Found 25 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prothrombin
(Homo sapiens (Human)) | BDBM50289560
(CHEMBL289389 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...)Show SMILES Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C21H28N6O5S/c1-14-9-10-17(25-33(31,32)13-15-6-3-2-4-7-15)20(30)27(14)12-18(28)24-16-8-5-11-26(19(16)29)21(22)23/h2-4,6-7,9-10,16,19,25,29H,5,8,11-13H2,1H3,(H3,22,23)(H,24,28)/t16-,19?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 0.467 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50076074
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O Show InChI InChI=1S/C20H26N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-4,6-7,9-10,15,19,24,29H,5,8,11-13H2,(H3,21,22)(H,23,27)/t15-,19?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 0.505 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50289559
(CHEMBL39475 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cc1ncc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C20H27N7O5S/c1-13-23-10-16(25-33(31,32)12-14-6-3-2-4-7-14)19(30)27(13)11-17(28)24-15-8-5-9-26(18(15)29)20(21)22/h2-4,6-7,10,15,18,25,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,24,28)/t15-,18?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50071693
(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O Show InChI InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Serine protease 1
(Homo sapiens (Human)) | BDBM50289560
(CHEMBL289389 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...)Show SMILES Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C21H28N6O5S/c1-14-9-10-17(25-33(31,32)13-15-6-3-2-4-7-15)20(30)27(14)12-18(28)24-16-8-5-11-26(19(16)29)21(22)23/h2-4,6-7,9-10,16,19,25,29H,5,8,11-13H2,1H3,(H3,22,23)(H,24,28)/t16-,19?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human trypsin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50076074
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O Show InChI InChI=1S/C20H26N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-4,6-7,9-10,15,19,24,29H,5,8,11-13H2,(H3,21,22)(H,23,27)/t15-,19?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human factor Xa enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Serine protease 1
(Homo sapiens (Human)) | BDBM50076074
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O Show InChI InChI=1S/C20H26N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-4,6-7,9-10,15,19,24,29H,5,8,11-13H2,(H3,21,22)(H,23,27)/t15-,19?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human trypsin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50289558
(CHEMBL40071 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cn1cc(NS(=O)(=O)Cc2ccccc2)c(=O)n(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O Show InChI InChI=1S/C20H27N7O6S/c1-25-10-15(24-34(32,33)12-13-6-3-2-4-7-13)18(30)27(20(25)31)11-16(28)23-14-8-5-9-26(17(14)29)19(21)22/h2-4,6-7,10,14,17,24,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,23,28)/t14-,17?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Serine protease 1
(Homo sapiens (Human)) | BDBM50289559
(CHEMBL39475 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cc1ncc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C20H27N7O5S/c1-13-23-10-16(25-33(31,32)12-14-6-3-2-4-7-14)19(30)27(13)11-17(28)24-15-8-5-9-26(18(15)29)20(21)22/h2-4,6-7,10,15,18,25,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,24,28)/t15-,18?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human trypsin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Serine protease 1
(Homo sapiens (Human)) | BDBM50289558
(CHEMBL40071 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cn1cc(NS(=O)(=O)Cc2ccccc2)c(=O)n(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O Show InChI InChI=1S/C20H27N7O6S/c1-25-10-15(24-34(32,33)12-13-6-3-2-4-7-13)18(30)27(20(25)31)11-16(28)23-14-8-5-9-26(17(14)29)19(21)22/h2-4,6-7,10,14,17,24,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,23,28)/t14-,17?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 396 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human trypsin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50289560
(CHEMBL289389 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...)Show SMILES Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C21H28N6O5S/c1-14-9-10-17(25-33(31,32)13-15-6-3-2-4-7-15)20(30)27(14)12-18(28)24-16-8-5-11-26(19(16)29)21(22)23/h2-4,6-7,9-10,16,19,25,29H,5,8,11-13H2,1H3,(H3,22,23)(H,24,28)/t16-,19?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 447 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human factor Xa enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Serine protease 1
(Homo sapiens (Human)) | BDBM50071693
(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O Show InChI InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 791 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human trypsin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50289559
(CHEMBL39475 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cc1ncc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C20H27N7O5S/c1-13-23-10-16(25-33(31,32)12-14-6-3-2-4-7-14)19(30)27(13)11-17(28)24-15-8-5-9-26(18(15)29)20(21)22/h2-4,6-7,10,15,18,25,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,24,28)/t15-,18?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 905 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human factor Xa enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50289558
(CHEMBL40071 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cn1cc(NS(=O)(=O)Cc2ccccc2)c(=O)n(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O Show InChI InChI=1S/C20H27N7O6S/c1-25-10-15(24-34(32,33)12-13-6-3-2-4-7-13)18(30)27(20(25)31)11-16(28)23-14-8-5-9-26(17(14)29)19(21)22/h2-4,6-7,10,14,17,24,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,23,28)/t14-,17?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human Tissue type plasminogen activator was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50071693
(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O Show InChI InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human factor Xa enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50076074
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O Show InChI InChI=1S/C20H26N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-4,6-7,9-10,15,19,24,29H,5,8,11-13H2,(H3,21,22)(H,23,27)/t15-,19?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human Tissue type plasminogen activator was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50289558
(CHEMBL40071 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cn1cc(NS(=O)(=O)Cc2ccccc2)c(=O)n(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O Show InChI InChI=1S/C20H27N7O6S/c1-25-10-15(24-34(32,33)12-13-6-3-2-4-7-13)18(30)27(20(25)31)11-16(28)23-14-8-5-9-26(17(14)29)19(21)22/h2-4,6-7,10,14,17,24,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,23,28)/t14-,17?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human plasmin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50289559
(CHEMBL39475 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cc1ncc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C20H27N7O5S/c1-13-23-10-16(25-33(31,32)12-14-6-3-2-4-7-14)19(30)27(13)11-17(28)24-15-8-5-9-26(18(15)29)20(21)22/h2-4,6-7,10,15,18,25,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,24,28)/t15-,18?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human Tissue type plasminogen activator was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50076074
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O Show InChI InChI=1S/C20H26N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-4,6-7,9-10,15,19,24,29H,5,8,11-13H2,(H3,21,22)(H,23,27)/t15-,19?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human plasmin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50289559
(CHEMBL39475 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cc1ncc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C20H27N7O5S/c1-13-23-10-16(25-33(31,32)12-14-6-3-2-4-7-14)19(30)27(13)11-17(28)24-15-8-5-9-26(18(15)29)20(21)22/h2-4,6-7,10,15,18,25,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,24,28)/t15-,18?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human plasmin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50071693
(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O Show InChI InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human plasmin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50071693
(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O Show InChI InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human Tissue type plasminogen activator was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50289560
(CHEMBL289389 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...)Show SMILES Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C21H28N6O5S/c1-14-9-10-17(25-33(31,32)13-15-6-3-2-4-7-15)20(30)27(14)12-18(28)24-16-8-5-11-26(19(16)29)21(22)23/h2-4,6-7,9-10,16,19,25,29H,5,8,11-13H2,1H3,(H3,22,23)(H,24,28)/t16-,19?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human Tissue type plasminogen activator was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50289558
(CHEMBL40071 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)Show SMILES Cn1cc(NS(=O)(=O)Cc2ccccc2)c(=O)n(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O Show InChI InChI=1S/C20H27N7O6S/c1-25-10-15(24-34(32,33)12-13-6-3-2-4-7-13)18(30)27(20(25)31)11-16(28)23-14-8-5-9-26(17(14)29)19(21)22/h2-4,6-7,10,14,17,24,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,23,28)/t14-,17?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human factor Xa enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50289560
(CHEMBL289389 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...)Show SMILES Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C21H28N6O5S/c1-14-9-10-17(25-33(31,32)13-15-6-3-2-4-7-15)20(30)27(14)12-18(28)24-16-8-5-11-26(19(16)29)21(22)23/h2-4,6-7,9-10,16,19,25,29H,5,8,11-13H2,1H3,(H3,22,23)(H,24,28)/t16-,19?/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound required to inhibit human plasmin enzyme was determined |
Bioorg Med Chem Lett 7: 1543-1548 (1997)
Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX |
More data for this
Ligand-Target Pair | |
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