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Articleid 50029547

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50033969
PNG
(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C34H40F2N4OS/c1-2-3-4-5-13-22-40(34(41)37-30-21-20-28(35)25-29(30)36)23-14-8-15-24-42-33-38-31(26-16-9-6-10-17-26)32(39-33)27-18-11-7-12-19-27/h6-7,9-12,16-21,25H,2-5,8,13-15,22-24H2,1H3,(H,37,41)(H,38,39)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285443
PNG
(Benzooxazol-2-yl-[5-(4,5-diphenyl-1H-imidazol-2-yl...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)c1nc2ccccc2o1
Show InChI InChI=1S/C34H40N4OS/c1-2-3-4-5-15-24-38(34-35-29-22-13-14-23-30(29)39-34)25-16-8-17-26-40-33-36-31(27-18-9-6-10-19-27)32(37-33)28-20-11-7-12-21-28/h6-7,9-14,18-23H,2-5,8,15-17,24-26H2,1H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285426
PNG
(2-[5-(4,5-diphenyl-1H-2-imidazolylsulfanyl)pentyls...)
Show SMILES C(CCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)CCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C35H32N4S2/c1-6-16-26(17-7-1)30-31(27-18-8-2-9-19-27)37-34(36-30)40-24-14-5-15-25-41-35-38-32(28-20-10-3-11-21-28)33(39-35)29-22-12-4-13-23-29/h1-4,6-13,16-23H,5,14-15,24-25H2,(H,36,37)(H,38,39)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50051901
PNG
(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285434
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES COCCOCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C34H40N4O5S/c1-39-22-23-42-21-20-38(34-35-29-9-5-6-10-30(29)43-34)19-7-4-8-24-44-33-36-31(25-11-15-27(40-2)16-12-25)32(37-33)26-13-17-28(41-3)18-14-26/h5-6,9-18H,4,7-8,19-24H2,1-3H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285442
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C36H44N4O3S/c1-4-5-6-7-11-24-40(36-37-31-14-9-10-15-32(31)43-36)25-12-8-13-26-44-35-38-33(27-16-20-29(41-2)21-17-27)34(39-35)28-18-22-30(42-3)23-19-28/h9-10,14-23H,4-8,11-13,24-26H2,1-3H3,(H,38,39)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285435
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-dimethylamino-phen...)
Show SMILES CCN(CCCCCSc1nc(c([nH]1)-c1ccc(cc1)N(C)C)-c1ccc(cc1)N(C)C)c1nc2ccccc2o1
Show InChI InChI=1S/C33H40N6OS/c1-6-39(33-34-28-12-8-9-13-29(28)40-33)22-10-7-11-23-41-32-35-30(24-14-18-26(19-15-24)37(2)3)31(36-32)25-16-20-27(21-17-25)38(4)5/h8-9,12-21H,6-7,10-11,22-23H2,1-5H3,(H,35,36)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285432
PNG
(1N,1N-dimethyl-4-[2-{5-[4,5-di(4-dimethylaminophen...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(SCCCCCSc2nc(c([nH]2)-c2ccc(cc2)N(C)C)-c2ccc(cc2)N(C)C)[nH]c1-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C43H52N8S2/c1-48(2)34-20-12-30(13-21-34)38-39(31-14-22-35(23-15-31)49(3)4)45-42(44-38)52-28-10-9-11-29-53-43-46-40(32-16-24-36(25-17-32)50(5)6)41(47-43)33-18-26-37(27-19-33)51(7)8/h12-27H,9-11,28-29H2,1-8H3,(H,44,45)(H,46,47)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285420
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES CCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C33H38N4O3S/c1-4-5-21-37(33-34-28-11-7-8-12-29(28)40-33)22-9-6-10-23-41-32-35-30(24-13-17-26(38-2)18-14-24)31(36-32)25-15-19-27(39-3)20-16-25/h7-8,11-20H,4-6,9-10,21-23H2,1-3H3,(H,35,36)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285447
PNG
(CHEMBL53397 | {5-[4,5-Bis-(4-methoxy-phenyl)-1H-im...)
Show SMILES CCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2cc(ccc2o1)C(C)(C)C
Show InChI InChI=1S/C37H46N4O3S/c1-7-8-22-41(36-38-31-25-28(37(2,3)4)16-21-32(31)44-36)23-10-9-11-24-45-35-39-33(26-12-17-29(42-5)18-13-26)34(40-35)27-14-19-30(43-6)20-15-27/h12-21,25H,7-11,22-24H2,1-6H3,(H,39,40)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285442
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C36H44N4O3S/c1-4-5-6-7-11-24-40(36-37-31-14-9-10-15-32(31)43-36)25-12-8-13-26-44-35-38-33(27-16-20-29(41-2)21-17-27)34(39-35)28-18-22-30(42-3)23-19-28/h9-10,14-23H,4-8,11-13,24-26H2,1-3H3,(H,38,39)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285444
PNG
(1N,1N-dimethyl-4-{5-(4-dimethylaminophenyl)-2-[5-(...)
Show SMILES CC(C)c1nc2ccccc2n1CCCCCSc1nc(c([nH]1)-c1ccc(cc1)N(C)C)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C34H42N6S/c1-24(2)33-35-29-12-8-9-13-30(29)40(33)22-10-7-11-23-41-34-36-31(25-14-18-27(19-15-25)38(3)4)32(37-34)26-16-20-28(21-17-26)39(5)6/h8-9,12-21,24H,7,10-11,22-23H2,1-6H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285420
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES CCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C33H38N4O3S/c1-4-5-21-37(33-34-28-11-7-8-12-29(28)40-33)22-9-6-10-23-41-32-35-30(24-13-17-26(38-2)18-14-24)31(36-32)25-15-19-27(39-3)20-16-25/h7-8,11-20H,4-6,9-10,21-23H2,1-3H3,(H,35,36)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285447
PNG
(CHEMBL53397 | {5-[4,5-Bis-(4-methoxy-phenyl)-1H-im...)
Show SMILES CCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2cc(ccc2o1)C(C)(C)C
Show InChI InChI=1S/C37H46N4O3S/c1-7-8-22-41(36-38-31-25-28(37(2,3)4)16-21-32(31)44-36)23-10-9-11-24-45-35-39-33(26-12-17-29(42-5)18-13-26)34(40-35)27-14-19-30(43-6)20-15-27/h12-21,25H,7-11,22-24H2,1-6H3,(H,39,40)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285434
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES COCCOCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C34H40N4O5S/c1-39-22-23-42-21-20-38(34-35-29-9-5-6-10-30(29)43-34)19-7-4-8-24-44-33-36-31(25-11-15-27(40-2)16-12-25)32(37-33)26-13-17-28(41-3)18-14-26/h5-6,9-18H,4,7-8,19-24H2,1-3H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285432
PNG
(1N,1N-dimethyl-4-[2-{5-[4,5-di(4-dimethylaminophen...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(SCCCCCSc2nc(c([nH]2)-c2ccc(cc2)N(C)C)-c2ccc(cc2)N(C)C)[nH]c1-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C43H52N8S2/c1-48(2)34-20-12-30(13-21-34)38-39(31-14-22-35(23-15-31)49(3)4)45-42(44-38)52-28-10-9-11-29-53-43-46-40(32-16-24-36(25-17-32)50(5)6)41(47-43)33-18-26-37(27-19-33)51(7)8/h12-27H,9-11,28-29H2,1-8H3,(H,44,45)(H,46,47)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285430
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-dimethylamino-phen...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(SCCCCCNc2nc3ccccc3o2)[nH]c1-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C31H36N6OS/c1-36(2)24-16-12-22(13-17-24)28-29(23-14-18-25(19-15-23)37(3)4)35-31(34-28)39-21-9-5-8-20-32-30-33-26-10-6-7-11-27(26)38-30/h6-7,10-19H,5,8-9,20-21H2,1-4H3,(H,32,33)(H,34,35)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285425
PNG
((1H-Benzoimidazol-2-yl)-{5-[4,5-bis-(4-methoxy-phe...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C36H45N5O2S/c1-4-5-6-7-11-24-41(35-37-31-14-9-10-15-32(31)38-35)25-12-8-13-26-44-36-39-33(27-16-20-29(42-2)21-17-27)34(40-36)28-18-22-30(43-3)23-19-28/h9-10,14-23H,4-8,11-13,24-26H2,1-3H3,(H,37,38)(H,39,40)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285427
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES CCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C31H34N4O3S/c1-4-35(31-32-26-10-6-7-11-27(26)38-31)20-8-5-9-21-39-30-33-28(22-12-16-24(36-2)17-13-22)29(34-30)23-14-18-25(37-3)19-15-23/h6-7,10-19H,4-5,8-9,20-21H2,1-3H3,(H,33,34)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50051901
PNG
(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285427
PNG
(Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES CCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C31H34N4O3S/c1-4-35(31-32-26-10-6-7-11-27(26)38-31)20-8-5-9-21-39-30-33-28(22-12-16-24(36-2)17-13-22)29(34-30)23-14-18-25(37-3)19-15-23/h6-7,10-19H,4-5,8-9,20-21H2,1-3H3,(H,33,34)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285419
PNG
(2-{5-[4,5-di(4-methoxyphenyl)-1H-2-imidazolylsulfa...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCSc2nc(c([nH]2)-c2ccc(OC)cc2)-c2ccc(OC)cc2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C39H40N4O4S2/c1-44-30-16-8-26(9-17-30)34-35(27-10-18-31(45-2)19-11-27)41-38(40-34)48-24-6-5-7-25-49-39-42-36(28-12-20-32(46-3)21-13-28)37(43-39)29-14-22-33(47-4)23-15-29/h8-23H,5-7,24-25H2,1-4H3,(H,40,41)(H,42,43)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285419
PNG
(2-{5-[4,5-di(4-methoxyphenyl)-1H-2-imidazolylsulfa...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCSc2nc(c([nH]2)-c2ccc(OC)cc2)-c2ccc(OC)cc2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C39H40N4O4S2/c1-44-30-16-8-26(9-17-30)34-35(27-10-18-31(45-2)19-11-27)41-38(40-34)48-24-6-5-7-25-49-39-42-36(28-12-20-32(46-3)21-13-28)37(43-39)29-14-22-33(47-4)23-15-29/h8-23H,5-7,24-25H2,1-4H3,(H,40,41)(H,42,43)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285428
PNG
(1-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCn2c(nc3ccccc23)C(C)C)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C32H36N4O2S/c1-22(2)31-33-27-10-6-7-11-28(27)36(31)20-8-5-9-21-39-32-34-29(23-12-16-25(37-3)17-13-23)30(35-32)24-14-18-26(38-4)19-15-24/h6-7,10-19,22H,5,8-9,20-21H2,1-4H3,(H,34,35)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285433
PNG
(1N,1N-dimethyl-4-{5-(4-dimethylaminophenyl)-2-[5-(...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(SCCCCCn2nc(C)cc2C)[nH]c1-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H38N6S/c1-21-20-22(2)35(32-21)18-8-7-9-19-36-29-30-27(23-10-14-25(15-11-23)33(3)4)28(31-29)24-12-16-26(17-13-24)34(5)6/h10-17,20H,7-9,18-19H2,1-6H3,(H,30,31)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285443
PNG
(Benzooxazol-2-yl-[5-(4,5-diphenyl-1H-imidazol-2-yl...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)c1nc2ccccc2o1
Show InChI InChI=1S/C34H40N4OS/c1-2-3-4-5-15-24-38(34-35-29-22-13-14-23-30(29)39-34)25-16-8-17-26-40-33-36-31(27-18-9-6-10-19-27)32(37-33)28-20-11-7-12-21-28/h6-7,9-14,18-23H,2-5,8,15-17,24-26H2,1H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285428
PNG
(1-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCn2c(nc3ccccc23)C(C)C)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C32H36N4O2S/c1-22(2)31-33-27-10-6-7-11-28(27)36(31)20-8-5-9-21-39-32-34-29(23-12-16-25(37-3)17-13-23)30(35-32)24-14-18-26(38-4)19-15-24/h6-7,10-19,22H,5,8-9,20-21H2,1-4H3,(H,34,35)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285444
PNG
(1N,1N-dimethyl-4-{5-(4-dimethylaminophenyl)-2-[5-(...)
Show SMILES CC(C)c1nc2ccccc2n1CCCCCSc1nc(c([nH]1)-c1ccc(cc1)N(C)C)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C34H42N6S/c1-24(2)33-35-29-12-8-9-13-30(29)40(33)22-10-7-11-23-41-34-36-31(25-14-18-27(19-15-25)38(3)4)32(37-34)26-16-20-28(21-17-26)39(5)6/h8-9,12-21,24H,7,10-11,22-23H2,1-6H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285425
PNG
((1H-Benzoimidazol-2-yl)-{5-[4,5-bis-(4-methoxy-phe...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C36H45N5O2S/c1-4-5-6-7-11-24-41(35-37-31-14-9-10-15-32(31)38-35)25-12-8-13-26-44-36-39-33(27-16-20-29(42-2)21-17-27)34(40-36)28-18-22-30(43-3)23-19-28/h9-10,14-23H,4-8,11-13,24-26H2,1-3H3,(H,37,38)(H,39,40)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285424
PNG
(Benzooxazol-2-yl-{4-[4,5-bis-(4-methoxy-phenyl)-1H...)
Show SMILES CCCCCCCN(CCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1
Show InChI InChI=1S/C35H42N4O3S/c1-4-5-6-7-10-23-39(35-36-30-13-8-9-14-31(30)42-35)24-11-12-25-43-34-37-32(26-15-19-28(40-2)20-16-26)33(38-34)27-17-21-29(41-3)22-18-27/h8-9,13-22H,4-7,10-12,23-25H2,1-3H3,(H,37,38)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285418
PNG
(Benzooxazol-2-yl-ethyl-{5-[5-(4-methylsulfanyl-phe...)
Show SMILES CCN(CCCCCSc1nc(c([nH]1)-c1ccc(SC)cc1)-c1ccccc1)c1nc2ccccc2o1
Show InChI InChI=1S/C30H32N4OS2/c1-3-34(30-31-25-14-8-9-15-26(25)35-30)20-10-5-11-21-37-29-32-27(22-12-6-4-7-13-22)28(33-29)23-16-18-24(36-2)19-17-23/h4,6-9,12-19H,3,5,10-11,20-21H2,1-2H3,(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285431
PNG
(2-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCSc2nc3ccccc3[nH]2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C29H30N4O2S2/c1-34-22-14-10-20(11-15-22)26-27(21-12-16-23(35-2)17-13-21)33-29(32-26)37-19-7-3-6-18-36-28-30-24-8-4-5-9-25(24)31-28/h4-5,8-17H,3,6-7,18-19H2,1-2H3,(H,30,31)(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285422
PNG
((1-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yl...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCn2c(Nc3ccccc3)nc3ccccc23)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C35H35N5O2S/c1-41-28-19-15-25(16-20-28)32-33(26-17-21-29(42-2)22-18-26)39-35(38-32)43-24-10-4-9-23-40-31-14-8-7-13-30(31)37-34(40)36-27-11-5-3-6-12-27/h3,5-8,11-22H,4,9-10,23-24H2,1-2H3,(H,36,37)(H,38,39)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285421
PNG
(Benzothiazol-2-yl-[5-(4,5-diphenyl-1H-imidazol-2-y...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)c1nc2ccccc2s1
Show InChI InChI=1S/C34H40N4S2/c1-2-3-4-5-15-24-38(34-35-29-22-13-14-23-30(29)40-34)25-16-8-17-26-39-33-36-31(27-18-9-6-10-19-27)32(37-33)28-20-11-7-12-21-28/h6-7,9-14,18-23H,2-5,8,15-17,24-26H2,1H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285439
PNG
(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Show SMILES CC(C)c1nc2ccccc2n1CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C30H32N4S/c1-22(2)29-31-25-18-10-11-19-26(25)34(29)20-12-5-13-21-35-30-32-27(23-14-6-3-7-15-23)28(33-30)24-16-8-4-9-17-24/h3-4,6-11,14-19,22H,5,12-13,20-21H2,1-2H3,(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285418
PNG
(Benzooxazol-2-yl-ethyl-{5-[5-(4-methylsulfanyl-phe...)
Show SMILES CCN(CCCCCSc1nc(c([nH]1)-c1ccc(SC)cc1)-c1ccccc1)c1nc2ccccc2o1
Show InChI InChI=1S/C30H32N4OS2/c1-3-34(30-31-25-14-8-9-15-26(25)35-30)20-10-5-11-21-37-29-32-27(22-12-6-4-7-13-22)28(33-29)23-16-18-24(36-2)19-17-23/h4,6-9,12-19H,3,5,10-11,20-21H2,1-2H3,(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285439
PNG
(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Show SMILES CC(C)c1nc2ccccc2n1CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C30H32N4S/c1-22(2)29-31-25-18-10-11-19-26(25)34(29)20-12-5-13-21-35-30-32-27(23-14-6-3-7-15-23)28(33-30)24-16-8-4-9-17-24/h3-4,6-11,14-19,22H,5,12-13,20-21H2,1-2H3,(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285422
PNG
((1-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yl...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCn2c(Nc3ccccc3)nc3ccccc23)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C35H35N5O2S/c1-41-28-19-15-25(16-20-28)32-33(26-17-21-29(42-2)22-18-26)39-35(38-32)43-24-10-4-9-23-40-31-14-8-7-13-30(31)37-34(40)36-27-11-5-3-6-12-27/h3,5-8,11-22H,4,9-10,23-24H2,1-2H3,(H,36,37)(H,38,39)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285431
PNG
(2-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCSc2nc3ccccc3[nH]2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C29H30N4O2S2/c1-34-22-14-10-20(11-15-22)26-27(21-12-16-23(35-2)17-13-21)33-29(32-26)37-19-7-3-6-18-36-28-30-24-8-4-5-9-25(24)31-28/h4-5,8-17H,3,6-7,18-19H2,1-2H3,(H,30,31)(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285437
PNG
(8-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCSc2nc3ncncc3[nH]2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C27H28N6O2S2/c1-34-20-10-6-18(7-11-20)23-24(19-8-12-21(35-2)13-9-19)32-27(31-23)37-15-5-3-4-14-36-26-30-22-16-28-17-29-25(22)33-26/h6-13,16-17H,3-5,14-15H2,1-2H3,(H,31,32)(H,28,29,30,33)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285423
PNG
(1-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCn2c(SC)nc3ccccc23)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C30H32N4O2S2/c1-35-23-15-11-21(12-16-23)27-28(22-13-17-24(36-2)18-14-22)33-29(32-27)38-20-8-4-7-19-34-26-10-6-5-9-25(26)31-30(34)37-3/h5-6,9-18H,4,7-8,19-20H2,1-3H3,(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50033969
PNG
(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C34H40F2N4OS/c1-2-3-4-5-13-22-40(34(41)37-30-21-20-28(35)25-29(30)36)23-14-8-15-24-42-33-38-31(26-16-9-6-10-17-26)32(39-33)27-18-11-7-12-19-27/h6-7,9-12,16-21,25H,2-5,8,13-15,22-24H2,1H3,(H,37,41)(H,38,39)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285438
PNG
(CHEMBL299338 | {5-[4,5-Bis-(4-methoxy-phenyl)-1H-i...)
Show SMILES CCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2cc(Cl)c(cc2o1)[N+]([O-])=O
Show InChI InChI=1S/C33H36ClN5O5S/c1-4-5-17-38(33-35-27-20-26(34)28(39(40)41)21-29(27)44-33)18-7-6-8-19-45-32-36-30(22-9-13-24(42-2)14-10-22)31(37-32)23-11-15-25(43-3)16-12-23/h9-16,20-21H,4-8,17-19H2,1-3H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285423
PNG
(1-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCn2c(SC)nc3ccccc23)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C30H32N4O2S2/c1-35-23-15-11-21(12-16-23)27-28(22-13-17-24(36-2)18-14-22)33-29(32-27)38-20-8-4-7-19-34-26-10-6-5-9-25(26)31-30(34)37-3/h5-6,9-18H,4,7-8,19-20H2,1-3H3,(H,32,33)
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n/an/a 1.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285445
PNG
(2-{3-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCC(C)(CSc2nc3ccccc3o2)c2ccccc2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C34H31N3O3S2/c1-34(25-9-5-4-6-10-25,22-42-33-35-28-11-7-8-12-29(28)40-33)21-41-32-36-30(23-13-17-26(38-2)18-14-23)31(37-32)24-15-19-27(39-3)20-16-24/h4-20H,21-22H2,1-3H3,(H,36,37)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285441
PNG
(6-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCSc2ncnc3nc[nH]c23)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C27H28N6O2S2/c1-34-20-10-6-18(7-11-20)22-23(19-8-12-21(35-2)13-9-19)33-27(32-22)37-15-5-3-4-14-36-26-24-25(29-16-28-24)30-17-31-26/h6-13,16-17H,3-5,14-15H2,1-2H3,(H,32,33)(H,28,29,30,31)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285440
PNG
(Benzooxazol-2-yl-[5-(4,5-diphenyl-1H-imidazol-2-yl...)
Show SMILES CC(CCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)(CNc1nc2ccccc2o1)c1ccccc1
Show InChI InChI=1S/C34H32N4OS/c1-34(27-18-9-4-10-19-27,24-35-32-36-28-20-11-12-21-29(28)39-32)22-13-23-40-33-37-30(25-14-5-2-6-15-25)31(38-33)26-16-7-3-8-17-26/h2-12,14-21H,13,22-24H2,1H3,(H,35,36)(H,37,38)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285446
PNG
(Benzooxazol-2-yl-{1-[3-(4,5-diphenyl-1H-imidazol-2...)
Show SMILES C(Nc1nc2ccccc2o1)C1(CCCC1)c1cccc(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)c1
Show InChI InChI=1S/C35H32N4OS/c1-3-13-26(14-4-1)31-32(27-15-5-2-6-16-27)39-34(38-31)41-23-25-12-11-17-28(22-25)35(20-9-10-21-35)24-36-33-37-29-18-7-8-19-30(29)40-33/h1-8,11-19,22H,9-10,20-21,23-24H2,(H,36,37)(H,38,39)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285426
PNG
(2-[5-(4,5-diphenyl-1H-2-imidazolylsulfanyl)pentyls...)
Show SMILES C(CCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)CCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C35H32N4S2/c1-6-16-26(17-7-1)30-31(27-18-8-2-9-19-27)37-34(36-30)40-24-14-5-15-25-41-35-38-32(28-20-10-3-11-21-28)33(39-35)29-22-12-4-13-23-29/h1-4,6-13,16-23H,5,14-15,24-25H2,(H,36,37)(H,38,39)
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n/an/a 6.92E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285448
PNG
(6-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Show SMILES C(CCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)CCSc1ncnc2nc[nH]c12
Show InChI InChI=1S/C25H24N6S2/c1-4-10-18(11-5-1)20-21(19-12-6-2-7-13-19)31-25(30-20)33-15-9-3-8-14-32-24-22-23(27-16-26-22)28-17-29-24/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H,30,31)(H,26,27,28,29)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285436
PNG
(8-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCSc2nc3n(C)c(=O)n(C)c(=O)c3[nH]2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C29H32N6O4S2/c1-34-25-24(26(36)35(2)29(34)37)32-28(33-25)41-17-7-5-6-16-40-27-30-22(18-8-12-20(38-3)13-9-18)23(31-27)19-10-14-21(39-4)15-11-19/h8-15H,5-7,16-17H2,1-4H3,(H,30,31)(H,32,33)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285429
PNG
(9-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCn2c3ccccc3c3ccccc23)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C34H33N3O2S/c1-38-26-18-14-24(15-19-26)32-33(25-16-20-27(39-2)21-17-25)36-34(35-32)40-23-9-3-8-22-37-30-12-6-4-10-28(30)29-11-5-7-13-31(29)37/h4-7,10-21H,3,8-9,22-23H2,1-2H3,(H,35,36)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assay

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Mus musculus)		BDBM50285429
PNG
(9-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES COc1ccc(cc1)-c1nc(SCCCCCn2c3ccccc3c3ccccc23)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C34H33N3O2S/c1-38-26-18-14-24(15-19-26)32-33(25-16-20-27(39-2)21-17-25)36-34(35-32)40-23-9-3-8-22-37-30-12-6-4-10-28(30)29-11-5-7-13-31(29)37/h4-7,10-21H,3,8-9,22-23H2,1-2H3,(H,35,36)
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Article
n/an/a 5.57E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture

Bioorg Med Chem Lett 5: 177-180 (1995)


Article DOI: 10.1016/0960-894X(95)00003-C
BindingDB Entry DOI: 10.7270/Q2PG1RQJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%