Found 11 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22891
(3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-y...)Show SMILES [#7]\[#6](-[#7])=[#7]\c1nc(-[#6]-[#16]-[#6]-[#6]-[#6](-[#7])=[#7]S([#7])(=O)=O)cs1 |w:13.13| Show InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14) | PDB
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PC sid
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| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22568
(1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)Show SMILES [#6]-[#7]-[#6](-[#7]C#N)=[#7]-[#6]-[#6]-[#16]-[#6]-c1csc(\[#7]=[#6](\[#7])-[#7])n1 |w:6.6| Show InChI InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22884
(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)Show SMILES Cc1nc[nH]c1CSCCN=C(N)NCCCc1cnc[nH]1 |w:10.10| Show InChI InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22893
(CHEMBL512 | Ranitidine | ZANTAC | dimethyl[(5-{[(2...)Show SMILES CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1 Show InChI InChI=1S/C13H21N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9H,6-8,10H2,1-3H3,(H,14,15)/q-1/p+1 | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22889
((Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidaz...)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM81468
(CAS_34839-70-8 | Metiamide | NSC_1548992)Show InChI InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14) | PDB
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PC cid
PC sid
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| Article
PubMed
| 510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22888
(1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea | B...)Show InChI InChI=1S/C9H16N4S/c1-10-9(14)12-5-3-2-4-8-6-11-7-13-8/h6-7H,2-5H2,1H3,(H,11,13)(H2,10,12,14) | PDB
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PubMed
| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | PDB
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MCE
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PC cid
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UniChem
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| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)Show InChI InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8) | PDB
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PC cid
PC sid
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| Article
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22880
(2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine | 4-Met...)Show InChI InChI=1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9) | PDB
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PC sid
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM82086
(CAS_34970-65-5 | CHEMBL72427 | SK&F 91581 | SKF915...)Show InChI InChI=1S/C8H14N4S/c1-9-8(13)11-4-2-3-7-5-10-6-12-7/h5-6H,2-4H2,1H3,(H,10,12)(H2,9,11,13) | PDB
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PC cid
PC sid
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
| |
Nature 304: 65-7 (1983)
Article DOI: 10.1038/304065a0
BindingDB Entry DOI: 10.7270/Q2930RN2 |
More data for this
Ligand-Target Pair | |
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