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PubMed code 2822930

Compile data set for download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50007329
PNG
((R)-2-[(R)-2-(2-{2-[(R)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m1/s1
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 2.5n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50007329
PNG
((R)-2-[(R)-2-(2-{2-[(R)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m1/s1
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 9.40n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018637
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CC(=O)NCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)32-22-15-23(35)30-12-4-7-20(24(29)36)31-26(38)21(33-27(22)39)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,38)(H,32,37)(H,33,39)/t19-,20-,21-,22+/m0/s1
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 9.60n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001467
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21-,22-/m0/s1
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 10n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018640
PNG
(10-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C24H29N5O5S2/c25-17(10-15-6-8-16(30)9-7-15)22(32)29-20-13-36-35-12-19(21(26)31)28-23(33)18(27-24(20)34)11-14-4-2-1-3-5-14/h1-9,17-20,30H,10-13,25H2,(H2,26,31)(H,27,34)(H,28,33)(H,29,32)/t17-,18-,19-,20+/m0/s1
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 11n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018631
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](CCc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C28H36N6O6/c29-20(15-18-8-11-19(35)12-9-18)26(38)32-21-7-4-14-31-24(36)16-23(25(30)37)34-28(40)22(33-27(21)39)13-10-17-5-2-1-3-6-17/h1-3,5-6,8-9,11-12,20-23,35H,4,7,10,13-16,29H2,(H2,30,37)(H,31,36)(H,32,38)(H,33,39)(H,34,40)/t20-,21+,22-,23-/m0/s1
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 12n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018635
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21+,22-/m0/s1
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 22n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018639
PNG
(11-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CC(=O)NCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C26H32N6O6/c27-18(12-16-6-8-17(33)9-7-16)24(36)31-21-14-22(34)29-11-10-19(23(28)35)30-25(37)20(32-26(21)38)13-15-4-2-1-3-5-15/h1-9,18-21,33H,10-14,27H2,(H2,28,35)(H,29,34)(H,30,37)(H,31,36)(H,32,38)/t18-,19-,20-,21+/m0/s1
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 25n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018638
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc(cc2)[N+]([O-])=O)NC1=O)C(N)=O
Show InChI InChI=1S/C27H33N7O8/c28-19(12-15-5-9-18(35)10-6-15)25(38)31-20-2-1-11-30-23(36)14-21(24(29)37)32-27(40)22(33-26(20)39)13-16-3-7-17(8-4-16)34(41)42/h3-10,19-22,35H,1-2,11-14,28H2,(H2,29,37)(H,30,36)(H,31,38)(H,32,40)(H,33,39)/t19-,20+,21-,22-/m0/s1
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 273n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018640
PNG
(10-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C24H29N5O5S2/c25-17(10-15-6-8-16(30)9-7-15)22(32)29-20-13-36-35-12-19(21(26)31)28-23(33)18(27-24(20)34)11-14-4-2-1-3-5-14/h1-9,17-20,30H,10-13,25H2,(H2,26,31)(H,27,34)(H,28,33)(H,29,32)/t17-,18-,19-,20+/m0/s1
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 373n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018635
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21+,22-/m0/s1
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 422n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018633
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@@H](NC1=O)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C26H38N6O6/c27-18(13-15-8-10-17(33)11-9-15)24(36)30-19-7-4-12-29-21(34)14-20(23(28)35)31-26(38)22(32-25(19)37)16-5-2-1-3-6-16/h8-11,16,18-20,22,33H,1-7,12-14,27H2,(H2,28,35)(H,29,34)(H,30,36)(H,31,38)(H,32,37)/t18-,19+,20-,22-/m0/s1
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 445n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards mu Opioid receptor in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018631
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](CCc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C28H36N6O6/c29-20(15-18-8-11-19(35)12-9-18)26(38)32-21-7-4-14-31-24(36)16-23(25(30)37)34-28(40)22(33-27(21)39)13-10-17-5-2-1-3-6-17/h1-3,5-6,8-9,11-12,20-23,35H,4,7,10,13-16,29H2,(H2,30,37)(H,31,36)(H,32,38)(H,33,39)(H,34,40)/t20-,21+,22-,23-/m0/s1
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 849n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018637
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CC(=O)NCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)32-22-15-23(35)30-12-4-7-20(24(29)36)31-26(38)21(33-27(22)39)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,38)(H,32,37)(H,33,39)/t19-,20-,21-,22+/m0/s1
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 1.32E+3n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001467
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21-,22-/m0/s1
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 2.22E+3n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018632
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21-,22+/m0/s1
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 3.04E+3n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018633
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@@H](NC1=O)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C26H38N6O6/c27-18(13-15-8-10-17(33)11-9-15)24(36)30-19-7-4-12-29-21(34)14-20(23(28)35)31-26(38)22(32-25(19)37)16-5-2-1-3-6-16/h8-11,16,18-20,22,33H,1-7,12-14,27H2,(H2,28,35)(H,29,34)(H,30,36)(H,31,38)(H,32,37)/t18-,19+,20-,22-/m0/s1
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 3.57E+3n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018636
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES CN1[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(=O)NCCC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C1=O)C(N)=O
Show InChI InChI=1S/C28H36N6O6/c1-34-23(15-17-6-3-2-4-7-17)27(39)33-22(25(30)37)16-24(36)31-13-5-8-21(28(34)40)32-26(38)20(29)14-18-9-11-19(35)12-10-18/h2-4,6-7,9-12,20-23,35H,5,8,13-16,29H2,1H3,(H2,30,37)(H,31,36)(H,32,38)(H,33,39)/t20-,21+,22-,23-/m0/s1
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 3.57E+3n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018639
PNG
(11-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CC(=O)NCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C26H32N6O6/c27-18(12-16-6-8-17(33)9-7-16)24(36)31-21-14-22(34)29-11-10-19(23(28)35)30-25(37)20(32-26(21)38)13-15-4-2-1-3-5-15/h1-9,18-21,33H,10-14,27H2,(H2,28,35)(H,29,34)(H,30,37)(H,31,36)(H,32,38)/t18-,19-,20-,21+/m0/s1
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 4.17E+3n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018634
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20-,21-,22-/m0/s1
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 4.83E+3n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Binding affinity towards mu Opioid receptor in rat brain membrane using [3H]-DAGO as radioligand

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018638
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc(cc2)[N+]([O-])=O)NC1=O)C(N)=O
Show InChI InChI=1S/C27H33N7O8/c28-19(12-15-5-9-18(35)10-6-15)25(38)31-20-2-1-11-30-23(36)14-21(24(29)37)32-27(40)22(33-26(20)39)13-16-3-7-17(8-4-16)34(41)42/h3-10,19-22,35H,1-2,11-14,28H2,(H2,29,37)(H,30,36)(H,31,38)(H,32,40)(H,33,39)/t19-,20+,21-,22-/m0/s1
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 5.06E+3n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018636
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES CN1[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(=O)NCCC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C1=O)C(N)=O
Show InChI InChI=1S/C28H36N6O6/c1-34-23(15-17-6-3-2-4-7-17)27(39)33-22(25(30)37)16-24(36)31-13-5-8-21(28(34)40)32-26(38)20(29)14-18-9-11-19(35)12-10-18/h2-4,6-7,9-12,20-23,35H,5,8,13-16,29H2,1H3,(H2,30,37)(H,31,36)(H,32,38)(H,33,39)/t20-,21+,22-,23-/m0/s1
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 2.81E+4n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018634
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20-,21-,22-/m0/s1
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>6.00E+4n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50018632
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21-,22+/m0/s1
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>3.80E+5n/an/an/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DSLET binding to rat brain membrane Opioid receptor delta 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50007329
PNG
((R)-2-[(R)-2-(2-{2-[(R)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards delta Opioid receptor using guinea pig ileum (GPI) assay was determined for the compound

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50001467
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21-,22-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing mu opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018640
PNG
(10-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C24H29N5O5S2/c25-17(10-15-6-8-16(30)9-7-15)22(32)29-20-13-36-35-12-19(21(26)31)28-23(33)18(27-24(20)34)11-14-4-2-1-3-5-14/h1-9,17-20,30H,10-13,25H2,(H2,26,31)(H,27,34)(H,28,33)(H,29,32)/t17-,18-,19-,20+/m0/s1
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n/an/a 65n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards Opioid receptor mu 1 using guinea pig ileum (GPI) assay was determined for the compound

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018631
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](CCc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C28H36N6O6/c29-20(15-18-8-11-19(35)12-9-18)26(38)32-21-7-4-14-31-24(36)16-23(25(30)37)34-28(40)22(33-27(21)39)13-10-17-5-2-1-3-6-17/h1-3,5-6,8-9,11-12,20-23,35H,4,7,10,13-16,29H2,(H2,30,37)(H,31,36)(H,32,38)(H,33,39)(H,34,40)/t20-,21+,22-,23-/m0/s1
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n/an/a 111n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50007329
PNG
((R)-2-[(R)-2-(2-{2-[(R)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m1/s1
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n/an/a 246n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards Opioid receptor mu 1 using guinea pig ileum (GPI) assay was determined for the compound

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018639
PNG
(11-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CC(=O)NCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C26H32N6O6/c27-18(12-16-6-8-17(33)9-7-16)24(36)31-21-14-22(34)29-11-10-19(23(28)35)30-25(37)20(32-26(21)38)13-15-4-2-1-3-5-15/h1-9,18-21,33H,10-14,27H2,(H2,28,35)(H,29,34)(H,30,37)(H,31,36)(H,32,38)/t18-,19-,20-,21+/m0/s1
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n/an/a 279n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018637
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CC(=O)NCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)32-22-15-23(35)30-12-4-7-20(24(29)36)31-26(38)21(33-27(22)39)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,38)(H,32,37)(H,33,39)/t19-,20-,21-,22+/m0/s1
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n/an/a 522n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018635
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21+,22-/m0/s1
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n/an/a 632n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50018640
PNG
(10-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C24H29N5O5S2/c25-17(10-15-6-8-16(30)9-7-15)22(32)29-20-13-36-35-12-19(21(26)31)28-23(33)18(27-24(20)34)11-14-4-2-1-3-5-14/h1-9,17-20,30H,10-13,25H2,(H2,26,31)(H,27,34)(H,28,33)(H,29,32)/t17-,18-,19-,20+/m0/s1
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Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards delta Opioid receptor using guinea pig ileum (GPI) assay was determined for the compound

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018631
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](CCc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C28H36N6O6/c29-20(15-18-8-11-19(35)12-9-18)26(38)32-21-7-4-14-31-24(36)16-23(25(30)37)34-28(40)22(33-27(21)39)13-10-17-5-2-1-3-6-17/h1-3,5-6,8-9,11-12,20-23,35H,4,7,10,13-16,29H2,(H2,30,37)(H,31,36)(H,32,38)(H,33,39)(H,34,40)/t20-,21+,22-,23-/m0/s1
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n/an/a 1.37E+3n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018636
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES CN1[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(=O)NCCC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C1=O)C(N)=O
Show InChI InChI=1S/C28H36N6O6/c1-34-23(15-17-6-3-2-4-7-17)27(39)33-22(25(30)37)16-24(36)31-13-5-8-21(28(34)40)32-26(38)20(29)14-18-9-11-19(35)12-10-18/h2-4,6-7,9-12,20-23,35H,5,8,13-16,29H2,1H3,(H2,30,37)(H,31,36)(H,32,38)(H,33,39)/t20-,21+,22-,23-/m0/s1
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n/an/a 1.38E+3n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018633
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@@H](NC1=O)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C26H38N6O6/c27-18(13-15-8-10-17(33)11-9-15)24(36)30-19-7-4-12-29-21(34)14-20(23(28)35)31-26(38)22(32-25(19)37)16-5-2-1-3-6-16/h8-11,16,18-20,22,33H,1-7,12-14,27H2,(H2,28,35)(H,29,34)(H,30,36)(H,31,38)(H,32,37)/t18-,19+,20-,22-/m0/s1
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n/an/a 1.66E+3n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018639
PNG
(11-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CC(=O)NCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C26H32N6O6/c27-18(12-16-6-8-17(33)9-7-16)24(36)31-21-14-22(34)29-11-10-19(23(28)35)30-25(37)20(32-26(21)38)13-15-4-2-1-3-5-15/h1-9,18-21,33H,10-14,27H2,(H2,28,35)(H,29,34)(H,30,37)(H,31,36)(H,32,38)/t18-,19-,20-,21+/m0/s1
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n/an/a 2.03E+3n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018638
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc(cc2)[N+]([O-])=O)NC1=O)C(N)=O
Show InChI InChI=1S/C27H33N7O8/c28-19(12-15-5-9-18(35)10-6-15)25(38)31-20-2-1-11-30-23(36)14-21(24(29)37)32-27(40)22(33-26(20)39)13-16-3-7-17(8-4-16)34(41)42/h3-10,19-22,35H,1-2,11-14,28H2,(H2,29,37)(H,30,36)(H,31,38)(H,32,40)(H,33,39)/t19-,20+,21-,22-/m0/s1
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Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50001467
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21-,22-/m0/s1
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Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018635
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21+,22-/m0/s1
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n/an/a 4.81E+3n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018636
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES CN1[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(=O)NCCC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C1=O)C(N)=O
Show InChI InChI=1S/C28H36N6O6/c1-34-23(15-17-6-3-2-4-7-17)27(39)33-22(25(30)37)16-24(36)31-13-5-8-21(28(34)40)32-26(38)20(29)14-18-9-11-19(35)12-10-18/h2-4,6-7,9-12,20-23,35H,5,8,13-16,29H2,1H3,(H2,30,37)(H,31,36)(H,32,38)(H,33,39)/t20-,21+,22-,23-/m0/s1
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n/an/a 6.46E+3n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018637
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CC(=O)NCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)32-22-15-23(35)30-12-4-7-20(24(29)36)31-26(38)21(33-27(22)39)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,38)(H,32,37)(H,33,39)/t19-,20-,21-,22+/m0/s1
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n/an/a 8.57E+3n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018632
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21-,22+/m0/s1
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Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018634
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20-,21-,22-/m0/s1
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n/an/a 1.68E+4n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018633
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@@H](NC1=O)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C26H38N6O6/c27-18(13-15-8-10-17(33)11-9-15)24(36)30-19-7-4-12-29-21(34)14-20(23(28)35)31-26(38)22(32-25(19)37)16-5-2-1-3-6-16/h8-11,16,18-20,22,33H,1-7,12-14,27H2,(H2,28,35)(H,29,34)(H,30,36)(H,31,38)(H,32,37)/t18-,19+,20-,22-/m0/s1
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n/an/a 1.84E+4n/an/an/an/an/an/a



Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50018632
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20+,21-,22+/m0/s1
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Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in guinea pig ileum expressing Opioid receptor mu 1

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018638
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc(cc2)[N+]([O-])=O)NC1=O)C(N)=O
Show InChI InChI=1S/C27H33N7O8/c28-19(12-15-5-9-18(35)10-6-15)25(38)31-20-2-1-11-30-23(36)14-21(24(29)37)32-27(40)22(33-26(20)39)13-16-3-7-17(8-4-16)34(41)42/h3-10,19-22,35H,1-2,11-14,28H2,(H2,29,37)(H,30,36)(H,31,38)(H,32,40)(H,33,39)/t19-,20+,21-,22-/m0/s1
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Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50018634
PNG
(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C27H34N6O6/c28-19(13-17-8-10-18(34)11-9-17)25(37)31-20-7-4-12-30-23(35)15-21(24(29)36)32-27(39)22(33-26(20)38)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,34H,4,7,12-15,28H2,(H2,29,36)(H,30,35)(H,31,37)(H,32,39)(H,33,38)/t19-,20-,21-,22-/m0/s1
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Clinical Research Institute of Montreal

Curated by ChEMBL


Assay Description
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor

J Med Chem 30: 2094-9 (1987)


BindingDB Entry DOI: 10.7270/Q2416W24
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%