Affinity Data by PubMed id=28345882

PubMed code 28345882

Found 4 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 [1-322] (Homo sapiens (Human))	BDBM50166435 (5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-...) Show SMILES COc1ccc(cc1N1CC(=O)NS1(=O)=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	2.40E+3	n/a	4.80E+3	n/a	n/a	n/a	n/a	7.0	n/a
University of Missouri					Assay Description Assays for the reversible inhibition of PTP1B (72 nM) contained the test compound(2a, 2b, 5a, or 5b) in Bis-Tris (50 mM), NaCl (100 mM), EDTA (2 mM),...				Biochemistry 56: 2051-2060 (2017) Article DOI: 10.1021/acs.biochem.7b00151 BindingDB Entry DOI: 10.7270/Q2HX1BJ8
University of Missouri					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 [1-322] (Homo sapiens (Human))	BDBM223197 (2-Bromo-N-[3'-(1,1-dioxido-4-oxo-1,2,5-thiadia...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.70E+4	n/a	5.40E+4	n/a	n/a	n/a	n/a	7.0	n/a
University of Missouri					Assay Description Assays for the reversible inhibition of PTP1B (72 nM) contained the test compound(2a, 2b, 5a, or 5b) in Bis-Tris (50 mM), NaCl (100 mM), EDTA (2 mM),...				Biochemistry 56: 2051-2060 (2017) Article DOI: 10.1021/acs.biochem.7b00151 BindingDB Entry DOI: 10.7270/Q2HX1BJ8
University of Missouri					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 [1-322] (Homo sapiens (Human))	BDBM223198 (N-[3'-(1,1-Dioxido-4-oxo-1,2,5-thiadiazolidin-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.20E+4	n/a	6.40E+4	n/a	n/a	n/a	n/a	7.0	n/a
University of Missouri					Assay Description Assays for the reversible inhibition of PTP1B (72 nM) contained the test compound(2a, 2b, 5a, or 5b) in Bis-Tris (50 mM), NaCl (100 mM), EDTA (2 mM),...				Biochemistry 56: 2051-2060 (2017) Article DOI: 10.1021/acs.biochem.7b00151 BindingDB Entry DOI: 10.7270/Q2HX1BJ8
University of Missouri					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 [1-322] (Homo sapiens (Human))	BDBM223199 (5-(4-Methyl[1,1'-biphenyl]-3-yl)-1,2,5-thiadia...) Show SMILES Cc1ccc(cc1N1CC(=O)NS1(=O)=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.85E+4	n/a	7.70E+4	n/a	n/a	n/a	n/a	7.0	n/a
University of Missouri					Assay Description Assays for the reversible inhibition of PTP1B (72 nM) contained the test compound(2a, 2b, 5a, or 5b) in Bis-Tris (50 mM), NaCl (100 mM), EDTA (2 mM),...				Biochemistry 56: 2051-2060 (2017) Article DOI: 10.1021/acs.biochem.7b00151 BindingDB Entry DOI: 10.7270/Q2HX1BJ8
University of Missouri					More data for this Ligand-Target Pair

* indicates data uncertainty>20%