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PubMed code 27964995

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207645
PNG
(CHEMBL3971179)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C23H20F2N2O2/c1-15(18-12-19(24)14-20(25)13-18)27(23(29)17-10-6-3-7-11-17)21(22(26)28)16-8-4-2-5-9-16/h2-15,21H,1H3,(H2,26,28)/t15-,21-/m1/s1
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n/an/a 80n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Rattus norvegicus (Rat))		BDBM50207645
PNG
(CHEMBL3971179)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C23H20F2N2O2/c1-15(18-12-19(24)14-20(25)13-18)27(23(29)17-10-6-3-7-11-17)21(22(26)28)16-8-4-2-5-9-16/h2-15,21H,1H3,(H2,26,28)/t15-,21-/m1/s1
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n/an/a 89n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM based ...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207659
PNG
(CHEMBL3944840)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1O)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C23H21ClN2O3/c1-15(17-10-7-11-18(24)14-17)26(23(29)19-12-5-6-13-20(19)27)21(22(25)28)16-8-3-2-4-9-16/h2-15,21,27H,1H3,(H2,25,28)/t15-,21-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207647
PNG
(CHEMBL3926952)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C23H20ClFN2O2/c1-15(18-12-19(24)14-20(25)13-18)27(23(29)17-10-6-3-7-11-17)21(22(26)28)16-8-4-2-5-9-16/h2-15,21H,1H3,(H2,26,28)/t15-,21-/m1/s1
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n/an/a 180n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207568
PNG
(CHEMBL3980601)
Show SMILES COC(=O)[C@H](N(Cc1cccc(OC)c1)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H23NO4/c1-28-21-15-9-10-18(16-21)17-25(23(26)20-13-7-4-8-14-20)22(24(27)29-2)19-11-5-3-6-12-19/h3-16,22H,17H2,1-2H3/t22-/m1/s1
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Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207657
PNG
(CHEMBL3917717)
Show SMILES COc1cccc(c1)[C@@H](C)N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H24N2O3/c1-17(20-14-9-15-21(16-20)29-2)26(24(28)19-12-7-4-8-13-19)22(23(25)27)18-10-5-3-6-11-18/h3-17,22H,1-2H3,(H2,25,27)/t17-,22-/m1/s1
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Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207649
PNG
(CHEMBL3907933)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1C)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C24H23ClN2O2/c1-16-9-6-7-14-21(16)24(29)27(17(2)19-12-8-13-20(25)15-19)22(23(26)28)18-10-4-3-5-11-18/h3-15,17,22H,1-2H3,(H2,26,28)/t17-,22-/m1/s1
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n/an/a 390n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207658
PNG
(CHEMBL3898642)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C23H21ClN2O2/c1-16(19-13-8-14-20(24)15-19)26(23(28)18-11-6-3-7-12-18)21(22(25)27)17-9-4-2-5-10-17/h2-16,21H,1H3,(H2,25,27)/t16-,21-/m1/s1
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n/an/a 400n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50331290
PNG
(CHEMBL1289953 | N-(3-aminopropyl)-2-(3-methylbenzy...)
Show SMILES Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1
Show InChI InChI=1S/C23H26N2O2S/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3
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n/an/a 414n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207670
PNG
(CHEMBL3889978)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1N)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C23H22ClN3O2/c1-15(17-10-7-11-18(24)14-17)27(23(29)19-12-5-6-13-20(19)25)21(22(26)28)16-8-3-2-4-9-16/h2-15,21H,25H2,1H3,(H2,26,28)/t15-,21-/m1/s1
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Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50331290
PNG
(CHEMBL1289953 | N-(3-aminopropyl)-2-(3-methylbenzy...)
Show SMILES Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1
Show InChI InChI=1S/C23H26N2O2S/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3
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n/an/a 447n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase by Fluo-4 AM based...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50331290
PNG
(CHEMBL1289953 | N-(3-aminopropyl)-2-(3-methylbenzy...)
Show SMILES Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1
Show InChI InChI=1S/C23H26N2O2S/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3
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n/an/a 448n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase by Fluo-4 AM based...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50331290
PNG
(CHEMBL1289953 | N-(3-aminopropyl)-2-(3-methylbenzy...)
Show SMILES Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1
Show InChI InChI=1S/C23H26N2O2S/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3
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n/an/a 589n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant full length TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase preinc...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207688
PNG
(CHEMBL3916922)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccc(C)cc1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C24H23ClN2O2/c1-16-11-13-19(14-12-16)24(29)27(17(2)20-9-6-10-21(25)15-20)22(23(26)28)18-7-4-3-5-8-18/h3-15,17,22H,1-2H3,(H2,26,28)/t17-,22-/m1/s1
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Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207646
PNG
(CHEMBL3959823)
Show SMILES Cc1cccc(CN([C@@H](C(N)=O)c2ccccc2)C(=O)c2ccccc2)c1 |r|
Show InChI InChI=1S/C23H22N2O2/c1-17-9-8-10-18(15-17)16-25(23(27)20-13-6-3-7-14-20)21(22(24)26)19-11-4-2-5-12-19/h2-15,21H,16H2,1H3,(H2,24,26)/t21-/m1/s1
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n/an/a 870n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207651
PNG
(CHEMBL3934736)
Show SMILES COc1cccc(CN([C@@H](C(N)=O)c2ccccc2)C(=O)c2ccccc2)c1 |r|
Show InChI InChI=1S/C23H22N2O3/c1-28-20-14-8-9-17(15-20)16-25(23(27)19-12-6-3-7-13-19)21(22(24)26)18-10-4-2-5-11-18/h2-15,21H,16H2,1H3,(H2,24,26)/t21-/m1/s1
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Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207662
PNG
(CHEMBL3943602)
Show SMILES COc1cccc(CN([C@@H](C(N)=O)c2ccccc2)C(=O)c2cccs2)c1 |r|
Show InChI InChI=1S/C21H20N2O3S/c1-26-17-10-5-7-15(13-17)14-23(21(25)18-11-6-12-27-18)19(20(22)24)16-8-3-2-4-9-16/h2-13,19H,14H2,1H3,(H2,22,24)/t19-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207664
PNG
(CHEMBL3935896)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1cccc(C)c1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C24H23ClN2O2/c1-16-8-6-12-20(14-16)24(29)27(17(2)19-11-7-13-21(25)15-19)22(23(26)28)18-9-4-3-5-10-18/h3-15,17,22H,1-2H3,(H2,26,28)/t17-,22-/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207660
PNG
(CHEMBL3898903)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1cccnc1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C22H20ClN3O2/c1-15(17-9-5-11-19(23)13-17)26(22(28)18-10-6-12-25-14-18)20(21(24)27)16-7-3-2-4-8-16/h2-15,20H,1H3,(H2,24,27)/t15-,20-/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207573
PNG
(CHEMBL3897350)
Show SMILES NC(=O)[C@H](N(Cc1cccc(Cl)c1)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C22H19ClN2O2/c23-19-13-7-8-16(14-19)15-25(22(27)18-11-5-2-6-12-18)20(21(24)26)17-9-3-1-4-10-17/h1-14,20H,15H2,(H2,24,26)/t20-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207644
PNG
(CHEMBL3918002)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1cccnc1)C(=O)c1ccccc1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C22H20ClN3O2/c1-15(17-9-5-11-19(23)13-17)26(22(28)16-7-3-2-4-8-16)20(21(24)27)18-10-6-12-25-14-18/h2-15,20H,1H3,(H2,24,27)/t15-,20-/m1/s1
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n/an/a 4.10E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207689
PNG
(CHEMBL3970879)
Show SMILES NC(=O)[C@H](N(Cc1cccc(OC(F)(F)F)c1)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C23H19F3N2O3/c24-23(25,26)31-19-13-7-8-16(14-19)15-28(22(30)18-11-5-2-6-12-18)20(21(27)29)17-9-3-1-4-10-17/h1-14,20H,15H2,(H2,27,29)/t20-/m1/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207655
PNG
(CHEMBL3899728)
Show SMILES NC(=O)[C@H](N(Cc1cccc(c1)C(F)(F)F)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C23H19F3N2O2/c24-23(25,26)19-13-7-8-16(14-19)15-28(22(30)18-11-5-2-6-12-18)20(21(27)29)17-9-3-1-4-10-17/h1-14,20H,15H2,(H2,27,29)/t20-/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207668
PNG
(CHEMBL3908765)
Show SMILES NC(=O)[C@H](N(Cc1ccccc1Cl)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C22H19ClN2O2/c23-19-14-8-7-13-18(19)15-25(22(27)17-11-5-2-6-12-17)20(21(24)26)16-9-3-1-4-10-16/h1-14,20H,15H2,(H2,24,26)/t20-/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207661
PNG
(CHEMBL3927831)
Show SMILES NC(=O)[C@H](N(Cc1cccc(F)c1)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C22H19FN2O2/c23-19-13-7-8-16(14-19)15-25(22(27)18-11-5-2-6-12-18)20(21(24)26)17-9-3-1-4-10-17/h1-14,20H,15H2,(H2,24,26)/t20-/m1/s1
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n/an/a 8.10E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207665
PNG
(CHEMBL3973096)
Show SMILES COc1cc(CN(CC(N)=O)C(=O)c2cccs2)ccc1OCc1ccc(F)cc1
Show InChI InChI=1S/C22H21FN2O4S/c1-28-19-11-16(6-9-18(19)29-14-15-4-7-17(23)8-5-15)12-25(13-21(24)26)22(27)20-3-2-10-30-20/h2-11H,12-14H2,1H3,(H2,24,26)
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n/an/a 9.10E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207667
PNG
(CHEMBL3972562)
Show SMILES CNC(=O)[C@H](N(Cc1cccc(OC)c1)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H24N2O3/c1-25-23(27)22(19-11-5-3-6-12-19)26(24(28)20-13-7-4-8-14-20)17-18-10-9-15-21(16-18)29-2/h3-16,22H,17H2,1-2H3,(H,25,27)/t22-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207654
PNG
(CHEMBL3900408)
Show SMILES NC(=O)[C@H](N(Cc1ccccc1)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C22H20N2O2/c23-21(25)20(18-12-6-2-7-13-18)24(16-17-10-4-1-5-11-17)22(26)19-14-8-3-9-15-19/h1-15,20H,16H2,(H2,23,25)/t20-/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207663
PNG
(CHEMBL3981569)
Show SMILES COc1cccc(CN([C@@H](C(N)=O)c2ccccc2)C(=O)Cc2ccccc2)c1 |r|
Show InChI InChI=1S/C24H24N2O3/c1-29-21-14-8-11-19(15-21)17-26(22(27)16-18-9-4-2-5-10-18)23(24(25)28)20-12-6-3-7-13-20/h2-15,23H,16-17H2,1H3,(H2,25,28)/t23-/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207669
PNG
(CHEMBL3926675)
Show SMILES CC[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H24N2O2/c1-2-21(18-12-6-3-7-13-18)26(24(28)20-16-10-5-11-17-20)22(23(25)27)19-14-8-4-9-15-19/h3-17,21-22H,2H2,1H3,(H2,25,27)/t21-,22-/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207656
PNG
(CHEMBL3979103)
Show SMILES NC(=O)[C@H](N(Cc1ccc(Cl)cc1)C(=O)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C22H19ClN2O2/c23-19-13-11-16(12-14-19)15-25(22(27)18-9-5-2-6-10-18)20(21(24)26)17-7-3-1-4-8-17/h1-14,20H,15H2,(H2,24,26)/t20-/m1/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))		BDBM50207645
PNG
(CHEMBL3971179)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C23H20F2N2O2/c1-15(18-12-19(24)14-20(25)13-18)27(23(29)17-10-6-3-7-11-17)21(22(26)28)16-8-4-2-5-9-16/h2-15,21H,1H3,(H2,26,28)/t15-,21-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced calcium increase by Fluo-4 AM based a...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50207645
PNG
(CHEMBL3971179)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C23H20F2N2O2/c1-15(18-12-19(24)14-20(25)13-18)27(23(29)17-10-6-3-7-11-17)21(22(26)28)16-8-4-2-5-9-16/h2-15,21H,1H3,(H2,26,28)/t15-,21-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium increase by Fluo-4 AM ba...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50207645
PNG
(CHEMBL3971179)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C23H20F2N2O2/c1-15(18-12-19(24)14-20(25)13-18)27(23(29)17-10-6-3-7-11-17)21(22(26)28)16-8-4-2-5-9-16/h2-15,21H,1H3,(H2,26,28)/t15-,21-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in HEK293 cells assessed as inhibition of RN-1747-induced calcium increase by Fura-2 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207666
PNG
(CHEMBL3892508)
Show SMILES COc1cccc(CN([C@H](Cc2ccccc2)C(N)=O)C(=O)c2cccs2)c1 |r|
Show InChI InChI=1S/C22H22N2O3S/c1-27-18-10-5-9-17(13-18)15-24(22(26)20-11-6-12-28-20)19(21(23)25)14-16-7-3-2-4-8-16/h2-13,19H,14-15H2,1H3,(H2,23,25)/t19-/m1/s1
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n/an/a 3.70E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207595
PNG
(CHEMBL3889714)
Show SMILES COc1cccc(c1)[C@H](C)N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H24N2O3/c1-17(20-14-9-15-21(16-20)29-2)26(24(28)19-12-7-4-8-13-19)22(23(25)27)18-10-5-3-6-11-18/h3-17,22H,1-2H3,(H2,25,27)/t17-,22+/m0/s1
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n/an/a 4.30E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207650
PNG
(CHEMBL3908930)
Show SMILES COc1cccc(CN([C@H](C(N)=O)c2ccccc2)C(=O)c2cccs2)c1 |r|
Show InChI InChI=1S/C21H20N2O3S/c1-26-17-10-5-7-15(13-17)14-23(21(25)18-11-6-12-27-18)19(20(22)24)16-8-3-2-4-9-16/h2-13,19H,14H2,1H3,(H2,22,24)/t19-/m0/s1
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n/an/a 5.40E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207652
PNG
(CHEMBL3910516)
Show SMILES COc1cccc(CN(C(C(O)=O)c2ccccc2)C(=O)c2ccccc2)c1
Show InChI InChI=1S/C23H21NO4/c1-28-20-14-8-9-17(15-20)16-24(22(25)19-12-6-3-7-13-19)21(23(26)27)18-10-4-2-5-11-18/h2-15,21H,16H2,1H3,(H,26,27)
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n/an/a 5.90E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207653
PNG
(CHEMBL3901461)
Show SMILES COc1cccc(CN([C@@H](C(=O)N(C)C)c2ccccc2)C(=O)c2ccccc2)c1 |r|
Show InChI InChI=1S/C25H26N2O3/c1-26(2)25(29)23(20-12-6-4-7-13-20)27(24(28)21-14-8-5-9-15-21)18-19-11-10-16-22(17-19)30-3/h4-17,23H,18H2,1-3H3/t23-/m1/s1
PDB

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n/an/a 8.60E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207648
PNG
(CHEMBL3952818)
Show SMILES COc1cccc(CN([C@H](C)C(N)=O)C(=O)c2ccccc2)c1 |r|
Show InChI InChI=1S/C18H20N2O3/c1-13(17(19)21)20(18(22)15-8-4-3-5-9-15)12-14-7-6-10-16(11-14)23-2/h3-11,13H,12H2,1-2H3,(H2,19,21)/t13-/m1/s1
PDB

KEGG

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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50207567
PNG
(CHEMBL3936873)
Show SMILES COc1cc(CN([C@@H](C(N)=O)c2ccccc2)C(=O)c2cccs2)ccc1OCc1ccc(F)cc1 |r|
Show InChI InChI=1S/C28H25FN2O4S/c1-34-24-16-20(11-14-23(24)35-18-19-9-12-22(29)13-10-19)17-31(28(33)25-8-5-15-36-25)26(27(30)32)21-6-3-2-4-7-21/h2-16,26H,17-18H2,1H3,(H2,30,32)/t26-/m1/s1
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KEGG

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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))		BDBM50207645
PNG
(CHEMBL3971179)
Show SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C23H20F2N2O2/c1-15(18-12-19(24)14-20(25)13-18)27(23(29)17-10-6-3-7-11-17)21(22(26)28)16-8-4-2-5-9-16/h2-15,21H,1H3,(H2,26,28)/t15-,21-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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n/an/an/an/a>3.00E+4n/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant TRPA1 expressed in HEK293 cells assessed as increase in calcium flux by Fluo-4-AM based assay

Bioorg Med Chem 25: 727-742 (2017)


Article DOI: 10.1016/j.bmc.2016.11.049
BindingDB Entry DOI: 10.7270/Q2445PF7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%