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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50287800 (5-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | Article | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50287796 (CHEMBL308150 | ICI-215001 | {4-[2-((S)-2-Hydroxy-3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article | 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287800 (5-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50287800 (5-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287796 (CHEMBL308150 | ICI-215001 | {4-[2-((S)-2-Hydroxy-3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article | 520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO Beta-3 adrenergic receptor cell membrane. | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287799 (4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 760 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | 960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50287795 (3-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50287799 (4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50287799 (4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50287796 (CHEMBL308150 | ICI-215001 | {4-[2-((S)-2-Hydroxy-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article | 2.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50287795 (3-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 3.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287795 (3-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 3.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50287798 (4-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylam...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50287797 (3-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50287798 (4-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 1.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287798 (4-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylam...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 3.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50287797 (3-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylam...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 5.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287797 (3-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylam...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 1.46E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287796 (CHEMBL308150 | ICI-215001 | {4-[2-((S)-2-Hydroxy-3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO-beta-3 adrenergic receptor cell membrane. | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287799 (4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | n/a | n/a | 630 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand... | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287795 (3-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | n/a | n/a | 2.76E+3 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO Beta-3 adrenergic receptor cell membrane. | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50287797 (3-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylam...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | n/a | n/a | 2.76E+4 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO Beta-3 adrenergic receptor cell membrane. | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50002133 ((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | 680 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO-beta-3 adrenergic receptor cell membrane. | Bioorg Med Chem Lett 6: 2253-2258 (1996) Article DOI: 10.1016/0960-894X(96)00417-9 BindingDB Entry DOI: 10.7270/Q2RJ4JGC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
