Found 42 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3032
(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta (PDGF beta-R) |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290838
(4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline | CH...)Show InChI InChI=1S/C16H13BrN2O3/c1-20-14-7-12-13(8-15(14)21-2)18-9-19-16(12)22-11-5-3-4-10(17)6-11/h3-9H,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | MMDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor (PDGF-R) in human aortic smooth muscle cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) in A431 cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290836
((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)Show InChI InChI=1S/C17H15BrN2O2/c1-21-16-9-13-14(20-12-5-3-4-11(18)8-12)6-7-19-15(13)10-17(16)22-2/h3-10H,1-2H3,(H,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290847
(6,7-Dimethoxy-4-(3-methoxy-phenoxy)-quinoline | CH...)Show InChI InChI=1S/C18H17NO4/c1-20-12-5-4-6-13(9-12)23-16-7-8-19-15-11-18(22-3)17(21-2)10-14(15)16/h4-11H,1-3H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290850
(3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol | CHEMBL...)Show InChI InChI=1S/C17H15NO4/c1-20-16-9-13-14(10-17(16)21-2)18-7-6-15(13)22-12-5-3-4-11(19)8-12/h3-10,19H,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290837
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinazolin...)Show InChI InChI=1S/C18H18N2O5/c1-21-14-6-5-11(7-15(14)22-2)25-18-12-8-16(23-3)17(24-4)9-13(12)19-10-20-18/h5-10H,1-4H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290848
(6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline | CH...)Show InChI InChI=1S/C18H17NO4/c1-20-15-6-4-5-7-16(15)23-14-8-9-19-13-11-18(22-3)17(21-2)10-12(13)14/h4-11H,1-3H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290844
(6,7-Dimethoxy-4-(3-nitro-phenoxy)-quinoline | CHEM...)Show SMILES COc1cc2nccc(Oc3cccc(c3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C17H14N2O5/c1-22-16-9-13-14(10-17(16)23-2)18-7-6-15(13)24-12-5-3-4-11(8-12)19(20)21/h3-10H,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290853
(6,7-Dimethoxy-4-phenoxy-quinoline | CHEMBL327534)Show InChI InChI=1S/C17H15NO3/c1-19-16-10-13-14(11-17(16)20-2)18-9-8-15(13)21-12-6-4-3-5-7-12/h3-11H,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290841
(4-(3-Fluoro-phenoxy)-6,7-dimethoxy-quinoline | CHE...)Show InChI InChI=1S/C17H14FNO3/c1-20-16-9-13-14(10-17(16)21-2)19-7-6-15(13)22-12-5-3-4-11(18)8-12/h3-10H,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290846
(3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine | C...)Show InChI InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-7-6-15(13)22-12-5-3-4-11(18)8-12/h3-10H,18H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290842
(6,7-Dimethoxy-4-(4-methoxy-phenoxy)-quinoline | CH...)Show InChI InChI=1S/C18H17NO4/c1-20-12-4-6-13(7-5-12)23-16-8-9-19-15-11-18(22-3)17(21-2)10-14(15)16/h4-11H,1-3H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290839
(4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline | CHEM...)Show InChI InChI=1S/C17H14BrNO3/c1-20-16-9-13-14(10-17(16)21-2)19-7-6-15(13)22-12-5-3-4-11(18)8-12/h3-10H,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290849
((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinolin-4-y...)Show InChI InChI=1S/C19H20N2O4/c1-22-16-6-5-12(9-17(16)23-2)21-14-7-8-20-15-11-19(25-4)18(24-3)10-13(14)15/h5-11H,1-4H3,(H,20,21) | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290835
((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)Show InChI InChI=1S/C18H19N3O4/c1-22-14-6-5-11(7-15(14)23-2)21-18-12-8-16(24-3)17(25-4)9-13(12)19-10-20-18/h5-10H,1-4H3,(H,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290840
(4-(2,3-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-15-6-5-7-16(19(15)24-4)25-14-8-9-20-13-11-18(23-3)17(22-2)10-12(13)14/h5-11H,1-4H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290835
((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)Show InChI InChI=1S/C18H19N3O4/c1-22-14-6-5-11(7-15(14)23-2)21-18-12-8-16(24-3)17(25-4)9-13(12)19-10-20-18/h5-10H,1-4H3,(H,19,20,21) | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290852
(4-(3,5-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-12-7-13(22-2)9-14(8-12)25-17-5-6-20-16-11-19(24-4)18(23-3)10-15(16)17/h5-11H,1-4H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290845
(6,7-Dimethoxy-4-m-tolyloxy-quinoline | CHEMBL98839)Show InChI InChI=1S/C18H17NO3/c1-12-5-4-6-13(9-12)22-16-7-8-19-15-11-18(21-3)17(20-2)10-14(15)16/h4-11H,1-3H3 | Reactome pathway
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| Article
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290839
(4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline | CHEM...)Show InChI InChI=1S/C17H14BrNO3/c1-20-16-9-13-14(10-17(16)21-2)19-7-6-15(13)22-12-5-3-4-11(18)8-12/h3-10H,1-2H3 | Reactome pathway
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| Article
| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290843
(4-(3-Ethyl-phenoxy)-6,7-dimethoxy-quinoline | CHEM...)Show InChI InChI=1S/C19H19NO3/c1-4-13-6-5-7-14(10-13)23-17-8-9-20-16-12-19(22-3)18(21-2)11-15(16)17/h5-12H,4H2,1-3H3 | Reactome pathway
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| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Cdc2 |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Protein kinase A |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1/3
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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NCI pathway
Reactome pathway
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| CHEMBL
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UniChem
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| Article
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor (PDGF-R) from NIH 3T3 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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| CHEMBL
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UniChem
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| Article
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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Reactome pathway
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| Article
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MAPKK |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290851
(4-(3-Ethoxy-phenoxy)-6,7-dimethoxy-quinoline | CHE...)Show InChI InChI=1S/C19H19NO4/c1-4-23-13-6-5-7-14(10-13)24-17-8-9-20-16-12-19(22-3)18(21-2)11-15(16)17/h5-12H,4H2,1-3H3 | Reactome pathway
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PC sid
UniChem
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| n/a | n/a | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290838
(4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline | CH...)Show InChI InChI=1S/C16H13BrN2O3/c1-20-14-7-12-13(8-15(14)21-2)18-9-19-16(12)22-11-5-3-4-10(17)6-11/h3-9H,1-2H3 | Reactome pathway
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| n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Protein kinase C |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290836
((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)Show InChI InChI=1S/C17H15BrN2O2/c1-21-16-9-13-14(20-12-5-3-4-11(18)8-12)6-7-19-15(13)10-17(16)22-2/h3-10H,1-2H3,(H,19,20) | Reactome pathway
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| Article
| n/a | n/a | 2.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM3032
(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | Reactome pathway
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| n/a | n/a | 2.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290854
(4-(2,6-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-15-6-5-7-16(22-2)19(15)25-14-8-9-20-13-11-18(24-4)17(23-3)10-12(13)14/h5-11H,1-4H3 | Reactome pathway
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| n/a | n/a | 6.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290849
((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinolin-4-y...)Show InChI InChI=1S/C19H20N2O4/c1-22-16-6-5-12(9-17(16)23-2)21-14-7-8-20-15-11-19(25-4)18(24-3)10-13(14)15/h5-11H,1-4H3,(H,20,21) | PDB
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| n/a | n/a | 8.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290837
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinazolin...)Show InChI InChI=1S/C18H18N2O5/c1-21-14-6-5-11(7-15(14)22-2)25-18-12-8-16(23-3)17(24-4)9-13(12)19-10-20-18/h5-10H,1-4H3 | PDB
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UniChem
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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| CHEMBL
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UniChem
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| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) in A431 cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Fibroblast growth factor receptor in NIH 3T3 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of insulin beta-R in HepG2 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
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