Affinity Data by PubMed id=6620311

PubMed code 6620311

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50028190 (7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-puri...) Show SMILES CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50028190 (7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-puri...) Show SMILES CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50028191 ((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50028190 (7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-puri...) Show SMILES CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human lung high-affinity cGMP phosphodiesterases (0.5-2 microM/L)				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50028192 ((S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human lung high-affinity cGMP phosphodiesterases (0.5-2 microM/L)				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50028191 ((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human lung high-affinity cGMP phosphodiesterases (0.5-2 microM/L)				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50028192 ((S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	7.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50028191 ((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	1.10E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50028192 ((S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1.20E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against catechol O-methyltransferase				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%