Found 30 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank PC cid PC sid PDB UniChem
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| PDB PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Noncompetitive Iinhibitory activity against human liver DHPR enzyme |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50017543
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r| Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
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| PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase using 10 uM qBH2 and 50 uM NADH assays |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50225476
(CHEMBL330849)Show SMILES [H][C@]12C[C@H](CSC)CN(CCC)[C@]1([H])Cc1cccc(O)c1C2 Show InChI InChI=1S/C18H27NOS/c1-3-7-19-11-13(12-21-2)8-15-9-16-14(10-17(15)19)5-4-6-18(16)20/h4-6,13,15,17,20H,3,7-12H2,1-2H3/t13-,15+,17+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase (DHPR) |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50225361
(Etisulergine)Show SMILES [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Noncompetitive Inhibitory activity against rat striatal synaptosomal DHPR enzyme |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50225361
(Etisulergine)Show SMILES [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against serotonin receptor from rat frontal cortex using [3H]spiperone as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50225362
(Norprolac | QUINAGOLIDE)Show SMILES [H][C@]12C[C@@H](CN(CCC)[C@]1([H])Cc1cccc(O)c1C2)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C20H33N3O3S/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3/t16-,17+,19-/m1/s1 | PDB
UniProtKB/SwissProt
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MCE PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against dopamine receptor from calf caudate using [3H]spiperone as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50225476
(CHEMBL330849)Show SMILES [H][C@]12C[C@H](CSC)CN(CCC)[C@]1([H])Cc1cccc(O)c1C2 Show InChI InChI=1S/C18H27NOS/c1-3-7-19-11-13(12-21-2)8-15-9-16-14(10-17(15)19)5-4-6-18(16)20/h4-6,13,15,17,20H,3,7-12H2,1-2H3/t13-,15+,17+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against Dihydrofolate reductase of rat liver |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50225361
(Etisulergine)Show SMILES [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human liver Dihydrodipicolinate reductase (DHPR) |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50017543
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r| Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against Dihydrofolate reductase of rat liver |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50017543
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r| Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against dopamine receptor from calf caudate using [3H]spiperone as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50017543
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r| Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against Dihydrofolate reductase of rat liver |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50225362
(Norprolac | QUINAGOLIDE)Show SMILES [H][C@]12C[C@@H](CN(CCC)[C@]1([H])Cc1cccc(O)c1C2)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C20H33N3O3S/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3/t16-,17+,19-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human liver Dihydropteridine reductase using 10 uM qBH2 and 50 uM NADH assays |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225476
(CHEMBL330849)Show SMILES [H][C@]12C[C@H](CSC)CN(CCC)[C@]1([H])Cc1cccc(O)c1C2 Show InChI InChI=1S/C18H27NOS/c1-3-7-19-11-13(12-21-2)8-15-9-16-14(10-17(15)19)5-4-6-18(16)20/h4-6,13,15,17,20H,3,7-12H2,1-2H3/t13-,15+,17+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against alpha-2 adrenergic receptor from rat brain minus cerebellum using [3H]clonidine as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50017543
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r| Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 385 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against serotonin receptor from whole rat brain using [3H]5-HT as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against alpha-2 adrenergic receptor from rat brain minus cerebellum using [3H]clonidine as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225361
(Etisulergine)Show SMILES [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against alpha-2 adrenergic receptor from rat brain minus cerebellum using [3H]clonidine as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50017543
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r| Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against Dihydrofolate reductase Inhibitor of chicken liver |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50225476
(CHEMBL330849)Show SMILES [H][C@]12C[C@H](CSC)CN(CCC)[C@]1([H])Cc1cccc(O)c1C2 Show InChI InChI=1S/C18H27NOS/c1-3-7-19-11-13(12-21-2)8-15-9-16-14(10-17(15)19)5-4-6-18(16)20/h4-6,13,15,17,20H,3,7-12H2,1-2H3/t13-,15+,17+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human liver Dihydrodipicolinate reductase (DHPR) |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50225476
(CHEMBL330849)Show SMILES [H][C@]12C[C@H](CSC)CN(CCC)[C@]1([H])Cc1cccc(O)c1C2 Show InChI InChI=1S/C18H27NOS/c1-3-7-19-11-13(12-21-2)8-15-9-16-14(10-17(15)19)5-4-6-18(16)20/h4-6,13,15,17,20H,3,7-12H2,1-2H3/t13-,15+,17+/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against Dihydrofolate reductase of rat liver |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
D(1A)/D(2) dopamine receptor
(BOVINE) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase (DHPR) |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50225476
(CHEMBL330849)Show SMILES [H][C@]12C[C@H](CSC)CN(CCC)[C@]1([H])Cc1cccc(O)c1C2 Show InChI InChI=1S/C18H27NOS/c1-3-7-19-11-13(12-21-2)8-15-9-16-14(10-17(15)19)5-4-6-18(16)20/h4-6,13,15,17,20H,3,7-12H2,1-2H3/t13-,15+,17+/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against serotonin receptor from whole rat brain using [3H]5-HT as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50225361
(Etisulergine)Show SMILES [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase (DHPR) |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against serotonin receptor from rat frontal cortex using [3H]spiperone as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50225362
(Norprolac | QUINAGOLIDE)Show SMILES [H][C@]12C[C@@H](CN(CCC)[C@]1([H])Cc1cccc(O)c1C2)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C20H33N3O3S/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3/t16-,17+,19-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against serotonin receptor from whole rat brain using [3H]5-HT as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50225361
(Etisulergine)Show SMILES [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against Dihydrofolate reductase of rat liver |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50225362
(Norprolac | QUINAGOLIDE)Show SMILES [H][C@]12C[C@@H](CN(CCC)[C@]1([H])Cc1cccc(O)c1C2)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C20H33N3O3S/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3/t16-,17+,19-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against Dihydrofolate reductase of rat liver |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225362
(Norprolac | QUINAGOLIDE)Show SMILES [H][C@]12C[C@@H](CN(CCC)[C@]1([H])Cc1cccc(O)c1C2)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C20H33N3O3S/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3/t16-,17+,19-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against alpha-2 adrenergic receptor from rat brain minus cerebellum using [3H]clonidine as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PubMed
| n/a | n/a | 7.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase (DHPR) |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50225362
(Norprolac | QUINAGOLIDE)Show SMILES [H][C@]12C[C@@H](CN(CCC)[C@]1([H])Cc1cccc(O)c1C2)NS(=O)(=O)N(CC)CC Show InChI InChI=1S/C20H33N3O3S/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3/t16-,17+,19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against alpha-1 adrenergic receptor from whole rat brain using [3H]WB-4101 as radioligand |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |
Metalloproteinase inhibitor 3
(Rattus norvegicus) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Noncompetitive Inhibitory activity against rat striatal synaptosomal DHPR enzyme |
J Med Chem 28: 367-75 (1985)
BindingDB Entry DOI: 10.7270/Q22V2J98 |
More data for this Ligand-Target Pair | |