BindingDB logo
myBDB logout

Articleid 50040983

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50391330
PNG
(CHEMBL42931)
Show SMILES CC(C)[C@@H](O)C(=O)NCCC(=O)NCCNC(=O)C[C@@H](O)CC(O)=O
Show InChI InChI=1S/C15H27N3O7/c1-9(2)14(24)15(25)18-4-3-11(20)16-5-6-17-12(21)7-10(19)8-13(22)23/h9-10,14,19,24H,3-8H2,1-2H3,(H,16,20)(H,17,21)(H,18,25)(H,22,23)/t10-,14-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against rat hepatic microsomal HMG-CoA reductase; lacked significant inhibitory activity

Bioorg Med Chem Lett 1: 161-164 (1991)


Article DOI: 10.1016/S0960-894X(01)80791-5
BindingDB Entry DOI: 10.7270/Q2RN392R
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50391329
PNG
(CHEMBL42791)
Show SMILES CC(C)[C@@H](O)C(=O)NCCC(=O)NCCNCC(O)CC(O)CC(O)=O
Show InChI InChI=1S/C16H31N3O7/c1-10(2)15(25)16(26)19-4-3-13(22)18-6-5-17-9-12(21)7-11(20)8-14(23)24/h10-12,15,17,20-21,25H,3-9H2,1-2H3,(H,18,22)(H,19,26)(H,23,24)/t11?,12?,15-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem
Article
n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against rat hepatic microsomal HMG-CoA reductase; lacked significant inhibitory activity

Bioorg Med Chem Lett 1: 161-164 (1991)


Article DOI: 10.1016/S0960-894X(01)80791-5
BindingDB Entry DOI: 10.7270/Q2RN392R
More data for this
Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50391331
PNG
(CHEMBL44196)
Show SMILES CC(C)[C@@H](O)C(=O)NCCC(=O)NCCNC(=O)C[C@@](C)(O)CC(O)=O
Show InChI InChI=1S/C16H29N3O7/c1-10(2)14(24)15(25)19-5-4-11(20)17-6-7-18-12(21)8-16(3,26)9-13(22)23/h10,14,24,26H,4-9H2,1-3H3,(H,17,20)(H,18,21)(H,19,25)(H,22,23)/t14-,16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against rat hepatic microsomal HMG-CoA reductase; lacked significant inhibitory activity

Bioorg Med Chem Lett 1: 161-164 (1991)


Article DOI: 10.1016/S0960-894X(01)80791-5
BindingDB Entry DOI: 10.7270/Q2RN392R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%