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PubMed code 28408220

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Meprin A subunit beta


(Homo sapiens)		BDBM50240418
PNG
(CHEMBL4096803)
Show SMILES [Na+].[Na+].[Na+].[Na+].Cc1nc(\N=N\c2cc(c3cc(cc(c3c2)S([O-])(=O)=O)[N+]([O-])=O)S([O-])(=O)=O)c(COP([O-])([O-])=O)c(C(O)=O)c1O
Show InChI InChI=1S/C18H15N4O15PS2/c1-7-16(23)15(18(24)25)12(6-37-38(28,29)30)17(19-7)21-20-8-2-10-11(13(3-8)39(31,32)33)4-9(22(26)27)5-14(10)40(34,35)36/h2-5,23H,6H2,1H3,(H,24,25)(H2,28,29,30)(H,31,32,33)(H,34,35,36)/p-4/b21-20+
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 8n/an/an/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in baculovirus infected Sf9 insect cells using (MCA)-EDEDED-(K-epsilon-dnp) as substrate by flu...

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240455
PNG
(CHEMBL1253351)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)c1ccc(NC(=O)c2cc(NC(=O)Nc3cc(cc(c3)C(=O)Nc3ccc(cc3S([O-])(=O)=O)S([O-])(=O)=O)C(=O)Nc3ccc(cc3S([O-])(=O)=O)S([O-])(=O)=O)cc(c2)C(=O)Nc2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(c1)S([O-])(=O)=O
Show InChI InChI=1S/C41H32N6O29S8/c48-37(44-29-5-1-25(77(53,54)55)15-33(29)81(65,66)67)19-9-20(38(49)45-30-6-2-26(78(56,57)58)16-34(30)82(68,69)70)12-23(11-19)42-41(52)43-24-13-21(39(50)46-31-7-3-27(79(59,60)61)17-35(31)83(71,72)73)10-22(14-24)40(51)47-32-8-4-28(80(62,63)64)18-36(32)84(74,75)76/h1-18H,(H,44,48)(H,45,49)(H,46,50)(H,47,51)(H2,42,43,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)/p-8
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 22n/an/an/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in baculovirus infected Sf9 insect cells using (MCA)-EDEDED-(K-epsilon-dnp) as substrate by flu...

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50089194
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
Show SMILES CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO
Show InChI InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1
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 2.00E+3n/an/an/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrate

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM13080
PNG
(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16)
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 7.40E+3n/an/an/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrate

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 0.300n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of APMA-activated recombinant human MMP13 expressed in mouse NS0 cells using Mca-PLGL-(DapDnp)-AR-NH2 as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 2n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of APMA-activated recombinant human MMP2 expressed in CHO cells using Mca-PLGL-(DapDnp)-AR-NH2 as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 50n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of APMA-activated recombinant human MMP9 expressed in CHO cells using Mca-PLGL-(DapDnp)-AR-NH2 as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240414
PNG
(CHEMBL4105563)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)S(=O)(=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H16N2O8S/c20-15(18-25)10-19(9-11-3-1-4-12(7-11)16(21)22)28(26,27)14-6-2-5-13(8-14)17(23)24/h1-8,25H,9-10H2,(H,18,20)(H,21,22)(H,23,24)
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n/an/a 60n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 60n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240465
PNG
(CHEMBL4099123)
Show SMILES ONC(=O)CCNS(=O)(=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C10H12N2O6S/c13-9(12-16)4-5-11-19(17,18)8-3-1-2-7(6-8)10(14)15/h1-3,6,11,16H,4-5H2,(H,12,13)(H,14,15)
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n/an/a 220n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240405
PNG
(CHEMBL4102689)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)S(=O)(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C17H16N2O8S/c20-16(18-23)9-19(8-11-2-1-3-12(6-11)17(21)22)28(24,25)13-4-5-14-15(7-13)27-10-26-14/h1-7,23H,8-10H2,(H,18,20)(H,21,22)
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n/an/a 270n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240445
PNG
(CHEMBL4083600)
Show SMILES ONC(=O)CNS(=O)(=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C9H10N2O6S/c12-8(11-15)5-10-18(16,17)7-3-1-2-6(4-7)9(13)14/h1-4,10,15H,5H2,(H,11,12)(H,13,14)
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n/an/a 310n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240417
PNG
(CHEMBL4087683)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C17H16N2O8S/c20-15(18-25)10-19(9-11-2-1-3-13(8-11)17(23)24)28(26,27)14-6-4-12(5-7-14)16(21)22/h1-8,25H,9-10H2,(H,18,20)(H,21,22)(H,23,24)
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n/an/a 320n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240454
PNG
(CHEMBL4072148)
Show SMILES ONC(=O)CCNS(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C10H12N2O6S/c13-9(12-16)5-6-11-19(17,18)8-3-1-7(2-4-8)10(14)15/h1-4,11,16H,5-6H2,(H,12,13)(H,14,15)
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n/an/a 340n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240397
PNG
(CHEMBL4096428)
Show SMILES ONC(=O)CCNS(=O)(=O)c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C9H10Cl2N2O5S/c10-6-3-5(4-7(11)9(6)15)19(17,18)12-2-1-8(14)13-16/h3-4,12,15-16H,1-2H2,(H,13,14)
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n/an/a 400n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240443
PNG
(CHEMBL4101604)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C9H10N2O6S/c12-8(11-15)5-10-18(16,17)7-3-1-6(2-4-7)9(13)14/h1-4,10,15H,5H2,(H,11,12)(H,13,14)
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n/an/a 410n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aldose reductase isolated from human placenta

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240450
PNG
(CHEMBL4063534)
Show SMILES ONC(=O)CNS(=O)(=O)c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C8H8Cl2N2O5S/c9-5-1-4(2-6(10)8(5)14)18(16,17)11-3-7(13)12-15/h1-2,11,14-15H,3H2,(H,12,13)
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n/an/a 430n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240409
PNG
(CHEMBL4067530)
Show SMILES COc1ccc(cc1F)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H17FN2O7S/c1-27-15-6-5-13(8-14(15)18)28(25,26)20(10-16(21)19-24)9-11-3-2-4-12(7-11)17(22)23/h2-8,24H,9-10H2,1H3,(H,19,21)(H,22,23)
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n/an/a 650n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240468
PNG
(CHEMBL4083361)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)S(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C17H15F3N2O7S/c18-17(19,20)29-13-4-6-14(7-5-13)30(27,28)22(10-15(23)21-26)9-11-2-1-3-12(8-11)16(24)25/h1-8,26H,9-10H2,(H,21,23)(H,24,25)
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n/an/a 700n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240403
PNG
(CHEMBL4079395)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-6-8-15(9-7-14)27(24,25)19(11-16(20)18-23)10-12-2-4-13(5-3-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 980n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240413
PNG
(CHEMBL4098334)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C16H15FN2O6S/c17-13-4-6-14(7-5-13)26(24,25)19(10-15(20)18-23)9-11-2-1-3-12(8-11)16(21)22/h1-8,23H,9-10H2,(H,18,20)(H,21,22)
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n/an/a 1.06E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240411
PNG
(CHEMBL4071300)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H20N2O6S/c25-21(23-28)15-24(14-16-5-4-8-19(13-16)22(26)27)31(29,30)20-11-9-18(10-12-20)17-6-2-1-3-7-17/h1-13,28H,14-15H2,(H,23,25)(H,26,27)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 1.24E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminal His6-tagged ADAM17 expressed in baculovirus infected Sf21 cells using Abz-LANAVRSSSR-(DapDnp)-NH2 as subst...

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240401
PNG
(CHEMBL4061533)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccc2OCOc2c1
Show InChI InChI=1S/C17H18N2O7S/c1-24-13-3-5-14(6-4-13)27(22,23)19(10-17(20)18-21)9-12-2-7-15-16(8-12)26-11-25-15/h2-8,21H,9-11H2,1H3,(H,18,20)
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n/an/a 1.93E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240402
PNG
(CHEMBL4097429)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCC(O)=O)CC(=O)NO
Show InChI InChI=1S/C12H16N2O7S/c1-21-9-2-4-10(5-3-9)22(19,20)14(7-6-12(16)17)8-11(15)13-18/h2-5,18H,6-8H2,1H3,(H,13,15)(H,16,17)
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n/an/a 2.55E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)		BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 3.29E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in S2 insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50294120
PNG
(2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide | ...)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O4S/c17-14(16-18)10-15-21(19,20)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,15,18H,10H2,(H,16,17)
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n/an/a 3.85E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240463
PNG
(CHEMBL4064607)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C15H16N2O5S/c1-22-13-6-2-11(3-7-13)12-4-8-14(9-5-12)23(20,21)16-10-15(18)17-19/h2-9,16,19H,10H2,1H3,(H,17,18)
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n/an/a 4.42E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240452
PNG
(CHEMBL4091383)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C10H12N2O6S/c13-9(12-16)6-11-19(17,18)8-3-1-7(2-4-8)5-10(14)15/h1-4,11,16H,5-6H2,(H,12,13)(H,14,15)
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n/an/a 5.03E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240441
PNG
(CHEMBL4073192)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN2O4S/c15-12-5-1-10(2-6-12)11-3-7-13(8-4-11)22(20,21)16-9-14(18)17-19/h1-8,16,19H,9H2,(H,17,18)
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n/an/a 5.65E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50246600
PNG
(2-(N-(2-(hydroxyamino)-2-oxoethyl)-4-methoxyphenyl...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(O)=O)CC(=O)NO
Show InChI InChI=1S/C11H14N2O7S/c1-20-8-2-4-9(5-3-8)21(18,19)13(7-11(15)16)6-10(14)12-17/h2-5,17H,6-7H2,1H3,(H,12,14)(H,15,16)
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n/an/a 5.98E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240422
PNG
(CHEMBL4085117)
Show SMILES COc1ccc(cc1F)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C9H11FN2O5S/c1-17-8-3-2-6(4-7(8)10)18(15,16)11-5-9(13)12-14/h2-4,11,14H,5H2,1H3,(H,12,13)
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n/an/a 6.19E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240435
PNG
(CHEMBL4093873)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C14H13FN2O4S/c15-12-5-1-10(2-6-12)11-3-7-13(8-4-11)22(20,21)16-9-14(18)17-19/h1-8,16,19H,9H2,(H,17,18)
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n/an/a 7.31E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240421
PNG
(CHEMBL4095310)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C10H12N2O6S/c13-10(12-14)6-11-19(15,16)7-1-2-8-9(5-7)18-4-3-17-8/h1-2,5,11,14H,3-4,6H2,(H,12,13)
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n/an/a 7.42E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM11328
PNG
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
Show SMILES COc1ccc(cc1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C9H12N2O5S/c1-16-7-2-4-8(5-3-7)17(14,15)10-6-9(12)11-13/h2-5,10,13H,6H2,1H3,(H,11,12)
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n/an/a 9.02E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240429
PNG
(CHEMBL4084150)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C9H8ClF3N2O4S/c10-7-2-1-5(3-6(7)9(11,12)13)20(18,19)14-4-8(16)15-17/h1-3,14,17H,4H2,(H,15,16)
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n/an/a 1.03E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10


(Homo sapiens (Human))		BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 1.17E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminal His10-tagged ADAM10 expressed in baculovirus infected Sf21 cells using Abz-LANAVRSSSR-(DapDnp)-NH2 as subs...

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240428
PNG
(CHEMBL4087610)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C8H9FN2O4S/c9-6-1-3-7(4-2-6)16(14,15)10-5-8(12)11-13/h1-4,10,13H,5H2,(H,11,12)
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n/an/a 1.43E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240423
PNG
(CHEMBL4079737)
Show SMILES Cc1ccc(c(C)c1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C10H14N2O4S/c1-7-3-4-9(8(2)5-7)17(15,16)11-6-10(13)12-14/h3-5,11,14H,6H2,1-2H3,(H,12,13)
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n/an/a 1.48E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM13080
PNG
(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16)
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n/an/a 1.71E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240427
PNG
(CHEMBL4066258)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C8H9ClN2O4S/c9-6-1-3-7(4-2-6)16(14,15)10-5-8(12)11-13/h1-4,10,13H,5H2,(H,11,12)
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n/an/a 1.72E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240461
PNG
(CHEMBL4062444)
Show SMILES Cc1ccc(F)cc1S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C9H11FN2O4S/c1-6-2-3-7(10)4-8(6)17(15,16)11-5-9(13)12-14/h2-4,11,14H,5H2,1H3,(H,12,13)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50175548
PNG
(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O5S/c17-14(16-18)10-15-22(19,20)13-8-6-12(7-9-13)21-11-4-2-1-3-5-11/h1-9,15,18H,10H2,(H,16,17)
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n/an/a 1.88E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240420
PNG
(CHEMBL4070398)
Show SMILES COc1cccc(c1)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C9H12N2O5S/c1-16-7-3-2-4-8(5-7)17(14,15)10-6-9(12)11-13/h2-5,10,13H,6H2,1H3,(H,11,12)
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n/an/a 1.89E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240459
PNG
(CHEMBL4103999)
Show SMILES COc1cc(C)ccc1S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C10H14N2O5S/c1-7-3-4-9(8(5-7)17-2)18(15,16)11-6-10(13)12-14/h3-5,11,14H,6H2,1-2H3,(H,12,13)
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n/an/a 2.57E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240458
PNG
(CHEMBL4074872)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)NCC(=O)NO
Show InChI InChI=1S/C10H14N2O6S/c1-17-8-4-3-7(5-9(8)18-2)19(15,16)11-6-10(13)12-14/h3-5,11,14H,6H2,1-2H3,(H,12,13)
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n/an/a 2.69E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)		BDBM50240414
PNG
(CHEMBL4105563)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)S(=O)(=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H16N2O8S/c20-15(18-25)10-19(9-11-3-1-4-12(7-11)16(21)22)28(26,27)14-6-2-5-13(8-14)17(23)24/h1-8,25H,9-10H2,(H,18,20)(H,21,22)(H,23,24)
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n/an/a 2.74E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in S2 insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240466
PNG
(CHEMBL4060490)
Show SMILES CCN(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C11H16N2O5S/c1-3-13(8-11(14)12-15)19(16,17)10-6-4-9(18-2)5-7-10/h4-7,15H,3,8H2,1-2H3,(H,12,14)
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n/an/a 3.12E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240398
PNG
(CHEMBL4088725)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(C)CC(=O)NO
Show InChI InChI=1S/C10H14N2O5S/c1-12(7-10(13)11-14)18(15,16)9-5-3-8(17-2)4-6-9/h3-6,14H,7H2,1-2H3,(H,11,13)
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n/an/a 3.25E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM13105
PNG
(CGS 27023A Analog 33 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(CN(CC(=O)NO)S(=O)(=O)c2ccc(OC)cc2)cc1
Show InChI InChI=1S/C17H20N2O6S/c1-24-14-5-3-13(4-6-14)11-19(12-17(20)18-21)26(22,23)16-9-7-15(25-2)8-10-16/h3-10,21H,11-12H2,1-2H3,(H,18,20)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240400
PNG
(CHEMBL4080850)
Show SMILES CCCCN(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C13H20N2O5S/c1-3-4-9-15(10-13(16)14-17)21(18,19)12-7-5-11(20-2)6-8-12/h5-8,17H,3-4,9-10H2,1-2H3,(H,14,16)
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n/an/a 3.75E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM13098
PNG
(CGS 27023A Analog 26 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCC(C)C)CC(=O)NO
Show InChI InChI=1S/C14H22N2O5S/c1-11(2)8-9-16(10-14(17)15-18)22(19,20)13-6-4-12(21-3)5-7-13/h4-7,11,18H,8-10H2,1-3H3,(H,15,17)
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n/an/a 3.88E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM11331
PNG
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccccc1
Show InChI InChI=1S/C16H18N2O5S/c1-23-14-7-9-15(10-8-14)24(21,22)18(12-16(19)17-20)11-13-5-3-2-4-6-13/h2-10,20H,11-12H2,1H3,(H,17,19)
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n/an/a 4.05E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM13095
PNG
(CGS 27023A Analog 23 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C17H20N2O5S/c1-24-15-7-9-16(10-8-15)25(22,23)19(13-17(20)18-21)12-11-14-5-3-2-4-6-14/h2-10,21H,11-13H2,1H3,(H,18,20)
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n/an/a 4.29E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit beta


(Homo sapiens)		BDBM50240467
PNG
(CHEMBL4105128)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC1CC2CCC1C2)CC(=O)NO
Show InChI InChI=1S/C17H24N2O5S/c1-24-15-4-6-16(7-5-15)25(22,23)19(11-17(20)18-21)10-14-9-12-2-3-13(14)8-12/h4-7,12-14,21H,2-3,8-11H2,1H3,(H,18,20)
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n/an/a 4.39E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay

Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%