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PubMed code 660589

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasma kallikrein


(Homo sapiens (Human))
BDBM50009926
PNG
(CHEMBL3250026)
Show SMILES [Br-].NC(=[NH2+])SCc1ccc(CS(=O)(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C15H15N3O5S2.BrH/c16-15(17)24-9-11-1-3-12(4-2-11)10-25(21,22)23-14-7-5-13(6-8-14)18(19)20;/h1-8H,9-10H2,(H3,16,17);1H
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
3.20E+5n/an/an/an/an/an/a6.0n/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of 2 X 10'-7 M human plasma kallikrein using Z-Lys-nitrophenyl ester as substrate incubated up to 1 hr at pH 6


J Med Chem 21: 456-9 (1978)


BindingDB Entry DOI: 10.7270/Q2736SFF
More data for this
Ligand-Target Pair
Thrombin


(Bos taurus (Bovine))
BDBM50009926
PNG
(CHEMBL3250026)
Show SMILES [Br-].NC(=[NH2+])SCc1ccc(CS(=O)(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C15H15N3O5S2.BrH/c16-15(17)24-9-11-1-3-12(4-2-11)10-25(21,22)23-14-7-5-13(6-8-14)18(19)20;/h1-8H,9-10H2,(H3,16,17);1H
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
9.30E+5n/an/an/an/an/an/a6.0n/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of 16 X 10'-7 M bovine thrombin using Z-Lys-nitrophenyl ester as substrate incubated up to 1 hr at pH 6


J Med Chem 21: 456-9 (1978)


BindingDB Entry DOI: 10.7270/Q2736SFF
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50009926
PNG
(CHEMBL3250026)
Show SMILES [Br-].NC(=[NH2+])SCc1ccc(CS(=O)(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C15H15N3O5S2.BrH/c16-15(17)24-9-11-1-3-12(4-2-11)10-25(21,22)23-14-7-5-13(6-8-14)18(19)20;/h1-8H,9-10H2,(H3,16,17);1H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
1.20E+6n/an/an/an/an/an/a6.0n/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of 4.8 X 10'-7 M human plasmin using Z-Lys-nitrophenyl ester as substrate incubated up to 1 hr at pH 6


J Med Chem 21: 456-9 (1978)


BindingDB Entry DOI: 10.7270/Q2736SFF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%