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PubMed code 3027330

Compile data set for download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50021572
PNG
((2S,3S)-2-(3,4-Dimethoxy-phenyl)-3-methyl-5-propyl...)
Show SMILES CCCc1cc2[C@H](C)[C@H](Oc2cc1O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H24O4/c1-5-6-13-9-15-12(2)20(24-18(15)11-16(13)21)14-7-8-17(22-3)19(10-14)23-4/h7-12,20-21H,5-6H2,1-4H3/t12-,20-/m0/s1
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n/an/a 0n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.

J Med Chem 30: 136-42 (1987)


BindingDB Entry DOI: 10.7270/Q25T3M2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50405462
PNG
(CHEMBL2115332)
Show SMILES CCCC1=C[C@]2(OC)[C@H](C)[C@H](OC2=CC1=O)c1ccc(OC)c(OC)c1 |c:13,t:3|
Show InChI InChI=1S/C21H26O5/c1-6-7-15-12-21(25-5)13(2)20(26-19(21)11-16(15)22)14-8-9-17(23-3)18(10-14)24-4/h8-13,20H,6-7H2,1-5H3/t13-,20+,21+/m1/s1
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n/an/a 70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.

J Med Chem 30: 136-42 (1987)


BindingDB Entry DOI: 10.7270/Q25T3M2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50001747
PNG
((+)-Kadsurenone | (Kadsurenone)5-Allyl-2-(3,4-dime...)
Show SMILES COc1ccc(cc1OC)[C@H]1OC2=CC(=O)C(CC=C)=C[C@]2(OC)[C@@H]1C |c:20,t:13|
Show InChI InChI=1S/C21H24O5/c1-6-7-15-12-21(25-5)13(2)20(26-19(21)11-16(15)22)14-8-9-17(23-3)18(10-14)24-4/h6,8-13,20H,1,7H2,2-5H3/t13-,20+,21+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitor concentration required to block 50% of the specific [3H]PAF binding, obtained as natural product.

J Med Chem 30: 136-42 (1987)


BindingDB Entry DOI: 10.7270/Q25T3M2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50001747
PNG
((+)-Kadsurenone | (Kadsurenone)5-Allyl-2-(3,4-dime...)
Show SMILES COc1ccc(cc1OC)[C@H]1OC2=CC(=O)C(CC=C)=C[C@]2(OC)[C@@H]1C |c:20,t:13|
Show InChI InChI=1S/C21H24O5/c1-6-7-15-12-21(25-5)13(2)20(26-19(21)11-16(15)22)14-8-9-17(23-3)18(10-14)24-4/h6,8-13,20H,1,7H2,2-5H3/t13-,20+,21+/m1/s1
MMDB

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n/an/a 120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.

J Med Chem 30: 136-42 (1987)


BindingDB Entry DOI: 10.7270/Q25T3M2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50001747
PNG
((+)-Kadsurenone | (Kadsurenone)5-Allyl-2-(3,4-dime...)
Show SMILES COc1ccc(cc1OC)[C@H]1OC2=CC(=O)C(CC=C)=C[C@]2(OC)[C@@H]1C |c:20,t:13|
Show InChI InChI=1S/C21H24O5/c1-6-7-15-12-21(25-5)13(2)20(26-19(21)11-16(15)22)14-8-9-17(23-3)18(10-14)24-4/h6,8-13,20H,1,7H2,2-5H3/t13-,20+,21+/m1/s1
MMDB

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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition concentration required to block 50% of the specific [3H]PAF binding, obtained from Chiralpak column at low temperatures.

J Med Chem 30: 136-42 (1987)


BindingDB Entry DOI: 10.7270/Q25T3M2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50001747
PNG
((+)-Kadsurenone | (Kadsurenone)5-Allyl-2-(3,4-dime...)
Show SMILES COc1ccc(cc1OC)[C@H]1OC2=CC(=O)C(CC=C)=C[C@]2(OC)[C@@H]1C |c:20,t:13|
Show InChI InChI=1S/C21H24O5/c1-6-7-15-12-21(25-5)13(2)20(26-19(21)11-16(15)22)14-8-9-17(23-3)18(10-14)24-4/h6,8-13,20H,1,7H2,2-5H3/t13-,20+,21+/m1/s1
MMDB

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n/an/a 240n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitor concentration required to block 50 %of the specific [3H]PAF binding to rabbit platelet membranes.

J Med Chem 30: 136-42 (1987)


BindingDB Entry DOI: 10.7270/Q25T3M2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50021571
PNG
((2S,3R)-5-Allyl-2-(3,4-dimethoxy-phenyl)-3a-ethoxy...)
Show SMILES CCOC12C=C(CC=C)C(=O)C=C1O[C@@H]([C@H]2C)c1ccc(OC)c(OC)c1 |c:11,t:4|
Show InChI InChI=1S/C22H26O5/c1-6-8-16-13-22(26-7-2)14(3)21(27-20(22)12-17(16)23)15-9-10-18(24-4)19(11-15)25-5/h6,9-14,21H,1,7-8H2,2-5H3/t14-,21+,22?/m1/s1
MMDB

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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.

J Med Chem 30: 136-42 (1987)


BindingDB Entry DOI: 10.7270/Q25T3M2X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%