Affinity Data by BDB articleid=50029924

Articleid 50029924

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-1 adrenergic receptor (GUINEA PIG)	BDBM25756 ((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...) Show SMILES COCCc1ccc(OCC(O)CNC(C)C)cc1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for beta1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right ...				Bioorg Med Chem Lett 7: 1273-1274 (1997) Article DOI: 10.1016/S0960-894X(97)00207-2 BindingDB Entry DOI: 10.7270/Q2SX6D7F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (GUINEA PIG)	BDBM25756 ((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...) Show SMILES COCCc1ccc(OCC(O)CNC(C)C)cc1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle o...				Bioorg Med Chem Lett 7: 1273-1274 (1997) Article DOI: 10.1016/S0960-894X(97)00207-2 BindingDB Entry DOI: 10.7270/Q2SX6D7F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor (Rattus norvegicus (Rat))	BDBM25756 ((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...) Show SMILES COCCc1ccc(OCC(O)CNC(C)C)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle o...				Bioorg Med Chem Lett 7: 1273-1274 (1997) Article DOI: 10.1016/S0960-894X(97)00207-2 BindingDB Entry DOI: 10.7270/Q2SX6D7F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (GUINEA PIG)	BDBM50289372 ((S)-1,1-Difluoro-3-isopropylamino-1-[4-(2-methoxy-...) Show SMILES COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right...				Bioorg Med Chem Lett 7: 1273-1274 (1997) Article DOI: 10.1016/S0960-894X(97)00207-2 BindingDB Entry DOI: 10.7270/Q2SX6D7F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor (Rattus norvegicus (Rat))	BDBM50289372 ((S)-1,1-Difluoro-3-isopropylamino-1-[4-(2-methoxy-...) Show SMILES COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for beta1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right ...				Bioorg Med Chem Lett 7: 1273-1274 (1997) Article DOI: 10.1016/S0960-894X(97)00207-2 BindingDB Entry DOI: 10.7270/Q2SX6D7F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (GUINEA PIG)	BDBM50289372 ((S)-1,1-Difluoro-3-isopropylamino-1-[4-(2-methoxy-...) Show SMILES COCCc1ccc(OC(F)(F)[C@@H](O)CNC(C)C)cc1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	2.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle o...				Bioorg Med Chem Lett 7: 1273-1274 (1997) Article DOI: 10.1016/S0960-894X(97)00207-2 BindingDB Entry DOI: 10.7270/Q2SX6D7F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor (Rattus norvegicus (Rat))	BDBM50214285 (CHEMBL279012) Show SMILES COCCc1ccc(OC(F)(F)[C@H](O)CNC(C)C)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description The compound was tested for its ability to inhibit (-)-[3H]dihydroalprenolol binding to beta-adrenergic receptor sites in rat cortex				Bioorg Med Chem Lett 7: 1273-1274 (1997) Article DOI: 10.1016/S0960-894X(97)00207-2 BindingDB Entry DOI: 10.7270/Q2SX6D7F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%