Found 140 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234161
(CHEMBL4091680)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C23H21N7O/c1-30-22(23(11-12-23)16-5-3-2-4-6-16)28-21(29-30)17-13-26-19(24)18(27-17)14-7-9-15(10-8-14)20(25)31/h2-10,13H,11-12H2,1H3,(H2,24,26)(H2,25,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234157
(CHEMBL4089227)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C Show InChI InChI=1S/C22H24N8O/c1-21(2,3)20-28-27-18(31-20)15-16(23)24-12-14(25-15)17-26-19(30(4)29-17)22(10-11-22)13-8-6-5-7-9-13/h5-9,12H,10-11H2,1-4H3,(H2,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234157
(CHEMBL4089227)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C Show InChI InChI=1S/C22H24N8O/c1-21(2,3)20-28-27-18(31-20)15-16(23)24-12-14(25-15)17-26-19(30(4)29-17)22(10-11-22)13-8-6-5-7-9-13/h5-9,12H,10-11H2,1-4H3,(H2,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.631 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234161
(CHEMBL4091680)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C23H21N7O/c1-30-22(23(11-12-23)16-5-3-2-4-6-16)28-21(29-30)17-13-26-19(24)18(27-17)14-7-9-15(10-8-14)20(25)31/h2-10,13H,11-12H2,1H3,(H2,24,26)(H2,25,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.631 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.794 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.794 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234158
(CHEMBL4072500)Show SMILES CN(C)S(=O)(=O)n1cc(cn1)-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 Show InChI InChI=1S/C21H23N9O2S/c1-28(2)33(31,32)30-13-14(11-24-30)17-18(22)23-12-16(25-17)19-26-20(29(3)27-19)21(9-10-21)15-7-5-4-6-8-15/h4-8,11-13H,9-10H2,1-3H3,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.794 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PI3K subunit p110gamma assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234158
(CHEMBL4072500)Show SMILES CN(C)S(=O)(=O)n1cc(cn1)-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 Show InChI InChI=1S/C21H23N9O2S/c1-28(2)33(31,32)30-13-14(11-24-30)17-18(22)23-12-16(25-17)19-26-20(29(3)27-19)21(9-10-21)15-7-5-4-6-8-15/h4-8,11-13H,9-10H2,1-3H3,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234159
(CHEMBL4099419)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1cc(cn1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-19(20(7-8-20)13-5-3-2-4-6-13)26-17(27-28)14-10-23-15(21)18(25-14)29-11-12(9-24-29)16(22)30/h2-6,9-11H,7-8H2,1H3,(H2,21,23)(H2,22,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234154
(CHEMBL4100327)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C24H21N7/c1-31-23(24(11-12-24)15-7-3-2-4-8-15)29-22(30-31)19-14-27-21(25)20(28-19)17-13-26-18-10-6-5-9-16(17)18/h2-10,13-14,26H,11-12H2,1H3,(H2,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234150
(CHEMBL4061634)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C22H19N9/c1-30-21(22(11-12-22)14-7-3-2-4-8-14)26-19(28-30)16-13-24-18(23)20(25-16)31-17-10-6-5-9-15(17)27-29-31/h2-10,13H,11-12H2,1H3,(H2,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234150
(CHEMBL4061634)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C22H19N9/c1-30-21(22(11-12-22)14-7-3-2-4-8-14)26-19(28-30)16-13-24-18(23)20(25-16)31-17-10-6-5-9-15(17)27-29-31/h2-10,13H,11-12H2,1H3,(H2,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234143
(CHEMBL4091640)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cn[nH]c1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(7-8-19)13-5-3-2-4-6-13)25-17(26-27)14-11-21-16(20)15(24-14)12-9-22-23-10-12/h2-6,9-11H,7-8H2,1H3,(H2,20,21)(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234152
(CHEMBL4092139)Show SMILES Cn1nc(nc1C1(Cc2ccccc2)CC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C23H21N9/c1-31-22(23(11-12-23)13-15-7-3-2-4-8-15)27-20(29-31)17-14-25-19(24)21(26-17)32-18-10-6-5-9-16(18)28-30-32/h2-10,14H,11-13H2,1H3,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234143
(CHEMBL4091640)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cn[nH]c1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(7-8-19)13-5-3-2-4-6-13)25-17(26-27)14-11-21-16(20)15(24-14)12-9-22-23-10-12/h2-6,9-11H,7-8H2,1H3,(H2,20,21)(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234168
(CHEMBL4061055)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cnn(c1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-18(20(7-8-20)13-5-3-2-4-6-13)26-17(27-28)14-10-23-16(21)15(25-14)12-9-24-29(11-12)19(22)30/h2-6,9-11H,7-8H2,1H3,(H2,21,23)(H2,22,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234170
(CHEMBL4068963)Show SMILES Cn1nc(nc1-c1cnc(N)c(n1)-n1nnc2ccccc12)C1(CC1)c1ccccc1 Show InChI InChI=1S/C22H19N9/c1-30-19(26-21(28-30)22(11-12-22)14-7-3-2-4-8-14)16-13-24-18(23)20(25-16)31-17-10-6-5-9-15(17)27-29-31/h2-10,13H,11-12H2,1H3,(H2,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234166
(CHEMBL4070762)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(N)nc1 Show InChI InChI=1S/C21H20N8/c1-29-20(21(9-10-21)14-5-3-2-4-6-14)27-19(28-29)15-12-25-18(23)17(26-15)13-7-8-16(22)24-11-13/h2-8,11-12H,9-10H2,1H3,(H2,22,24)(H2,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234153
(CHEMBL4060598)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1ncc2ccccc12 Show InChI InChI=1S/C23H20N8/c1-30-22(23(11-12-23)16-8-3-2-4-9-16)28-20(29-30)17-14-25-19(24)21(27-17)31-18-10-6-5-7-15(18)13-26-31/h2-10,13-14H,11-12H2,1H3,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234163
(CHEMBL4082434)Show SMILES Cn1nc(nc1C(C)(C)C1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C21H25N9O/c1-21(2,13-8-10-31-11-9-13)20-25-18(27-29(20)3)15-12-23-17(22)19(24-15)30-16-7-5-4-6-14(16)26-28-30/h4-7,12-13H,8-11H2,1-3H3,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234157
(CHEMBL4089227)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C Show InChI InChI=1S/C22H24N8O/c1-21(2,3)20-28-27-18(31-20)15-16(23)24-12-14(25-15)17-26-19(30(4)29-17)22(10-11-22)13-8-6-5-7-9-13/h5-9,12H,10-11H2,1-4H3,(H2,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta-mediated AKT phosphorylation at ser473 residue in human JeKo1 cells preincubated for 60 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234171
(CHEMBL4090043)Show SMILES Nc1ncc(nc1-n1nnc2ccccc12)-c1n[nH]c(n1)C1(CC1)c1ccccc1 Show InChI InChI=1S/C21H17N9/c22-17-19(30-16-9-5-4-8-14(16)26-29-30)24-15(12-23-17)18-25-20(28-27-18)21(10-11-21)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H2,22,23)(H,25,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234145
(CHEMBL4096090)Show SMILES Cn1nc(nc1Cc1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H17N9/c1-28-17(11-13-7-3-2-4-8-13)24-19(26-28)15-12-22-18(21)20(23-15)29-16-10-6-5-9-14(16)25-27-29/h2-10,12H,11H2,1H3,(H2,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234147
(CHEMBL4092724)Show SMILES Cn1nc(nc1CC1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C19H21N9O/c1-27-16(10-12-6-8-29-9-7-12)23-18(25-27)14-11-21-17(20)19(22-14)28-15-5-3-2-4-13(15)24-26-28/h2-5,11-12H,6-10H2,1H3,(H2,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234146
(CHEMBL4064890)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(F)nc1 Show InChI InChI=1S/C21H18FN7/c1-29-20(21(9-10-21)14-5-3-2-4-6-14)27-19(28-29)15-12-25-18(23)17(26-15)13-7-8-16(22)24-11-13/h2-8,11-12H,9-10H2,1H3,(H2,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234149
(CHEMBL4099886)Show SMILES C[C@H](c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12)c1ccccc1 |r| Show InChI InChI=1S/C21H19N9/c1-13(14-8-4-3-5-9-14)20-25-19(27-29(20)2)16-12-23-18(22)21(24-16)30-17-11-7-6-10-15(17)26-28-30/h3-13H,1-2H3,(H2,22,23)/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234161
(CHEMBL4091680)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C23H21N7O/c1-30-22(23(11-12-23)16-5-3-2-4-6-16)28-21(29-30)17-13-26-19(24)18(27-17)14-7-9-15(10-8-14)20(25)31/h2-10,13H,11-12H2,1H3,(H2,24,26)(H2,25,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta-mediated AKT phosphorylation at ser473 residue in human JeKo1 cells preincubated for 60 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234172
(CHEMBL4088819)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1cnc2ccccc12 Show InChI InChI=1S/C23H20N8/c1-30-22(23(11-12-23)15-7-3-2-4-8-15)28-20(29-30)17-13-25-19(24)21(27-17)31-14-26-16-9-5-6-10-18(16)31/h2-10,13-14H,11-12H2,1H3,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234167
(CHEMBL4062135)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cc[nH]n1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(8-9-19)12-5-3-2-4-6-12)24-17(26-27)14-11-21-16(20)15(23-14)13-7-10-22-25-13/h2-7,10-11H,8-9H2,1H3,(H2,20,21)(H,22,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234160
(CHEMBL4063902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1ccc(n1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-19(20(8-9-20)12-5-3-2-4-6-12)25-17(27-28)14-11-23-15(21)18(24-14)29-10-7-13(26-29)16(22)30/h2-7,10-11H,8-9H2,1H3,(H2,21,23)(H2,22,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234164
(CHEMBL4100450)Show SMILES Cn1nc(nc1CN1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C18H20N10O/c1-26-15(11-27-6-8-29-9-7-27)22-17(24-26)13-10-20-16(19)18(21-13)28-14-5-3-2-4-12(14)23-25-28/h2-5,10H,6-9,11H2,1H3,(H2,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234165
(CHEMBL4090281)Show SMILES C[C@H](N1CCOCC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 |r| Show InChI InChI=1S/C19H22N10O/c1-12(28-7-9-30-10-8-28)18-23-17(25-27(18)2)14-11-21-16(20)19(22-14)29-15-6-4-3-5-13(15)24-26-29/h3-6,11-12H,7-10H2,1-2H3,(H2,20,21)/t12-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234157
(CHEMBL4089227)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C Show InChI InChI=1S/C22H24N8O/c1-21(2,3)20-28-27-18(31-20)15-16(23)24-12-14(25-15)17-26-19(30(4)29-17)22(10-11-22)13-8-6-5-7-9-13/h5-9,12H,10-11H2,1-4H3,(H2,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234158
(CHEMBL4072500)Show SMILES CN(C)S(=O)(=O)n1cc(cn1)-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 Show InChI InChI=1S/C21H23N9O2S/c1-28(2)33(31,32)30-13-14(11-24-30)17-18(22)23-12-16(25-17)19-26-20(29(3)27-19)21(9-10-21)15-7-5-4-6-8-15/h4-8,11-13H,9-10H2,1-3H3,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta-mediated AKT phosphorylation at ser473 residue in human JeKo1 cells preincubated for 60 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234173
(CHEMBL4062277)Show SMILES C[C@@H](N1CCOCC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 |r| Show InChI InChI=1S/C19H22N10O/c1-12(28-7-9-30-10-8-28)18-23-17(25-27(18)2)14-11-21-16(20)19(22-14)29-15-6-4-3-5-13(15)24-26-29/h3-6,11-12H,7-10H2,1-2H3,(H2,20,21)/t12-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234143
(CHEMBL4091640)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cn[nH]c1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(7-8-19)13-5-3-2-4-6-13)25-17(26-27)14-11-21-16(20)15(24-14)12-9-22-23-10-12/h2-6,9-11H,7-8H2,1H3,(H2,20,21)(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta-mediated AKT phosphorylation at ser473 residue in human JeKo1 cells preincubated for 60 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta-mediated AKT phosphorylation at ser473 residue in human JeKo1 cells preincubated for 60 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234140
(CHEMBL4102352)Show SMILES Cn1nc(nc1C1(CO)CC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C17H17N9O/c1-25-16(17(9-27)6-7-17)21-14(23-25)11-8-19-13(18)15(20-11)26-12-5-3-2-4-10(12)22-24-26/h2-5,8,27H,6-7,9H2,1H3,(H2,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234142
(CHEMBL4078043)Show SMILES Cn1nc(nc1C1(CC1)N1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H22N10O/c1-28-19(20(6-7-20)29-8-10-31-11-9-29)24-17(26-28)14-12-22-16(21)18(23-14)30-15-5-3-2-4-13(15)25-27-30/h2-5,12H,6-11H2,1H3,(H2,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged recombinant human DYRK1A expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234148
(CHEMBL4064432)Show SMILES CN1CCN(CC1)C1(CC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C21H25N11/c1-29-9-11-31(12-10-29)21(7-8-21)20-25-18(27-30(20)2)15-13-23-17(22)19(24-15)32-16-6-4-3-5-14(16)26-28-32/h3-6,13H,7-12H2,1-2H3,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234145
(CHEMBL4096090)Show SMILES Cn1nc(nc1Cc1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H17N9/c1-28-17(11-13-7-3-2-4-8-13)24-19(26-28)15-12-22-18(21)20(23-15)29-16-10-6-5-9-14(16)25-27-29/h2-10,12H,11H2,1H3,(H2,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234140
(CHEMBL4102352)Show SMILES Cn1nc(nc1C1(CO)CC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C17H17N9O/c1-25-16(17(9-27)6-7-17)21-14(23-25)11-8-19-13(18)15(20-11)26-12-5-3-2-4-10(12)22-24-26/h2-5,8,27H,6-7,9H2,1H3,(H2,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234147
(CHEMBL4092724)Show SMILES Cn1nc(nc1CC1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C19H21N9O/c1-27-16(10-12-6-8-29-9-7-12)23-18(25-27)14-11-21-17(20)19(22-14)28-15-5-3-2-4-13(15)24-26-28/h2-5,11-12H,6-10H2,1H3,(H2,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234154
(CHEMBL4100327)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C24H21N7/c1-31-23(24(11-12-24)15-7-3-2-4-8-15)29-22(30-31)19-14-27-21(25)20(28-19)17-13-26-18-10-6-5-9-16(17)18/h2-10,13-14,26H,11-12H2,1H3,(H2,25,27) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234152
(CHEMBL4092139)Show SMILES Cn1nc(nc1C1(Cc2ccccc2)CC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C23H21N9/c1-31-22(23(11-12-23)13-15-7-3-2-4-8-15)27-20(29-31)17-14-25-19(24)21(26-17)32-18-10-6-5-9-16(18)28-30-32/h2-10,14H,11-13H2,1H3,(H2,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234164
(CHEMBL4100450)Show SMILES Cn1nc(nc1CN1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C18H20N10O/c1-26-15(11-27-6-8-29-9-7-27)22-17(24-26)13-10-20-16(19)18(21-13)28-14-5-3-2-4-12(14)23-25-28/h2-5,10H,6-9,11H2,1H3,(H2,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234150
(CHEMBL4061634)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C22H19N9/c1-30-21(22(11-12-22)14-7-3-2-4-8-14)26-19(28-30)16-13-24-18(23)20(25-16)31-17-10-6-5-9-15(17)27-29-31/h2-10,13H,11-12H2,1H3,(H2,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234157
(CHEMBL4089227)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C Show InChI InChI=1S/C22H24N8O/c1-21(2,3)20-28-27-18(31-20)15-16(23)24-12-14(25-15)17-26-19(30(4)29-17)22(10-11-22)13-8-6-5-7-9-13/h5-9,12H,10-11H2,1-4H3,(H2,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Endothelin-converting enzyme 1
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-tagged truncated recombinant human ECE1 expressed in mammalian expression system |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234151
(CHEMBL4084383)Show SMILES Cn1nc(nc1C1(CC1)S(C)(=O)=O)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C17H17N9O2S/c1-25-16(17(7-8-17)29(2,27)28)21-14(23-25)11-9-19-13(18)15(20-11)26-12-6-4-3-5-10(12)22-24-26/h3-6,9H,7-8H2,1-2H3,(H2,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234163
(CHEMBL4082434)Show SMILES Cn1nc(nc1C(C)(C)C1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C21H25N9O/c1-21(2,13-8-10-31-11-9-13)20-25-18(27-29(20)3)15-12-23-17(22)19(24-15)30-16-7-5-4-6-14(16)26-28-30/h4-7,12-13H,8-11H2,1-3H3,(H2,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234156
(CHEMBL4092591)Show InChI InChI=1S/C17H15N7/c1-24-16(17(7-8-17)11-5-3-2-4-6-11)22-15(23-24)13-10-20-14(19)12(9-18)21-13/h2-6,10H,7-8H2,1H3,(H2,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234147
(CHEMBL4092724)Show SMILES Cn1nc(nc1CC1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C19H21N9O/c1-27-16(10-12-6-8-29-9-7-12)23-18(25-27)14-11-21-17(20)19(22-14)28-15-5-3-2-4-13(15)24-26-28/h2-5,11-12H,6-10H2,1H3,(H2,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234145
(CHEMBL4096090)Show SMILES Cn1nc(nc1Cc1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H17N9/c1-28-17(11-13-7-3-2-4-8-13)24-19(26-28)15-12-22-18(21)20(23-15)29-16-10-6-5-9-14(16)25-27-29/h2-10,12H,11H2,1H3,(H2,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged recombinant human DYRK1B expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234158
(CHEMBL4072500)Show SMILES CN(C)S(=O)(=O)n1cc(cn1)-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 Show InChI InChI=1S/C21H23N9O2S/c1-28(2)33(31,32)30-13-14(11-24-30)17-18(22)23-12-16(25-17)19-26-20(29(3)27-19)21(9-10-21)15-7-5-4-6-8-15/h4-8,11-13H,9-10H2,1-3H3,(H2,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234152
(CHEMBL4092139)Show SMILES Cn1nc(nc1C1(Cc2ccccc2)CC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C23H21N9/c1-31-22(23(11-12-23)13-15-7-3-2-4-8-15)27-20(29-31)17-14-25-19(24)21(26-17)32-18-10-6-5-9-16(18)28-30-32/h2-10,14H,11-13H2,1H3,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234163
(CHEMBL4082434)Show SMILES Cn1nc(nc1C(C)(C)C1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C21H25N9O/c1-21(2,13-8-10-31-11-9-13)20-25-18(27-29(20)3)15-12-23-17(22)19(24-15)30-16-7-5-4-6-14(16)26-28-30/h4-7,12-13H,8-11H2,1-3H3,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234164
(CHEMBL4100450)Show SMILES Cn1nc(nc1CN1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C18H20N10O/c1-26-15(11-27-6-8-29-9-7-27)22-17(24-26)13-10-20-16(19)18(21-13)28-14-5-3-2-4-12(14)23-25-28/h2-5,10H,6-9,11H2,1H3,(H2,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234154
(CHEMBL4100327)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C24H21N7/c1-31-23(24(11-12-24)15-7-3-2-4-8-15)29-22(30-31)19-14-27-21(25)20(28-19)17-13-26-18-10-6-5-9-16(17)18/h2-10,13-14,26H,11-12H2,1H3,(H2,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform gamma-3
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged recombinant human CSNK1G3 expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234149
(CHEMBL4099886)Show SMILES C[C@H](c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12)c1ccccc1 |r| Show InChI InChI=1S/C21H19N9/c1-13(14-8-4-3-5-9-14)20-25-19(27-29(20)2)16-12-23-18(22)21(24-16)30-17-11-7-6-10-15(17)26-28-30/h3-13H,1-2H3,(H2,22,23)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234151
(CHEMBL4084383)Show SMILES Cn1nc(nc1C1(CC1)S(C)(=O)=O)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C17H17N9O2S/c1-25-16(17(7-8-17)29(2,27)28)21-14(23-25)11-9-19-13(18)15(20-11)26-12-6-4-3-5-10(12)22-24-26/h3-6,9H,7-8H2,1-2H3,(H2,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234149
(CHEMBL4099886)Show SMILES C[C@H](c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12)c1ccccc1 |r| Show InChI InChI=1S/C21H19N9/c1-13(14-8-4-3-5-9-14)20-25-19(27-29(20)2)16-12-23-18(22)21(24-16)30-17-11-7-6-10-15(17)26-28-30/h3-13H,1-2H3,(H2,22,23)/t13-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234150
(CHEMBL4061634)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C22H19N9/c1-30-21(22(11-12-22)14-7-3-2-4-8-14)26-19(28-30)16-13-24-18(23)20(25-16)31-17-10-6-5-9-15(17)27-29-31/h2-10,13H,11-12H2,1H3,(H2,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234159
(CHEMBL4099419)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1cc(cn1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-19(20(7-8-20)13-5-3-2-4-6-13)26-17(27-28)14-10-23-15(21)18(25-14)29-11-12(9-24-29)16(22)30/h2-6,9-11H,7-8H2,1H3,(H2,21,23)(H2,22,30) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234140
(CHEMBL4102352)Show SMILES Cn1nc(nc1C1(CO)CC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C17H17N9O/c1-25-16(17(9-27)6-7-17)21-14(23-25)11-8-19-13(18)15(20-11)26-12-5-3-2-4-10(12)22-24-26/h2-5,8,27H,6-7,9H2,1H3,(H2,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of 5HT1A receptor (unknown origin) |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234145
(CHEMBL4096090)Show SMILES Cn1nc(nc1Cc1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H17N9/c1-28-17(11-13-7-3-2-4-8-13)24-19(26-28)15-12-22-18(21)20(23-15)29-16-10-6-5-9-14(16)25-27-29/h2-10,12H,11H2,1H3,(H2,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234164
(CHEMBL4100450)Show SMILES Cn1nc(nc1CN1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C18H20N10O/c1-26-15(11-27-6-8-29-9-7-27)22-17(24-26)13-10-20-16(19)18(21-13)28-14-5-3-2-4-12(14)23-25-28/h2-5,10H,6-9,11H2,1H3,(H2,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234158
(CHEMBL4072500)Show SMILES CN(C)S(=O)(=O)n1cc(cn1)-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 Show InChI InChI=1S/C21H23N9O2S/c1-28(2)33(31,32)30-13-14(11-24-30)17-18(22)23-12-16(25-17)19-26-20(29(3)27-19)21(9-10-21)15-7-5-4-6-8-15/h4-8,11-13H,9-10H2,1-3H3,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234151
(CHEMBL4084383)Show SMILES Cn1nc(nc1C1(CC1)S(C)(=O)=O)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C17H17N9O2S/c1-25-16(17(7-8-17)29(2,27)28)21-14(23-25)11-9-19-13(18)15(20-11)26-12-6-4-3-5-10(12)22-24-26/h3-6,9H,7-8H2,1-2H3,(H2,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234147
(CHEMBL4092724)Show SMILES Cn1nc(nc1CC1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C19H21N9O/c1-27-16(10-12-6-8-29-9-7-12)23-18(25-27)14-11-21-17(20)19(22-14)28-15-5-3-2-4-13(15)24-26-28/h2-5,11-12H,6-10H2,1H3,(H2,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234142
(CHEMBL4078043)Show SMILES Cn1nc(nc1C1(CC1)N1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H22N10O/c1-28-19(20(6-7-20)29-8-10-31-11-9-29)24-17(26-28)14-12-22-16(21)18(23-14)30-15-5-3-2-4-13(15)25-27-30/h2-5,12H,6-11H2,1H3,(H2,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234173
(CHEMBL4062277)Show SMILES C[C@@H](N1CCOCC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 |r| Show InChI InChI=1S/C19H22N10O/c1-12(28-7-9-30-10-8-28)18-23-17(25-27(18)2)14-11-21-16(20)19(22-14)29-15-6-4-3-5-13(15)24-26-29/h3-6,11-12H,7-10H2,1-2H3,(H2,20,21)/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234159
(CHEMBL4099419)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1cc(cn1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-19(20(7-8-20)13-5-3-2-4-6-13)26-17(27-28)14-10-23-15(21)18(25-14)29-11-12(9-24-29)16(22)30/h2-6,9-11H,7-8H2,1H3,(H2,21,23)(H2,22,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234157
(CHEMBL4089227)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C Show InChI InChI=1S/C22H24N8O/c1-21(2,3)20-28-27-18(31-20)15-16(23)24-12-14(25-15)17-26-19(30(4)29-17)22(10-11-22)13-8-6-5-7-9-13/h5-9,12H,10-11H2,1-4H3,(H2,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234161
(CHEMBL4091680)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C23H21N7O/c1-30-22(23(11-12-23)16-5-3-2-4-6-16)28-21(29-30)17-13-26-19(24)18(27-17)14-7-9-15(10-8-14)20(25)31/h2-10,13H,11-12H2,1H3,(H2,24,26)(H2,25,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234173
(CHEMBL4062277)Show SMILES C[C@@H](N1CCOCC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 |r| Show InChI InChI=1S/C19H22N10O/c1-12(28-7-9-30-10-8-28)18-23-17(25-27(18)2)14-11-21-16(20)19(22-14)29-15-6-4-3-5-13(15)24-26-29/h3-6,11-12H,7-10H2,1-2H3,(H2,20,21)/t12-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234142
(CHEMBL4078043)Show SMILES Cn1nc(nc1C1(CC1)N1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H22N10O/c1-28-19(20(6-7-20)29-8-10-31-11-9-29)24-17(26-28)14-12-22-16(21)18(23-14)30-15-5-3-2-4-13(15)25-27-30/h2-5,12H,6-11H2,1H3,(H2,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234165
(CHEMBL4090281)Show SMILES C[C@H](N1CCOCC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 |r| Show InChI InChI=1S/C19H22N10O/c1-12(28-7-9-30-10-8-28)18-23-17(25-27(18)2)14-11-21-16(20)19(22-14)29-15-6-4-3-5-13(15)24-26-29/h3-6,11-12H,7-10H2,1-2H3,(H2,20,21)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234161
(CHEMBL4091680)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C23H21N7O/c1-30-22(23(11-12-23)16-5-3-2-4-6-16)28-21(29-30)17-13-26-19(24)18(27-17)14-7-9-15(10-8-14)20(25)31/h2-10,13H,11-12H2,1H3,(H2,24,26)(H2,25,31) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234140
(CHEMBL4102352)Show SMILES Cn1nc(nc1C1(CO)CC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C17H17N9O/c1-25-16(17(9-27)6-7-17)21-14(23-25)11-8-19-13(18)15(20-11)26-12-5-3-2-4-10(12)22-24-26/h2-5,8,27H,6-7,9H2,1H3,(H2,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234165
(CHEMBL4090281)Show SMILES C[C@H](N1CCOCC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 |r| Show InChI InChI=1S/C19H22N10O/c1-12(28-7-9-30-10-8-28)18-23-17(25-27(18)2)14-11-21-16(20)19(22-14)29-15-6-4-3-5-13(15)24-26-29/h3-6,11-12H,7-10H2,1-2H3,(H2,20,21)/t12-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234149
(CHEMBL4099886)Show SMILES C[C@H](c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12)c1ccccc1 |r| Show InChI InChI=1S/C21H19N9/c1-13(14-8-4-3-5-9-14)20-25-19(27-29(20)2)16-12-23-18(22)21(24-16)30-17-11-7-6-10-15(17)26-28-30/h3-13H,1-2H3,(H2,22,23)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234148
(CHEMBL4064432)Show SMILES CN1CCN(CC1)C1(CC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C21H25N11/c1-29-9-11-31(12-10-29)21(7-8-21)20-25-18(27-30(20)2)15-13-23-17(22)19(24-15)32-16-6-4-3-5-14(16)26-28-32/h3-6,13H,7-12H2,1-2H3,(H2,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234153
(CHEMBL4060598)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1ncc2ccccc12 Show InChI InChI=1S/C23H20N8/c1-30-22(23(11-12-23)16-8-3-2-4-9-16)28-20(29-30)17-14-25-19(24)21(27-17)31-18-10-6-5-7-15(18)13-26-31/h2-10,13-14H,11-12H2,1H3,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234143
(CHEMBL4091640)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cn[nH]c1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(7-8-19)13-5-3-2-4-6-13)25-17(26-27)14-11-21-16(20)15(24-14)12-9-22-23-10-12/h2-6,9-11H,7-8H2,1H3,(H2,20,21)(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234143
(CHEMBL4091640)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cn[nH]c1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(7-8-19)13-5-3-2-4-6-13)25-17(26-27)14-11-21-16(20)15(24-14)12-9-22-23-10-12/h2-6,9-11H,7-8H2,1H3,(H2,20,21)(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234158
(CHEMBL4072500)Show SMILES CN(C)S(=O)(=O)n1cc(cn1)-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 Show InChI InChI=1S/C21H23N9O2S/c1-28(2)33(31,32)30-13-14(11-24-30)17-18(22)23-12-16(25-17)19-26-20(29(3)27-19)21(9-10-21)15-7-5-4-6-8-15/h4-8,11-13H,9-10H2,1-3H3,(H2,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234152
(CHEMBL4092139)Show SMILES Cn1nc(nc1C1(Cc2ccccc2)CC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C23H21N9/c1-31-22(23(11-12-23)13-15-7-3-2-4-8-15)27-20(29-31)17-14-25-19(24)21(26-17)32-18-10-6-5-9-16(18)28-30-32/h2-10,14H,11-13H2,1H3,(H2,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234141
(CHEMBL4083866)Show SMILES Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 |(25.94,-39.46,;25.61,-37.95,;26.63,-36.8,;25.86,-35.48,;24.36,-35.81,;23.2,-34.79,;24.21,-37.34,;22.88,-38.12,;21.55,-37.36,;20.22,-38.13,;20.22,-39.67,;21.55,-40.44,;22.89,-39.67,;24.22,-40.44,;18.88,-37.35,;18.72,-35.82,;17.22,-35.5,;16.45,-36.83,;14.92,-36.99,;17.48,-37.98,;16.54,-34.1,;15.21,-34.87,;15.21,-33.33,;17.29,-32.76,;18.83,-32.73,;19.57,-31.39,;18.78,-30.06,;17.23,-30.1,;16.49,-31.45,)| Show InChI InChI=1S/C21H22N8/c1-12-16(13(2)27-26-12)17-18(22)23-11-15(24-17)19-25-20(29(3)28-19)21(9-10-21)14-7-5-4-6-8-14/h4-8,11H,9-10H2,1-3H3,(H2,22,23)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234173
(CHEMBL4062277)Show SMILES C[C@@H](N1CCOCC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 |r| Show InChI InChI=1S/C19H22N10O/c1-12(28-7-9-30-10-8-28)18-23-17(25-27(18)2)14-11-21-16(20)19(22-14)29-15-6-4-3-5-13(15)24-26-29/h3-6,11-12H,7-10H2,1-2H3,(H2,20,21)/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Mus musculus (Mouse)) | BDBM50234157
(CHEMBL4089227)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C Show InChI InChI=1S/C22H24N8O/c1-21(2,3)20-28-27-18(31-20)15-16(23)24-12-14(25-15)17-26-19(30(4)29-17)22(10-11-22)13-8-6-5-7-9-13/h5-9,12H,10-11H2,1-4H3,(H2,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kgamma-mediated AKT phosphorylation at ser473 in mouse RAW246 cells preincubated for 3 hrs followed by C5a stimulation measured afte... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234165
(CHEMBL4090281)Show SMILES C[C@H](N1CCOCC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 |r| Show InChI InChI=1S/C19H22N10O/c1-12(28-7-9-30-10-8-28)18-23-17(25-27(18)2)14-11-21-16(20)19(22-14)29-15-6-4-3-5-13(15)24-26-29/h3-6,11-12H,7-10H2,1-2H3,(H2,20,21)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234154
(CHEMBL4100327)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C24H21N7/c1-31-23(24(11-12-24)15-7-3-2-4-8-15)29-22(30-31)19-14-27-21(25)20(28-19)17-13-26-18-10-6-5-9-16(17)18/h2-10,13-14,26H,11-12H2,1H3,(H2,25,27) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234168
(CHEMBL4061055)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cnn(c1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-18(20(7-8-20)13-5-3-2-4-6-13)26-17(27-28)14-10-23-16(21)15(25-14)12-9-24-29(11-12)19(22)30/h2-6,9-11H,7-8H2,1H3,(H2,21,23)(H2,22,30) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234153
(CHEMBL4060598)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1ncc2ccccc12 Show InChI InChI=1S/C23H20N8/c1-30-22(23(11-12-23)16-8-3-2-4-9-16)28-20(29-30)17-14-25-19(24)21(27-17)31-18-10-6-5-7-15(18)13-26-31/h2-10,13-14H,11-12H2,1H3,(H2,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234168
(CHEMBL4061055)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cnn(c1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-18(20(7-8-20)13-5-3-2-4-6-13)26-17(27-28)14-10-23-16(21)15(25-14)12-9-24-29(11-12)19(22)30/h2-6,9-11H,7-8H2,1H3,(H2,21,23)(H2,22,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
UniProtKB/SwissProt
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antibodypedia
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CHEMBL
MCE
PC cid
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Similars
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234166
(CHEMBL4070762)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(N)nc1 Show InChI InChI=1S/C21H20N8/c1-29-20(21(9-10-21)14-5-3-2-4-6-14)27-19(28-29)15-12-25-18(23)17(26-15)13-7-8-16(22)24-11-13/h2-8,11-12H,9-10H2,1H3,(H2,22,24)(H2,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234163
(CHEMBL4082434)Show SMILES Cn1nc(nc1C(C)(C)C1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C21H25N9O/c1-21(2,13-8-10-31-11-9-13)20-25-18(27-29(20)3)15-12-23-17(22)19(24-15)30-16-7-5-4-6-14(16)26-28-30/h4-7,12-13H,8-11H2,1-3H3,(H2,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234166
(CHEMBL4070762)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(N)nc1 Show InChI InChI=1S/C21H20N8/c1-29-20(21(9-10-21)14-5-3-2-4-6-14)27-19(28-29)15-12-25-18(23)17(26-15)13-7-8-16(22)24-11-13/h2-8,11-12H,9-10H2,1H3,(H2,22,24)(H2,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234150
(CHEMBL4061634)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C22H19N9/c1-30-21(22(11-12-22)14-7-3-2-4-8-14)26-19(28-30)16-13-24-18(23)20(25-16)31-17-10-6-5-9-15(17)27-29-31/h2-10,13H,11-12H2,1H3,(H2,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234160
(CHEMBL4063902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1ccc(n1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-19(20(8-9-20)12-5-3-2-4-6-12)25-17(27-28)14-11-23-15(21)18(24-14)29-10-7-13(26-29)16(22)30/h2-7,10-11H,8-9H2,1H3,(H2,21,23)(H2,22,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234167
(CHEMBL4062135)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cc[nH]n1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(8-9-19)12-5-3-2-4-6-12)24-17(26-27)14-11-21-16(20)15(23-14)13-7-10-22-25-13/h2-7,10-11H,8-9H2,1H3,(H2,20,21)(H,22,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234172
(CHEMBL4088819)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1cnc2ccccc12 Show InChI InChI=1S/C23H20N8/c1-30-22(23(11-12-23)15-7-3-2-4-8-15)28-20(29-30)17-13-25-19(24)21(27-17)31-14-26-16-9-5-6-10-18(16)31/h2-10,13-14H,11-12H2,1H3,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Mus musculus (Mouse)) | BDBM50234158
(CHEMBL4072500)Show SMILES CN(C)S(=O)(=O)n1cc(cn1)-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 Show InChI InChI=1S/C21H23N9O2S/c1-28(2)33(31,32)30-13-14(11-24-30)17-18(22)23-12-16(25-17)19-26-20(29(3)27-19)21(9-10-21)15-7-5-4-6-8-15/h4-8,11-13H,9-10H2,1-3H3,(H2,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kgamma-mediated AKT phosphorylation at ser473 in mouse RAW246 cells preincubated for 3 hrs followed by C5a stimulation measured afte... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234146
(CHEMBL4064890)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(F)nc1 Show InChI InChI=1S/C21H18FN7/c1-29-20(21(9-10-21)14-5-3-2-4-6-14)27-19(28-29)15-12-25-18(23)17(26-15)13-7-8-16(22)24-11-13/h2-8,11-12H,9-10H2,1H3,(H2,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234148
(CHEMBL4064432)Show SMILES CN1CCN(CC1)C1(CC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C21H25N11/c1-29-9-11-31(12-10-29)21(7-8-21)20-25-18(27-30(20)2)15-13-23-17(22)19(24-15)32-16-6-4-3-5-14(16)26-28-32/h3-6,13H,7-12H2,1-2H3,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234161
(CHEMBL4091680)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C23H21N7O/c1-30-22(23(11-12-23)16-5-3-2-4-6-16)28-21(29-30)17-13-26-19(24)18(27-17)14-7-9-15(10-8-14)20(25)31/h2-10,13H,11-12H2,1H3,(H2,24,26)(H2,25,31) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234172
(CHEMBL4088819)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1cnc2ccccc12 Show InChI InChI=1S/C23H20N8/c1-30-22(23(11-12-23)15-7-3-2-4-8-15)28-20(29-30)17-13-25-19(24)21(27-17)31-14-26-16-9-5-6-10-18(16)31/h2-10,13-14H,11-12H2,1H3,(H2,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234159
(CHEMBL4099419)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1cc(cn1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-19(20(7-8-20)13-5-3-2-4-6-13)26-17(27-28)14-10-23-15(21)18(25-14)29-11-12(9-24-29)16(22)30/h2-6,9-11H,7-8H2,1H3,(H2,21,23)(H2,22,30) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234146
(CHEMBL4064890)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(F)nc1 Show InChI InChI=1S/C21H18FN7/c1-29-20(21(9-10-21)14-5-3-2-4-6-14)27-19(28-29)15-12-25-18(23)17(26-15)13-7-8-16(22)24-11-13/h2-8,11-12H,9-10H2,1H3,(H2,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234143
(CHEMBL4091640)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cn[nH]c1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(7-8-19)13-5-3-2-4-6-13)25-17(26-27)14-11-21-16(20)15(24-14)12-9-22-23-10-12/h2-6,9-11H,7-8H2,1H3,(H2,20,21)(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234153
(CHEMBL4060598)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1ncc2ccccc12 Show InChI InChI=1S/C23H20N8/c1-30-22(23(11-12-23)16-8-3-2-4-9-16)28-20(29-30)17-14-25-19(24)21(27-17)31-18-10-6-5-7-15(18)13-26-31/h2-10,13-14H,11-12H2,1H3,(H2,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234151
(CHEMBL4084383)Show SMILES Cn1nc(nc1C1(CC1)S(C)(=O)=O)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C17H17N9O2S/c1-25-16(17(7-8-17)29(2,27)28)21-14(23-25)11-9-19-13(18)15(20-11)26-12-6-4-3-5-10(12)22-24-26/h3-6,9H,7-8H2,1-2H3,(H2,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234141
(CHEMBL4083866)Show SMILES Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 |(25.94,-39.46,;25.61,-37.95,;26.63,-36.8,;25.86,-35.48,;24.36,-35.81,;23.2,-34.79,;24.21,-37.34,;22.88,-38.12,;21.55,-37.36,;20.22,-38.13,;20.22,-39.67,;21.55,-40.44,;22.89,-39.67,;24.22,-40.44,;18.88,-37.35,;18.72,-35.82,;17.22,-35.5,;16.45,-36.83,;14.92,-36.99,;17.48,-37.98,;16.54,-34.1,;15.21,-34.87,;15.21,-33.33,;17.29,-32.76,;18.83,-32.73,;19.57,-31.39,;18.78,-30.06,;17.23,-30.1,;16.49,-31.45,)| Show InChI InChI=1S/C21H22N8/c1-12-16(13(2)27-26-12)17-18(22)23-11-15(24-17)19-25-20(29(3)28-19)21(9-10-21)14-7-5-4-6-8-14/h4-8,11H,9-10H2,1-3H3,(H2,22,23)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234169
(CHEMBL4101902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1 Show InChI InChI=1S/C23H20FN7O/c1-31-22(23(9-10-23)14-5-3-2-4-6-14)29-21(30-31)17-12-27-19(25)18(28-17)13-7-8-15(20(26)32)16(24)11-13/h2-8,11-12H,9-10H2,1H3,(H2,25,27)(H2,26,32) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50234155
(CHEMBL4073489)Show InChI InChI=1S/C16H16N6/c1-22-15(16(7-8-16)11-5-3-2-4-6-11)20-14(21-22)12-9-19-13(17)10-18-12/h2-6,9-10H,7-8H2,1H3,(H2,17,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234142
(CHEMBL4078043)Show SMILES Cn1nc(nc1C1(CC1)N1CCOCC1)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C20H22N10O/c1-28-19(20(6-7-20)29-8-10-31-11-9-29)24-17(26-28)14-12-22-16(21)18(23-14)30-15-5-3-2-4-13(15)25-27-30/h2-5,12H,6-11H2,1H3,(H2,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234167
(CHEMBL4062135)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cc[nH]n1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(8-9-19)12-5-3-2-4-6-12)24-17(26-27)14-11-21-16(20)15(23-14)13-7-10-22-25-13/h2-7,10-11H,8-9H2,1H3,(H2,20,21)(H,22,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234156
(CHEMBL4092591)Show InChI InChI=1S/C17H15N7/c1-24-16(17(7-8-17)11-5-3-2-4-6-11)22-15(23-24)13-10-20-14(19)12(9-18)21-13/h2-6,10H,7-8H2,1H3,(H2,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234166
(CHEMBL4070762)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(N)nc1 Show InChI InChI=1S/C21H20N8/c1-29-20(21(9-10-21)14-5-3-2-4-6-14)27-19(28-29)15-12-25-18(23)17(26-15)13-7-8-16(22)24-11-13/h2-8,11-12H,9-10H2,1H3,(H2,22,24)(H2,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234160
(CHEMBL4063902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1ccc(n1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-19(20(8-9-20)12-5-3-2-4-6-12)25-17(27-28)14-11-23-15(21)18(24-14)29-10-7-13(26-29)16(22)30/h2-7,10-11H,8-9H2,1H3,(H2,21,23)(H2,22,30) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234160
(CHEMBL4063902)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1ccc(n1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-19(20(8-9-20)12-5-3-2-4-6-12)25-17(27-28)14-11-23-15(21)18(24-14)29-10-7-13(26-29)16(22)30/h2-7,10-11H,8-9H2,1H3,(H2,21,23)(H2,22,30) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234141
(CHEMBL4083866)Show SMILES Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 |(25.94,-39.46,;25.61,-37.95,;26.63,-36.8,;25.86,-35.48,;24.36,-35.81,;23.2,-34.79,;24.21,-37.34,;22.88,-38.12,;21.55,-37.36,;20.22,-38.13,;20.22,-39.67,;21.55,-40.44,;22.89,-39.67,;24.22,-40.44,;18.88,-37.35,;18.72,-35.82,;17.22,-35.5,;16.45,-36.83,;14.92,-36.99,;17.48,-37.98,;16.54,-34.1,;15.21,-34.87,;15.21,-33.33,;17.29,-32.76,;18.83,-32.73,;19.57,-31.39,;18.78,-30.06,;17.23,-30.1,;16.49,-31.45,)| Show InChI InChI=1S/C21H22N8/c1-12-16(13(2)27-26-12)17-18(22)23-11-15(24-17)19-25-20(29(3)28-19)21(9-10-21)14-7-5-4-6-8-14/h4-8,11H,9-10H2,1-3H3,(H2,22,23)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234155
(CHEMBL4073489)Show InChI InChI=1S/C16H16N6/c1-22-15(16(7-8-16)11-5-3-2-4-6-11)20-14(21-22)12-9-19-13(17)10-18-12/h2-6,9-10H,7-8H2,1H3,(H2,17,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50234155
(CHEMBL4073489)Show InChI InChI=1S/C16H16N6/c1-22-15(16(7-8-16)11-5-3-2-4-6-11)20-14(21-22)12-9-19-13(17)10-18-12/h2-6,9-10H,7-8H2,1H3,(H2,17,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234156
(CHEMBL4092591)Show InChI InChI=1S/C17H15N7/c1-24-16(17(7-8-17)11-5-3-2-4-6-11)22-15(23-24)13-10-20-14(19)12(9-18)21-13/h2-6,10H,7-8H2,1H3,(H2,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234141
(CHEMBL4083866)Show SMILES Cc1n[nH]c(C)c1-c1nc(cnc1N)-c1nc(n(C)n1)C1(CC1)c1ccccc1 |(25.94,-39.46,;25.61,-37.95,;26.63,-36.8,;25.86,-35.48,;24.36,-35.81,;23.2,-34.79,;24.21,-37.34,;22.88,-38.12,;21.55,-37.36,;20.22,-38.13,;20.22,-39.67,;21.55,-40.44,;22.89,-39.67,;24.22,-40.44,;18.88,-37.35,;18.72,-35.82,;17.22,-35.5,;16.45,-36.83,;14.92,-36.99,;17.48,-37.98,;16.54,-34.1,;15.21,-34.87,;15.21,-33.33,;17.29,-32.76,;18.83,-32.73,;19.57,-31.39,;18.78,-30.06,;17.23,-30.1,;16.49,-31.45,)| Show InChI InChI=1S/C21H22N8/c1-12-16(13(2)27-26-12)17-18(22)23-11-15(24-17)19-25-20(29(3)28-19)21(9-10-21)14-7-5-4-6-8-14/h4-8,11H,9-10H2,1-3H3,(H2,22,23)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234172
(CHEMBL4088819)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-n1cnc2ccccc12 Show InChI InChI=1S/C23H20N8/c1-30-22(23(11-12-23)15-7-3-2-4-8-15)28-20(29-30)17-13-25-19(24)21(27-17)31-14-26-16-9-5-6-10-18(16)31/h2-10,13-14H,11-12H2,1H3,(H2,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234156
(CHEMBL4092591)Show InChI InChI=1S/C17H15N7/c1-24-16(17(7-8-17)11-5-3-2-4-6-11)22-15(23-24)13-10-20-14(19)12(9-18)21-13/h2-6,10H,7-8H2,1H3,(H2,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50234155
(CHEMBL4073489)Show InChI InChI=1S/C16H16N6/c1-22-15(16(7-8-16)11-5-3-2-4-6-11)20-14(21-22)12-9-19-13(17)10-18-12/h2-6,9-10H,7-8H2,1H3,(H2,17,19) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234146
(CHEMBL4064890)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(F)nc1 Show InChI InChI=1S/C21H18FN7/c1-29-20(21(9-10-21)14-5-3-2-4-6-14)27-19(28-29)15-12-25-18(23)17(26-15)13-7-8-16(22)24-11-13/h2-8,11-12H,9-10H2,1H3,(H2,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234168
(CHEMBL4061055)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cnn(c1)C(N)=O Show InChI InChI=1S/C20H19N9O/c1-28-18(20(7-8-20)13-5-3-2-4-6-13)26-17(27-28)14-10-23-16(21)15(25-14)12-9-24-29(11-12)19(22)30/h2-6,9-11H,7-8H2,1H3,(H2,21,23)(H2,22,30) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234167
(CHEMBL4062135)Show SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1cc[nH]n1 Show InChI InChI=1S/C19H18N8/c1-27-18(19(8-9-19)12-5-3-2-4-6-12)24-17(26-27)14-11-21-16(20)15(23-14)13-7-10-22-25-13/h2-7,10-11H,8-9H2,1H3,(H2,20,21)(H,22,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50234148
(CHEMBL4064432)Show SMILES CN1CCN(CC1)C1(CC1)c1nc(nn1C)-c1cnc(N)c(n1)-n1nnc2ccccc12 Show InChI InChI=1S/C21H25N11/c1-29-9-11-31(12-10-29)21(7-8-21)20-25-18(27-30(20)2)15-13-23-17(22)19(24-15)32-16-6-4-3-5-14(16)26-28-32/h3-6,13H,7-12H2,1-2H3,(H2,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi... |
Bioorg Med Chem Lett 27: 679-687 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.004
BindingDB Entry DOI: 10.7270/Q2TF00MM |
More data for this
Ligand-Target Pair | |
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