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PubMed code 3373484

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023655
PNG
(11-[2-(1-Methyl-piperidin-2-yl)-acetyl]-5,11-dihyd...)
Show SMILES CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C20H22N4O2/c1-23-12-5-4-7-14(23)13-18(25)24-17-10-3-2-8-15(17)20(26)22-16-9-6-11-21-19(16)24/h2-3,6,8-11,14H,4-5,7,12-13H2,1H3,(H,22,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023655
PNG
(11-[2-(1-Methyl-piperidin-2-yl)-acetyl]-5,11-dihyd...)
Show SMILES CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C20H22N4O2/c1-23-12-5-4-7-14(23)13-18(25)24-17-10-3-2-8-15(17)20(26)22-16-9-6-11-21-19(16)24/h2-3,6,8-11,14H,4-5,7,12-13H2,1H3,(H,22,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023662
PNG
(11-[2-(1-Methyl-pyrrolidin-3-yl)-acetyl]-5,11-dihy...)
Show SMILES CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)C1
Show InChI InChI=1S/C19H20N4O2/c1-22-10-8-13(12-22)11-17(24)23-16-7-3-2-5-14(16)19(25)21-15-6-4-9-20-18(15)23/h2-7,9,13H,8,10-12H2,1H3,(H,21,25)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50021847
PNG
(5-[2-(4-Methyl-piperazin-1-yl)-acetyl]-5,10-dihydr...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C20H22N4O2/c1-22-10-12-23(13-11-22)14-19(25)24-17-8-4-2-6-15(17)20(26)21-16-7-3-5-9-18(16)24/h2-9H,10-14H2,1H3,(H,21,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023659
PNG
(11-(4-Dimethylamino-butyryl)-5,11-dihydro-benzo[e]...)
Show SMILES CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C18H20N4O2/c1-21(2)12-6-10-16(23)22-15-9-4-3-7-13(15)18(24)20-14-8-5-11-19-17(14)22/h3-5,7-9,11H,6,10,12H2,1-2H3,(H,20,24)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023662
PNG
(11-[2-(1-Methyl-pyrrolidin-3-yl)-acetyl]-5,11-dihy...)
Show SMILES CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)C1
Show InChI InChI=1S/C19H20N4O2/c1-22-10-8-13(12-22)11-17(24)23-16-7-3-2-5-14(16)19(25)21-15-6-4-9-20-18(15)23/h2-7,9,13H,8,10-12H2,1H3,(H,21,25)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023654
PNG
(4-[2-(4-Methyl-piperazin-1-yl)-acetyl]-4,9-dihydro...)
Show SMILES CN1CCN(CC(=O)N2c3cscc3C(=O)Nc3ccccc23)CC1
Show InChI InChI=1S/C18H20N4O2S/c1-20-6-8-21(9-7-20)10-17(23)22-15-5-3-2-4-14(15)19-18(24)13-11-25-12-16(13)22/h2-5,11-12H,6-10H2,1H3,(H,19,24)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023652
PNG
(6-Oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazep...)
Show SMILES CN1CCN(CC1)NC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C18H20N6O2/c1-22-9-11-23(12-10-22)21-18(26)24-15-7-3-2-5-13(15)17(25)20-14-6-4-8-19-16(14)24/h2-8H,9-12H2,1H3,(H,20,25)(H,21,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023656
PNG
(11-[2-(1-Methyl-piperidin-4-yl)-acetyl]-5,11-dihyd...)
Show SMILES CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H22N4O2/c1-23-11-8-14(9-12-23)13-18(25)24-17-7-3-2-5-15(17)20(26)22-16-6-4-10-21-19(16)24/h2-7,10,14H,8-9,11-13H2,1H3,(H,22,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023650
PNG
(6-Oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazep...)
Show SMILES CN1CCC(CC1)OC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C19H20N4O3/c1-22-11-8-13(9-12-22)26-19(25)23-16-7-3-2-5-14(16)18(24)21-15-6-4-10-20-17(15)23/h2-7,10,13H,8-9,11-12H2,1H3,(H,21,24)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023659
PNG
(11-(4-Dimethylamino-butyryl)-5,11-dihydro-benzo[e]...)
Show SMILES CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C18H20N4O2/c1-21(2)12-6-10-16(23)22-15-9-4-3-7-13(15)18(24)20-14-8-5-11-19-17(14)22/h3-5,7-9,11H,6,10,12H2,1-2H3,(H,20,24)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50021847
PNG
(5-[2-(4-Methyl-piperazin-1-yl)-acetyl]-5,10-dihydr...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C20H22N4O2/c1-22-10-12-23(13-11-22)14-19(25)24-17-8-4-2-6-15(17)20(26)21-16-7-3-5-9-18(16)24/h2-9H,10-14H2,1H3,(H,21,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023658
PNG
(11-[2-(1-Methyl-azepan-4-yl)-acetyl]-5,11-dihydro-...)
Show SMILES CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C21H24N4O2/c1-24-12-5-6-15(10-13-24)14-19(26)25-18-9-3-2-7-16(18)21(27)23-17-8-4-11-22-20(17)25/h2-4,7-9,11,15H,5-6,10,12-14H2,1H3,(H,23,27)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023653
PNG
(11-[2-(1-Methyl-piperidin-3-yl)-acetyl]-5,11-dihyd...)
Show SMILES CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)C1
Show InChI InChI=1S/C20H22N4O2/c1-23-11-5-6-14(13-23)12-18(25)24-17-9-3-2-7-15(17)20(26)22-16-8-4-10-21-19(16)24/h2-4,7-10,14H,5-6,11-13H2,1H3,(H,22,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023653
PNG
(11-[2-(1-Methyl-piperidin-3-yl)-acetyl]-5,11-dihyd...)
Show SMILES CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)C1
Show InChI InChI=1S/C20H22N4O2/c1-23-11-5-6-14(13-23)12-18(25)24-17-9-3-2-7-15(17)20(26)22-16-8-4-10-21-19(16)24/h2-4,7-10,14H,5-6,11-13H2,1H3,(H,22,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023657
PNG
(11-(4-Methyl-piperazine-1-carbonyl)-5,11-dihydro-b...)
Show SMILES CN1CCN(CC1)C(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C18H19N5O2/c1-21-9-11-22(12-10-21)18(25)23-15-7-3-2-5-13(15)17(24)20-14-6-4-8-19-16(14)23/h2-8H,9-12H2,1H3,(H,20,24)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023658
PNG
(11-[2-(1-Methyl-azepan-4-yl)-acetyl]-5,11-dihydro-...)
Show SMILES CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C21H24N4O2/c1-24-12-5-6-15(10-13-24)14-19(26)25-18-9-3-2-7-16(18)21(27)23-17-8-4-11-22-20(17)25/h2-4,7-9,11,15H,5-6,10,12-14H2,1H3,(H,23,27)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50021850
PNG
(11-(3-Dimethylamino-propionyl)-5,11-dihydro-benzo[...)
Show SMILES CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C17H18N4O2/c1-20(2)11-9-15(22)21-14-8-4-3-6-12(14)17(23)19-13-7-5-10-18-16(13)21/h3-8,10H,9,11H2,1-2H3,(H,19,23)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023648
PNG
(6-Oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazep...)
Show SMILES CN1CCC(CC1)NC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C19H21N5O2/c1-23-11-8-13(9-12-23)21-19(26)24-16-7-3-2-5-14(16)18(25)22-15-6-4-10-20-17(15)24/h2-7,10,13H,8-9,11-12H2,1H3,(H,21,26)(H,22,25)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50021850
PNG
(11-(3-Dimethylamino-propionyl)-5,11-dihydro-benzo[...)
Show SMILES CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C17H18N4O2/c1-20(2)11-9-15(22)21-14-8-4-3-6-12(14)17(23)19-13-7-5-10-18-16(13)21/h3-8,10H,9,11H2,1-2H3,(H,19,23)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023649
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6,11-dihyd...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-6-15(16)21-19(26)14-5-4-8-20-18(14)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 300n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023654
PNG
(4-[2-(4-Methyl-piperazin-1-yl)-acetyl]-4,9-dihydro...)
Show SMILES CN1CCN(CC(=O)N2c3cscc3C(=O)Nc3ccccc23)CC1
Show InChI InChI=1S/C18H20N4O2S/c1-20-6-8-21(9-7-20)10-17(23)22-15-5-3-2-4-14(15)19-18(24)13-11-25-12-16(13)22/h2-5,11-12H,6-10H2,1H3,(H,19,24)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023651
PNG
(11-(5-Dimethylamino-pentanoyl)-5,11-dihydro-benzo[...)
Show SMILES CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C19H22N4O2/c1-22(2)13-6-5-11-17(24)23-16-10-4-3-8-14(16)19(25)21-15-9-7-12-20-18(15)23/h3-4,7-10,12H,5-6,11,13H2,1-2H3,(H,21,25)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023657
PNG
(11-(4-Methyl-piperazine-1-carbonyl)-5,11-dihydro-b...)
Show SMILES CN1CCN(CC1)C(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C18H19N5O2/c1-21-9-11-22(12-10-21)18(25)23-15-7-3-2-5-13(15)17(24)20-14-6-4-8-19-16(14)23/h2-8H,9-12H2,1H3,(H,20,24)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023651
PNG
(11-(5-Dimethylamino-pentanoyl)-5,11-dihydro-benzo[...)
Show SMILES CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C19H22N4O2/c1-22(2)13-6-5-11-17(24)23-16-10-4-3-8-14(16)19(25)21-15-9-7-12-20-18(15)23/h3-4,7-10,12H,5-6,11,13H2,1-2H3,(H,21,25)
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n/an/a 600n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023656
PNG
(11-[2-(1-Methyl-piperidin-4-yl)-acetyl]-5,11-dihyd...)
Show SMILES CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H22N4O2/c1-23-11-8-14(9-12-23)13-18(25)24-17-7-3-2-5-15(17)20(26)22-16-6-4-10-21-19(16)24/h2-7,10,14H,8-9,11-13H2,1H3,(H,22,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023661
PNG
(11-(2-Dimethylamino-acetyl)-5,11-dihydro-benzo[e]p...)
Show SMILES CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C16H16N4O2/c1-19(2)10-14(21)20-13-8-4-3-6-11(13)16(22)18-12-7-5-9-17-15(12)20/h3-9H,10H2,1-2H3,(H,18,22)
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n/an/a 700n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023650
PNG
(6-Oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazep...)
Show SMILES CN1CCC(CC1)OC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C19H20N4O3/c1-22-11-8-13(9-12-22)26-19(25)23-16-7-3-2-5-14(16)18(24)21-15-6-4-10-20-17(15)23/h2-7,10,13H,8-9,11-12H2,1H3,(H,21,24)
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n/an/a 900n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023652
PNG
(6-Oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazep...)
Show SMILES CN1CCN(CC1)NC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C18H20N6O2/c1-22-9-11-23(12-10-22)21-18(26)24-15-7-3-2-5-13(15)17(25)20-14-6-4-8-19-16(14)24/h2-8H,9-12H2,1H3,(H,20,25)(H,21,26)
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n/an/a 900n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023648
PNG
(6-Oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazep...)
Show SMILES CN1CCC(CC1)NC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C19H21N5O2/c1-23-11-8-13(9-12-23)21-19(26)24-16-7-3-2-5-14(16)18(25)22-15-6-4-10-20-17(15)24/h2-7,10,13H,8-9,11-12H2,1H3,(H,21,26)(H,22,25)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023661
PNG
(11-(2-Dimethylamino-acetyl)-5,11-dihydro-benzo[e]p...)
Show SMILES CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C16H16N4O2/c1-19(2)10-14(21)20-13-8-4-3-6-11(13)16(22)18-12-7-5-9-17-15(12)20/h3-9H,10H2,1-2H3,(H,18,22)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023649
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6,11-dihyd...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-6-15(16)21-19(26)14-5-4-8-20-18(14)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50023660
PNG
(11-[3-(4-Methyl-piperazin-1-yl)-propionyl]-5,11-di...)
Show SMILES CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H23N5O2/c1-23-11-13-24(14-12-23)10-8-18(26)25-17-7-3-2-5-15(17)20(27)22-16-6-4-9-21-19(16)25/h2-7,9H,8,10-14H2,1H3,(H,22,27)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50023660
PNG
(11-[3-(4-Methyl-piperazin-1-yl)-propionyl]-5,11-di...)
Show SMILES CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H23N5O2/c1-23-11-13-24(14-12-23)10-8-18(26)25-17-7-3-2-5-15(17)20(27)22-16-6-4-9-21-19(16)25/h2-7,9H,8,10-14H2,1H3,(H,22,27)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2

J Med Chem 31: 1169-74 (1988)


BindingDB Entry DOI: 10.7270/Q2DV1HW6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%