Affinity Data by PubMed id=27992102

PubMed code 27992102

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	8.1	n/a
University of Siena					Assay Description The RNA-dependent DNA polymerase (RDDP) activity associated with HIV-1 RT was measured by use of the Invitrogen EnzCheck Reverse Transcriptase Assay ...				Chembiochem 18: 374-377 (2017) Article DOI: 10.1002/cbic.201600592 BindingDB Entry DOI: 10.7270/Q2N29VS8
University of Siena					More data for this Ligand-Target Pair				3D Structure (crystal)
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM50179009 (CHEMBL377937 \| Kuwanon L) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	7.8	n/a
University of Siena					Assay Description The RNase H activity associated with HIV-1 RT was measured in a 100 mL reactionvolume containing Tris�HCl (pH 7.8, 50 mm), MgCl2 (6 mm), dithiothreit...				Chembiochem 18: 374-377 (2017) Article DOI: 10.1002/cbic.201600592 BindingDB Entry DOI: 10.7270/Q2N29VS8
University of Siena					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM50179009 (CHEMBL377937 \| Kuwanon L) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	8.1	n/a
University of Siena					Assay Description The RNA-dependent DNA polymerase (RDDP) activity associated with HIV-1 RT was measured by use of the Invitrogen EnzCheck Reverse Transcriptase Assay ...				Chembiochem 18: 374-377 (2017) Article DOI: 10.1002/cbic.201600592 BindingDB Entry DOI: 10.7270/Q2N29VS8
University of Siena					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189342 (RDS1759) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	7.8	n/a
University of Siena					Assay Description The RNase H activity associated with HIV-1 RT was measured in a 100 mL reactionvolume containing Tris�HCl (pH 7.8, 50 mm), MgCl2 (6 mm), dithiothreit...				Chembiochem 18: 374-377 (2017) Article DOI: 10.1002/cbic.201600592 BindingDB Entry DOI: 10.7270/Q2N29VS8
University of Siena					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.8	n/a
University of Siena					Assay Description The RNase H activity associated with HIV-1 RT was measured in a 100 mL reactionvolume containing Tris�HCl (pH 7.8, 50 mm), MgCl2 (6 mm), dithiothreit...				Chembiochem 18: 374-377 (2017) Article DOI: 10.1002/cbic.201600592 BindingDB Entry DOI: 10.7270/Q2N29VS8
University of Siena					More data for this Ligand-Target Pair				3D Structure (crystal)
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189342 (RDS1759) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	8.1	n/a
University of Siena					Assay Description The RNA-dependent DNA polymerase (RDDP) activity associated with HIV-1 RT was measured by use of the Invitrogen EnzCheck Reverse Transcriptase Assay ...				Chembiochem 18: 374-377 (2017) Article DOI: 10.1002/cbic.201600592 BindingDB Entry DOI: 10.7270/Q2N29VS8
University of Siena					More data for this Ligand-Target Pair

* indicates data uncertainty>20%