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Articleid 50034724

Compile data set for download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280553
PNG
(8-Methyl-2,2-diphenyl-1,3-dioxa-8-aza-spiro[4.5]de...)
Show SMILES CN1CCC2(COC(O2)(c2ccccc2)c2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2/c1-21-14-12-19(13-15-21)16-22-20(23-19,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11H,12-16H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM73209
PNG
((+)-CIS-DIOXOLANE | CHEMBL105457 | MLS000069362 | ...)
Show SMILES C[C@H]1OC[C@@H](C[N+](C)(C)C)O1
Show InChI InChI=1S/C8H18NO2/c1-7-10-6-8(11-7)5-9(2,3)4/h7-8H,5-6H2,1-4H3/q+1/t7-,8+/m0/s1
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 6.40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280553
PNG
(8-Methyl-2,2-diphenyl-1,3-dioxa-8-aza-spiro[4.5]de...)
Show SMILES CN1CCC2(COC(O2)(c2ccccc2)c2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2/c1-21-14-12-19(13-15-21)16-22-20(23-19,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11H,12-16H2,1H3
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 8.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50006243
PNG
(((2S,4R,5S)-4-Hydroxy-5-methyl-tetrahydro-furan-2-...)
Show SMILES C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O
Show InChI InChI=1S/C9H20NO2/c1-7-9(11)5-8(12-7)6-10(2,3)4/h7-9,11H,5-6H2,1-4H3/q+1/t7-,8-,9+/m0/s1
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 12n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280540
PNG
(Azaspirodioxolane analogue | CHEMBL170388)
Show SMILES CC1OC[C@@]2(CN3CCC2C3)O1 |TLB:3:4:10:8.7,THB:11:4:10:8.7|
Show InChI InChI=1S/C9H15NO2/c1-7-11-6-9(12-7)5-10-3-2-8(9)4-10/h7-8H,2-6H2,1H3/t7?,8?,9-/m1/s1
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 30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280536
PNG
((S)-2,8-Dimethyl-1,3-dioxa-8-aza-spiro[4.5]decane ...)
Show SMILES C[C@H]1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C9H17NO2/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3/t8-/m0/s1
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 85n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280558
PNG
(2-Ethyl-8-methyl-8-aza-spiro[4.5]decane-1,3-dione ...)
Show SMILES CCC1C(=O)CC2(CCN(C)CC2)C1=O
Show InChI InChI=1S/C12H19NO2/c1-3-9-10(14)8-12(11(9)15)4-6-13(2)7-5-12/h9H,3-8H2,1-2H3
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 87n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50005848
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C[C@@H]1OCC2(CN3CCC2CC3)O1 |wD:1.0,(15.15,-4.25,;14.53,-5.65,;15.3,-6.97,;14.28,-8.13,;12.87,-7.51,;12.87,-9.05,;11.53,-9.82,;10.2,-9.05,;10.2,-7.51,;11.53,-6.74,;11,-7.9,;12.13,-8.54,;13.03,-5.97,)|
Show InChI InChI=1S/C10H17NO2/c1-8-12-7-10(13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m1/s1
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 90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50034640
PNG
(2,8-Dimethyl-1,3-dioxa-8-aza-spiro[4.5]decane | CH...)
Show SMILES CC1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C9H17NO2/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3
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 100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50449645
PNG
(AF-102B | CHEMBL2021361 | FKS-508 | SND-5008 | SNI...)
Show SMILES C[C@H]1OC2(CS1)CN1CCC2CC1 |r,wD:1.0,(26.77,-12.75,;25.3,-13.54,;24.07,-12.62,;22.81,-13.51,;23.3,-15.01,;24.79,-15.01,;22.81,-11.93,;21.47,-11.16,;20.92,-12.45,;22.01,-13.12,;21.47,-14.28,;20.15,-13.51,;20.15,-11.98,)|
Show InChI InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m0/s1
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 105n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280545
PNG
(2-Methyl-1,3-dioxa-8-aza-spiro[4.5]decane | CHEMBL...)
Show SMILES CC1OCC2(CCNCC2)O1
Show InChI InChI=1S/C8H15NO2/c1-7-10-6-8(11-7)2-4-9-5-3-8/h7,9H,2-6H2,1H3
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 145n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280556
PNG
(2,8-Dimethyl-8-aza-spiro[4.5]decane-1,3-dione | CH...)
Show SMILES CC1C(=O)CC2(CCN(C)CC2)C1=O
Show InChI InChI=1S/C11H17NO2/c1-8-9(13)7-11(10(8)14)3-5-12(2)6-4-11/h8H,3-7H2,1-2H3
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 175n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280550
PNG
(Azaspirodioxolane analogue | CHEMBL170489)
Show SMILES C[C@@H]1OCC2(CN3CCC2C3)O1 |TLB:11:4:10:8.7,THB:3:4:10:8.7|
Show InChI InChI=1S/C9H15NO2/c1-7-11-6-9(12-7)5-10-3-2-8(9)4-10/h7-8H,2-6H2,1H3/t7-,8?,9?/m1/s1
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 180n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280539
PNG
(2,8-Dimethyl-1-oxa-3-thia-8-aza-spiro[4.5]decane |...)
Show SMILES CC1OC2(CS1)CCN(C)CC2
Show InChI InChI=1S/C9H17NOS/c1-8-11-9(7-12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3
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 185n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its muscarinic m1 receptor agonist potency in the ileum model as a functional measure of peripheral muscarinic m1 re...

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50449644
PNG
(CHEMBL2371594)
Show SMILES [H][C@]1([#7]-[#6](=O)-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-c2ccccc2)-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#16]-[#16]-[#6]-[#6@H](-[#7]-[#6](=O)[C@@]([H])([#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6]1=O)[#6@@H](-[#6])-[#6]-[#6])-[#6](=O)-[#7]-1-[#6]-[#6@@H](-[#6]-c2ccccc-12)-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#8])[#6@@H](-[#6])-[#6]-[#6]
Show InChI InChI=1S/C72H112N24O20S2/c1-6-36(3)55-66(112)90-47(28-54(101)102)63(109)87-44(20-14-24-81-71(76)77)62(108)95-56(37(4)7-2)67(113)93-50(68(114)96-31-41(27-40-18-11-12-22-51(40)96)58(104)88-45(69(115)116)21-15-25-82-72(78)79)35-118-117-34-49(92-64(110)48(33-98)91-59(105)42(73)32-97)65(111)85-38(5)57(103)89-46(26-39-16-9-8-10-17-39)60(106)84-29-52(99)83-30-53(100)86-43(61(107)94-55)19-13-23-80-70(74)75/h8-12,16-18,22,36-38,41-50,55-56,97-98H,6-7,13-15,19-21,23-35,73H2,1-5H3,(H,83,99)(H,84,106)(H,85,111)(H,86,100)(H,87,109)(H,88,104)(H,89,103)(H,90,112)(H,91,105)(H,92,110)(H,93,113)(H,94,107)(H,95,108)(H,101,102)(H,115,116)(H4,74,75,80)(H4,76,77,81)(H4,78,79,82)/t36-,37-,38-,41+,42-,43+,44-,45+,46+,47+,48-,49-,50-,55-,56-/m0/s1
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 200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280555
PNG
(2,8,8-Trimethyl-1,3-dioxa-8-azonia-spiro[4.5]decan...)
Show SMILES CC1OCC2(CC[N+](C)(C)CC2)O1
Show InChI InChI=1S/C10H20NO2/c1-9-12-8-10(13-9)4-6-11(2,3)7-5-10/h9H,4-8H2,1-3H3/q+1
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 210n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280547
PNG
((R)-2,8-Dimethyl-1,3-dioxa-8-aza-spiro[4.5]decane ...)
Show SMILES C[C@@H]1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C9H17NO2/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3/t8-/m1/s1
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 240n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280554
PNG
(2-Ethynyl-8-methyl-1,3-dioxa-8-aza-spiro[4.5]decan...)
Show SMILES CN1CCC2(COC(O2)C#C)CC1
Show InChI InChI=1S/C10H15NO2/c1-3-9-12-8-10(13-9)4-6-11(2)7-5-10/h1,9H,4-8H2,2H3
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 295n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50449645
PNG
(AF-102B | CHEMBL2021361 | FKS-508 | SND-5008 | SNI...)
Show SMILES C[C@H]1OC2(CS1)CN1CCC2CC1 |r,wD:1.0,(26.77,-12.75,;25.3,-13.54,;24.07,-12.62,;22.81,-13.51,;23.3,-15.01,;24.79,-15.01,;22.81,-11.93,;21.47,-11.16,;20.92,-12.45,;22.01,-13.12,;21.47,-14.28,;20.15,-13.51,;20.15,-11.98,)|
Show InChI InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m0/s1
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 430n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280535
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5...)
Show SMILES C[C@@H]1OC2(CS1)CN1CCC2CC1 |wU:1.0,TLB:4:3:11.12:9.8,THB:2:3:11.12:9.8,(.21,-.57,;1.01,-1.91,;.38,-3.34,;1.55,-4.38,;2.87,-3.58,;2.54,-2.07,;.71,-5.22,;.71,-6.59,;2.3,-7.55,;3.1,-6.4,;1.55,-5.48,;-.16,-6.25,;-.96,-7.48,)|
Show InChI InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m1/s1
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 515n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280552
PNG
(2,8-Dimethyl-1,3-dithia-8-aza-spiro[4.5]decane | C...)
Show SMILES CC1SCC2(CCN(C)CC2)S1
Show InChI InChI=1S/C9H17NS2/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3
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 530n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50449646
PNG
(CHEMBL2021360)
Show SMILES C[C@H]1OC2(CCN(C)C2)CS1 |r|
Show InChI InChI=1S/C8H15NOS/c1-7-10-8(6-11-7)3-4-9(2)5-8/h7H,3-6H2,1-2H3/t7-,8?/m0/s1
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 585n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280546
PNG
(8-Methyl-2-phenyl-1,3-dioxa-8-aza-spiro[4.5]decane...)
Show SMILES CN1CCC2(COC(O2)c2ccccc2)CC1
Show InChI InChI=1S/C14H19NO2/c1-15-9-7-14(8-10-15)11-16-13(17-14)12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3
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 620n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280542
PNG
(2,8-Dimethyl-3-oxa-1-thia-8-aza-spiro[4.5]decane |...)
Show SMILES CC1OCC2(CCN(C)CC2)S1
Show InChI InChI=1S/C9H17NOS/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3
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 720n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280537
PNG
(2-Ethyl-8-methyl-1,3-dioxa-8-aza-spiro[4.5]decane ...)
Show SMILES CCC1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C10H19NO2/c1-3-9-12-8-10(13-9)4-6-11(2)7-5-10/h9H,3-8H2,1-2H3
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 745n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280558
PNG
(2-Ethyl-8-methyl-8-aza-spiro[4.5]decane-1,3-dione ...)
Show SMILES CCC1C(=O)CC2(CCN(C)CC2)C1=O
Show InChI InChI=1S/C12H19NO2/c1-3-9-10(14)8-12(11(9)15)4-6-13(2)7-5-12/h9H,3-8H2,1-2H3
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 765n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280548
PNG
(2-Methoxy-8-methyl-1,3-dioxa-8-aza-spiro[4.5]decan...)
Show SMILES COC1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C9H17NO3/c1-10-5-3-9(4-6-10)7-12-8(11-2)13-9/h8H,3-7H2,1-2H3
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 870n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50449644
PNG
(CHEMBL2371594)
Show SMILES [H][C@]1([#7]-[#6](=O)-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-c2ccccc2)-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#16]-[#16]-[#6]-[#6@H](-[#7]-[#6](=O)[C@@]([H])([#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6]1=O)[#6@@H](-[#6])-[#6]-[#6])-[#6](=O)-[#7]-1-[#6]-[#6@@H](-[#6]-c2ccccc-12)-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#8])[#6@@H](-[#6])-[#6]-[#6]
Show InChI InChI=1S/C72H112N24O20S2/c1-6-36(3)55-66(112)90-47(28-54(101)102)63(109)87-44(20-14-24-81-71(76)77)62(108)95-56(37(4)7-2)67(113)93-50(68(114)96-31-41(27-40-18-11-12-22-51(40)96)58(104)88-45(69(115)116)21-15-25-82-72(78)79)35-118-117-34-49(92-64(110)48(33-98)91-59(105)42(73)32-97)65(111)85-38(5)57(103)89-46(26-39-16-9-8-10-17-39)60(106)84-29-52(99)83-30-53(100)86-43(61(107)94-55)19-13-23-80-70(74)75/h8-12,16-18,22,36-38,41-50,55-56,97-98H,6-7,13-15,19-21,23-35,73H2,1-5H3,(H,83,99)(H,84,106)(H,85,111)(H,86,100)(H,87,109)(H,88,104)(H,89,103)(H,90,112)(H,91,105)(H,92,110)(H,93,113)(H,94,107)(H,95,108)(H,101,102)(H,115,116)(H4,74,75,80)(H4,76,77,81)(H4,78,79,82)/t36-,37-,38-,41+,42-,43+,44-,45+,46+,47+,48-,49-,50-,55-,56-/m0/s1
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 960n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280557
PNG
(8-Methyl-1,3-dioxa-8-aza-spiro[4.5]decane | CHEMBL...)
Show SMILES CN1CCC2(COCO2)CC1
Show InChI InChI=1S/C8H15NO2/c1-9-4-2-8(3-5-9)6-10-7-11-8/h2-7H2,1H3
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 1.20E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280535
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5...)
Show SMILES C[C@@H]1OC2(CS1)CN1CCC2CC1 |wU:1.0,TLB:4:3:11.12:9.8,THB:2:3:11.12:9.8,(.21,-.57,;1.01,-1.91,;.38,-3.34,;1.55,-4.38,;2.87,-3.58,;2.54,-2.07,;.71,-5.22,;.71,-6.59,;2.3,-7.55,;3.1,-6.4,;1.55,-5.48,;-.16,-6.25,;-.96,-7.48,)|
Show InChI InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m1/s1
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 1.25E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280537
PNG
(2-Ethyl-8-methyl-1,3-dioxa-8-aza-spiro[4.5]decane ...)
Show SMILES CCC1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C10H19NO2/c1-3-9-12-8-10(13-9)4-6-11(2)7-5-10/h9H,3-8H2,1-2H3
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 1.33E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50005848
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C[C@@H]1OCC2(CN3CCC2CC3)O1 |wD:1.0,(15.15,-4.25,;14.53,-5.65,;15.3,-6.97,;14.28,-8.13,;12.87,-7.51,;12.87,-9.05,;11.53,-9.82,;10.2,-9.05,;10.2,-7.51,;11.53,-6.74,;11,-7.9,;12.13,-8.54,;13.03,-5.97,)|
Show InChI InChI=1S/C10H17NO2/c1-8-12-7-10(13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m1/s1
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 1.58E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280549
PNG
((Trans)-(R)-2,7-Dimethyl-1,3-dioxa-7-aza-spiro[4.4...)
Show SMILES C[C@@H]1OCC2(CCN(C)C2)O1
Show InChI InChI=1S/C8H15NO2/c1-7-10-6-8(11-7)3-4-9(2)5-8/h7H,3-6H2,1-2H3/t7-,8?/m1/s1
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 1.75E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280549
PNG
((Trans)-(R)-2,7-Dimethyl-1,3-dioxa-7-aza-spiro[4.4...)
Show SMILES C[C@@H]1OCC2(CCN(C)C2)O1
Show InChI InChI=1S/C8H15NO2/c1-7-10-6-8(11-7)3-4-9(2)5-8/h7H,3-6H2,1-2H3/t7-,8?/m1/s1
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 1.75E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50067479
PNG
(2'-methyl-(2'S)-spiro[4-azabicyclo[2.2.1]heptane-2...)
Show SMILES C[C@H]1OCC2(CN3CCC2C3)O1 |TLB:3:4:10:8.7,THB:11:4:10:8.7|
Show InChI InChI=1S/C9H15NO2/c1-7-11-6-9(12-7)5-10-3-2-8(9)4-10/h7-8H,2-6H2,1H3/t7-,8?,9?/m0/s1
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 1.85E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280540
PNG
(Azaspirodioxolane analogue | CHEMBL170388)
Show SMILES CC1OC[C@@]2(CN3CCC2C3)O1 |TLB:3:4:10:8.7,THB:11:4:10:8.7|
Show InChI InChI=1S/C9H15NO2/c1-7-11-6-9(12-7)5-10-3-2-8(9)4-10/h7-8H,2-6H2,1H3/t7?,8?,9-/m1/s1
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 1.95E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM73209
PNG
((+)-CIS-DIOXOLANE | CHEMBL105457 | MLS000069362 | ...)
Show SMILES C[C@H]1OC[C@@H](C[N+](C)(C)C)O1
Show InChI InChI=1S/C8H18NO2/c1-7-10-6-8(11-7)5-9(2,3)4/h7-8H,5-6H2,1-4H3/q+1/t7-,8+/m0/s1
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 2.10E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280552
PNG
(2,8-Dimethyl-1,3-dithia-8-aza-spiro[4.5]decane | C...)
Show SMILES CC1SCC2(CCN(C)CC2)S1
Show InChI InChI=1S/C9H17NS2/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3
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 2.10E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280539
PNG
(2,8-Dimethyl-1-oxa-3-thia-8-aza-spiro[4.5]decane |...)
Show SMILES CC1OC2(CS1)CCN(C)CC2
Show InChI InChI=1S/C9H17NOS/c1-8-11-9(7-12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3
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 2.65E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280546
PNG
(8-Methyl-2-phenyl-1,3-dioxa-8-aza-spiro[4.5]decane...)
Show SMILES CN1CCC2(COC(O2)c2ccccc2)CC1
Show InChI InChI=1S/C14H19NO2/c1-15-9-7-14(8-10-15)11-16-13(17-14)12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3
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 2.80E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280554
PNG
(2-Ethynyl-8-methyl-1,3-dioxa-8-aza-spiro[4.5]decan...)
Show SMILES CN1CCC2(COC(O2)C#C)CC1
Show InChI InChI=1S/C10H15NO2/c1-3-9-12-8-10(13-9)4-6-11(2)7-5-10/h1,9H,4-8H2,2H3
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 3.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280542
PNG
(2,8-Dimethyl-3-oxa-1-thia-8-aza-spiro[4.5]decane |...)
Show SMILES CC1OCC2(CCN(C)CC2)S1
Show InChI InChI=1S/C9H17NOS/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3
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Article
 3.16E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its muscarinic m1 receptor agonist potency in the ileum model as a functional measure of peripheral muscarinic m1 re...

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280556
PNG
(2,8-Dimethyl-8-aza-spiro[4.5]decane-1,3-dione | CH...)
Show SMILES CC1C(=O)CC2(CCN(C)CC2)C1=O
Show InChI InChI=1S/C11H17NO2/c1-8-9(13)7-11(10(8)14)3-5-12(2)6-4-11/h8H,3-7H2,1-2H3
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 4.05E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280555
PNG
(2,8,8-Trimethyl-1,3-dioxa-8-azonia-spiro[4.5]decan...)
Show SMILES CC1OCC2(CC[N+](C)(C)CC2)O1
Show InChI InChI=1S/C10H20NO2/c1-9-12-8-10(13-9)4-6-11(2,3)7-5-10/h9H,4-8H2,1-3H3/q+1
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 5.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280536
PNG
((S)-2,8-Dimethyl-1,3-dioxa-8-aza-spiro[4.5]decane ...)
Show SMILES C[C@H]1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C9H17NO2/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3/t8-/m0/s1
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 5.33E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50006243
PNG
(((2S,4R,5S)-4-Hydroxy-5-methyl-tetrahydro-furan-2-...)
Show SMILES C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O
Show InChI InChI=1S/C9H20NO2/c1-7-9(11)5-8(12-7)6-10(2,3)4/h7-9,11H,5-6H2,1-4H3/q+1/t7-,8-,9+/m0/s1
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 5.68E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50034640
PNG
(2,8-Dimethyl-1,3-dioxa-8-aza-spiro[4.5]decane | CH...)
Show SMILES CC1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C9H17NO2/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3
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 5.83E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280550
PNG
(Azaspirodioxolane analogue | CHEMBL170489)
Show SMILES C[C@@H]1OCC2(CN3CCC2C3)O1 |TLB:11:4:10:8.7,THB:3:4:10:8.7|
Show InChI InChI=1S/C9H15NO2/c1-7-11-6-9(12-7)5-10-3-2-8(9)4-10/h7-8H,2-6H2,1H3/t7-,8?,9?/m1/s1
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 6.40E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50449646
PNG
(CHEMBL2021360)
Show SMILES C[C@H]1OC2(CCN(C)C2)CS1 |r|
Show InChI InChI=1S/C8H15NOS/c1-7-10-8(6-11-7)3-4-9(2)5-8/h7H,3-6H2,1-2H3/t7-,8?/m0/s1
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 6.70E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280547
PNG
((R)-2,8-Dimethyl-1,3-dioxa-8-aza-spiro[4.5]decane ...)
Show SMILES C[C@@H]1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C9H17NO2/c1-8-11-7-9(12-8)3-5-10(2)6-4-9/h8H,3-7H2,1-2H3/t8-/m1/s1
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 7.69E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50449647
PNG
(CHEMBL2021359)
Show SMILES C[C@@H]1OCC2(CCN(C)C2)S1 |r|
Show InChI InChI=1S/C8H15NOS/c1-7-10-6-8(11-7)3-4-9(2)5-8/h7H,3-6H2,1-2H3/t7-,8?/m1/s1
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Article
 9.15E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280557
PNG
(8-Methyl-1,3-dioxa-8-aza-spiro[4.5]decane | CHEMBL...)
Show SMILES CN1CCC2(COCO2)CC1
Show InChI InChI=1S/C8H15NO2/c1-9-4-2-8(3-5-9)6-10-7-11-8/h2-7H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50067479
PNG
(2'-methyl-(2'S)-spiro[4-azabicyclo[2.2.1]heptane-2...)
Show SMILES C[C@H]1OCC2(CN3CCC2C3)O1 |TLB:3:4:10:8.7,THB:11:4:10:8.7|
Show InChI InChI=1S/C9H15NO2/c1-7-11-6-9(12-7)5-10-3-2-8(9)4-10/h7-8H,2-6H2,1H3/t7-,8?,9?/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280538
PNG
(2,2,8-Trimethyl-1,3-dioxa-8-aza-spiro[4.5]decane |...)
Show SMILES CN1CCC2(COC(C)(C)O2)CC1
Show InChI InChI=1S/C10H19NO2/c1-9(2)12-8-10(13-9)4-6-11(3)7-5-10/h4-8H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280538
PNG
(2,2,8-Trimethyl-1,3-dioxa-8-aza-spiro[4.5]decane |...)
Show SMILES CN1CCC2(COC(C)(C)O2)CC1
Show InChI InChI=1S/C10H19NO2/c1-9(2)12-8-10(13-9)4-6-11(3)7-5-10/h4-8H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its efficacy in the ileum model as a functional measure of peripheral muscarinic m1 receptor activity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50449647
PNG
(CHEMBL2021359)
Show SMILES C[C@@H]1OCC2(CCN(C)C2)S1 |r|
Show InChI InChI=1S/C8H15NOS/c1-7-10-6-8(11-7)3-4-9(2)5-8/h7H,3-6H2,1-2H3/t7-,8?/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280548
PNG
(2-Methoxy-8-methyl-1,3-dioxa-8-aza-spiro[4.5]decan...)
Show SMILES COC1OCC2(CCN(C)CC2)O1
Show InChI InChI=1S/C9H17NO3/c1-10-5-3-9(4-6-10)7-12-8(11-2)13-9/h8H,3-7H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280545
PNG
(2-Methyl-1,3-dioxa-8-aza-spiro[4.5]decane | CHEMBL...)
Show SMILES CC1OCC2(CCNCC2)O1
Show InChI InChI=1S/C8H15NO2/c1-7-10-6-8(11-7)2-4-9-5-3-8/h7,9H,2-6H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)		BDBM50280549
PNG
((Trans)-(R)-2,7-Dimethyl-1,3-dioxa-7-aza-spiro[4.4...)
Show SMILES C[C@@H]1OCC2(CCN(C)C2)O1
Show InChI InChI=1S/C8H15NO2/c1-7-10-6-8(11-7)3-4-9(2)5-8/h7H,3-6H2,1-2H3/t7-,8?/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity

Bioorg Med Chem Lett 2: 815-820 (1992)


Article DOI: 10.1016/S0960-894X(00)80537-5
BindingDB Entry DOI: 10.7270/Q23X8734
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%