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PubMed code 7490727

Compile data set for download or QSAR
Found 72 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029792
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-iodo-phenyl)-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(I)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22INO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 1.62n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029787
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-iodo-phenyl)-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(I)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22INO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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 1.71n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029786
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Show SMILES COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5|
Show InChI InChI=1S/C23H25NO3/c1-24-11-10-23(17-4-3-5-18(25)13-17)14-21(24)20(22(26)15-23)12-16-6-8-19(27-2)9-7-16/h3-9,12-13,21,25H,10-11,14-15H2,1-2H3
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 1.90n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029789
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-naphthalen-2-yl...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc3ccccc3c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C26H25NO2/c1-27-12-11-26(21-7-4-8-22(28)15-21)16-24(27)23(25(29)17-26)14-18-9-10-19-5-2-3-6-20(19)13-18/h2-10,13-15,24,28H,11-12,16-17H2,1H3
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 2.20n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029791
PNG
(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 3.10n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029786
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Show SMILES COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5|
Show InChI InChI=1S/C23H25NO3/c1-24-11-10-23(17-4-3-5-18(25)13-17)14-21(24)20(22(26)15-23)12-16-6-8-19(27-2)9-7-16/h3-9,12-13,21,25H,10-11,14-15H2,1-2H3
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 3.90n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029786
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Show SMILES COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5|
Show InChI InChI=1S/C23H25NO3/c1-24-11-10-23(17-4-3-5-18(25)13-17)14-21(24)20(22(26)15-23)12-16-6-8-19(27-2)9-7-16/h3-9,12-13,21,25H,10-11,14-15H2,1-2H3
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 3.90n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029788
PNG
(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)c(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H21Cl2NO2/c1-25-8-7-22(15-3-2-4-16(26)11-15)12-20(25)17(21(27)13-22)9-14-5-6-18(23)19(24)10-14/h2-6,9-11,20,26H,7-8,12-13H2,1H3
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 6.10n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029788
PNG
(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)c(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H21Cl2NO2/c1-25-8-7-22(15-3-2-4-16(26)11-15)12-20(25)17(21(27)13-22)9-14-5-6-18(23)19(24)10-14/h2-6,9-11,20,26H,7-8,12-13H2,1H3
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 6.10n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029785
PNG
(8-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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 6.40n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029786
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Show SMILES COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5|
Show InChI InChI=1S/C23H25NO3/c1-24-11-10-23(17-4-3-5-18(25)13-17)14-21(24)20(22(26)15-23)12-16-6-8-19(27-2)9-7-16/h3-9,12-13,21,25H,10-11,14-15H2,1-2H3
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 7.80n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029784
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-methoxy-phenyl)-meth-...)
Show SMILES COc1cccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)c1 |w:7.6|
Show InChI InChI=1S/C23H25NO3/c1-24-10-9-23(17-6-4-7-18(25)13-17)14-21(24)20(22(26)15-23)12-16-5-3-8-19(11-16)27-2/h3-8,11-13,21,25H,9-10,14-15H2,1-2H3
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 7.90n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029784
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-methoxy-phenyl)-meth-...)
Show SMILES COc1cccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)c1 |w:7.6|
Show InChI InChI=1S/C23H25NO3/c1-24-10-9-23(17-6-4-7-18(25)13-17)14-21(24)20(22(26)15-23)12-16-5-3-8-19(11-16)27-2/h3-8,11-13,21,25H,9-10,14-15H2,1-2H3
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 7.90n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029792
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-iodo-phenyl)-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(I)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22INO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 9.10n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029782
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccccc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H23NO2/c1-23-11-10-22(17-8-5-9-18(24)13-17)14-20(23)19(21(25)15-22)12-16-6-3-2-4-7-16/h2-9,12-13,20,24H,10-11,14-15H2,1H3
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 9.40n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029782
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccccc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H23NO2/c1-23-11-10-22(17-8-5-9-18(24)13-17)14-20(23)19(21(25)15-22)12-16-6-3-2-4-7-16/h2-9,12-13,20,24H,10-11,14-15H2,1H3
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 9.40n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029793
PNG
(8-[1-Cyclopropyl-meth-(E)-ylidene]-5-(3-hydroxy-ph...)
Show SMILES CN1CCC2(CC1C(=CC1CC1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C19H23NO2/c1-20-8-7-19(14-3-2-4-15(21)10-14)11-17(20)16(18(22)12-19)9-13-5-6-13/h2-4,9-10,13,17,21H,5-8,11-12H2,1H3
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 11.2n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029791
PNG
(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 11.8n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029784
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-methoxy-phenyl)-meth-...)
Show SMILES COc1cccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)c1 |w:7.6|
Show InChI InChI=1S/C23H25NO3/c1-24-10-9-23(17-6-4-7-18(25)13-17)14-21(24)20(22(26)15-23)12-16-5-3-8-19(11-16)27-2/h3-8,11-13,21,25H,9-10,14-15H2,1-2H3
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 11.8n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029791
PNG
(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 11.8n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029784
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-methoxy-phenyl)-meth-...)
Show SMILES COc1cccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)c1 |w:7.6|
Show InChI InChI=1S/C23H25NO3/c1-24-10-9-23(17-6-4-7-18(25)13-17)14-21(24)20(22(26)15-23)12-16-5-3-8-19(11-16)27-2/h3-8,11-13,21,25H,9-10,14-15H2,1-2H3
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 12.6n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029789
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-naphthalen-2-yl...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc3ccccc3c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C26H25NO2/c1-27-12-11-26(21-7-4-8-22(28)15-21)16-24(27)23(25(29)17-26)14-18-9-10-19-5-2-3-6-20(19)13-18/h2-10,13-15,24,28H,11-12,16-17H2,1H3
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 16.6n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029787
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-iodo-phenyl)-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(I)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22INO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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 26.7n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029782
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccccc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H23NO2/c1-23-11-10-22(17-8-5-9-18(24)13-17)14-20(23)19(21(25)15-22)12-16-6-3-2-4-7-16/h2-9,12-13,20,24H,10-11,14-15H2,1H3
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 33.9n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029783
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-2-aza-bicyclo[3.3.1]...)
Show SMILES CN1CCC2(CC1CC(=O)C2)c1cccc(O)c1
Show InChI InChI=1S/C15H19NO2/c1-16-6-5-15(9-12(16)8-14(18)10-15)11-3-2-4-13(17)7-11/h2-4,7,12,17H,5-6,8-10H2,1H3
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 35.5n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029783
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-2-aza-bicyclo[3.3.1]...)
Show SMILES CN1CCC2(CC1CC(=O)C2)c1cccc(O)c1
Show InChI InChI=1S/C15H19NO2/c1-16-6-5-15(9-12(16)8-14(18)10-15)11-3-2-4-13(17)7-11/h2-4,7,12,17H,5-6,8-10H2,1H3
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 36n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029785
PNG
(8-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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 48n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029791
PNG
(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 51.3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029793
PNG
(8-[1-Cyclopropyl-meth-(E)-ylidene]-5-(3-hydroxy-ph...)
Show SMILES CN1CCC2(CC1C(=CC1CC1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C19H23NO2/c1-20-8-7-19(14-3-2-4-15(21)10-14)11-17(20)16(18(22)12-19)9-13-5-6-13/h2-4,9-10,13,17,21H,5-8,11-12H2,1H3
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 62.3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029788
PNG
(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)c(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H21Cl2NO2/c1-25-8-7-22(15-3-2-4-16(26)11-15)12-20(25)17(21(27)13-22)9-14-5-6-18(23)19(24)10-14/h2-6,9-11,20,26H,7-8,12-13H2,1H3
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 65.3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029788
PNG
(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)c(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H21Cl2NO2/c1-25-8-7-22(15-3-2-4-16(26)11-15)12-20(25)17(21(27)13-22)9-14-5-6-18(23)19(24)10-14/h2-6,9-11,20,26H,7-8,12-13H2,1H3
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 65.3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029786
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Show SMILES COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5|
Show InChI InChI=1S/C23H25NO3/c1-24-11-10-23(17-4-3-5-18(25)13-17)14-21(24)20(22(26)15-23)12-16-6-8-19(27-2)9-7-16/h3-9,12-13,21,25H,10-11,14-15H2,1-2H3
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 127n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029790
PNG
(5-(3-Methoxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES COc1cccc(c1)C12CCN(C)C(C1)C(=Cc1ccccc1)C(=O)C2 |w:16.18|
Show InChI InChI=1S/C23H25NO2/c1-24-12-11-23(18-9-6-10-19(14-18)26-2)15-21(24)20(22(25)16-23)13-17-7-4-3-5-8-17/h3-10,13-14,21H,11-12,15-16H2,1-2H3
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 138n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029790
PNG
(5-(3-Methoxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES COc1cccc(c1)C12CCN(C)C(C1)C(=Cc1ccccc1)C(=O)C2 |w:16.18|
Show InChI InChI=1S/C23H25NO2/c1-24-12-11-23(18-9-6-10-19(14-18)26-2)15-21(24)20(22(25)16-23)13-17-7-4-3-5-8-17/h3-10,13-14,21H,11-12,15-16H2,1-2H3
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 138n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029792
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-iodo-phenyl)-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(I)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22INO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 141n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029789
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-naphthalen-2-yl...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc3ccccc3c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C26H25NO2/c1-27-12-11-26(21-7-4-8-22(28)15-21)16-24(27)23(25(29)17-26)14-18-9-10-19-5-2-3-6-20(19)13-18/h2-10,13-15,24,28H,11-12,16-17H2,1H3
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 142n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029784
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-methoxy-phenyl)-meth-...)
Show SMILES COc1cccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)c1 |w:7.6|
Show InChI InChI=1S/C23H25NO3/c1-24-10-9-23(17-6-4-7-18(25)13-17)14-21(24)20(22(26)15-23)12-16-5-3-8-19(11-16)27-2/h3-8,11-13,21,25H,9-10,14-15H2,1-2H3
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 175n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029791
PNG
(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 217n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029791
PNG
(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 222n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029788
PNG
(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)c(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H21Cl2NO2/c1-25-8-7-22(15-3-2-4-16(26)11-15)12-20(25)17(21(27)13-22)9-14-5-6-18(23)19(24)10-14/h2-6,9-11,20,26H,7-8,12-13H2,1H3
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 240n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029788
PNG
(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)c(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H21Cl2NO2/c1-25-8-7-22(15-3-2-4-16(26)11-15)12-20(25)17(21(27)13-22)9-14-5-6-18(23)19(24)10-14/h2-6,9-11,20,26H,7-8,12-13H2,1H3
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 240n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029791
PNG
(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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 246n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029790
PNG
(5-(3-Methoxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES COc1cccc(c1)C12CCN(C)C(C1)C(=Cc1ccccc1)C(=O)C2 |w:16.18|
Show InChI InChI=1S/C23H25NO2/c1-24-12-11-23(18-9-6-10-19(14-18)26-2)15-21(24)20(22(25)16-23)13-17-7-4-3-5-8-17/h3-10,13-14,21H,11-12,15-16H2,1-2H3
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>250n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029790
PNG
(5-(3-Methoxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES COc1cccc(c1)C12CCN(C)C(C1)C(=Cc1ccccc1)C(=O)C2 |w:16.18|
Show InChI InChI=1S/C23H25NO2/c1-24-12-11-23(18-9-6-10-19(14-18)26-2)15-21(24)20(22(25)16-23)13-17-7-4-3-5-8-17/h3-10,13-14,21H,11-12,15-16H2,1-2H3
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>250n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029787
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-iodo-phenyl)-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(I)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22INO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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 321n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029785
PNG
(8-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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 336n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029782
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccccc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H23NO2/c1-23-11-10-22(17-8-5-9-18(24)13-17)14-20(23)19(21(25)15-22)12-16-6-3-2-4-7-16/h2-9,12-13,20,24H,10-11,14-15H2,1H3
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 392n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029784
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-methoxy-phenyl)-meth-...)
Show SMILES COc1cccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)c1 |w:7.6|
Show InChI InChI=1S/C23H25NO3/c1-24-10-9-23(17-6-4-7-18(25)13-17)14-21(24)20(22(26)15-23)12-16-5-3-8-19(11-16)27-2/h3-8,11-13,21,25H,9-10,14-15H2,1-2H3
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>400n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029784
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-methoxy-phenyl)-meth-...)
Show SMILES COc1cccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)c1 |w:7.6|
Show InChI InChI=1S/C23H25NO3/c1-24-10-9-23(17-6-4-7-18(25)13-17)14-21(24)20(22(26)15-23)12-16-5-3-8-19(11-16)27-2/h3-8,11-13,21,25H,9-10,14-15H2,1-2H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029789
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-naphthalen-2-yl...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc3ccccc3c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C26H25NO2/c1-27-12-11-26(21-7-4-8-22(28)15-21)16-24(27)23(25(29)17-26)14-18-9-10-19-5-2-3-6-20(19)13-18/h2-10,13-15,24,28H,11-12,16-17H2,1H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029785
PNG
(8-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029786
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Show SMILES COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5|
Show InChI InChI=1S/C23H25NO3/c1-24-11-10-23(17-4-3-5-18(25)13-17)14-21(24)20(22(26)15-23)12-16-6-8-19(27-2)9-7-16/h3-9,12-13,21,25H,10-11,14-15H2,1-2H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029782
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccccc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H23NO2/c1-23-11-10-22(17-8-5-9-18(24)13-17)14-20(23)19(21(25)15-22)12-16-6-3-2-4-7-16/h2-9,12-13,20,24H,10-11,14-15H2,1H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029792
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(3-iodo-phenyl)-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1cccc(I)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22INO2/c1-24-9-8-22(16-5-3-7-18(25)12-16)13-20(24)19(21(26)14-22)11-15-4-2-6-17(23)10-15/h2-7,10-12,20,25H,8-9,13-14H2,1H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029790
PNG
(5-(3-Methoxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES COc1cccc(c1)C12CCN(C)C(C1)C(=Cc1ccccc1)C(=O)C2 |w:16.18|
Show InChI InChI=1S/C23H25NO2/c1-24-12-11-23(18-9-6-10-19(14-18)26-2)15-21(24)20(22(25)16-23)13-17-7-4-3-5-8-17/h3-10,13-14,21H,11-12,15-16H2,1-2H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029790
PNG
(5-(3-Methoxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES COc1cccc(c1)C12CCN(C)C(C1)C(=Cc1ccccc1)C(=O)C2 |w:16.18|
Show InChI InChI=1S/C23H25NO2/c1-24-12-11-23(18-9-6-10-19(14-18)26-2)15-21(24)20(22(25)16-23)13-17-7-4-3-5-8-17/h3-10,13-14,21H,11-12,15-16H2,1-2H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029786
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Show SMILES COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5|
Show InChI InChI=1S/C23H25NO3/c1-24-11-10-23(17-4-3-5-18(25)13-17)14-21(24)20(22(26)15-23)12-16-6-8-19(27-2)9-7-16/h3-9,12-13,21,25H,10-11,14-15H2,1-2H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029788
PNG
(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)c(Cl)c1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H21Cl2NO2/c1-25-8-7-22(15-3-2-4-16(26)11-15)12-20(25)17(21(27)13-22)9-14-5-6-18(23)19(24)10-14/h2-6,9-11,20,26H,7-8,12-13H2,1H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029782
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccccc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H23NO2/c1-23-11-10-22(17-8-5-9-18(24)13-17)14-20(23)19(21(25)15-22)12-16-6-3-2-4-7-16/h2-9,12-13,20,24H,10-11,14-15H2,1H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029785
PNG
(8-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029793
PNG
(8-[1-Cyclopropyl-meth-(E)-ylidene]-5-(3-hydroxy-ph...)
Show SMILES CN1CCC2(CC1C(=CC1CC1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C19H23NO2/c1-20-8-7-19(14-3-2-4-15(21)10-14)11-17(20)16(18(22)12-19)9-13-5-6-13/h2-4,9-10,13,17,21H,5-8,11-12H2,1H3
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>500n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029783
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-2-aza-bicyclo[3.3.1]...)
Show SMILES CN1CCC2(CC1CC(=O)C2)c1cccc(O)c1
Show InChI InChI=1S/C15H19NO2/c1-16-6-5-15(9-12(16)8-14(18)10-15)11-3-2-4-13(17)7-11/h2-4,7,12,17H,5-6,8-10H2,1H3
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 505n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029783
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-2-aza-bicyclo[3.3.1]...)
Show SMILES CN1CCC2(CC1CC(=O)C2)c1cccc(O)c1
Show InChI InChI=1S/C15H19NO2/c1-16-6-5-15(9-12(16)8-14(18)10-15)11-3-2-4-13(17)7-11/h2-4,7,12,17H,5-6,8-10H2,1H3
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 505n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029785
PNG
(8-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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 759n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029785
PNG
(8-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(Cl)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22ClNO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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 759n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029783
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-2-aza-bicyclo[3.3.1]...)
Show SMILES CN1CCC2(CC1CC(=O)C2)c1cccc(O)c1
Show InChI InChI=1S/C15H19NO2/c1-16-6-5-15(9-12(16)8-14(18)10-15)11-3-2-4-13(17)7-11/h2-4,7,12,17H,5-6,8-10H2,1H3
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 762n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50029783
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-2-aza-bicyclo[3.3.1]...)
Show SMILES CN1CCC2(CC1CC(=O)C2)c1cccc(O)c1
Show InChI InChI=1S/C15H19NO2/c1-16-6-5-15(9-12(16)8-14(18)10-15)11-3-2-4-13(17)7-11/h2-4,7,12,17H,5-6,8-10H2,1H3
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 762n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029782
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccccc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H23NO2/c1-23-11-10-22(17-8-5-9-18(24)13-17)14-20(23)19(21(25)15-22)12-16-6-3-2-4-7-16/h2-9,12-13,20,24H,10-11,14-15H2,1H3
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 889n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029787
PNG
(5-(3-Hydroxy-phenyl)-8-[1-(4-iodo-phenyl)-meth-(E)...)
Show SMILES CN1CCC2(CC1C(=Cc1ccc(I)cc1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C22H22INO2/c1-24-10-9-22(16-3-2-4-18(25)12-16)13-20(24)19(21(26)14-22)11-15-5-7-17(23)8-6-15/h2-8,11-12,20,25H,9-10,13-14H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50029793
PNG
(8-[1-Cyclopropyl-meth-(E)-ylidene]-5-(3-hydroxy-ph...)
Show SMILES CN1CCC2(CC1C(=CC1CC1)C(=O)C2)c1cccc(O)c1 |w:8.9|
Show InChI InChI=1S/C19H23NO2/c1-20-8-7-19(14-3-2-4-15(21)10-14)11-17(20)16(18(22)12-19)9-13-5-6-13/h2-4,9-10,13,17,21H,5-8,11-12H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-DADLE binding to rat brain delta receptor

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029790
PNG
(5-(3-Methoxy-phenyl)-2-methyl-8-[1-phenyl-meth-(E)...)
Show SMILES COc1cccc(c1)C12CCN(C)C(C1)C(=Cc1ccccc1)C(=O)C2 |w:16.18|
Show InChI InChI=1S/C23H25NO2/c1-24-12-11-23(18-9-6-10-19(14-18)26-2)15-21(24)20(22(25)16-23)13-17-7-4-3-5-8-17/h3-10,13-14,21H,11-12,15-16H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50029783
PNG
(5-(3-Hydroxy-phenyl)-2-methyl-2-aza-bicyclo[3.3.1]...)
Show SMILES CN1CCC2(CC1CC(=O)C2)c1cccc(O)c1
Show InChI InChI=1S/C15H19NO2/c1-16-6-5-15(9-12(16)8-14(18)10-15)11-3-2-4-13(17)7-11/h2-4,7,12,17H,5-6,8-10H2,1H3
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 2.54E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]-U69,593 binding to guinea pig Opioid receptor kappa 1

J Med Chem 38: 4776-85 (1996)


BindingDB Entry DOI: 10.7270/Q2XW4HVW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%