Found 19 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282045
(1-{3-[5-(3-Chloro-4-methoxy-phenyl)-tetrahydro-fur...)Show SMILES COc1ccc(cc1Cl)C1CCC(OCCCn2c(C)nc3cnccc23)O1 Show InChI InChI=1S/C21H24ClN3O3/c1-14-24-17-13-23-9-8-18(17)25(14)10-3-11-27-21-7-6-19(28-21)15-4-5-20(26-2)16(22)12-15/h4-5,8-9,12-13,19,21H,3,6-7,10-11H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282044
(1-{3-[5-(3,4-Dichloro-phenyl)-tetrahydro-furan-2-y...)Show SMILES Cc1nc2cnccc2n1CCCOC1CCC(O1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H21Cl2N3O2/c1-13-24-17-12-23-8-7-18(17)25(13)9-2-10-26-20-6-5-19(27-20)14-3-4-15(21)16(22)11-14/h3-4,7-8,11-12,19-20H,2,5-6,9-10H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282036
(1-{3-[(2S,5R)-5-(3,4-Dimethoxy-phenyl)-tetrahydro-...)Show SMILES COc1ccc(cc1OC)[C@H]1CC[C@@H](OCCCn2c(C)nc3cnccc23)O1 Show InChI InChI=1S/C22H27N3O4/c1-15-24-17-14-23-10-9-18(17)25(15)11-4-12-28-22-8-7-19(29-22)16-5-6-20(26-2)21(13-16)27-3/h5-6,9-10,13-14,19,22H,4,7-8,11-12H2,1-3H3/t19-,22+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282042
(1-{3-[5-(4-Fluoro-phenyl)-tetrahydro-furan-2-yloxy...)Show InChI InChI=1S/C20H22FN3O2/c1-14-23-17-13-22-10-9-18(17)24(14)11-2-12-25-20-8-7-19(26-20)15-3-5-16(21)6-4-15/h3-6,9-10,13,19-20H,2,7-8,11-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282037
(1-{3-[5-(4-Bromo-phenyl)-tetrahydro-furan-2-yloxy]...)Show InChI InChI=1S/C20H22BrN3O2/c1-14-23-17-13-22-10-9-18(17)24(14)11-2-12-25-20-8-7-19(26-20)15-3-5-16(21)6-4-15/h3-6,9-10,13,19-20H,2,7-8,11-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM81972
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282036
(1-{3-[(2S,5R)-5-(3,4-Dimethoxy-phenyl)-tetrahydro-...)Show SMILES COc1ccc(cc1OC)[C@H]1CC[C@@H](OCCCn2c(C)nc3cnccc23)O1 Show InChI InChI=1S/C22H27N3O4/c1-15-24-17-14-23-10-9-18(17)25(15)11-4-12-28-22-8-7-19(29-22)16-5-6-20(26-2)21(13-16)27-3/h5-6,9-10,13-14,19,22H,4,7-8,11-12H2,1-3H3/t19-,22+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282032
(2-Methyl-1-{3-[5-(3,4,5-trimethoxy-phenyl)-tetrahy...)Show SMILES COc1cc(cc(OC)c1OC)C1CCC(OCCCn2c(C)nc3cnccc23)O1 Show InChI InChI=1S/C23H29N3O5/c1-15-25-17-14-24-9-8-18(17)26(15)10-5-11-30-22-7-6-19(31-22)16-12-20(27-2)23(29-4)21(13-16)28-3/h8-9,12-14,19,22H,5-7,10-11H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282038
(1-{3-[(2S,5S)-5-(3,4-Dimethoxy-phenyl)-tetrahydro-...)Show SMILES COc1ccc(cc1OC)[C@@H]1CC[C@@H](OCCCn2c(C)nc3cnccc23)O1 Show InChI InChI=1S/C22H27N3O4/c1-15-24-17-14-23-10-9-18(17)25(15)11-4-12-28-22-8-7-19(29-22)16-5-6-20(26-2)21(13-16)27-3/h5-6,9-10,13-14,19,22H,4,7-8,11-12H2,1-3H3/t19-,22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282040
(3-{3-[(2R,5S)-5-(3,4,5-Trimethoxy-phenyl)-tetrahyd...)Show SMILES COc1cc(cc(OC)c1OC)[C@@H]1CC[C@H](OCCCc2cccnc2)O1 Show InChI InChI=1S/C21H27NO5/c1-23-18-12-16(13-19(24-2)21(18)25-3)17-8-9-20(27-17)26-11-5-7-15-6-4-10-22-14-15/h4,6,10,12-14,17,20H,5,7-9,11H2,1-3H3/t17-,20+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282047
(1-[3-(5-Heptyl-tetrahydro-furan-2-yloxy)-propyl]-2...)Show InChI InChI=1S/C21H33N3O2/c1-3-4-5-6-7-9-18-10-11-21(26-18)25-15-8-14-24-17(2)23-19-16-22-13-12-20(19)24/h12-13,16,18,21H,3-11,14-15H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282034
(3-(3-{[(2R,5S)-5-(3,4-dimethoxyphenyl)tetrahydrofu...)Show SMILES COc1ccc(cc1OC)[C@@H]1CC[C@H](OCCCc2cccnc2)O1 Show InChI InChI=1S/C20H25NO4/c1-22-18-8-7-16(13-19(18)23-2)17-9-10-20(25-17)24-12-4-6-15-5-3-11-21-14-15/h3,5,7-8,11,13-14,17,20H,4,6,9-10,12H2,1-2H3/t17-,20+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282046
(2-Methyl-1-[3-(5-phenyl-tetrahydro-furan-2-yloxy)-...)Show InChI InChI=1S/C20H23N3O2/c1-15-22-17-14-21-11-10-18(17)23(15)12-5-13-24-20-9-8-19(25-20)16-6-3-2-4-7-16/h2-4,6-7,10-11,14,19-20H,5,8-9,12-13H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282043
(4-{3-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)Show InChI InChI=1S/C19H27N3O4/c1-13-20-21-14(2)22(13)10-5-11-25-19-9-8-16(26-19)15-6-7-17(23-3)18(12-15)24-4/h6-7,12,16,19H,5,8-11H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50280482
(BB-182 | CHEMBL418608 | N-Cyclohexyl-N-methyl-4-(2...)Show SMILES CN(C1CCCCC1)S(=O)(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1 Show InChI InChI=1S/C22H27N3O2S/c1-17-23-21-10-6-7-11-22(21)25(17)16-18-12-14-20(15-13-18)28(26,27)24(2)19-8-4-3-5-9-19/h6-7,10-15,19H,3-5,8-9,16H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282035
(1-{4-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)Show SMILES COc1ccc(cc1OC)C1CCC(OCCCCn2c(C)nc3cnccc23)O1 Show InChI InChI=1S/C23H29N3O4/c1-16-25-18-15-24-11-10-19(18)26(16)12-4-5-13-29-23-9-8-20(30-23)17-6-7-21(27-2)22(14-17)28-3/h6-7,10-11,14-15,20,23H,4-5,8-9,12-13H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282039
(1-{2-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)Show SMILES COc1ccc(cc1OC)C1CCC(COCCn2c(C)nc3cnccc23)O1 Show InChI InChI=1S/C22H27N3O4/c1-15-24-18-13-23-9-8-19(18)25(15)10-11-28-14-17-5-7-20(29-17)16-4-6-21(26-2)22(12-16)27-3/h4,6,8-9,12-13,17,20H,5,7,10-11,14H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282041
(1-{4-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)Show SMILES COc1ccc(cc1OC)C1CCC(OCc2ccc(cc2)-n2c(C)nc3ccccc23)O1 Show InChI InChI=1S/C27H28N2O4/c1-18-28-22-6-4-5-7-23(22)29(18)21-11-8-19(9-12-21)17-32-27-15-14-24(33-27)20-10-13-25(30-2)26(16-20)31-3/h4-13,16,24,27H,14-15,17H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50282033
(1-{4-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)Show SMILES COc1ccc(cc1OC)C1CCC(OCc2ccc(Cn3c(C)nc4ccccc34)cc2)O1 Show InChI InChI=1S/C28H30N2O4/c1-19-29-23-6-4-5-7-24(23)30(19)17-20-8-10-21(11-9-20)18-33-28-15-14-25(34-28)22-12-13-26(31-2)27(16-22)32-3/h4-13,16,25,28H,14-15,17-18H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro |
Bioorg Med Chem Lett 3: 1499-1504 (1993)
Article DOI: 10.1016/S0960-894X(00)80006-2 BindingDB Entry DOI: 10.7270/Q2CC115V |
More data for this Ligand-Target Pair | |