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PubMed code 2888898

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367437
PNG
(CHEMBL1743956)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCCCc3ccnc4ccccc34)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C30H27F2N3/c31-22-8-11-24(12-9-22)35-29-13-10-23(32)19-26(29)27-20-34(18-15-30(27)35)17-4-3-5-21-14-16-33-28-7-2-1-6-25(21)28/h1-2,6-14,16,19H,3-5,15,17-18,20H2
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 1n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367438
PNG
(CHEMBL1743957)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCc3ccc4ccccc4n3)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C28H23F2N3/c29-20-6-10-23(11-7-20)33-27-12-8-21(30)17-24(27)25-18-32(16-14-28(25)33)15-13-22-9-5-19-3-1-2-4-26(19)31-22/h1-12,17H,13-16,18H2
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 1n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 1.80n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound; value may ra...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367417
PNG
(CHEMBL1743943)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCc3ccccn3)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H21F2N3/c25-17-4-7-20(8-5-17)29-23-9-6-18(26)15-21(23)22-16-28(14-11-24(22)29)13-10-19-3-1-2-12-27-19/h1-9,12,15H,10-11,13-14,16H2
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 3.60n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue; value may range from 2.4 to 5.3

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 4n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]-Spiperone as the radioligand in rat limbic system at 1 uM concentration of compound

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367419
PNG
(CHEMBL1743958)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCc3cnccn3)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C23H20F2N4/c24-16-1-4-19(5-2-16)29-22-6-3-17(25)13-20(22)21-15-28(12-8-23(21)29)11-7-18-14-26-9-10-27-18/h1-6,9-10,13-14H,7-8,11-12,15H2
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 5n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367417
PNG
(CHEMBL1743943)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCc3ccccn3)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H21F2N3/c25-17-4-7-20(8-5-17)29-23-9-6-18(26)15-21(23)22-16-28(14-11-24(22)29)13-10-19-3-1-2-12-27-19/h1-9,12,15H,10-11,13-14,16H2
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 7n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367433
PNG
(CHEMBL1743945)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCCCc3ccncc3)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C26H25F2N3/c27-20-4-7-22(8-5-20)31-25-9-6-21(28)17-23(25)24-18-30(16-12-26(24)31)15-2-1-3-19-10-13-29-14-11-19/h4-11,13-14,17H,1-3,12,15-16,18H2
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 7n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]-Spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may ...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 10n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]-Spiperone as the radioligand in rat cortical tissue.

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367432
PNG
(CHEMBL1743937)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCc3ccncc3)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H21F2N3/c25-18-1-4-20(5-2-18)29-23-6-3-19(26)15-21(23)22-16-28(14-10-24(22)29)13-9-17-7-11-27-12-8-17/h1-8,11-12,15H,9-10,13-14,16H2
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 12n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367425
PNG
(CHEMBL1743955)
Show SMILES Fc1ccc(cc1)C(CCCN1CCc2[nH]c3ccc(F)cc3c2C1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F3N2/c28-20-7-3-18(4-8-20)23(19-5-9-21(29)10-6-19)2-1-14-32-15-13-27-25(17-32)24-16-22(30)11-12-26(24)31-27/h3-12,16,23,31H,1-2,13-15,17H2
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 18n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367419
PNG
(CHEMBL1743958)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCc3cnccn3)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C23H20F2N4/c24-16-1-4-19(5-2-16)29-22-6-3-17(25)13-20(22)21-15-28(12-8-23(21)29)11-7-18-14-26-9-10-27-18/h1-6,9-10,13-14H,7-8,11-12,15H2
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 23n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue; value may range from 6 to 75

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367422
PNG
(CHEMBL1743935)
Show SMILES Fc1ccc2[nH]c3CCN(CCc4ccccn4)Cc3c2c1
Show InChI InChI=1S/C18H18FN3/c19-13-4-5-17-15(11-13)16-12-22(10-7-18(16)21-17)9-6-14-3-1-2-8-20-14/h1-5,8,11,21H,6-7,9-10,12H2
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 26n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 27n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound; value may ra...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367435
PNG
(CHEMBL1743938)
Show SMILES Clc1ccc2[nH]c3CCN(CCCc4cccnc4)Cc3c2c1
Show InChI InChI=1S/C19H20ClN3/c20-15-5-6-18-16(11-15)17-13-23(10-7-19(17)22-18)9-2-4-14-3-1-8-21-12-14/h1,3,5-6,8,11-12,22H,2,4,7,9-10,13H2
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 28n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]-Spiperone as the radioligand in rat cortical tissue; value may range from 12 to 66

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 34n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]-Spiperone as the radioligand in rat limbic system at 1 uM concentration of compound

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367432
PNG
(CHEMBL1743937)
Show SMILES Fc1ccc(cc1)-n1c2CCN(CCc3ccncc3)Cc2c2cc(F)ccc12
Show InChI InChI=1S/C24H21F2N3/c25-18-1-4-20(5-2-18)29-23-6-3-19(26)15-21(23)22-16-28(14-10-24(22)29)13-9-17-7-11-27-12-8-17/h1-8,11-12,15H,9-10,13-14,16H2
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 55n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound; value may ra...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367430
PNG
(CHEMBL1743934)
Show SMILES Clc1ccc2[nH]c3CCN(CCCN4CCN(CC4)c4ncccn4)Cc3c2c1
Show InChI InChI=1S/C22H27ClN6/c23-17-3-4-20-18(15-17)19-16-28(10-5-21(19)26-20)9-2-8-27-11-13-29(14-12-27)22-24-6-1-7-25-22/h1,3-4,6-7,15,26H,2,5,8-14,16H2
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 55n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367436
PNG
(CHEMBL1743947)
Show SMILES C(CN1CCN(CC1)c1ncccn1)CN1CCc2[nH]c3ccccc3c2C1
Show InChI InChI=1S/C22H28N6/c1-2-6-20-18(5-1)19-17-27(12-7-21(19)25-20)11-4-10-26-13-15-28(16-14-26)22-23-8-3-9-24-22/h1-3,5-6,8-9,25H,4,7,10-17H2
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 60n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367431
PNG
(CHEMBL1743959)
Show SMILES Clc1ccc2[nH]c3CCN(CCCCc4ccncc4)Cc3c2c1
Show InChI InChI=1S/C20H22ClN3/c21-16-4-5-19-17(13-16)18-14-24(12-8-20(18)23-19)11-2-1-3-15-6-9-22-10-7-15/h4-7,9-10,13,23H,1-3,8,11-12,14H2
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 60n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue; value may range from 29 to 132

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367434
PNG
(CHEMBL1743951)
Show SMILES Fc1ccc2[nH]c3CCN(CCc4cnccn4)Cc3c2c1
Show InChI InChI=1S/C17H17FN4/c18-12-1-2-16-14(9-12)15-11-22(8-4-17(15)21-16)7-3-13-10-19-5-6-20-13/h1-2,5-6,9-10,21H,3-4,7-8,11H2
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 63n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367426
PNG
(CHEMBL1743962)
Show SMILES Clc1ccc2[nH]c3CCN(CCc4ccc5ccccc5n4)Cc3c2c1
Show InChI InChI=1S/C22H20ClN3/c23-16-6-8-21-18(13-16)19-14-26(12-10-22(19)25-21)11-9-17-7-5-15-3-1-2-4-20(15)24-17/h1-8,13,25H,9-12,14H2
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 82n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367421
PNG
(CHEMBL1743941)
Show SMILES Clc1ccc2[nH]c3CCN(CCc4ccccn4)Cc3c2c1
Show InChI InChI=1S/C18H18ClN3/c19-13-4-5-17-15(11-13)16-12-22(10-7-18(16)21-17)9-6-14-3-1-2-8-20-14/h1-5,8,11,21H,6-7,9-10,12H2
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 103n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367423
PNG
(CHEMBL1743949)
Show SMILES Fc1ccc2[nH]c3CCN(CCCc4cccnc4)Cc3c2c1
Show InChI InChI=1S/C19H20FN3/c20-15-5-6-18-16(11-15)17-13-23(10-7-19(17)22-18)9-2-4-14-3-1-8-21-12-14/h1,3,5-6,8,11-12,22H,2,4,7,9-10,13H2
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 104n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367431
PNG
(CHEMBL1743959)
Show SMILES Clc1ccc2[nH]c3CCN(CCCCc4ccncc4)Cc3c2c1
Show InChI InChI=1S/C20H22ClN3/c21-16-4-5-19-17(13-16)18-14-24(12-8-20(18)23-19)11-2-1-3-15-6-9-22-10-7-15/h4-7,9-10,13,23H,1-3,8,11-12,14H2
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 106n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]-Spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may ...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367418
PNG
(CHEMBL1743952 | Carvotroline hydrochloride)
Show SMILES Fc1ccc2[nH]c3CCN(CCc4ccncc4)Cc3c2c1
Show InChI InChI=1S/C18H18FN3/c19-14-1-2-17-15(11-14)16-12-22(10-6-18(16)21-17)9-5-13-3-7-20-8-4-13/h1-4,7-8,11,21H,5-6,9-10,12H2
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 110n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 118n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound; value may ra...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367435
PNG
(CHEMBL1743938)
Show SMILES Clc1ccc2[nH]c3CCN(CCCc4cccnc4)Cc3c2c1
Show InChI InChI=1S/C19H20ClN3/c20-15-5-6-18-16(11-15)17-13-23(10-7-19(17)22-18)9-2-4-14-3-1-8-21-12-14/h1,3,5-6,8,11-12,22H,2,4,7,9-10,13H2
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 126n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367423
PNG
(CHEMBL1743949)
Show SMILES Fc1ccc2[nH]c3CCN(CCCc4cccnc4)Cc3c2c1
Show InChI InChI=1S/C19H20FN3/c20-15-5-6-18-16(11-15)17-13-23(10-7-19(17)22-18)9-2-4-14-3-1-8-21-12-14/h1,3,5-6,8,11-12,22H,2,4,7,9-10,13H2
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 136n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue.; value may range from 76 to 299

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367428
PNG
(CHEMBL1743953)
Show SMILES C(CN1CC(c2[nH]c3ccccc3c2C1)c1ccccc1)Cc1cccnc1
Show InChI InChI=1S/C25H25N3/c1-2-10-20(11-3-1)22-17-28(15-7-9-19-8-6-14-26-16-19)18-23-21-12-4-5-13-24(21)27-25(22)23/h1-6,8,10-14,16,22,27H,7,9,15,17-18H2
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 140n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]-Spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may ...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367427
PNG
(CHEMBL1743939)
Show SMILES Fc1ccc2[nH]c3CCN(CCCCc4ccncc4)Cc3c2c1
Show InChI InChI=1S/C20H22FN3/c21-16-4-5-19-17(13-16)18-14-24(12-8-20(18)23-19)11-2-1-3-15-6-9-22-10-7-15/h4-7,9-10,13,23H,1-3,8,11-12,14H2
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 143n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367422
PNG
(CHEMBL1743935)
Show SMILES Fc1ccc2[nH]c3CCN(CCc4ccccn4)Cc3c2c1
Show InChI InChI=1S/C18H18FN3/c19-13-4-5-17-15(11-13)16-12-22(10-7-18(16)21-17)9-6-14-3-1-2-8-20-14/h1-5,8,11,21H,6-7,9-10,12H2
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 173n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue; value may range from 136 to 220

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367429
PNG
(CHEMBL1743942)
Show SMILES Fc1ccc2[nH]c3CCN(CCc4ccc5ccccc5n4)Cc3c2c1
Show InChI InChI=1S/C22H20FN3/c23-16-6-8-21-18(13-16)19-14-26(12-10-22(19)25-21)11-9-17-7-5-15-3-1-2-4-20(15)24-17/h1-8,13,25H,9-12,14H2
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 185n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound.

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367418
PNG
(CHEMBL1743952 | Carvotroline hydrochloride)
Show SMILES Fc1ccc2[nH]c3CCN(CCc4ccncc4)Cc3c2c1
Show InChI InChI=1S/C18H18FN3/c19-14-1-2-17-15(11-14)16-12-22(10-6-18(16)21-17)9-5-13-3-7-20-8-4-13/h1-4,7-8,11,21H,5-6,9-10,12H2
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 211n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue; value may range from 165 to 263

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50226309
PNG
(CHEMBL1743948)
Show SMILES Cl.C(CN1CCc2[nH]c3ccccc3c2C1)Cc1cccnc1
Show InChI InChI=1S/C19H21N3/c1-2-8-18-16(7-1)17-14-22(12-9-19(17)21-18)11-4-6-15-5-3-10-20-13-15/h1-3,5,7-8,10,13,21H,4,6,9,11-12,14H2
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 252n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue; value may range from 197 to 341

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367424
PNG
(CHEMBL1743950)
Show SMILES C(Cc1ccc2ccccc2n1)N1CCc2[nH]c3ccccc3c2C1
Show InChI InChI=1S/C22H21N3/c1-3-7-20-16(5-1)9-10-17(23-20)11-13-25-14-12-22-19(15-25)18-6-2-4-8-21(18)24-22/h1-10,24H,11-15H2
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 331n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367420
PNG
(CHEMBL1743960)
Show SMILES C(CCc1ccncc1)CN1CC(c2[nH]c3ccccc3c2C1)c1ccccc1
Show InChI InChI=1S/C26H27N3/c1-2-9-21(10-3-1)23-18-29(17-7-6-8-20-13-15-27-16-14-20)19-24-22-11-4-5-12-25(22)28-26(23)24/h1-5,9-16,23,28H,6-8,17-19H2
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 404n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50367427
PNG
(CHEMBL1743939)
Show SMILES Fc1ccc2[nH]c3CCN(CCCCc4ccncc4)Cc3c2c1
Show InChI InChI=1S/C20H22FN3/c21-16-4-5-19-17(13-16)18-14-24(12-8-20(18)23-19)11-2-1-3-15-6-9-22-10-7-15/h4-7,9-10,13,23H,1-3,8,11-12,14H2
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 480n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue.; value may range from 140 to 980

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50367439
PNG
(CHEMBL1743954)
Show SMILES C(Cc1ccccn1)N1CC(c2[nH]c3ccccc3c2C1)c1ccccc1
Show InChI InChI=1S/C24H23N3/c1-2-8-18(9-3-1)21-16-27(15-13-19-10-6-7-14-25-19)17-22-20-11-4-5-12-23(20)26-24(21)22/h1-12,14,21,26H,13,15-17H2
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 600n/an/an/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound ; value may r...

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50019742
PNG
(9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...)
Show SMILES C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1 |r|
Show InChI InChI=1S/C21H27N3/c1-16-14-23(15-17(2)22-16)12-7-13-24-20-10-5-3-8-18(20)19-9-4-6-11-21(19)24/h3-6,8-11,16-17,22H,7,12-15H2,1-2H3/t16-,17+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound.

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50019742
PNG
(9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...)
Show SMILES C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1 |r|
Show InChI InChI=1S/C21H27N3/c1-16-14-23(15-17(2)22-16)12-7-13-24-20-10-5-3-8-18(20)19-9-4-6-11-21(19)24/h3-6,8-11,16-17,22H,7,12-15H2,1-2H3/t16-,17+
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n/an/a>5.00E+4n/an/an/an/an/an/a



Wyeth Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue.

J Med Chem 30: 1818-23 (1987)


BindingDB Entry DOI: 10.7270/Q2NS0VG2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%