Found 32 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288501
(2-{2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#7]-2-[#6](=O)-c3ccccc3-[#6]-2=O)c1 Show InChI InChI=1S/C29H24ClN3O3/c30-21-9-10-22-20(16-21)8-7-19-4-3-13-31-27(19)26(22)18-11-14-32(15-12-18)25(34)17-33-28(35)23-5-1-2-6-24(23)29(33)36/h1-6,9-10,13,16H,7-8,11-12,14-15,17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288481
(8-Chloro-11-(1-ethenesulfonyl-piperidin-4-ylidene)...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)S(=O)(=O)[#6]=[#6])c1 Show InChI InChI=1S/C21H21ClN2O2S/c1-2-27(25,26)24-12-9-15(10-13-24)20-19-8-7-18(22)14-17(19)6-5-16-4-3-11-23-21(16)20/h2-4,7-8,11,14H,1,5-6,9-10,12-13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288479
(8-Chloro-11-(1-phenylmethanesulfonyl-piperidin-4-y...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)S(=O)(=O)[#6]-c2ccccc2)c1 Show InChI InChI=1S/C26H25ClN2O2S/c27-23-10-11-24-22(17-23)9-8-21-7-4-14-28-26(21)25(24)20-12-15-29(16-13-20)32(30,31)18-19-5-2-1-3-6-19/h1-7,10-11,14,17H,8-9,12-13,15-16,18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288506
(CHEMBL101603 | [(R)-2-[4-(8-Chloro-5,6-dihydro-ben...)Show SMILES [#8]-c1ccc(-[#6]-[#6@@H](-[#7]-[#6](=O)-[#8]-[#6]-c2ccccc2)-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2\c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C36H34ClN3O4/c37-29-12-15-31-28(22-29)11-10-27-7-4-18-38-34(27)33(31)26-16-19-40(20-17-26)35(42)32(21-24-8-13-30(41)14-9-24)39-36(43)44-23-25-5-2-1-3-6-25/h1-9,12-15,18,22,32,41H,10-11,16-17,19-21,23H2,(H,39,43)/t32-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288495
(4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b...)Show SMILES [#6]-[#7](-[#6])S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C21H24ClN3O2S/c1-24(2)28(26,27)25-12-9-15(10-13-25)20-19-8-7-18(22)14-17(19)6-5-16-4-3-11-23-21(16)20/h3-4,7-8,11,14H,5-6,9-10,12-13H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288498
(8-Chloro-11-(1-methanesulfonyl-piperidin-4-ylidene...)Show SMILES [#6]S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C20H21ClN2O2S/c1-26(24,25)23-11-8-14(9-12-23)19-18-7-6-17(21)13-16(18)5-4-15-3-2-10-22-20(15)19/h2-3,6-7,10,13H,4-5,8-9,11-12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288499
(2-{2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#7]2-[#6](=O)-c3ccccc3S2(=O)=O)c1 Show InChI InChI=1S/C28H24ClN3O4S/c29-21-9-10-22-20(16-21)8-7-19-4-3-13-30-27(19)26(22)18-11-14-31(15-12-18)25(33)17-32-28(34)23-5-1-2-6-24(23)37(32,35)36/h1-6,9-10,13,16H,7-8,11-12,14-15,17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288507
(CHEMBL318268 | [(S)-2-[4-(8-Chloro-5,6-dihydro-ben...)Show SMILES [#6]-[#8]-c1ccc(-[#6]-[#16]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#8]C([#6])([#6])[#6])-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C35H40ClN3O4S/c1-35(2,3)43-34(41)38-30(22-44-21-23-7-12-28(42-4)13-8-23)33(40)39-18-15-24(16-19-39)31-29-14-11-27(36)20-26(29)10-9-25-6-5-17-37-32(25)31/h5-8,11-14,17,20,30H,9-10,15-16,18-19,21-22H2,1-4H3,(H,38,41)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 3.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288502
(2-[(R)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cycloh...)Show SMILES Clc1ccc2c(CCc3cccnc3C2=C2CCN(CC2)C(=O)[C@@H](Cc2cnc[nH]2)N2C(=O)c3ccccc3C2=O)c1 |wU:23.33,(15.73,-5.66,;14.26,-6.05,;13.6,-7.48,;12.05,-7.6,;11.17,-6.32,;11.82,-4.92,;11.17,-3.53,;9.63,-3.2,;8.44,-4.18,;7.09,-3.41,;5.76,-4.18,;5.76,-5.73,;7.09,-6.48,;8.44,-5.73,;9.67,-6.68,;9.32,-8.19,;10.48,-9.21,;10.14,-10.71,;8.68,-11.18,;7.53,-10.13,;7.87,-8.64,;8.32,-12.69,;6.87,-13.14,;9.46,-13.73,;10.94,-13.26,;11.69,-12.28,;12.91,-12.3,;13.32,-11.12,;12.34,-10.37,;11.3,-11.09,;9.14,-15.23,;10.17,-16.37,;11.69,-16.23,;9.37,-17.71,;9.82,-19.16,;8.79,-20.28,;7.29,-19.94,;6.84,-18.48,;7.87,-17.36,;7.73,-15.85,;6.39,-15.05,;13.37,-4.79,)| Show InChI InChI=1S/C33H28ClN5O3/c34-23-9-10-25-22(16-23)8-7-21-4-3-13-36-30(21)29(25)20-11-14-38(15-12-20)33(42)28(17-24-18-35-19-37-24)39-31(40)26-5-1-2-6-27(26)32(39)41/h1-6,9-10,13,16,18-19,28H,7-8,11-12,14-15,17H2,(H,35,37)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288478
(2-{(R)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cycloh...)Show SMILES [#6]-[#6@@H](-[#7]-1-[#6](=O)-c2ccccc2-[#6]-1=O)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C30H26ClN3O3/c1-18(34-29(36)24-6-2-3-7-25(24)30(34)37)28(35)33-15-12-19(13-16-33)26-23-11-10-22(31)17-21(23)9-8-20-5-4-14-32-27(20)26/h2-7,10-11,14,17-18H,8-9,12-13,15-16H2,1H3/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288480
(2-{(R)-1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cycloh...)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6@@H](-[#7]-1-[#6](=O)-c2ccccc2-[#6]-1=O)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C32H30ClN3O3S/c1-40-18-14-27(36-30(37)25-6-2-3-7-26(25)31(36)38)32(39)35-16-12-20(13-17-35)28-24-11-10-23(33)19-22(24)9-8-21-5-4-15-34-29(21)28/h2-7,10-11,15,19,27H,8-9,12-14,16-18H2,1H3/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288505
((R)-5-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6@@H](-[#6]-[#6]-[#6](=O)-[#7]-c2ccccc2)-[#7]-2-[#6](=O)-c3ccccc3-[#6]-2=O)c1 Show InChI InChI=1S/C38H33ClN4O4/c39-27-14-15-29-26(23-27)13-12-25-7-6-20-40-35(25)34(29)24-18-21-42(22-19-24)38(47)32(16-17-33(44)41-28-8-2-1-3-9-28)43-36(45)30-10-4-5-11-31(30)37(43)46/h1-11,14-15,20,23,32H,12-13,16-19,21-22H2,(H,41,44)/t32-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288500
(11-[1-(Butane-1-sulfonyl)-piperidin-4-ylidene]-8-c...)Show SMILES [#6]-[#6]-[#6]-[#6]S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C23H27ClN2O2S/c1-2-3-15-29(27,28)26-13-10-17(11-14-26)22-21-9-8-20(24)16-19(21)7-6-18-5-4-12-25-23(18)22/h4-5,8-9,12,16H,2-3,6-7,10-11,13-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288491
(8-Chloro-11-(1-ethanesulfonyl-piperidin-4-ylidene)...)Show SMILES [#6]-[#6]S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C21H23ClN2O2S/c1-2-27(25,26)24-12-9-15(10-13-24)20-19-8-7-18(22)14-17(19)6-5-16-4-3-11-23-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288509
((S)-2-Amino-1-[4-(8-chloro-5,6-dihydro-benzo[5,6]c...)Show SMILES [#6]-[#8]-c1ccc(-[#6]-[#16]-[#6]-[#6@@H](-[#7])-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2\c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C30H32ClN3O2S/c1-36-25-9-4-20(5-10-25)18-37-19-27(32)30(35)34-15-12-21(13-16-34)28-26-11-8-24(31)17-23(26)7-6-22-3-2-14-33-29(22)28/h2-5,8-11,14,17,27H,6-7,12-13,15-16,18-19,32H2,1H3/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 6.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288493
(CHEMBL323298 | {2-[4-(8-Chloro-5,6-dihydro-benzo[5...)Show SMILES [#6]C([#6])([#6])[#8]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C26H30ClN3O3/c1-26(2,3)33-25(32)29-16-22(31)30-13-10-17(11-14-30)23-21-9-8-20(27)15-19(21)7-6-18-5-4-12-28-24(18)23/h4-5,8-9,12,15H,6-7,10-11,13-14,16H2,1-3H3,(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288490
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES [#6]C1([#6])[#6]-2-[#6]-[#6]C1([#6]S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-13)[#6](-[#8])-[#6]-2 |TLB:34:33:1:5.4| Show InChI InChI=1S/C29H35ClN2O3S/c1-28(2)22-9-12-29(28,25(33)17-22)18-36(34,35)32-14-10-19(11-15-32)26-24-8-7-23(30)16-21(24)6-5-20-4-3-13-31-27(20)26/h3-4,7-8,13,16,22,25,33H,5-6,9-12,14-15,17-18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288504
(CHEMBL101936 | N-{2-[4-(8-Chloro-5,6-dihydro-benzo...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-c2ccccc2)c1 Show InChI InChI=1S/C29H28ClN3O2/c30-24-10-11-25-23(18-24)9-8-22-7-4-14-31-29(22)28(25)21-12-15-33(16-13-21)27(35)19-32-26(34)17-20-5-2-1-3-6-20/h1-7,10-11,14,18H,8-9,12-13,15-17,19H2,(H,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288497
(CHEMBL432011 | {2-[4-(8-Chloro-5,6-dihydro-benzo[5...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#7]-[#6](=O)-[#8]-[#6]-c2ccccc2)c1 Show InChI InChI=1S/C29H28ClN3O3/c30-24-10-11-25-23(17-24)9-8-22-7-4-14-31-28(22)27(25)21-12-15-33(16-13-21)26(34)18-32-29(35)36-19-20-5-2-1-3-6-20/h1-7,10-11,14,17H,8-9,12-13,15-16,18-19H2,(H,32,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288487
(CHEMBL318886 | N-{2-[4-(8-Chloro-5,6-dihydro-benzo...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#7]-[#6](=O)-c2ccccc2)c1 Show InChI InChI=1S/C28H26ClN3O2/c29-23-10-11-24-22(17-23)9-8-20-7-4-14-30-27(20)26(24)19-12-15-32(16-13-19)25(33)18-31-28(34)21-5-2-1-3-6-21/h1-7,10-11,14,17H,8-9,12-13,15-16,18H2,(H,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288492
(2-Benzylamino-1-[4-(8-chloro-5,6-dihydro-benzo[5,6...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#7]-[#6]-c2ccccc2)c1 Show InChI InChI=1S/C28H28ClN3O/c29-24-10-11-25-23(17-24)9-8-22-7-4-14-31-28(22)27(25)21-12-15-32(16-13-21)26(33)19-30-18-20-5-2-1-3-6-20/h1-7,10-11,14,17,30H,8-9,12-13,15-16,18-19H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288482
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#7]C(c2ccccc2)(c2ccccc2)c2ccccc2)c1 Show InChI InChI=1S/C40H36ClN3O/c41-35-20-21-36-31(27-35)19-18-30-11-10-24-42-39(30)38(36)29-22-25-44(26-23-29)37(45)28-43-40(32-12-4-1-5-13-32,33-14-6-2-7-15-33)34-16-8-3-9-17-34/h1-17,20-21,24,27,43H,18-19,22-23,25-26,28H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288508
(2-{(R)-1-Benzyl-2-[4-(8-chloro-5,6-dihydro-benzo[5...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6@@H](-[#6]-c2ccccc2)-[#7]-2-[#6](=O)-c3ccccc3-[#6]-2=O)c1 Show InChI InChI=1S/C36H30ClN3O3/c37-27-14-15-28-26(22-27)13-12-25-9-6-18-38-33(25)32(28)24-16-19-39(20-17-24)36(43)31(21-23-7-2-1-3-8-23)40-34(41)29-10-4-5-11-30(29)35(40)42/h1-11,14-15,18,22,31H,12-13,16-17,19-21H2/t31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288489
(2-{(R)-1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cycloh...)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@@H](-[#7]-1-[#6](=O)-c2ccccc2-[#6]-1=O)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C33H32ClN3O3/c1-20(2)18-28(37-31(38)26-7-3-4-8-27(26)32(37)39)33(40)36-16-13-21(14-17-36)29-25-12-11-24(34)19-23(25)10-9-22-6-5-15-35-30(22)29/h3-8,11-12,15,19-20,28H,9-10,13-14,16-18H2,1-2H3/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288483
(2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES [#6]-[#8]-[#6](=O)-c1ccccc1S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C27H25ClN2O4S/c1-34-27(31)23-6-2-3-7-24(23)35(32,33)30-15-12-18(13-16-30)25-22-11-10-21(28)17-20(22)9-8-19-5-4-14-29-26(19)25/h2-7,10-11,14,17H,8-9,12-13,15-16H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288486
(2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES [#8]-[#6](=O)-c1ccccc1S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C26H23ClN2O4S/c27-20-9-10-21-19(16-20)8-7-18-4-3-13-28-25(18)24(21)17-11-14-29(15-12-17)34(32,33)23-6-2-1-5-22(23)26(30)31/h1-6,9-10,13,16H,7-8,11-12,14-15H2,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288488
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES [#6]C1([#6])[#6]-2-[#6]-[#6]C1([#6]S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-13)[#6](=O)-[#6]-2 |TLB:34:33:1:5.4| Show InChI InChI=1S/C29H33ClN2O3S/c1-28(2)22-9-12-29(28,25(33)17-22)18-36(34,35)32-14-10-19(11-15-32)26-24-8-7-23(30)16-21(24)6-5-20-4-3-13-31-27(20)26/h3-4,7-8,13,16,22H,5-6,9-12,14-15,17-18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288485
(8-Chloro-11-[1-(octane-1-sulfonyl)-piperidin-4-yli...)Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C27H35ClN2O2S/c1-2-3-4-5-6-7-19-33(31,32)30-17-14-21(15-18-30)26-25-13-12-24(28)20-23(25)11-10-22-9-8-16-29-27(22)26/h8-9,12-13,16,20H,2-7,10-11,14-15,17-19H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288484
(8-Chloro-11-[1-(4-nitro-benzenesulfonyl)-piperidin...)Show SMILES [#8-]-[#7+](=O)-c1ccc(cc1)S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C25H22ClN3O4S/c26-20-5-10-23-19(16-20)4-3-18-2-1-13-27-25(18)24(23)17-11-14-28(15-12-17)34(32,33)22-8-6-21(7-9-22)29(30)31/h1-2,5-10,13,16H,3-4,11-12,14-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288494
(8-Chloro-11-[1-(naphthalene-2-sulfonyl)-piperidin-...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)S(=O)(=O)c2ccc3ccccc3c2)c1 Show InChI InChI=1S/C29H25ClN2O2S/c30-25-10-12-27-24(18-25)8-7-22-6-3-15-31-29(22)28(27)21-13-16-32(17-14-21)35(33,34)26-11-9-20-4-1-2-5-23(20)19-26/h1-6,9-12,15,18-19H,7-8,13-14,16-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288496
(8-Chloro-11-[1-(thiophene-2-sulfonyl)-piperidin-4-...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)S(=O)(=O)c2cccs2)c1 Show InChI InChI=1S/C23H21ClN2O2S2/c24-19-7-8-20-18(15-19)6-5-17-3-1-11-25-23(17)22(20)16-9-12-26(13-10-16)30(27,28)21-4-2-14-29-21/h1-4,7-8,11,14-15H,5-6,9-10,12-13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50288503
(2-Amino-1-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclo...)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C21H22ClN3O/c22-17-5-6-18-16(12-17)4-3-15-2-1-9-24-21(15)20(18)14-7-10-25(11-8-14)19(26)13-23/h1-2,5-6,9,12H,3-4,7-8,10-11,13,23H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 2.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against protein farnesyltransferase. |
Bioorg Med Chem Lett 6: 2977-2982 (1996)
Article DOI: 10.1016/S0960-894X(96)00558-6
BindingDB Entry DOI: 10.7270/Q2B56JQR |
More data for this
Ligand-Target Pair | |
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