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Articleid 50029649

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286545
PNG
(3-Benzenesulfonyl-5-chloro-2-(1H-imidazol-2-yl)-1H...)
Show SMILES Clc1ccc2[nH]c(-c3ncc[nH]3)c(c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H12ClN3O2S/c18-11-6-7-14-13(10-11)16(15(21-14)17-19-8-9-20-17)24(22,23)12-4-2-1-3-5-12/h1-10,21H,(H,19,20)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
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PC cid
PC sid
UniChem
Article
n/an/a 3.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50230553
PNG
(3-Benzenesulfonyl-5-chloro-2-(5-methyl-1H-imidazol...)
Show SMILES Cc1c[nH]c(n1)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H14ClN3O2S/c1-11-10-20-18(21-11)16-17(14-9-12(19)7-8-15(14)22-16)25(23,24)13-5-3-2-4-6-13/h2-10,22H,1H3,(H,20,21)
PDB
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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
Article
n/an/a 4.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286549
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dimethyl-1H-imid...)
Show SMILES Cc1nc([nH]c1C)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H16ClN3O2S/c1-11-12(2)22-19(21-11)17-18(15-10-13(20)8-9-16(15)23-17)26(24,25)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,21,22)
PDB
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UniProtKB/TrEMBL

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UniChem
Article
n/an/a 5.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286550
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dihydro-1H-imida...)
Show SMILES Clc1ccc2[nH]c(C3=NCCN3)c(c2c1)S(=O)(=O)c1ccccc1 |t:7|
Show InChI InChI=1S/C17H14ClN3O2S/c18-11-6-7-14-13(10-11)16(15(21-14)17-19-8-9-20-17)24(22,23)12-4-2-1-3-5-12/h1-7,10,21H,8-9H2,(H,19,20)
PDB
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n/an/a 6.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286551
PNG
(2-(3-Benzenesulfonyl-5-chloro-1H-indol-2-yl)-4,5,6...)
Show SMILES Clc1ccc2[nH]c(-c3nc4CCCCc4[nH]3)c(c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H18ClN3O2S/c22-13-10-11-16-15(12-13)20(28(26,27)14-6-2-1-3-7-14)19(23-16)21-24-17-8-4-5-9-18(17)25-21/h1-3,6-7,10-12,23H,4-5,8-9H2,(H,24,25)
PDB
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UniChem
Article
n/an/a 8.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50230553
PNG
(3-Benzenesulfonyl-5-chloro-2-(5-methyl-1H-imidazol...)
Show SMILES Cc1c[nH]c(n1)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H14ClN3O2S/c1-11-10-20-18(21-11)16-17(14-9-12(19)7-8-15(14)22-16)25(23,24)13-5-3-2-4-6-13/h2-10,22H,1H3,(H,20,21)
PDB
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UniChem
Article
n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286543
PNG
(3-Benzenesulfonyl-5-chloro-2-(4-methyl-5-propyl-1H...)
Show SMILES CCCc1[nH]c(nc1C)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H20ClN3O2S/c1-3-7-17-13(2)23-21(25-17)19-20(16-12-14(22)10-11-18(16)24-19)28(26,27)15-8-5-4-6-9-15/h4-6,8-12,24H,3,7H2,1-2H3,(H,23,25)
PDB
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UniChem
Article
n/an/a 9.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286548
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-diethyl-1H-imida...)
Show SMILES CCc1nc([nH]c1CC)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H20ClN3O2S/c1-3-16-17(4-2)25-21(24-16)19-20(15-12-13(22)10-11-18(15)23-19)28(26,27)14-8-6-5-7-9-14/h5-12,23H,3-4H2,1-2H3,(H,24,25)
PDB
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UniProtKB/TrEMBL

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UniChem
Article
n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286542
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dihydro-thiazol-...)
Show SMILES Clc1ccc2[nH]c(C3=NCCS3)c(c2c1)S(=O)(=O)c1ccccc1 |t:7|
Show InChI InChI=1S/C17H13ClN2O2S2/c18-11-6-7-14-13(10-11)16(15(20-14)17-19-8-9-23-17)24(21,22)12-4-2-1-3-5-12/h1-7,10,20H,8-9H2
PDB
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UniProtKB/TrEMBL

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UniChem
Article
n/an/a 17n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286546
PNG
(4-(3-Benzenesulfonyl-5-chloro-1H-indol-2-yl)-4H-1l...)
Show SMILES Nc1nc(cs1)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H12ClN3O2S2/c18-10-6-7-13-12(8-10)16(15(20-13)14-9-24-17(19)21-14)25(22,23)11-4-2-1-3-5-11/h1-9,20H,(H2,19,21)
PDB
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UniProtKB/TrEMBL

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UniChem
Article
n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286549
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dimethyl-1H-imid...)
Show SMILES Cc1nc([nH]c1C)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H16ClN3O2S/c1-11-12(2)22-19(21-11)17-18(15-10-13(20)8-9-16(15)23-17)26(24,25)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,21,22)
PDB
MMDB

UniProtKB/TrEMBL

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UniChem
Article
n/an/a 22n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-2 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286545
PNG
(3-Benzenesulfonyl-5-chloro-2-(1H-imidazol-2-yl)-1H...)
Show SMILES Clc1ccc2[nH]c(-c3ncc[nH]3)c(c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H12ClN3O2S/c18-11-6-7-14-13(10-11)16(15(21-14)17-19-8-9-20-17)24(22,23)12-4-2-1-3-5-12/h1-10,21H,(H,19,20)
PDB
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UniProtKB/TrEMBL

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UniChem
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n/an/a 23n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-2 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286552
PNG
((3aS,7aS)-2-(3-Benzenesulfonyl-5-chloro-1H-indol-2...)
Show SMILES Clc1ccc2[nH]c(C3=N[C@H]4CCCC[C@@H]4N3)c(c2c1)S(=O)(=O)c1ccccc1 |t:7|
Show InChI InChI=1S/C21H20ClN3O2S/c22-13-10-11-16-15(12-13)20(28(26,27)14-6-2-1-3-7-14)19(23-16)21-24-17-8-4-5-9-18(17)25-21/h1-3,6-7,10-12,17-18,23H,4-5,8-9H2,(H,24,25)/t17-,18-/m0/s1
PDB
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n/an/a 29n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286544
PNG
(3-Benzenesulfonyl-5-chloro-2-(5,5-dimethyl-4,5-dih...)
Show SMILES CC1(C)CN=C(N1)c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1 |c:4|
Show InChI InChI=1S/C19H18ClN3O2S/c1-19(2)11-21-18(23-19)16-17(14-10-12(20)8-9-15(14)22-16)26(24,25)13-6-4-3-5-7-13/h3-10,22H,11H2,1-2H3,(H,21,23)
PDB
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UniProtKB/TrEMBL

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Article
n/an/a 50n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286543
PNG
(3-Benzenesulfonyl-5-chloro-2-(4-methyl-5-propyl-1H...)
Show SMILES CCCc1[nH]c(nc1C)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H20ClN3O2S/c1-3-7-17-13(2)23-21(25-17)19-20(16-12-14(22)10-11-18(16)24-19)28(26,27)15-8-5-4-6-9-15/h4-6,8-12,24H,3,7H2,1-2H3,(H,23,25)
PDB
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UniProtKB/TrEMBL

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UniChem
Article
n/an/a 210n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-2 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286546
PNG
(4-(3-Benzenesulfonyl-5-chloro-1H-indol-2-yl)-4H-1l...)
Show SMILES Nc1nc(cs1)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H12ClN3O2S2/c18-10-6-7-13-12(8-10)16(15(20-13)14-9-24-17(19)21-14)25(22,23)11-4-2-1-3-5-11/h1-9,20H,(H2,19,21)
PDB
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n/an/a 222n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286550
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dihydro-1H-imida...)
Show SMILES Clc1ccc2[nH]c(C3=NCCN3)c(c2c1)S(=O)(=O)c1ccccc1 |t:7|
Show InChI InChI=1S/C17H14ClN3O2S/c18-11-6-7-14-13(10-11)16(15(21-14)17-19-8-9-20-17)24(22,23)12-4-2-1-3-5-12/h1-7,10,21H,8-9H2,(H,19,20)
PDB
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n/an/a 358n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-2 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286545
PNG
(3-Benzenesulfonyl-5-chloro-2-(1H-imidazol-2-yl)-1H...)
Show SMILES Clc1ccc2[nH]c(-c3ncc[nH]3)c(c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H12ClN3O2S/c18-11-6-7-14-13(10-11)16(15(21-14)17-19-8-9-20-17)24(22,23)12-4-2-1-3-5-12/h1-10,21H,(H,19,20)
PDB
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Article
n/an/a 1.07E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N/Y181C double mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286542
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dihydro-thiazol-...)
Show SMILES Clc1ccc2[nH]c(C3=NCCS3)c(c2c1)S(=O)(=O)c1ccccc1 |t:7|
Show InChI InChI=1S/C17H13ClN2O2S2/c18-11-6-7-14-13(10-11)16(15(20-14)17-19-8-9-23-17)24(21,22)12-4-2-1-3-5-12/h1-7,10,20H,8-9H2
PDB
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UniProtKB/TrEMBL

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UniChem
Article
n/an/a 1.25E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286547
PNG
(3-Benzenesulfonyl-5-chloro-2-(1,4,5,6-tetrahydro-p...)
Show SMILES Clc1ccc2[nH]c(c(c2c1)S(=O)(=O)c1ccccc1)C1=NCCCN1 |t:22|
Show InChI InChI=1S/C18H16ClN3O2S/c19-12-7-8-15-14(11-12)17(16(22-15)18-20-9-4-10-21-18)25(23,24)13-5-2-1-3-6-13/h1-3,5-8,11,22H,4,9-10H2,(H,20,21)
PDB
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UniProtKB/TrEMBL

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PC sid
UniChem
Article
n/an/a 2.29E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 protease


(Human immunodeficiency virus type 1)
BDBM50286553
PNG
(3-Benzenesulfonyl-5-chloro-2-imidazol-1-yl-1H-indo...)
Show SMILES Clc1ccc2[nH]c(c(c2c1)S(=O)(=O)c1ccccc1)-n1ccnc1
Show InChI InChI=1S/C17H12ClN3O2S/c18-12-6-7-15-14(10-12)16(17(20-15)21-9-8-19-11-21)24(22,23)13-4-2-1-3-5-13/h1-11,20H
PDB
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UniProtKB/TrEMBL

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PC sid
UniChem
Article
n/an/a 2.39E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-1 RT with poly.rC-oligo.dG template primer


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286549
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dimethyl-1H-imid...)
Show SMILES Cc1nc([nH]c1C)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H16ClN3O2S/c1-11-12(2)22-19(21-11)17-18(15-10-13(20)8-9-16(15)23-17)26(24,25)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,21,22)
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Article
n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N/Y181C double mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286543
PNG
(3-Benzenesulfonyl-5-chloro-2-(4-methyl-5-propyl-1H...)
Show SMILES CCCc1[nH]c(nc1C)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H20ClN3O2S/c1-3-7-17-13(2)23-21(25-17)19-20(16-12-14(22)10-11-18(16)24-19)28(26,27)15-8-5-4-6-9-15/h4-6,8-12,24H,3,7H2,1-2H3,(H,23,25)
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n/an/a>3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-2 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286549
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dimethyl-1H-imid...)
Show SMILES Cc1nc([nH]c1C)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H16ClN3O2S/c1-11-12(2)22-19(21-11)17-18(15-10-13(20)8-9-16(15)23-17)26(24,25)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,21,22)
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Article
n/an/a>3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286550
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dihydro-1H-imida...)
Show SMILES Clc1ccc2[nH]c(C3=NCCN3)c(c2c1)S(=O)(=O)c1ccccc1 |t:7|
Show InChI InChI=1S/C17H14ClN3O2S/c18-11-6-7-14-13(10-11)16(15(21-14)17-19-8-9-20-17)24(22,23)12-4-2-1-3-5-12/h1-7,10,21H,8-9H2,(H,19,20)
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n/an/a>3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-2 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286542
PNG
(3-Benzenesulfonyl-5-chloro-2-(4,5-dihydro-thiazol-...)
Show SMILES Clc1ccc2[nH]c(C3=NCCS3)c(c2c1)S(=O)(=O)c1ccccc1 |t:7|
Show InChI InChI=1S/C17H13ClN2O2S2/c18-11-6-7-14-13(10-11)16(15(20-14)17-19-8-9-23-17)24(21,22)12-4-2-1-3-5-12/h1-7,10,20H,8-9H2
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n/an/a>3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286545
PNG
(3-Benzenesulfonyl-5-chloro-2-(1H-imidazol-2-yl)-1H...)
Show SMILES Clc1ccc2[nH]c(-c3ncc[nH]3)c(c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H12ClN3O2S/c18-11-6-7-14-13(10-11)16(15(21-14)17-19-8-9-20-17)24(22,23)12-4-2-1-3-5-12/h1-10,21H,(H,19,20)
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n/an/a>3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against HIV-2 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50286546
PNG
(4-(3-Benzenesulfonyl-5-chloro-1H-indol-2-yl)-4H-1l...)
Show SMILES Nc1nc(cs1)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H12ClN3O2S2/c18-10-6-7-13-12(8-10)16(15(20-13)14-9-24-17(19)21-14)25(22,23)11-4-2-1-3-5-11/h1-9,20H,(H2,19,21)
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n/an/a>3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50230553
PNG
(3-Benzenesulfonyl-5-chloro-2-(5-methyl-1H-imidazol...)
Show SMILES Cc1c[nH]c(n1)-c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H14ClN3O2S/c1-11-10-20-18(21-11)16-17(14-9-12(19)7-8-15(14)22-16)25(23,24)13-5-3-2-4-6-13/h2-10,22H,1H3,(H,20,21)
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Article
n/an/a>3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against K103N mutant of HIV-1 reverse transcriptase


Bioorg Med Chem Lett 5: 491-496 (1995)


Article DOI: 10.1016/0960-894X(95)00059-3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%