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PubMed code 2822927

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50226407
PNG
(CHEMBL299631 | Y-590)
Show SMILES CC1CC(=O)NN=C1c1ccc2N(C)C(=O)CCc2c1 |c:6|
Show InChI InChI=1S/C15H17N3O2/c1-9-7-13(19)16-17-15(9)11-3-5-12-10(8-11)4-6-14(20)18(12)2/h3,5,8-9H,4,6-7H2,1-2H3,(H,16,19)
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n/an/a 120n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a 600n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50226310
PNG
(CHEMBL58005)
Show SMILES O=C1CC2Cc3cc(ccc3C2=NN1)-n1cnc2CCCCc12 |c:13|
Show InChI InChI=1S/C18H18N4O/c23-17-9-12-7-11-8-13(5-6-14(11)18(12)21-20-17)22-10-19-15-3-1-2-4-16(15)22/h5-6,8,10,12H,1-4,7,9H2,(H,20,23)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50225943
PNG
(CHEMBL58460)
Show SMILES Oc1cc2Cc3cc(ccc3-c2nn1)-n1ccnc1
Show InChI InChI=1S/C14H10N4O/c19-13-7-10-5-9-6-11(18-4-3-15-8-18)1-2-12(9)14(10)17-16-13/h1-4,6-8H,5H2,(H,16,19)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50225944
PNG
(CHEMBL300175)
Show SMILES O=C1CC2Cc3cc(ccc3C2=NN1)-n1ccnc1 |c:13|
Show InChI InChI=1S/C14H12N4O/c19-13-7-10-5-9-6-11(18-4-3-15-8-18)1-2-12(9)14(10)17-16-13/h1-4,6,8,10H,5,7H2,(H,16,19)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50018627
PNG
(5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-...)
Show SMILES CC1=C(CC(C#N)C(=O)N1)c1ccc(cc1)-n1ccnc1 |t:1|
Show InChI InChI=1S/C16H14N4O/c1-11-15(8-13(9-17)16(21)19-11)12-2-4-14(5-3-12)20-7-6-18-10-20/h2-7,10,13H,8H2,1H3,(H,19,21)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50018617
PNG
(6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one | CH...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C13H10N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-9H,(H,16,18)
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n/an/a 7.20E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50225502
PNG
(MDL-19205 | Piroximone)
Show SMILES CCc1[nH]c(=O)[nH]c1C(=O)c1ccncc1
Show InChI InChI=1S/C11H11N3O2/c1-2-8-9(14-11(16)13-8)10(15)7-3-5-12-6-4-7/h3-6H,2H2,1H3,(H2,13,14,16)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50018620
PNG
(6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1
Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50241379
PNG
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Show SMILES CSc1ccc(cc1)C(=O)c1[nH]c(=O)[nH]c1C
Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018627
PNG
(5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-...)
Show SMILES CC1=C(CC(C#N)C(=O)N1)c1ccc(cc1)-n1ccnc1 |t:1|
Show InChI InChI=1S/C16H14N4O/c1-11-15(8-13(9-17)16(21)19-11)12-2-4-14(5-3-12)20-7-6-18-10-20/h2-7,10,13H,8H2,1H3,(H,19,21)
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n/an/a 3.90E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50018622
PNG
(6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...)
Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018627
PNG
(5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-...)
Show SMILES CC1=C(CC(C#N)C(=O)N1)c1ccc(cc1)-n1ccnc1 |t:1|
Show InChI InChI=1S/C16H14N4O/c1-11-15(8-13(9-17)16(21)19-11)12-2-4-14(5-3-12)20-7-6-18-10-20/h2-7,10,13H,8H2,1H3,(H,19,21)
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n/an/a 4.30E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM34651
PNG
(Amrinon | Amrinone | CHEMBL12856 | Cordemcura | IN...)
Show SMILES Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
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n/an/a 4.60E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50018613
PNG
(6-(4-Imidazol-1-yl-phenyl)-5-methyl-2H-pyridazin-3...)
Show SMILES Cc1cc(=O)[nH]nc1-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C14H12N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-9H,1H3,(H,16,19)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE III enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018627
PNG
(5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-...)
Show SMILES CC1=C(CC(C#N)C(=O)N1)c1ccc(cc1)-n1ccnc1 |t:1|
Show InChI InChI=1S/C16H14N4O/c1-11-15(8-13(9-17)16(21)19-11)12-2-4-14(5-3-12)20-7-6-18-10-20/h2-7,10,13H,8H2,1H3,(H,19,21)
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n/an/a 1.20E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018627
PNG
(5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-...)
Show SMILES CC1=C(CC(C#N)C(=O)N1)c1ccc(cc1)-n1ccnc1 |t:1|
Show InChI InChI=1S/C16H14N4O/c1-11-15(8-13(9-17)16(21)19-11)12-2-4-14(5-3-12)20-7-6-18-10-20/h2-7,10,13H,8H2,1H3,(H,19,21)
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n/an/a 1.30E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018613
PNG
(6-(4-Imidazol-1-yl-phenyl)-5-methyl-2H-pyridazin-3...)
Show SMILES Cc1cc(=O)[nH]nc1-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C14H12N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-9H,1H3,(H,16,19)
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n/an/a 1.70E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018620
PNG
(6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1
Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)
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n/an/a 1.80E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018617
PNG
(6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one | CH...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C13H10N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-9H,(H,16,18)
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n/an/a 1.90E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018617
PNG
(6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one | CH...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C13H10N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-9H,(H,16,18)
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n/an/a 1.90E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018620
PNG
(6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1
Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)
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n/an/a 1.90E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 2.00E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018613
PNG
(6-(4-Imidazol-1-yl-phenyl)-5-methyl-2H-pyridazin-3...)
Show SMILES Cc1cc(=O)[nH]nc1-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C14H12N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-9H,1H3,(H,16,19)
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n/an/a 2.10E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 2.20E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 3.10E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018620
PNG
(6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1
Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)
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n/an/a 3.30E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018622
PNG
(6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...)
Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)
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n/an/a 3.30E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 3.40E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50018622
PNG
(6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...)
Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)
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n/an/a 3.40E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a 4.60E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a 4.60E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018620
PNG
(6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1
Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)
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n/an/a 4.60E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a 5.00E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a 5.00E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018617
PNG
(6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one | CH...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C13H10N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-9H,(H,16,18)
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n/an/a 5.80E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM34651
PNG
(Amrinon | Amrinone | CHEMBL12856 | Cordemcura | IN...)
Show SMILES Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
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n/an/a 5.80E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM34651
PNG
(Amrinon | Amrinone | CHEMBL12856 | Cordemcura | IN...)
Show SMILES Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
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n/an/a 5.80E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cGMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018613
PNG
(6-(4-Imidazol-1-yl-phenyl)-5-methyl-2H-pyridazin-3...)
Show SMILES Cc1cc(=O)[nH]nc1-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C14H12N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-9H,1H3,(H,16,19)
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n/an/a 6.60E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018617
PNG
(6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one | CH...)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C13H10N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-9H,(H,16,18)
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n/an/a 6.60E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE II enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018622
PNG
(6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...)
Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)
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n/an/a 9.30E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018622
PNG
(6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...)
Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM34651
PNG
(Amrinon | Amrinone | CHEMBL12856 | Cordemcura | IN...)
Show SMILES Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50018613
PNG
(6-(4-Imidazol-1-yl-phenyl)-5-methyl-2H-pyridazin-3...)
Show SMILES Cc1cc(=O)[nH]nc1-c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C14H12N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-9H,1H3,(H,16,19)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM34651
PNG
(Amrinon | Amrinone | CHEMBL12856 | Cordemcura | IN...)
Show SMILES Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition cGMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE I enzyme

J Med Chem 30: 1963-72 (1987)


BindingDB Entry DOI: 10.7270/Q28K79P9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%