Affinity Data by PubMed id=6088770

PubMed code 6088770

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-1A adrenergic receptor (CALF)	BDBM31005 (2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...) Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PubMed	43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50013515 ((+)-yohimbine \| (16alpha,17alpha)-17-hydroxyyohimb...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026633 (1-(3-Fluoro-pyridin-2-yl)-4-methyl-piperazine \| CH...) Show SMILES CN1CCN(CC1)c1ncccc1F Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026636 (17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	940	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026637 (3-Chloro-1'-methyl-1',2',3',6'-tetrahydro-[2,4']bi...) Show SMILES CN1CCC(=CC1)c1ncccc1Cl \|c:4\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026634 (1-(2-pyridyl)piperazine \| 1-(pyridin-2-yl)piperazi...) Show SMILES C1CN(CCN1)c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026639 (1'-Methyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyri...) Show SMILES CN1CCC(CC1)c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026635 (1'-Methyl-1',2',3',6'-tetrahydro-[2,4']bipyridinyl...) Show SMILES CN1CCC(=CC1)c1ccccn1 \|c:4\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026632 (3,1'-Dimethyl-1',2',3',6'-tetrahydro-[2,4']bipyrid...) Show SMILES CN1CCC(=CC1)c1ncccc1C \|c:4\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026640 (3-Fluoro-1'-methyl-1',2',3',6'-tetrahydro-[2,4']bi...) Show SMILES CN1CCC(=CC1)c1ncccc1F \|c:4\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026630 (1',2',3',6'-Tetrahydro-[2,4']bipyridinyl \| CHEMBL2...) Show SMILES C1CC(=CCN1)c1ccccn1 \|c:2\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026638 (1'-Methyl-1',2',3',6'-tetrahydro-[3,4']bipyridinyl...) Show SMILES CN1CCC(=CC1)c1cccnc1 \|c:4\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (CALF)	BDBM50026631 (3'-Fluoro-1-methyl-1,2,3,6-tetrahydro-[4,4']bipyri...) Show SMILES CN1CCC(=CC1)c1ccncc1F \|c:4\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-prazosin from calf cerebral cortex alpha-1 adrenergic receptor				J Med Chem 27: 1182-5 (1984) BindingDB Entry DOI: 10.7270/Q2TM794F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%