNG
(CHEMBL3909995)
Show SMILES CCCc1c(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
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n/an/an/an/a 110n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/an/an/a>2.50E+4n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human mGlu1 expressed in hamster AV12 cells expressing EAAT1 assessed as increase in intracellular calcium level meas...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207413
PNG
(CHEMBL3945882)
Show SMILES CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
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n/an/an/an/a 310n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207404
PNG
(CHEMBL3935529)
Show SMILES CCCc1c(OCc2ccc(Oc3ccc(cn3)C(O)=O)cc2)ccc(C(C)=O)c1O
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n/an/an/an/a 1.43E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/an/an/a>1.25E+4n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu3 expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of glutamate-indu...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207412
PNG
(CHEMBL3920609)
Show SMILES CCCc1c(OCc2ccc(Oc3cccc(c3)-c3nn[nH]n3)nc2)ccc(C(C)=O)c1O
PDB

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n/an/an/an/a 562n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/an/an/a>1.25E+4n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu5 expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of glutamate-indu...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207406
PNG
(CHEMBL3890848)
Show SMILES CCCc1c(OCc2cccc(Oc3cc(ccn3)C(O)=O)c2)ccc(C(C)=O)c1O
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n/an/an/an/a 405n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207407
PNG
(CHEMBL3936830)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(Cl)c1O
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n/an/an/an/a 39n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207398
PNG
(CHEMBL3965244)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3cc(ccn3)-c3nn[nH]n3)c2)c(c1O)C(F)(F)F
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n/an/an/an/a 6n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
PDB
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n/an/an/an/a>2.50E+4n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human mGlu5 expressed in hamster AV12 cells expressing EAAT1 assessed as increase in intracellular calcium level meas...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207409
PNG
(CHEMBL3892611)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cccc(c3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/an/an/a 294n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207399
PNG
(CHEMBL3913281)
Show SMILES CCCc1c(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
PDB

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n/an/an/an/a 470n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207411
PNG
(CHEMBL3973048)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(c1O)C(F)(F)F
PDB

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n/an/an/an/a 18n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207405
PNG
(CHEMBL3918914)
Show SMILES CCCc1c(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
PDB

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n/an/an/an/a 319n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
PDB

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n/an/an/an/a>1.25E+4n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu1 expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of glutamate-indu...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
PDB

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n/an/an/an/a 201n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
PDB

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n/an/an/an/a>2.50E+4n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human mGlu3 expressed in hamster AV12 cells expressing EAAT1 assessed as increase in intracellular calcium level meas...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207408
PNG
(CHEMBL3943547)
Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(F)c1O
PDB

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n/an/an/an/a 1.08E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207400
PNG
(CHEMBL3899832)
Show SMILES CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
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n/an/an/an/a>2.50E+4n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as increase in intracellular calcium l...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50207403
PNG
(CHEMBL3911282)
Show SMILES CCCc1c(OCc2ccc(Oc3ccc(cn3)-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O
PDB

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n/an/an/an/a 682n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta...


Bioorg Med Chem Lett 27: 323-328 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.049
BindingDB Entry DOI: 10.7270/Q2DN471R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%