Found 21 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Polyunsaturated fatty acid lipoxygenase ALOX12
(Homo sapiens (Human)) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against human platelet 12-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid lipoxygenase ALOX15
(Homo sapiens (Human)) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against soyabean 15-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM50000540
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) | PDB
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| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against intact rat PMNL, PGE-2 cyclooxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50009941
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13) | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50009941
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13) | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50009941
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13) | PDB
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000540
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50009941
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13) | PDB
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| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000540
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) | PDB
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| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(Homo sapiens (Human)) | BDBM50000540
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) | PDB
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| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50000540
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) | PDB
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| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(Homo sapiens (Human)) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against human whole blood, TXB2 cyclooxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000540
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) | PDB
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(Homo sapiens (Human)) | BDBM50009004
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) | PDB
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| n/a | n/a | 9.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(Homo sapiens (Human)) | BDBM50000540
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) | PDB
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| n/a | n/a | 9.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Association rate constant of the compound was determined against 3-dehydroquinate synthase |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid lipoxygenase ALOX15
(Homo sapiens (Human)) | BDBM50000540
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) | PDB
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| n/a | n/a | 2.13E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against soyabean 15-lipoxygenase was evaluated |
Bioorg Med Chem Lett 2: 1353-1356 (1992)
Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2 |
More data for this
Ligand-Target Pair | |
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