Found 44 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50286671
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(3-met...)Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O3/c1-29-19-4-2-3-18(13-19)26-9-11-27(12-10-26)23(28)16-30-20-5-6-22-21(14-20)17(7-8-24)15-25-22/h2-6,13-15,25H,7-12,16,24H2,1H3 | PDB
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| CHEMBL
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PC sid
UniChem
Similars
| Article
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| Article
| 0.520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50033439
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3)cc12 Show InChI InChI=1S/C22H26N4O2/c23-9-8-17-15-24-21-7-6-19(14-20(17)21)28-16-22(27)26-12-10-25(11-13-26)18-4-2-1-3-5-18/h1-7,14-15,24H,8-13,16,23H2 | PDB
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| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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| 0.870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| Article
| 0.950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1A receptor was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50033439
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3)cc12 Show InChI InChI=1S/C22H26N4O2/c23-9-8-17-15-24-21-7-6-19(14-20(17)21)28-16-22(27)26-12-10-25(11-13-26)18-4-2-1-3-5-18/h1-7,14-15,24H,8-13,16,23H2 | PDB
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| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; va... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50286671
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(3-met...)Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O3/c1-29-19-4-2-3-18(13-19)26-9-11-27(12-10-26)23(28)16-30-20-5-6-22-21(14-20)17(7-8-24)15-25-22/h2-6,13-15,25H,7-12,16,24H2,1H3 | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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| Article
| 7.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxy tryptamine 1A (5-HT1A) receptor was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50005835
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 | PDB
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| DrugBank
Article
| 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| Article
| 8.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1A receptor was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50286671
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(3-met...)Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O3/c1-29-19-4-2-3-18(13-19)26-9-11-27(12-10-26)23(28)16-30-20-5-6-22-21(14-20)17(7-8-24)15-25-22/h2-6,13-15,25H,7-12,16,24H2,1H3 | PDB
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| 9.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50033439
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3)cc12 Show InChI InChI=1S/C22H26N4O2/c23-9-8-17-15-24-21-7-6-19(14-20(17)21)28-16-22(27)26-12-10-25(11-13-26)18-4-2-1-3-5-18/h1-7,14-15,24H,8-13,16,23H2 | PDB
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| Article
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxy tryptamine 1A (5-HT1A) receptor was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50005835
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 | PDB
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Article
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50005835
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 | PDB
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| 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxy tryptamine 1A (5-HT1A) receptor was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(GUINEA PIG) | BDBM50286672
((S)-2-(2-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-a...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)NCC(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)cc12 Show InChI InChI=1S/C23H27N5O5/c24-8-7-15-11-26-19-6-5-17(10-18(15)19)33-13-22(31)27-12-21(30)28-20(23(25)32)9-14-1-3-16(29)4-2-14/h1-6,10-11,20,26,29H,7-9,12-13,24H2,(H2,25,32)(H,27,31)(H,28,30)/t20-/m0/s1 | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| Article
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards 5-hydroxytryptamine 4 receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards 5-hydroxytryptamine 1C receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A/2B/2C
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| Article
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards muscarinic (M) receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards Alpha-1 adrenergic receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards dopaminergic (D2) receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
Adenosine receptor A2b
(Rattus norvegicus) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards Alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards histaminergic (H 1) receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards 5-hydroxytryptamine 1C receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A/2B/2C
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; va... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards histaminergic (H 1) receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards muscarinic (M) receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards 5-hydroxytryptamine 3 receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards 5-hydroxy tryptamine 4 receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
Adenosine receptor A2b
(Rattus norvegicus) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards Alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards dopaminergic (D2) receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50005835
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50033439
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3)cc12 Show InChI InChI=1S/C22H26N4O2/c23-9-8-17-15-24-21-7-6-19(14-20(17)21)28-16-22(27)26-12-10-25(11-13-26)18-4-2-1-3-5-18/h1-7,14-15,24H,8-13,16,23H2 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50005835
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its affinity towards 5-hydroxytryptamine 3 receptor |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50286671
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(3-met...)Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O3/c1-29-19-4-2-3-18(13-19)26-9-11-27(12-10-26)23(28)16-30-20-5-6-22-21(14-20)17(7-8-24)15-25-22/h2-6,13-15,25H,7-12,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; va... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50039947
(2-(5-Nonyloxy-1H-indol-3-yl)-ethylamine | CHEMBL97...)Show InChI InChI=1S/C19H30N2O/c1-2-3-4-5-6-7-8-13-22-17-9-10-19-18(14-17)16(11-12-20)15-21-19/h9-10,14-15,21H,2-8,11-13,20H2,1H3 | PDB
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| Article
| n/a | n/a | n/a | n/a | 68 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1Dbeta receptor in CHO-K1 cells |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50286671
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-[4-(3-met...)Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O3/c1-29-19-4-2-3-18(13-19)26-9-11-27(12-10-26)23(28)16-30-20-5-6-22-21(14-20)17(7-8-24)15-25-22/h2-6,13-15,25H,7-12,16,24H2,1H3 | PDB
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UniChem
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| n/a | n/a | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| n/a | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50033439
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-phenyl...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccccc3)cc12 Show InChI InChI=1S/C22H26N4O2/c23-9-8-17-15-24-21-7-6-19(14-20(17)21)28-16-22(27)26-12-10-25(11-13-26)18-4-2-1-3-5-18/h1-7,14-15,24H,8-13,16,23H2 | PDB
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| n/a | n/a | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1Dbeta receptor in CHO-K1 cells |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50286670
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphth...)Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3cccc4ccccc34)cc12 Show InChI InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 | PDB
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| n/a | n/a | n/a | n/a | 95 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50033447
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1 Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3 | PDB
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UniChem
Similars
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| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ... |
Bioorg Med Chem Lett 5: 663-666 (1995)
Article DOI: 10.1016/0960-894X(95)00091-7
BindingDB Entry DOI: 10.7270/Q2ZK5GMX |
More data for this
Ligand-Target Pair | |
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