Affinity Data by PubMed id=3336015

PubMed code 3336015

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (RAT)	BDBM50226982 (CHEMBL553214) Show SMILES [Cl-].O=C1CCCN1CC#CC[S+]1CCCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity to Muscarinic acetylcholine receptor in rat cerebral cortex				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (RAT)	BDBM50226980 (CHEMBL540395) Show SMILES [Cl-].C[S+](C)CC#CCN1CCCC1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity to Muscarinic acetylcholine receptor in rat cerebral cortex				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (RAT)	BDBM50005677 (CHEMBL23957 \| OXO-M \| Trimethyl-[4-(2-oxo-pyrrolid...) Show SMILES C[N+](C)(C)CC#CCN1CCCC1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity to Muscarinic acetylcholine receptor in rat cerebral cortex				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (RAT)	BDBM50226979 (CHEMBL554629) Show SMILES [Cl-].O=C1CCC(=O)N1CC#CC[S+]1CCCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity to Muscarinic acetylcholine receptor in rat cerebral cortex				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (RAT)	BDBM50226981 (CHEMBL541927) Show SMILES [Cl-].C[S+](C)CC#CCN1C(=O)CCC1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity to Muscarinic acetylcholine receptor in rat cerebral cortex				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50004656 ((2-Carbamoyloxy-ethyl)-trimethyl-ammonium \| (2-Car...) Show SMILES C[N+](C)(C)CCOC(N)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Dissociation constant of the drug-receptor complex was measured in guinea pig urinary bladder				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50004656 ((2-Carbamoyloxy-ethyl)-trimethyl-ammonium \| (2-Car...) Show SMILES C[N+](C)(C)CCOC(N)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description In vitro muscarinic activity was measured on isolated guinea pig ileum				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50004656 ((2-Carbamoyloxy-ethyl)-trimethyl-ammonium \| (2-Car...) Show SMILES C[N+](C)(C)CCOC(N)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	620	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description In vitro muscarinic activity was measured on isolated guinea pig urinary bladder				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
University of California Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%