Found 6 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50201033
(CHEMBL3924812)Show SMILES Cc1ccc(NC(=O)c2cc(ccn2)C(F)(F)F)cc1-c1cc(OCC(O)CP(O)(O)=O)nc(c1)N1CCOCC1 Show InChI InChI=1S/C26H28F3N4O7P/c1-16-2-3-19(31-25(35)22-12-18(4-5-30-22)26(27,28)29)13-21(16)17-10-23(33-6-8-39-9-7-33)32-24(11-17)40-14-20(34)15-41(36,37)38/h2-5,10-13,20,34H,6-9,14-15H2,1H3,(H,31,35)(H2,36,37,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Inhibition of 1 to 324 residues truncated c-Raf (unknown origin) expressed in baculovirus infected Sf9 insect cells using full length biotinylated ME... |
ACS Med Chem Lett 7: 1022-1023 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00435 BindingDB Entry DOI: 10.7270/Q27S7QRX |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50201031
(CHEMBL3961999)Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cnc(OCCOP(O)(O)=O)c(c1)N1CCOCC1 Show InChI InChI=1S/C25H26F3N4O7P/c1-16-2-3-19(31-23(33)17-4-5-29-22(13-17)25(26,27)28)14-20(16)18-12-21(32-6-8-37-9-7-32)24(30-15-18)38-10-11-39-40(34,35)36/h2-5,12-15H,6-11H2,1H3,(H,31,33)(H2,34,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Inhibition of 1 to 324 residues truncated c-Raf (unknown origin) expressed in baculovirus infected Sf9 insect cells using full length biotinylated ME... |
ACS Med Chem Lett 7: 1022-1023 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00435 BindingDB Entry DOI: 10.7270/Q27S7QRX |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50201030
(CHEMBL3929689)Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(OCCOP(O)(O)=O)nc(c1)N1CCOCC1 Show InChI InChI=1S/C25H26F3N4O7P/c1-16-2-3-19(30-24(33)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-8-37-9-7-32)31-23(14-18)38-10-11-39-40(34,35)36/h2-5,12-15H,6-11H2,1H3,(H,30,33)(H2,34,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Inhibition of 1 to 324 residues truncated c-Raf (unknown origin) expressed in baculovirus infected Sf9 insect cells using full length biotinylated ME... |
ACS Med Chem Lett 7: 1022-1023 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00435 BindingDB Entry DOI: 10.7270/Q27S7QRX |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50201034
(CHEMBL3952506)Show SMILES C[C@@H]1COCCN1c1cc(cc(OCCOP(O)(O)=O)n1)-c1cc(NC(=O)c2ccnc(c2)C(C)(F)F)ccc1C |r| Show InChI InChI=1S/C27H31F2N4O7P/c1-17-4-5-21(31-26(34)19-6-7-30-23(12-19)27(3,28)29)15-22(17)20-13-24(33-8-9-38-16-18(33)2)32-25(14-20)39-10-11-40-41(35,36)37/h4-7,12-15,18H,8-11,16H2,1-3H3,(H,31,34)(H2,35,36,37)/t18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Inhibition of 1 to 324 residues truncated c-Raf (unknown origin) expressed in baculovirus infected Sf9 insect cells using full length biotinylated ME... |
ACS Med Chem Lett 7: 1022-1023 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00435 BindingDB Entry DOI: 10.7270/Q27S7QRX |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50201029
(CHEMBL3892987)Show SMILES C[C@@H]1COCCN1c1cc(cc(OCCOP(O)(O)=O)n1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C |r| Show InChI InChI=1S/C26H28F3N4O7P/c1-16-3-4-20(31-25(34)18-5-6-30-22(11-18)26(27,28)29)14-21(16)19-12-23(33-7-8-38-15-17(33)2)32-24(13-19)39-9-10-40-41(35,36)37/h3-6,11-14,17H,7-10,15H2,1-2H3,(H,31,34)(H2,35,36,37)/t17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Inhibition of 1 to 324 residues truncated c-Raf (unknown origin) expressed in baculovirus infected Sf9 insect cells using full length biotinylated ME... |
ACS Med Chem Lett 7: 1022-1023 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00435 BindingDB Entry DOI: 10.7270/Q27S7QRX |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50201032
(CHEMBL3958235)Show SMILES C[C@@H]1COCCN1c1cc(cc(OCCOP(O)(O)=O)n1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C |r| Show InChI InChI=1S/C27H29F3N3O7P/c1-17-6-7-22(31-26(34)19-4-3-5-21(12-19)27(28,29)30)15-23(17)20-13-24(33-8-9-38-16-18(33)2)32-25(14-20)39-10-11-40-41(35,36)37/h3-7,12-15,18H,8-11,16H2,1-2H3,(H,31,34)(H2,35,36,37)/t18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Inhibition of 1 to 324 residues truncated c-Raf (unknown origin) expressed in baculovirus infected Sf9 insect cells using full length biotinylated ME... |
ACS Med Chem Lett 7: 1022-1023 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00435 BindingDB Entry DOI: 10.7270/Q27S7QRX |
More data for this Ligand-Target Pair | |