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Articleid 50028926

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280197
PNG
(1-(3-Chloro-phenyl)-pyrazolidin-3-one | CHEMBL3024...)
Show SMILES Clc1cccc(c1)N1CCC(=O)N1
Show InChI InChI=1S/C9H9ClN2O/c10-7-2-1-3-8(6-7)12-5-4-9(13)11-12/h1-3,6H,4-5H2,(H,11,13)
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n/an/a 730n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280185
PNG
(1-(4-Chloro-phenyl)-pyrazolidin-3-one | CHEMBL2960...)
Show SMILES Clc1ccc(cc1)N1CCC(=O)N1
Show InChI InChI=1S/C9H9ClN2O/c10-7-1-3-8(4-2-7)12-6-5-9(13)11-12/h1-4H,5-6H2,(H,11,13)
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n/an/a 1.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280192
PNG
(1-m-Tolyl-pyrazolidin-3-one | CHEMBL26084)
Show SMILES Cc1cccc(c1)N1CCC(=O)N1
Show InChI InChI=1S/C10H12N2O/c1-8-3-2-4-9(7-8)12-6-5-10(13)11-12/h2-4,7H,5-6H2,1H3,(H,11,13)
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n/an/a 1.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280176
PNG
(1-(3-Bromo-phenyl)-tetrahydro-pyridazin-3-one | CH...)
Show SMILES Brc1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C10H11BrN2O/c11-8-3-1-4-9(7-8)13-6-2-5-10(14)12-13/h1,3-4,7H,2,5-6H2,(H,12,14)
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n/an/a 1.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 1.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280196
PNG
(1-(3-Chloro-phenyl)-tetrahydro-pyridazin-3-one | C...)
Show SMILES Clc1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C10H11ClN2O/c11-8-3-1-4-9(7-8)13-6-2-5-10(14)12-13/h1,3-4,7H,2,5-6H2,(H,12,14)
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n/an/a 2.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280180
PNG
(1-(3-Ethyl-phenyl)-tetrahydro-pyridazin-3-one | CH...)
Show SMILES CCc1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C12H16N2O/c1-2-10-5-3-6-11(9-10)14-8-4-7-12(15)13-14/h3,5-6,9H,2,4,7-8H2,1H3,(H,13,15)
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n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280175
PNG
(1-m-Tolyl-tetrahydro-pyridazin-3-one | CHEMBL30151)
Show SMILES Cc1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C11H14N2O/c1-9-4-2-5-10(8-9)13-7-3-6-11(14)12-13/h2,4-5,8H,3,6-7H2,1H3,(H,12,14)
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n/an/a 3.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280198
PNG
(1-p-Tolyl-pyrazolidin-3-one | CHEMBL29508)
Show SMILES Cc1ccc(cc1)N1CCC(=O)N1
Show InChI InChI=1S/C10H12N2O/c1-8-2-4-9(5-3-8)12-7-6-10(13)11-12/h2-5H,6-7H2,1H3,(H,11,13)
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n/an/a 3.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280177
PNG
(1-(2-Chloro-phenyl)-pyrazolidin-3-one | CHEMBL2850...)
Show SMILES Clc1ccccc1N1CCC(=O)N1
Show InChI InChI=1S/C9H9ClN2O/c10-7-3-1-2-4-8(7)12-6-5-9(13)11-12/h1-4H,5-6H2,(H,11,13)
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n/an/a 3.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50009941
PNG
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Show SMILES O=C1CCCN(N1)c1ccccc1
Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)
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n/an/a 3.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280178
PNG
(1-(3-Trifluoromethyl-phenyl)-tetrahydro-pyridazin-...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C11H11F3N2O/c12-11(13,14)8-3-1-4-9(7-8)16-6-2-5-10(17)15-16/h1,3-4,7H,2,5-6H2,(H,15,17)
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n/an/a 5.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280174
PNG
(1-(3-Fluoro-phenyl)-tetrahydro-pyridazin-3-one | C...)
Show SMILES Fc1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C10H11FN2O/c11-8-3-1-4-9(7-8)13-6-2-5-10(14)12-13/h1,3-4,7H,2,5-6H2,(H,12,14)
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n/an/a 5.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280199
PNG
(3-(3-Oxo-tetrahydro-pyridazin-1-yl)-benzoic acid e...)
Show SMILES CCOC(=O)c1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C13H16N2O3/c1-2-18-13(17)10-5-3-6-11(9-10)15-8-4-7-12(16)14-15/h3,5-6,9H,2,4,7-8H2,1H3,(H,14,16)
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n/an/a 5.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280183
PNG
(1-Dodecyl-tetrahydro-pyridazin-3-one | CHEMBL25790)
Show SMILES CCCCCCCCCCCCN1CCCC(=O)N1
Show InChI InChI=1S/C16H32N2O/c1-2-3-4-5-6-7-8-9-10-11-14-18-15-12-13-16(19)17-18/h2-15H2,1H3,(H,17,19)
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n/an/a 6.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280173
PNG
(1-(3-Methoxy-phenyl)-tetrahydro-pyridazin-3-one | ...)
Show SMILES COc1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C11H14N2O2/c1-15-10-5-2-4-9(8-10)13-7-3-6-11(14)12-13/h2,4-5,8H,3,6-7H2,1H3,(H,12,14)
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n/an/a 6.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280202
PNG
(1-o-Tolyl-pyrazolidin-3-one | CHEMBL26143)
Show SMILES Cc1ccccc1N1CCC(=O)N1
Show InChI InChI=1S/C10H12N2O/c1-8-4-2-3-5-9(8)12-7-6-10(13)11-12/h2-5H,6-7H2,1H3,(H,11,13)
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n/an/a 8.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280187
PNG
(3-(3-Oxo-tetrahydro-pyridazin-1-yl)-benzonitrile |...)
Show SMILES O=C1CCCN(N1)c1cccc(c1)C#N
Show InChI InChI=1S/C11H11N3O/c12-8-9-3-1-4-10(7-9)14-6-2-5-11(15)13-14/h1,3-4,7H,2,5-6H2,(H,13,15)
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n/an/a 9.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280188
PNG
(1-[3-(2,2-Dimethyl-propionyl)-phenyl]-tetrahydro-p...)
Show SMILES CC(C)(C)C(=O)c1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C15H20N2O2/c1-15(2,3)14(19)11-6-4-7-12(10-11)17-9-5-8-13(18)16-17/h4,6-7,10H,5,8-9H2,1-3H3,(H,16,18)
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n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280181
PNG
(1-(3-Acetyl-phenyl)-tetrahydro-pyridazin-3-one | C...)
Show SMILES CC(=O)c1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C12H14N2O2/c1-9(15)10-4-2-5-11(8-10)14-7-3-6-12(16)13-14/h2,4-5,8H,3,6-7H2,1H3,(H,13,16)
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n/an/a 1.90E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280182
PNG
(1-Octyl-tetrahydro-pyridazin-3-one | CHEMBL30202)
Show SMILES CCCCCCCCN1CCCC(=O)N1
Show InChI InChI=1S/C12H24N2O/c1-2-3-4-5-6-7-10-14-11-8-9-12(15)13-14/h2-11H2,1H3,(H,13,15)
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n/an/a 2.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280184
PNG
(1-(2-Ethyl-phenyl)-tetrahydro-pyridazin-3-one | CH...)
Show SMILES CCc1ccccc1N1CCCC(=O)N1
Show InChI InChI=1S/C12H16N2O/c1-2-10-6-3-4-7-11(10)14-9-5-8-12(15)13-14/h3-4,6-7H,2,5,8-9H2,1H3,(H,13,15)
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n/an/a 3.90E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280193
PNG
(Butyric acid N'-phenyl-hydrazide | CHEMBL26851)
Show SMILES CCCC(=O)NNc1ccccc1
Show InChI InChI=1S/C10H14N2O/c1-2-6-10(13)12-11-9-7-4-3-5-8-9/h3-5,7-8,11H,2,6H2,1H3,(H,12,13)
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n/an/a 5.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280179
PNG
(1-(3-Hydroxymethyl-phenyl)-tetrahydro-pyridazin-3-...)
Show SMILES OCc1cccc(c1)N1CCCC(=O)N1
Show InChI InChI=1S/C11H14N2O2/c14-8-9-3-1-4-10(7-9)13-6-2-5-11(15)12-13/h1,3-4,7,14H,2,5-6,8H2,(H,12,15)
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n/an/a 5.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280200
PNG
(1-o-Tolyl-tetrahydro-pyridazin-3-one | CHEMBL28125...)
Show SMILES Cc1ccccc1N1CCCC(=O)N1
Show InChI InChI=1S/C11H14N2O/c1-9-5-2-3-6-10(9)13-8-4-7-11(14)12-13/h2-3,5-6H,4,7-8H2,1H3,(H,12,14)
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n/an/a 5.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280201
PNG
(Acetic acid N'-phenyl-hydrazide | CHEMBL30131)
Show SMILES CC(=O)NNc1ccccc1
Show InChI InChI=1S/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)
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n/an/a 6.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280186
PNG
(1-(4-Chloro-phenyl)-tetrahydro-pyridazin-3-one | C...)
Show SMILES Clc1ccc(cc1)N1CCCC(=O)N1
Show InChI InChI=1S/C10H11ClN2O/c11-8-3-5-9(6-4-8)13-7-1-2-10(14)12-13/h3-6H,1-2,7H2,(H,12,14)
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n/an/a 7.90E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280195
PNG
(1-(2-Chloro-phenyl)-tetrahydro-pyridazin-3-one | C...)
Show SMILES Clc1ccccc1N1CCCC(=O)N1
Show InChI InChI=1S/C10H11ClN2O/c11-8-4-1-2-5-9(8)13-7-3-6-10(14)12-13/h1-2,4-5H,3,6-7H2,(H,12,14)
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n/an/a 9.90E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280190
PNG
(1-(4-Ethyl-phenyl)-tetrahydro-pyridazin-3-one | CH...)
Show SMILES CCc1ccc(cc1)N1CCCC(=O)N1
Show InChI InChI=1S/C12H16N2O/c1-2-10-5-7-11(8-6-10)14-9-3-4-12(15)13-14/h5-8H,2-4,9H2,1H3,(H,13,15)
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n/an/a 1.25E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280191
PNG
(1-(4-Methoxy-phenyl)-tetrahydro-pyridazin-3-one | ...)
Show SMILES COc1ccc(cc1)N1CCCC(=O)N1
Show InChI InChI=1S/C11H14N2O2/c1-15-10-6-4-9(5-7-10)13-8-2-3-11(14)12-13/h4-7H,2-3,8H2,1H3,(H,12,14)
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n/an/a 1.56E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280194
PNG
(1-(2-Methoxy-phenyl)-tetrahydro-pyridazin-3-one | ...)
Show SMILES COc1ccccc1N1CCCC(=O)N1
Show InChI InChI=1S/C11H14N2O2/c1-15-10-6-3-2-5-9(10)13-8-4-7-11(14)12-13/h2-3,5-6H,4,7-8H2,1H3,(H,12,14)
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n/an/a 2.04E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50280189
PNG
(1-p-Tolyl-tetrahydro-pyridazin-3-one | CHEMBL43246...)
Show SMILES Cc1ccc(cc1)N1CCCC(=O)N1
Show InChI InChI=1S/C11H14N2O/c1-9-4-6-10(7-5-9)13-8-2-3-11(14)12-13/h4-7H,2-3,8H2,1H3,(H,12,14)
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n/an/a 2.77E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase.

Bioorg Med Chem Lett 2: 1357-1360 (1992)


Article DOI: 10.1016/S0960-894X(00)80512-0
BindingDB Entry DOI: 10.7270/Q2CC10M8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%