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Articleid 50029554

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285512
PNG
(CHEMBL77612 | N-{[(2,4,6-trimethoxyphenyl)amino]ca...)
Show SMILES CCCCCCCCCCCCCCCCC(C)S(=O)(=O)NC(=O)Nc1c(OC)cc(OC)cc1OC
Show InChI InChI=1S/C28H50N2O6S/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(2)37(32,33)30-28(31)29-27-25(35-4)21-24(34-3)22-26(27)36-5/h21-23H,6-20H2,1-5H3,(H2,29,30,31)
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n/an/a 85n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285501
PNG
(CHEMBL77898 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCS(=O)(=O)N(C)C(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C26H46N2O3S/c1-7-8-9-10-11-12-13-14-15-16-20-32(30,31)28(6)26(29)27-25-23(21(2)3)18-17-19-24(25)22(4)5/h17-19,21-22H,7-16,20H2,1-6H3,(H,27,29)
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n/an/a 86n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbits

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285500
PNG
(CHEMBL76780 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCCCS(=O)(=O)N(Cc1ccccc1)C(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C34H54N2O3S/c1-6-7-8-9-10-11-12-13-14-15-16-20-26-40(38,39)36(27-30-22-18-17-19-23-30)34(37)35-33-31(28(2)3)24-21-25-32(33)29(4)5/h17-19,21-25,28-29H,6-16,20,26-27H2,1-5H3,(H,35,37)
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n/an/a 520n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbits

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285501
PNG
(CHEMBL77898 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCS(=O)(=O)N(C)C(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C26H46N2O3S/c1-7-8-9-10-11-12-13-14-15-16-20-32(30,31)28(6)26(29)27-25-23(21(2)3)18-17-19-24(25)22(4)5/h17-19,21-22H,7-16,20H2,1-6H3,(H,27,29)
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n/an/a 675n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285511
PNG
(CHEMBL433319 | N-{[(2,6-isopropylphenyl)amino]carb...)
Show SMILES CCCCCCCCCCCCCC(C)(C)S(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C29H52N2O3S/c1-8-9-10-11-12-13-14-15-16-17-18-22-29(6,7)35(33,34)31-28(32)30-27-25(23(2)3)20-19-21-26(27)24(4)5/h19-21,23-24H,8-18,22H2,1-7H3,(H2,30,31,32)
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n/an/a 682n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285513
PNG
(CHEMBL306626 | N-{[(2,6-isopropylphenyl)amino]carb...)
Show SMILES CCCCCCCCCCCCCC(C)S(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C28H50N2O3S/c1-7-8-9-10-11-12-13-14-15-16-17-19-24(6)34(32,33)30-28(31)29-27-25(22(2)3)20-18-21-26(27)23(4)5/h18,20-24H,7-17,19H2,1-6H3,(H2,29,30,31)
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n/an/a 830n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285507
PNG
(CHEMBL76251 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C27H48N2O3S/c1-6-7-8-9-10-11-12-13-14-15-16-17-21-33(31,32)29-27(30)28-26-24(22(2)3)19-18-20-25(26)23(4)5/h18-20,22-23H,6-17,21H2,1-5H3,(H2,28,29,30)
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n/an/a 830n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbits

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285507
PNG
(CHEMBL76251 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C27H48N2O3S/c1-6-7-8-9-10-11-12-13-14-15-16-17-21-33(31,32)29-27(30)28-26-24(22(2)3)19-18-20-25(26)23(4)5/h18-20,22-23H,6-17,21H2,1-5H3,(H2,28,29,30)
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n/an/a 940n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285502
PNG
(CHEMBL77583 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCC(c1ccccc1)S(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C28H42N2O3S/c1-6-7-8-9-10-14-20-26(23-16-12-11-13-17-23)34(32,33)30-28(31)29-27-24(21(2)3)18-15-19-25(27)22(4)5/h11-13,15-19,21-22,26H,6-10,14,20H2,1-5H3,(H2,29,30,31)
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n/an/a 1.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound at 5 microM concentration was tested in vitro for inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cho...

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285504
PNG
(CHEMBL420942 | N-{[(2,6-isopropylphenyl)amino]carb...)
Show SMILES CCCCCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C26H46N2O3S/c1-6-7-8-9-10-11-12-13-14-15-16-20-32(30,31)28-26(29)27-25-23(21(2)3)18-17-19-24(25)22(4)5/h17-19,21-22H,6-16,20H2,1-5H3,(H2,27,28,29)
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbits

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285509
PNG
(CHEMBL76037 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C29H52N2O3S/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-35(33,34)31-29(32)30-28-26(24(2)3)21-20-22-27(28)25(4)5/h20-22,24-25H,6-19,23H2,1-5H3,(H2,30,31,32)
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n/an/a 1.27E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285510
PNG
(CHEMBL75853 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCC(C)S(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C23H40N2O3S/c1-7-8-9-10-11-12-14-19(6)29(27,28)25-23(26)24-22-20(17(2)3)15-13-16-21(22)18(4)5/h13,15-19H,7-12,14H2,1-6H3,(H2,24,25,26)
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n/an/a 1.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285509
PNG
(CHEMBL76037 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C29H52N2O3S/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-35(33,34)31-29(32)30-28-26(24(2)3)21-20-22-27(28)25(4)5/h20-22,24-25H,6-19,23H2,1-5H3,(H2,30,31,32)
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n/an/a 1.35E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbits

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285506
PNG
(CHEMBL75975 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCCCCCC(C)S(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C31H56N2O3S/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-27(6)37(35,36)33-31(34)32-30-28(25(2)3)23-21-24-29(30)26(4)5/h21,23-27H,7-20,22H2,1-6H3,(H2,32,33,34)
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n/an/a 1.39E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285504
PNG
(CHEMBL420942 | N-{[(2,6-isopropylphenyl)amino]carb...)
Show SMILES CCCCCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C26H46N2O3S/c1-6-7-8-9-10-11-12-13-14-15-16-20-32(30,31)28-26(29)27-25-23(21(2)3)18-17-19-24(25)22(4)5/h17-19,21-22H,6-16,20H2,1-5H3,(H2,27,28,29)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285498
PNG
(CHEMBL309595 | N-{[(2,6-isopropylphenyl)amino]carb...)
Show SMILES CCCCCCCCCCCCCC(c1ccccc1)S(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C33H52N2O3S/c1-6-7-8-9-10-11-12-13-14-15-19-25-31(28-21-17-16-18-22-28)39(37,38)35-33(36)34-32-29(26(2)3)23-20-24-30(32)27(4)5/h16-18,20-24,26-27,31H,6-15,19,25H2,1-5H3,(H2,34,35,36)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbits

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285498
PNG
(CHEMBL309595 | N-{[(2,6-isopropylphenyl)amino]carb...)
Show SMILES CCCCCCCCCCCCCC(c1ccccc1)S(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C33H52N2O3S/c1-6-7-8-9-10-11-12-13-14-15-19-25-31(28-21-17-16-18-22-28)39(37,38)35-33(36)34-32-29(26(2)3)23-20-24-30(32)27(4)5/h16-18,20-24,26-27,31H,6-15,19,25H2,1-5H3,(H2,34,35,36)
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n/an/a 2.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285503
PNG
(CHEMBL76088 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C25H44N2O3S/c1-6-7-8-9-10-11-12-13-14-15-19-31(29,30)27-25(28)26-24-22(20(2)3)17-16-18-23(24)21(4)5/h16-18,20-21H,6-15,19H2,1-5H3,(H2,26,27,28)
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n/an/a 2.33E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbits

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285503
PNG
(CHEMBL76088 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C25H44N2O3S/c1-6-7-8-9-10-11-12-13-14-15-19-31(29,30)27-25(28)26-24-22(20(2)3)17-16-18-23(24)21(4)5/h16-18,20-21H,6-15,19H2,1-5H3,(H2,26,27,28)
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n/an/a 3.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50040468
PNG
(2,6-Bis(1-methylethyl)phenyl[[2,6-Bis(1-methylethy...)
Show SMILES CC(C)c1cccc(C(C)C)c1OC(=O)[N-]S(=O)(=O)Oc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C25H35NO5S/c1-15(2)19-11-9-12-20(16(3)4)23(19)30-25(27)26-32(28,29)31-24-21(17(5)6)13-10-14-22(24)18(7)8/h9-18H,1-8H3,(H,26,27)/p-1
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n/an/a 5.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285497
PNG
(CHEMBL430795 | N-{[(2,4,6-methoxyphenyl)amino]carb...)
Show SMILES CCCCCCCCCCCCCC(C)(C)S(=O)(=O)NC(=O)Nc1c(OC)cc(OC)cc1OC
Show InChI InChI=1S/C26H46N2O6S/c1-7-8-9-10-11-12-13-14-15-16-17-18-26(2,3)35(30,31)28-25(29)27-24-22(33-5)19-21(32-4)20-23(24)34-6/h19-20H,7-18H2,1-6H3,(H2,27,28,29)
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n/an/a 8.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285499
PNG
(CHEMBL76524 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCCCS(=O)(=O)N(C)C(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C28H50N2O3S/c1-7-8-9-10-11-12-13-14-15-16-17-18-22-34(32,33)30(6)28(31)29-27-25(23(2)3)20-19-21-26(27)24(4)5/h19-21,23-24H,7-18,22H2,1-6H3,(H,29,31)
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n/an/a 8.83E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285502
PNG
(CHEMBL77583 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCC(c1ccccc1)S(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C28H42N2O3S/c1-6-7-8-9-10-14-20-26(23-16-12-11-13-17-23)34(32,33)30-28(31)29-27-24(21(2)3)18-15-19-25(27)22(4)5/h11-13,15-19,21-22,26H,6-10,14,20H2,1-5H3,(H2,29,30,31)
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n/an/a 9.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50285505
PNG
(CHEMBL75865 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C23H40N2O3S/c1-6-7-8-9-10-11-12-13-17-29(27,28)25-23(26)24-22-20(18(2)3)15-14-16-21(22)19(4)5/h14-16,18-19H,6-13,17H2,1-5H3,(H2,24,25,26)
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n/an/a 1.11E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbits

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285505
PNG
(CHEMBL75865 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C23H40N2O3S/c1-6-7-8-9-10-11-12-13-17-29(27,28)25-23(26)24-22-20(18(2)3)15-14-16-21(22)19(4)5/h14-16,18-19H,6-13,17H2,1-5H3,(H2,24,25,26)
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n/an/a 1.36E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285508
PNG
(CHEMBL77054 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCS(=O)(=O)NC(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C21H36N2O3S/c1-6-7-8-9-10-11-15-27(25,26)23-21(24)22-20-18(16(2)3)13-12-14-19(20)17(4)5/h12-14,16-17H,6-11,15H2,1-5H3,(H2,22,23,24)
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n/an/a 2.26E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed rats

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50285500
PNG
(CHEMBL76780 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Show SMILES CCCCCCCCCCCCCCS(=O)(=O)N(Cc1ccccc1)C(=O)Nc1c(cccc1C(C)C)C(C)C
Show InChI InChI=1S/C34H54N2O3S/c1-6-7-8-9-10-11-12-13-14-15-16-20-26-40(38,39)36(27-30-22-18-17-19-23-30)34(37)35-33-31(28(2)3)24-21-25-32(33)29(4)5/h17-19,21-25,28-29H,6-16,20,26-27H2,1-5H3,(H,35,37)
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n/an/a 3.80E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound at 5 microM concentration was tested in vitro for inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of choleste...

Bioorg Med Chem Lett 5: 2367-2370 (1995)


Article DOI: 10.1016/0960-894X(95)00408-L
BindingDB Entry DOI: 10.7270/Q21R6QF9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%