Affinity Data by PubMed id=2896247

PubMed code 2896247

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50227383 (CHEMBL556758) Show SMILES Cl.CN1C(Cc2c1cccc2Cl)C1=NCCN1 \|t:13\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50226939 (CHEMBL36616) Show SMILES CCN1C(Cc2ccccc12)C1=NCCN1 \|t:13\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	0.240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50227384 (CHEMBL172132) Show SMILES CCN1C(Cc2c1cccc2Cl)C1=NCCN1 \|t:14\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50226938 (CHEMBL38829) Show SMILES CN1C(Cc2ccccc12)C1=NCCN1 \|t:12\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50226961 (CHEMBL38788) Show SMILES CCCN1C(Cc2ccccc12)C1=NCCN1 \|t:14\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.960	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227384 (CHEMBL172132) Show SMILES CCN1C(Cc2c1cccc2Cl)C1=NCCN1 \|t:14\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]prazosin to alpha1-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50226937 (CHEMBL289153) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50226964 (CHEMBL41064) Show SMILES C1CN=C(N1)C1Cc2ccccc2N1c1ccccc1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226939 (CHEMBL36616) Show SMILES CCN1C(Cc2ccccc12)C1=NCCN1 \|t:13\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]prazosin to alpha1-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226961 (CHEMBL38788) Show SMILES CCCN1C(Cc2ccccc12)C1=NCCN1 \|t:14\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]prazosin to alpha1-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226938 (CHEMBL38829) Show SMILES CN1C(Cc2ccccc12)C1=NCCN1 \|t:12\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]prazosin to alpha-1 adrenergic receptor site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226964 (CHEMBL41064) Show SMILES C1CN=C(N1)C1Cc2ccccc2N1c1ccccc1 \|c:2\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	8.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]prazosin to alpha1-site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227383 (CHEMBL556758) Show SMILES Cl.CN1C(Cc2c1cccc2Cl)C1=NCCN1 \|t:13\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]prazosin to alpha-1 adrenergic receptor site in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226937 (CHEMBL289153) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Reckitt and Colman plc Curated by ChEMBL					Assay Description Inhibition of saturable binding of [3H]prazosin to alpha-1 adrenergic receptor in rat cerebral cortical membranes.				J Med Chem 31: 944-8 (1988) BindingDB Entry DOI: 10.7270/Q22F7QNK
Reckitt and Colman plc Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%