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PubMed code 7636877

Compile data set for download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoid X receptor beta


(Mus musculus)
BDBM50032674
PNG
(4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CO1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)13-18(15)24(14-27-24)17-8-6-16(7-9-17)21(25)26/h6-9,12-13H,10-11,14H2,1-5H3,(H,25,26)
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n/an/an/an/a 67n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032664
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16-14-20-21(24(4,5)11-10-23(20,2)3)15-19(16)25(12-13-25)18-8-6-17(7-9-18)22(26)27/h6-9,14-15H,10-13H2,1-5H3,(H,26,27)
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n/an/an/an/a 22n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032673
PNG
(2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccccc1C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-8-6-7-9-16(15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032665
PNG
(4-[1-(3,5,5-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2c(CCCC2(C)C)cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-20-18(6-5-11-22(20,3)4)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/a 1.16E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032671
PNG
(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
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n/an/an/an/a 4n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032669
PNG
(3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1cccc(c1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-11-18-19(23(4,5)10-9-22(18,2)3)13-17(14)20(24)15-7-6-8-16(12-15)21(25)26/h6-8,11-13H,9-10H2,1-5H3,(H,25,26)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032677
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CC(c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H30O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14,16H,11-12H2,1-6H3,(H,25,26)
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n/an/an/an/a 340n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032670
PNG
(4-[1-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES Cc1cc2c(cc1C(C)(C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H32O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)25(6,7)18-10-8-17(9-11-18)22(26)27/h8-11,14-15H,12-13H2,1-7H3,(H,26,27)
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n/an/an/an/a 1.90E+3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032668
PNG
(4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES [#6]\[#6](-[#6])=[#6](/c1ccc(cc1)-[#6](-[#8])=O)-c1cc2c(cc1-[#6])C([#6])([#6])[#6]-[#6]C2([#6])[#6]
Show InChI InChI=1S/C26H32O2/c1-16(2)23(18-8-10-19(11-9-18)24(27)28)20-15-22-21(14-17(20)3)25(4,5)12-13-26(22,6)7/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)
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n/an/an/an/a 300n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032669
PNG
(3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1cccc(c1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-11-18-19(23(4,5)10-9-22(18,2)3)13-17(14)20(24)15-7-6-8-16(12-15)21(25)26/h6-8,11-13H,9-10H2,1-5H3,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032665
PNG
(4-[1-(3,5,5-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2c(CCCC2(C)C)cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-20-18(6-5-11-22(20,3)4)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/an/a 770n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032666
PNG
(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H27NO2/c1-14-11-18-19(23(5,6)10-9-22(18,3)4)12-17(14)15(2)20-8-7-16(13-24-20)21(25)26/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,25,26)
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n/an/an/an/a 9n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032664
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16-14-20-21(24(4,5)11-10-23(20,2)3)15-19(16)25(12-13-25)18-8-6-17(7-9-18)22(26)27/h6-9,14-15H,10-13H2,1-5H3,(H,26,27)
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n/an/an/an/a 17n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032677
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CC(c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H30O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14,16H,11-12H2,1-6H3,(H,25,26)
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n/an/an/a 110n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032675
PNG
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
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n/an/an/a 36n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032674
PNG
(4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CO1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)13-18(15)24(14-27-24)17-8-6-16(7-9-17)21(25)26/h6-9,12-13H,10-11,14H2,1-5H3,(H,25,26)
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n/an/an/a 670n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032664
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16-14-20-21(24(4,5)11-10-23(20,2)3)15-19(16)25(12-13-25)18-8-6-17(7-9-18)22(26)27/h6-9,14-15H,10-13H2,1-5H3,(H,26,27)
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n/an/an/a 25n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032662
PNG
(4-[1-(1,1,2,3,3,6-Hexamethyl-indan-5-yl)-vinyl]-be...)
Show SMILES CC1C(C)(C)c2cc(C)c(cc2C1(C)C)C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-14-12-20-21(24(6,7)16(3)23(20,4)5)13-19(14)15(2)17-8-10-18(11-9-17)22(25)26/h8-13,16H,2H2,1,3-7H3,(H,25,26)
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n/an/an/a 176n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032668
PNG
(4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES [#6]\[#6](-[#6])=[#6](/c1ccc(cc1)-[#6](-[#8])=O)-c1cc2c(cc1-[#6])C([#6])([#6])[#6]-[#6]C2([#6])[#6]
Show InChI InChI=1S/C26H32O2/c1-16(2)23(18-8-10-19(11-9-18)24(27)28)20-15-22-21(14-17(20)3)25(4,5)12-13-26(22,6)7/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)
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n/an/an/a 50n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032667
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-6-8-16(9-7-15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/an/a 213n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032673
PNG
(2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccccc1C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-8-6-7-9-16(15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032669
PNG
(3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1cccc(c1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-11-18-19(23(4,5)10-9-22(18,2)3)13-17(14)20(24)15-7-6-8-16(12-15)21(25)26/h6-8,11-13H,9-10H2,1-5H3,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032662
PNG
(4-[1-(1,1,2,3,3,6-Hexamethyl-indan-5-yl)-vinyl]-be...)
Show SMILES CC1C(C)(C)c2cc(C)c(cc2C1(C)C)C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-14-12-20-21(24(6,7)16(3)23(20,4)5)13-19(14)15(2)17-8-10-18(11-9-17)22(25)26/h8-13,16H,2H2,1,3-7H3,(H,25,26)
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n/an/an/a 283n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032672
PNG
(4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2CCCC(C)(C)c2cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-18-6-5-11-22(3,4)20(18)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/an/a 2.40E+3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032673
PNG
(2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccccc1C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-8-6-7-9-16(15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032664
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16-14-20-21(24(4,5)11-10-23(20,2)3)15-19(16)25(12-13-25)18-8-6-17(7-9-18)22(26)27/h6-9,14-15H,10-13H2,1-5H3,(H,26,27)
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n/an/an/an/a 26n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032663
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Cc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H28O2/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)14-18(15)13-16-6-8-17(9-7-16)21(24)25/h6-9,12,14H,10-11,13H2,1-5H3,(H,24,25)
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n/an/an/an/a 440n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032676
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Oc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H26O3/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)25-16-8-6-15(7-9-16)20(23)24/h6-9,12-13H,10-11H2,1-5H3,(H,23,24)
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n/an/an/an/a 430n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032675
PNG
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
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n/an/an/an/a 25n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032676
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Oc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H26O3/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)25-16-8-6-15(7-9-16)20(23)24/h6-9,12-13H,10-11H2,1-5H3,(H,23,24)
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n/an/an/a 520n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032676
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Oc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H26O3/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)25-16-8-6-15(7-9-16)20(23)24/h6-9,12-13H,10-11H2,1-5H3,(H,23,24)
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n/an/an/a 770n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032673
PNG
(2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccccc1C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-8-6-7-9-16(15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032666
PNG
(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H27NO2/c1-14-11-18-19(23(5,6)10-9-22(18,3)4)12-17(14)15(2)20-8-7-16(13-24-20)21(25)26/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,25,26)
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n/an/an/a 22n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032675
PNG
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
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n/an/an/an/a 28n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid X receptor beta


(Mus musculus)
BDBM50032677
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CC(c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H30O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14,16H,11-12H2,1-6H3,(H,25,26)
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n/an/an/a 150n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032677
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CC(c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H30O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14,16H,11-12H2,1-6H3,(H,25,26)
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n/an/an/an/a 470n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032674
PNG
(4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CO1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)13-18(15)24(14-27-24)17-8-6-16(7-9-17)21(25)26/h6-9,12-13H,10-11,14H2,1-5H3,(H,25,26)
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n/an/an/a 190n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032670
PNG
(4-[1-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES Cc1cc2c(cc1C(C)(C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H32O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)25(6,7)18-10-8-17(9-11-18)22(26)27/h8-11,14-15H,12-13H2,1-7H3,(H,26,27)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032663
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Cc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H28O2/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)14-18(15)13-16-6-8-17(9-7-16)21(24)25/h6-9,12,14H,10-11,13H2,1-5H3,(H,24,25)
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n/an/an/an/a 460n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032673
PNG
(2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccccc1C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-8-6-7-9-16(15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032670
PNG
(4-[1-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES Cc1cc2c(cc1C(C)(C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H32O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)25(6,7)18-10-8-17(9-11-18)22(26)27/h8-11,14-15H,12-13H2,1-7H3,(H,26,27)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032674
PNG
(4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CO1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)13-18(15)24(14-27-24)17-8-6-16(7-9-17)21(25)26/h6-9,12-13H,10-11,14H2,1-5H3,(H,25,26)
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n/an/an/a 547n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032669
PNG
(3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1cccc(c1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-11-18-19(23(4,5)10-9-22(18,2)3)13-17(14)20(24)15-7-6-8-16(12-15)21(25)26/h6-8,11-13H,9-10H2,1-5H3,(H,25,26)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032670
PNG
(4-[1-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES Cc1cc2c(cc1C(C)(C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H32O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)25(6,7)18-10-8-17(9-11-18)22(26)27/h8-11,14-15H,12-13H2,1-7H3,(H,26,27)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032663
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Cc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H28O2/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)14-18(15)13-16-6-8-17(9-7-16)21(24)25/h6-9,12,14H,10-11,13H2,1-5H3,(H,24,25)
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n/an/an/an/a 1.20E+3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032667
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-6-8-16(9-7-15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/an/a 246n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032663
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Cc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H28O2/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)14-18(15)13-16-6-8-17(9-7-16)21(24)25/h6-9,12,14H,10-11,13H2,1-5H3,(H,24,25)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032667
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-6-8-16(9-7-15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/an/a 279n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032677
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CC(c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H30O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14,16H,11-12H2,1-6H3,(H,25,26)
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n/an/an/a 200n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032671
PNG
(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
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n/an/an/a 3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid X receptor gamma


(Mus musculus)
BDBM50032672
PNG
(4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2CCCC(C)(C)c2cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-18-6-5-11-22(3,4)20(18)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032666
PNG
(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H27NO2/c1-14-11-18-19(23(5,6)10-9-22(18,3)4)12-17(14)15(2)20-8-7-16(13-24-20)21(25)26/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,25,26)
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n/an/an/an/a 6n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032668
PNG
(4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES [#6]\[#6](-[#6])=[#6](/c1ccc(cc1)-[#6](-[#8])=O)-c1cc2c(cc1-[#6])C([#6])([#6])[#6]-[#6]C2([#6])[#6]
Show InChI InChI=1S/C26H32O2/c1-16(2)23(18-8-10-19(11-9-18)24(27)28)20-15-22-21(14-17(20)3)25(4,5)12-13-26(22,6)7/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)
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n/an/an/an/a 130n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032672
PNG
(4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2CCCC(C)(C)c2cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-18-6-5-11-22(3,4)20(18)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/an/a 2.60E+3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032666
PNG
(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H27NO2/c1-14-11-18-19(23(5,6)10-9-22(18,3)4)12-17(14)15(2)20-8-7-16(13-24-20)21(25)26/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,25,26)
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n/an/an/a 39n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032674
PNG
(4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CO1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)13-18(15)24(14-27-24)17-8-6-16(7-9-17)21(25)26/h6-9,12-13H,10-11,14H2,1-5H3,(H,25,26)
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n/an/an/an/a 51n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032669
PNG
(3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1cccc(c1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-11-18-19(23(4,5)10-9-22(18,2)3)13-17(14)20(24)15-7-6-8-16(12-15)21(25)26/h6-8,11-13H,9-10H2,1-5H3,(H,25,26)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032676
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Oc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H26O3/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)25-16-8-6-15(7-9-16)20(23)24/h6-9,12-13H,10-11H2,1-5H3,(H,23,24)
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n/an/an/an/a 1.90E+3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032667
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-6-8-16(9-7-15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/a 299n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032669
PNG
(3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1cccc(c1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-11-18-19(23(4,5)10-9-22(18,2)3)13-17(14)20(24)15-7-6-8-16(12-15)21(25)26/h6-8,11-13H,9-10H2,1-5H3,(H,25,26)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032664
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16-14-20-21(24(4,5)11-10-23(20,2)3)15-19(16)25(12-13-25)18-8-6-17(7-9-18)22(26)27/h6-9,14-15H,10-13H2,1-5H3,(H,26,27)
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n/an/an/a 46n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032665
PNG
(4-[1-(3,5,5-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2c(CCCC2(C)C)cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-20-18(6-5-11-22(20,3)4)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/a 853n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032675
PNG
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
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n/an/an/a 29n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid X receptor beta


(Mus musculus)
BDBM50032666
PNG
(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H27NO2/c1-14-11-18-19(23(5,6)10-9-22(18,3)4)12-17(14)15(2)20-8-7-16(13-24-20)21(25)26/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,25,26)
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n/an/an/a 61n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032664
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16-14-20-21(24(4,5)11-10-23(20,2)3)15-19(16)25(12-13-25)18-8-6-17(7-9-18)22(26)27/h6-9,14-15H,10-13H2,1-5H3,(H,26,27)
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n/an/an/a 70n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032671
PNG
(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
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n/an/an/a 3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032668
PNG
(4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES [#6]\[#6](-[#6])=[#6](/c1ccc(cc1)-[#6](-[#8])=O)-c1cc2c(cc1-[#6])C([#6])([#6])[#6]-[#6]C2([#6])[#6]
Show InChI InChI=1S/C26H32O2/c1-16(2)23(18-8-10-19(11-9-18)24(27)28)20-15-22-21(14-17(20)3)25(4,5)12-13-26(22,6)7/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)
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n/an/an/an/a 240n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032663
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Cc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H28O2/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)14-18(15)13-16-6-8-17(9-7-16)21(24)25/h6-9,12,14H,10-11,13H2,1-5H3,(H,24,25)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032671
PNG
(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
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n/an/an/a 3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032676
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Oc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H26O3/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)25-16-8-6-15(7-9-16)20(23)24/h6-9,12-13H,10-11H2,1-5H3,(H,23,24)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032677
PNG
(4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CC(c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H30O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14,16H,11-12H2,1-6H3,(H,25,26)
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n/an/an/an/a 310n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032662
PNG
(4-[1-(1,1,2,3,3,6-Hexamethyl-indan-5-yl)-vinyl]-be...)
Show SMILES CC1C(C)(C)c2cc(C)c(cc2C1(C)C)C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-14-12-20-21(24(6,7)16(3)23(20,4)5)13-19(14)15(2)17-8-10-18(11-9-17)22(25)26/h8-13,16H,2H2,1,3-7H3,(H,25,26)
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n/an/an/an/a 280n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032672
PNG
(4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2CCCC(C)(C)c2cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-18-6-5-11-22(3,4)20(18)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032673
PNG
(2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccccc1C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-8-6-7-9-16(15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032676
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Oc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C22H26O3/c1-14-12-17-18(22(4,5)11-10-21(17,2)3)13-19(14)25-16-8-6-15(7-9-16)20(23)24/h6-9,12-13H,10-11H2,1-5H3,(H,23,24)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032668
PNG
(4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES [#6]\[#6](-[#6])=[#6](/c1ccc(cc1)-[#6](-[#8])=O)-c1cc2c(cc1-[#6])C([#6])([#6])[#6]-[#6]C2([#6])[#6]
Show InChI InChI=1S/C26H32O2/c1-16(2)23(18-8-10-19(11-9-18)24(27)28)20-15-22-21(14-17(20)3)25(4,5)12-13-26(22,6)7/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)
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Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032672
PNG
(4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2CCCC(C)(C)c2cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-18-6-5-11-22(3,4)20(18)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032667
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-6-8-16(9-7-15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/a 138n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032670
PNG
(4-[1-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES Cc1cc2c(cc1C(C)(C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H32O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)25(6,7)18-10-8-17(9-11-18)22(26)27/h8-11,14-15H,12-13H2,1-7H3,(H,26,27)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032663
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1Cc1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H28O2/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)14-18(15)13-16-6-8-17(9-7-16)21(24)25/h6-9,12,14H,10-11,13H2,1-5H3,(H,24,25)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032671
PNG
(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
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n/an/an/an/a 4n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032666
PNG
(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H27NO2/c1-14-11-18-19(23(5,6)10-9-22(18,3)4)12-17(14)15(2)20-8-7-16(13-24-20)21(25)26/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,25,26)
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n/an/an/an/a 5n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032665
PNG
(4-[1-(3,5,5-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2c(CCCC2(C)C)cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-20-18(6-5-11-22(20,3)4)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/an/a 600n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032662
PNG
(4-[1-(1,1,2,3,3,6-Hexamethyl-indan-5-yl)-vinyl]-be...)
Show SMILES CC1C(C)(C)c2cc(C)c(cc2C1(C)C)C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-14-12-20-21(24(6,7)16(3)23(20,4)5)13-19(14)15(2)17-8-10-18(11-9-17)22(25)26/h8-13,16H,2H2,1,3-7H3,(H,25,26)
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n/an/an/an/a 500n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032665
PNG
(4-[1-(3,5,5-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2c(CCCC2(C)C)cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-20-18(6-5-11-22(20,3)4)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/a 1.74E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032668
PNG
(4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES [#6]\[#6](-[#6])=[#6](/c1ccc(cc1)-[#6](-[#8])=O)-c1cc2c(cc1-[#6])C([#6])([#6])[#6]-[#6]C2([#6])[#6]
Show InChI InChI=1S/C26H32O2/c1-16(2)23(18-8-10-19(11-9-18)24(27)28)20-15-22-21(14-17(20)3)25(4,5)12-13-26(22,6)7/h8-11,14-15H,12-13H2,1-7H3,(H,27,28)
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n/an/an/a 160n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032670
PNG
(4-[1-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra...)
Show SMILES Cc1cc2c(cc1C(C)(C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H32O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)25(6,7)18-10-8-17(9-11-18)22(26)27/h8-11,14-15H,12-13H2,1-7H3,(H,26,27)
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n/an/an/a>1.00E+3n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032672
PNG
(4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2CCCC(C)(C)c2cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-18-6-5-11-22(3,4)20(18)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/an/a 2.40E+3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032671
PNG
(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Show SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
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n/an/an/an/a 3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid X receptor beta


(Mus musculus)
BDBM50032662
PNG
(4-[1-(1,1,2,3,3,6-Hexamethyl-indan-5-yl)-vinyl]-be...)
Show SMILES CC1C(C)(C)c2cc(C)c(cc2C1(C)C)C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-14-12-20-21(24(6,7)16(3)23(20,4)5)13-19(14)15(2)17-8-10-18(11-9-17)22(25)26/h8-13,16H,2H2,1,3-7H3,(H,25,26)
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n/an/an/a 291n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032674
PNG
(4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Show SMILES Cc1cc2c(cc1C1(CO1)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O3/c1-15-12-19-20(23(4,5)11-10-22(19,2)3)13-18(15)24(14-27-24)17-8-6-16(7-9-17)21(25)26/h6-9,12-13H,10-11,14H2,1-5H3,(H,25,26)
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n/an/an/an/a 47n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032662
PNG
(4-[1-(1,1,2,3,3,6-Hexamethyl-indan-5-yl)-vinyl]-be...)
Show SMILES CC1C(C)(C)c2cc(C)c(cc2C1(C)C)C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-14-12-20-21(24(6,7)16(3)23(20,4)5)13-19(14)15(2)17-8-10-18(11-9-17)22(25)26/h8-13,16H,2H2,1,3-7H3,(H,25,26)
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n/an/an/an/a 300n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor gamma


(Mus musculus)
BDBM50032675
PNG
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
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n/an/an/an/a 20n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoid X receptor beta


(Mus musculus)
BDBM50032667
PNG
(4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C23H26O3/c1-14-12-18-19(23(4,5)11-10-22(18,2)3)13-17(14)20(24)15-6-8-16(9-7-15)21(25)26/h6-9,12-13H,10-11H2,1-5H3,(H,25,26)
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n/an/an/a 191n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
Retinoid X receptor beta


(Mus musculus)
BDBM50032675
PNG
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
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n/an/an/a 21n/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032665
PNG
(4-[1-(3,5,5-Trimethyl-5,6,7,8-tetrahydro-naphthale...)
Show SMILES Cc1cc2c(CCCC2(C)C)cc1C(=C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24O2/c1-14-12-20-18(6-5-11-22(20,3)4)13-19(14)15(2)16-7-9-17(10-8-16)21(23)24/h7-10,12-13H,2,5-6,11H2,1,3-4H3,(H,23,24)
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n/an/an/an/a 1.20E+3n/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.


J Med Chem 38: 3146-55 (1995)


BindingDB Entry DOI: 10.7270/Q2542MMT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%