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PubMed code 7683054

Compile data set for download or QSAR
Found 115 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2257
PNG
(2-Pyridinone derivative 37 | 3-{[(4,7-Dichlorobenz...)
Show SMILES CCc1cc(SCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H14Cl2N2O2S/c1-3-9-6-12(16(21)19-8(9)2)23-7-13-20-14-10(17)4-5-11(18)15(14)22-13/h4-6H,3,7H2,1-2H3,(H,19,21)
PDB
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n/an/a 11n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2257
PNG
(2-Pyridinone derivative 37 | 3-{[(4,7-Dichlorobenz...)
Show SMILES CCc1cc(SCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H14Cl2N2O2S/c1-3-9-6-12(16(21)19-8(9)2)23-7-13-20-14-10(17)4-5-11(18)15(14)22-13/h4-6H,3,7H2,1-2H3,(H,19,21)
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n/an/a 11n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2250
PNG
(2-Pyridinone derivative 30 | 3-[2-(4-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(F)cccc3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H17FN2OS/c1-3-11-9-12(17(22)19-10(11)2)7-8-15-20-16-13(18)5-4-6-14(16)21-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,22)
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n/an/a 13n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2250
PNG
(2-Pyridinone derivative 30 | 3-[2-(4-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(F)cccc3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H17FN2OS/c1-3-11-9-12(17(22)19-10(11)2)7-8-15-20-16-13(18)5-4-6-14(16)21-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,22)
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n/an/a 13n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2242
PNG
(2-Pyridinone derivative 22 | 3-[2-(4,7-Difluoroben...)
Show SMILES CCc1cc(CCc2nc3c(F)ccc(F)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H16F2N2O2/c1-3-10-8-11(17(22)20-9(10)2)4-7-14-21-15-12(18)5-6-13(19)16(15)23-14/h5-6,8H,3-4,7H2,1-2H3,(H,20,22)
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n/an/a 14n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2223
PNG
(2-Pyridinone derivative 21 | 3-[2-(4,7-dichloro-1,...)
Show SMILES CCc1cc(CCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H16Cl2N2O2/c1-3-10-8-11(17(22)20-9(10)2)4-7-14-21-15-12(18)5-6-13(19)16(15)23-14/h5-6,8H,3-4,7H2,1-2H3,(H,20,22)
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n/an/a 14n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2242
PNG
(2-Pyridinone derivative 22 | 3-[2-(4,7-Difluoroben...)
Show SMILES CCc1cc(CCc2nc3c(F)ccc(F)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H16F2N2O2/c1-3-10-8-11(17(22)20-9(10)2)4-7-14-21-15-12(18)5-6-13(19)16(15)23-14/h5-6,8H,3-4,7H2,1-2H3,(H,20,22)
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n/an/a 14n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2223
PNG
(2-Pyridinone derivative 21 | 3-[2-(4,7-dichloro-1,...)
Show SMILES CCc1cc(CCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H16Cl2N2O2/c1-3-10-8-11(17(22)20-9(10)2)4-7-14-21-15-12(18)5-6-13(19)16(15)23-14/h5-6,8H,3-4,7H2,1-2H3,(H,20,22)
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n/an/a 14n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2249
PNG
(2-Pyridinone derivative 29 | 3-[2-(4,7-Difluoroben...)
Show SMILES CCc1cc(CCc2nc3c(F)ccc(F)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H16F2N2OS/c1-3-10-8-11(17(23)20-9(10)2)4-7-14-21-15-12(18)5-6-13(19)16(15)22-14/h5-6,8H,3-4,7H2,1-2H3,(H,20,23)
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n/an/a 15n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2249
PNG
(2-Pyridinone derivative 29 | 3-[2-(4,7-Difluoroben...)
Show SMILES CCc1cc(CCc2nc3c(F)ccc(F)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H16F2N2OS/c1-3-10-8-11(17(23)20-9(10)2)4-7-14-21-15-12(18)5-6-13(19)16(15)22-14/h5-6,8H,3-4,7H2,1-2H3,(H,20,23)
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n/an/a 15n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2236
PNG
(2-Pyridinone derivative 16 | 3-[2-(4-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(F)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17FN2O2/c1-3-11-9-12(17(21)19-10(11)2)7-8-15-20-16-13(18)5-4-6-14(16)22-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,21)
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n/an/a 15n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2236
PNG
(2-Pyridinone derivative 16 | 3-[2-(4-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(F)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17FN2O2/c1-3-11-9-12(17(21)19-10(11)2)7-8-15-20-16-13(18)5-4-6-14(16)22-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,21)
PDB
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n/an/a 15n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1317
PNG
(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Show SMILES CCc1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H15Cl2N3O2/c1-3-9-6-12(16(22)20-8(9)2)19-7-13-21-14-10(17)4-5-11(18)15(14)23-13/h4-6,19H,3,7H2,1-2H3,(H,20,22)
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n/an/a 20n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM1317
PNG
(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Show SMILES CCc1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H15Cl2N3O2/c1-3-9-6-12(16(22)20-8(9)2)19-7-13-21-14-10(17)4-5-11(18)15(14)23-13/h4-6,19H,3,7H2,1-2H3,(H,20,22)
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n/an/a 20n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2215
PNG
(3-[2-(1,3-benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-...)
Show SMILES CCc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-7,10H,3,8-9H2,1-2H3,(H,18,20)
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n/an/a 23n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2215
PNG
(3-[2-(1,3-benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-...)
Show SMILES CCc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-7,10H,3,8-9H2,1-2H3,(H,18,20)
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n/an/a 23n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2246
PNG
(2-Pyridinone derivative 26 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CCc1cc(CCc2nc3ccccc3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H18N2OS/c1-3-12-10-13(17(21)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)20-16/h4-7,10H,3,8-9H2,1-2H3,(H,18,21)
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n/an/a 24n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2246
PNG
(2-Pyridinone derivative 26 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CCc1cc(CCc2nc3ccccc3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H18N2OS/c1-3-12-10-13(17(21)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)20-16/h4-7,10H,3,8-9H2,1-2H3,(H,18,21)
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n/an/a 24n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2222
PNG
(2-Pyridinone derivative 20 | 3-[2-(4,7-dimethyl-1,...)
Show SMILES CCc1cc(CCc2nc3c(C)ccc(C)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C19H22N2O2/c1-5-14-10-15(19(22)20-13(14)4)8-9-16-21-17-11(2)6-7-12(3)18(17)23-16/h6-7,10H,5,8-9H2,1-4H3,(H,20,22)
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n/an/a 28n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2222
PNG
(2-Pyridinone derivative 20 | 3-[2-(4,7-dimethyl-1,...)
Show SMILES CCc1cc(CCc2nc3c(C)ccc(C)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C19H22N2O2/c1-5-14-10-15(19(22)20-13(14)4)8-9-16-21-17-11(2)6-7-12(3)18(17)23-16/h6-7,10H,5,8-9H2,1-4H3,(H,20,22)
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n/an/a 28n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2253
PNG
(2-Pyridinone derivative 33 | 3-[2-(7-Chlorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3cccc(Cl)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H17ClN2OS/c1-3-11-9-12(17(22)19-10(11)2)7-8-15-20-14-6-4-5-13(18)16(14)21-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,22)
PDB
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UniProtKB/TrEMBL

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n/an/a 29n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2253
PNG
(2-Pyridinone derivative 33 | 3-[2-(7-Chlorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3cccc(Cl)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H17ClN2OS/c1-3-11-9-12(17(22)19-10(11)2)7-8-15-20-14-6-4-5-13(18)16(14)21-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,22)
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n/an/a 29n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2252
PNG
(2-Pyridinone derivative 32 | 3-[2-(4-Chlorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(Cl)cccc3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H17ClN2OS/c1-3-11-9-12(17(22)19-10(11)2)7-8-15-20-16-13(18)5-4-6-14(16)21-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,22)
PDB
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n/an/a 30n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2248
PNG
(2-Pyridinone derivative 28 | 3-[2-(4,7-Dichloroben...)
Show SMILES CCc1cc(CCc2nc3c(Cl)ccc(Cl)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H16Cl2N2OS/c1-3-10-8-11(17(23)20-9(10)2)4-7-14-21-15-12(18)5-6-13(19)16(15)22-14/h5-6,8H,3-4,7H2,1-2H3,(H,20,23)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2248
PNG
(2-Pyridinone derivative 28 | 3-[2-(4,7-Dichloroben...)
Show SMILES CCc1cc(CCc2nc3c(Cl)ccc(Cl)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H16Cl2N2OS/c1-3-10-8-11(17(23)20-9(10)2)4-7-14-21-15-12(18)5-6-13(19)16(15)22-14/h5-6,8H,3-4,7H2,1-2H3,(H,20,23)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2252
PNG
(2-Pyridinone derivative 32 | 3-[2-(4-Chlorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(Cl)cccc3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H17ClN2OS/c1-3-11-9-12(17(22)19-10(11)2)7-8-15-20-16-13(18)5-4-6-14(16)21-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,22)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2234
PNG
(2-Pyridinone derivative 14 | 3-[2-(4-Methylbenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(C)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-4-13-10-14(18(21)19-12(13)3)8-9-16-20-17-11(2)6-5-7-15(17)22-16/h5-7,10H,4,8-9H2,1-3H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2234
PNG
(2-Pyridinone derivative 14 | 3-[2-(4-Methylbenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(C)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-4-13-10-14(18(21)19-12(13)3)8-9-16-20-17-11(2)6-5-7-15(17)22-16/h5-7,10H,4,8-9H2,1-3H3,(H,19,21)
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n/an/a 33n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2276
PNG
(2-Pyridinone derivative 57 | 3-[2-(4,7-dichloro-1,...)
Show SMILES CCCc1cc(CCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H18Cl2N2O2/c1-3-4-11-9-12(18(23)21-10(11)2)5-8-15-22-16-13(19)6-7-14(20)17(16)24-15/h6-7,9H,3-5,8H2,1-2H3,(H,21,23)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2276
PNG
(2-Pyridinone derivative 57 | 3-[2-(4,7-dichloro-1,...)
Show SMILES CCCc1cc(CCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H18Cl2N2O2/c1-3-4-11-9-12(18(23)21-10(11)2)5-8-15-22-16-13(19)6-7-14(20)17(16)24-15/h6-7,9H,3-5,8H2,1-2H3,(H,21,23)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2239
PNG
(2-Pyridinone derivative 19 | 3-[2-(7-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3cccc(F)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17FN2O2/c1-3-11-9-12(17(21)19-10(11)2)7-8-15-20-14-6-4-5-13(18)16(14)22-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2239
PNG
(2-Pyridinone derivative 19 | 3-[2-(7-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3cccc(F)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17FN2O2/c1-3-11-9-12(17(21)19-10(11)2)7-8-15-20-14-6-4-5-13(18)16(14)22-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2238
PNG
(2-Pyridinone derivative 18 | 3-[2-(7-Chlorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3cccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17ClN2O2/c1-3-11-9-12(17(21)19-10(11)2)7-8-15-20-14-6-4-5-13(18)16(14)22-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2238
PNG
(2-Pyridinone derivative 18 | 3-[2-(7-Chlorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3cccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17ClN2O2/c1-3-11-9-12(17(21)19-10(11)2)7-8-15-20-14-6-4-5-13(18)16(14)22-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2237
PNG
(2-Pyridinone derivative 17 | 3-[2-(7-Methylbenzoxa...)
Show SMILES CCc1cc(CCc2nc3cccc(C)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-4-13-10-14(18(21)19-12(13)3)8-9-16-20-15-7-5-6-11(2)17(15)22-16/h5-7,10H,4,8-9H2,1-3H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2237
PNG
(2-Pyridinone derivative 17 | 3-[2-(7-Methylbenzoxa...)
Show SMILES CCc1cc(CCc2nc3cccc(C)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-4-13-10-14(18(21)19-12(13)3)8-9-16-20-15-7-5-6-11(2)17(15)22-16/h5-7,10H,4,8-9H2,1-3H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2251
PNG
(2-Pyridinone derivative 31 | 3-[ 2-(7-Fluorobenzox...)
Show SMILES CCc1cc(CCc2nc3cccc(F)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H17FN2OS/c1-3-11-9-12(17(22)19-10(11)2)7-8-15-20-14-6-4-5-13(18)16(14)21-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,22)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2251
PNG
(2-Pyridinone derivative 31 | 3-[ 2-(7-Fluorobenzox...)
Show SMILES CCc1cc(CCc2nc3cccc(F)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C17H17FN2OS/c1-3-11-9-12(17(22)19-10(11)2)7-8-15-20-14-6-4-5-13(18)16(14)21-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,22)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2268
PNG
(2-Pyridinone derivative 48 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CC(C)c1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-11(2)14-10-13(18(21)19-12(14)3)8-9-17-20-15-6-4-5-7-16(15)22-17/h4-7,10-11H,8-9H2,1-3H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2268
PNG
(2-Pyridinone derivative 48 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CC(C)c1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-11(2)14-10-13(18(21)19-12(14)3)8-9-17-20-15-6-4-5-7-16(15)22-17/h4-7,10-11H,8-9H2,1-3H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2247
PNG
(2-Pyridinone derivative 27 | 3-[2-(4,7-Dimethylben...)
Show SMILES CCc1cc(CCc2nc3c(C)ccc(C)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C19H22N2OS/c1-5-14-10-15(19(23)20-13(14)4)8-9-16-21-17-11(2)6-7-12(3)18(17)22-16/h6-7,10H,5,8-9H2,1-4H3,(H,20,23)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2247
PNG
(2-Pyridinone derivative 27 | 3-[2-(4,7-Dimethylben...)
Show SMILES CCc1cc(CCc2nc3c(C)ccc(C)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C19H22N2OS/c1-5-14-10-15(19(23)20-13(14)4)8-9-16-21-17-11(2)6-7-12(3)18(17)22-16/h6-7,10H,5,8-9H2,1-4H3,(H,20,23)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2230
PNG
(2-Pyridinone derivative 10 | 3-[2-(4,5,6,7-Tetrahy...)
Show SMILES CCc1cc(CCc2nc3CCCCc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H22N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h10H,3-9H2,1-2H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50407136
PNG
(CHEMBL176463)
Show SMILES CCc1cc(CCC2=NC3CCCCC3O2)c(=O)[nH]c1C |t:7|
Show InChI InChI=1S/C17H24N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h10,14-15H,3-9H2,1-2H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2235
PNG
(2-Pyridinone derivative 15 | 3-[2-(4-Chlorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(Cl)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17ClN2O2/c1-3-11-9-12(17(21)19-10(11)2)7-8-15-20-16-13(18)5-4-6-14(16)22-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2235
PNG
(2-Pyridinone derivative 15 | 3-[2-(4-Chlorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3c(Cl)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17ClN2O2/c1-3-11-9-12(17(21)19-10(11)2)7-8-15-20-16-13(18)5-4-6-14(16)22-15/h4-6,9H,3,7-8H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2267
PNG
(2-Pyridinone derivative 47 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CCCc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-3-6-13-11-14(18(21)19-12(13)2)9-10-17-20-15-7-4-5-8-16(15)22-17/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2267
PNG
(2-Pyridinone derivative 47 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CCCc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-3-6-13-11-14(18(21)19-12(13)2)9-10-17-20-15-7-4-5-8-16(15)22-17/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,19,21)
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n/an/a 83n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2256
PNG
(2-Pyridinone derivative 36 | 3-[(4,7-Dichlorobenzo...)
Show SMILES CCc1cc(OCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H14Cl2N2O3/c1-3-9-6-12(16(21)19-8(9)2)22-7-13-20-14-10(17)4-5-11(18)15(14)23-13/h4-6H,3,7H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2256
PNG
(2-Pyridinone derivative 36 | 3-[(4,7-Dichlorobenzo...)
Show SMILES CCc1cc(OCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H14Cl2N2O3/c1-3-9-6-12(16(21)19-8(9)2)22-7-13-20-14-10(17)4-5-11(18)15(14)23-13/h4-6H,3,7H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2275
PNG
(2-Pyridinone derivative 56 | 3-[2-(4,7-Diohloroben...)
Show SMILES Cc1cc(CCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H14Cl2N2O2/c1-8-7-10(16(21)19-9(8)2)3-6-13-20-14-11(17)4-5-12(18)15(14)22-13/h4-5,7H,3,6H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2275
PNG
(2-Pyridinone derivative 56 | 3-[2-(4,7-Diohloroben...)
Show SMILES Cc1cc(CCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H14Cl2N2O2/c1-8-7-10(16(21)19-9(8)2)3-6-13-20-14-11(17)4-5-12(18)15(14)22-13/h4-5,7H,3,6H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2217
PNG
(2-Pyridinone derivative 12 | 3-[2-(1-benzofuran-2-...)
Show SMILES CCc1cc(CCc2cc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H19NO2/c1-3-13-10-15(18(20)19-12(13)2)8-9-16-11-14-6-4-5-7-17(14)21-16/h4-7,10-11H,3,8-9H2,1-2H3,(H,19,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2217
PNG
(2-Pyridinone derivative 12 | 3-[2-(1-benzofuran-2-...)
Show SMILES CCc1cc(CCc2cc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H19NO2/c1-3-13-10-15(18(20)19-12(13)2)8-9-16-11-14-6-4-5-7-17(14)21-16/h4-7,10-11H,3,8-9H2,1-2H3,(H,19,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2266
PNG
(2-Pyridinone derivative 46 | 3-[2-(1,3-benzoxazol-...)
Show SMILES Cc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16N2O2/c1-10-9-12(16(19)17-11(10)2)7-8-15-18-13-5-3-4-6-14(13)20-15/h3-6,9H,7-8H2,1-2H3,(H,17,19)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2266
PNG
(2-Pyridinone derivative 46 | 3-[2-(1,3-benzoxazol-...)
Show SMILES Cc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16N2O2/c1-10-9-12(16(19)17-11(10)2)7-8-15-18-13-5-3-4-6-14(13)20-15/h3-6,9H,7-8H2,1-2H3,(H,17,19)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2243
PNG
(2-Pyridinone derivative 23 | 3-[2-(6-Methylbenzoxa...)
Show SMILES CCc1cc(CCc2nc3ccc(C)cc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-4-13-10-14(18(21)19-12(13)3)6-8-17-20-15-7-5-11(2)9-16(15)22-17/h5,7,9-10H,4,6,8H2,1-3H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2243
PNG
(2-Pyridinone derivative 23 | 3-[2-(6-Methylbenzoxa...)
Show SMILES CCc1cc(CCc2nc3ccc(C)cc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-4-13-10-14(18(21)19-12(13)3)6-8-17-20-15-7-5-11(2)9-16(15)22-17/h5,7,9-10H,4,6,8H2,1-3H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2274
PNG
(2-Pyridinone derivative 55 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CCc1c[nH]c(=O)c(CCc2nc3ccccc3o2)c1
Show InChI InChI=1S/C16H16N2O2/c1-2-11-9-12(16(19)17-10-11)7-8-15-18-13-5-3-4-6-14(13)20-15/h3-6,9-10H,2,7-8H2,1H3,(H,17,19)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2274
PNG
(2-Pyridinone derivative 55 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CCc1c[nH]c(=O)c(CCc2nc3ccccc3o2)c1
Show InChI InChI=1S/C16H16N2O2/c1-2-11-9-12(16(19)17-10-11)7-8-15-18-13-5-3-4-6-14(13)20-15/h3-6,9-10H,2,7-8H2,1H3,(H,17,19)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2255
PNG
(2-Pyridinone derivative 35 | 3-(1,3-benzoxazol-2-y...)
Show SMILES CCc1cc(OCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16N2O3/c1-3-11-8-14(16(19)17-10(11)2)20-9-15-18-12-6-4-5-7-13(12)21-15/h4-8H,3,9H2,1-2H3,(H,17,19)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2255
PNG
(2-Pyridinone derivative 35 | 3-(1,3-benzoxazol-2-y...)
Show SMILES CCc1cc(OCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16N2O3/c1-3-11-8-14(16(19)17-10(11)2)20-9-15-18-12-6-4-5-7-13(12)21-15/h4-8H,3,9H2,1-2H3,(H,17,19)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2259
PNG
(2-Pyridinone derivative 39 | 3-{[(4,7-Dichlorobenz...)
Show SMILES CCc1cc(c(=O)[nH]c1C)S(=O)(=O)Cc1nc2c(Cl)ccc(Cl)c2o1
Show InChI InChI=1S/C16H14Cl2N2O4S/c1-3-9-6-12(16(21)19-8(9)2)25(22,23)7-13-20-14-10(17)4-5-11(18)15(14)24-13/h4-6H,3,7H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2259
PNG
(2-Pyridinone derivative 39 | 3-{[(4,7-Dichlorobenz...)
Show SMILES CCc1cc(c(=O)[nH]c1C)S(=O)(=O)Cc1nc2c(Cl)ccc(Cl)c2o1
Show InChI InChI=1S/C16H14Cl2N2O4S/c1-3-9-6-12(16(21)19-8(9)2)25(22,23)7-13-20-14-10(17)4-5-11(18)15(14)24-13/h4-6H,3,7H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM1283
PNG
(3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...)
Show SMILES CCc1cc(NCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O2/c1-3-11-8-13(16(20)18-10(11)2)17-9-15-19-12-6-4-5-7-14(12)21-15/h4-8,17H,3,9H2,1-2H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1283
PNG
(3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...)
Show SMILES CCc1cc(NCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O2/c1-3-11-8-13(16(20)18-10(11)2)17-9-15-19-12-6-4-5-7-14(12)21-15/h4-8,17H,3,9H2,1-2H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2270
PNG
(2-Pyridinone derivative 50 | 3-[2-(Benzoxazold-yl)...)
Show SMILES Cc1[nH]c(=O)c(CCc2nc3ccccc3o2)cc1C#N
Show InChI InChI=1S/C16H13N3O2/c1-10-12(9-17)8-11(16(20)18-10)6-7-15-19-13-4-2-3-5-14(13)21-15/h2-5,8H,6-7H2,1H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2270
PNG
(2-Pyridinone derivative 50 | 3-[2-(Benzoxazold-yl)...)
Show SMILES Cc1[nH]c(=O)c(CCc2nc3ccccc3o2)cc1C#N
Show InChI InChI=1S/C16H13N3O2/c1-10-12(9-17)8-11(16(20)18-10)6-7-15-19-13-4-2-3-5-14(13)21-15/h2-5,8H,6-7H2,1H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2213
PNG
(2-Pyridinone derivative 8 | 3-[2-(1,3-benzothiazol...)
Show SMILES CCc1cc(CCc2nc3ccccc3s2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2OS/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-7,10H,3,8-9H2,1-2H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2213
PNG
(2-Pyridinone derivative 8 | 3-[2-(1,3-benzothiazol...)
Show SMILES CCc1cc(CCc2nc3ccccc3s2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2OS/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-7,10H,3,8-9H2,1-2H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2231
PNG
(2-Pyridinone derivative 11 | 3-[2-(5-Phenyloxazol-...)
Show SMILES CCc1cc(CCc2ncc(o2)-c2ccccc2)c(=O)[nH]c1C
Show InChI InChI=1S/C19H20N2O2/c1-3-14-11-16(19(22)21-13(14)2)9-10-18-20-12-17(23-18)15-7-5-4-6-8-15/h4-8,11-12H,3,9-10H2,1-2H3,(H,21,22)
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n/an/a 385n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2231
PNG
(2-Pyridinone derivative 11 | 3-[2-(5-Phenyloxazol-...)
Show SMILES CCc1cc(CCc2ncc(o2)-c2ccccc2)c(=O)[nH]c1C
Show InChI InChI=1S/C19H20N2O2/c1-3-14-11-16(19(22)21-13(14)2)9-10-18-20-12-17(23-18)15-7-5-4-6-8-15/h4-8,11-12H,3,9-10H2,1-2H3,(H,21,22)
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n/an/a 385n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2244
PNG
(2-Pyridinone derivative 24 | 3-[2-(6-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3ccc(F)cc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17FN2O2/c1-3-11-8-12(17(21)19-10(11)2)4-7-16-20-14-6-5-13(18)9-15(14)22-16/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,21)
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n/an/a 442n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2244
PNG
(2-Pyridinone derivative 24 | 3-[2-(6-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3ccc(F)cc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17FN2O2/c1-3-11-8-12(17(21)19-10(11)2)4-7-16-20-14-6-5-13(18)9-15(14)22-16/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2269
PNG
(2-Pyridinone derivative 49 | 3-[2-(1,3-benzoxazol-...)
Show SMILES Cc1[nH]c(=O)c(CCc2nc3ccccc3o2)cc1-c1ccccc1
Show InChI InChI=1S/C21H18N2O2/c1-14-17(15-7-3-2-4-8-15)13-16(21(24)22-14)11-12-20-23-18-9-5-6-10-19(18)25-20/h2-10,13H,11-12H2,1H3,(H,22,24)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2269
PNG
(2-Pyridinone derivative 49 | 3-[2-(1,3-benzoxazol-...)
Show SMILES Cc1[nH]c(=O)c(CCc2nc3ccccc3o2)cc1-c1ccccc1
Show InChI InChI=1S/C21H18N2O2/c1-14-17(15-7-3-2-4-8-15)13-16(21(24)22-14)11-12-20-23-18-9-5-6-10-19(18)25-20/h2-10,13H,11-12H2,1H3,(H,22,24)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2261
PNG
(2-Pyridinone derivative 41 | 3-[(1,3-benzoxazol-2-...)
Show SMILES CCc1cc(CNc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O2/c1-3-11-8-12(15(20)18-10(11)2)9-17-16-19-13-6-4-5-7-14(13)21-16/h4-8H,3,9H2,1-2H3,(H,17,19)(H,18,20)
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n/an/a 1.25E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2261
PNG
(2-Pyridinone derivative 41 | 3-[(1,3-benzoxazol-2-...)
Show SMILES CCc1cc(CNc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O2/c1-3-11-8-12(15(20)18-10(11)2)9-17-16-19-13-6-4-5-7-14(13)21-16/h4-8H,3,9H2,1-2H3,(H,17,19)(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2258
PNG
(2-Pyridinone derivative 38 | 3-{[(4,7-Dichlorobenz...)
Show SMILES CCc1cc(S(=O)Cc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H14Cl2N2O3S/c1-3-9-6-12(16(21)19-8(9)2)24(22)7-13-20-14-10(17)4-5-11(18)15(14)23-13/h4-6H,3,7H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2258
PNG
(2-Pyridinone derivative 38 | 3-{[(4,7-Dichlorobenz...)
Show SMILES CCc1cc(S(=O)Cc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H14Cl2N2O3S/c1-3-9-6-12(16(21)19-8(9)2)24(22)7-13-20-14-10(17)4-5-11(18)15(14)23-13/h4-6H,3,7H2,1-2H3,(H,19,21)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2245
PNG
(2-Pyridinone derivative 25 | 3-[2-(5-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3cc(F)ccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17FN2O2/c1-3-11-8-12(17(21)19-10(11)2)4-7-16-20-14-9-13(18)5-6-15(14)22-16/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2245
PNG
(2-Pyridinone derivative 25 | 3-[2-(5-Fluorobenzoxa...)
Show SMILES CCc1cc(CCc2nc3cc(F)ccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17FN2O2/c1-3-11-8-12(17(21)19-10(11)2)4-7-16-20-14-9-13(18)5-6-15(14)22-16/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,21)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2277
PNG
(2-Pyridinone derivative 54 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CN(C)c1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O2/c1-11-14(20(2)3)10-12(17(21)18-11)8-9-16-19-13-6-4-5-7-15(13)22-16/h4-7,10H,8-9H2,1-3H3,(H,18,21)
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n/an/a 1.85E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2277
PNG
(2-Pyridinone derivative 54 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CN(C)c1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O2/c1-11-14(20(2)3)10-12(17(21)18-11)8-9-16-19-13-6-4-5-7-15(13)22-16/h4-7,10H,8-9H2,1-3H3,(H,18,21)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2273
PNG
(2-Pyridinone derivative 53 | 3-[2-(1,3-benzoxazol-...)
Show SMILES COCc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2O3/c1-11-13(10-21-2)9-12(17(20)18-11)7-8-16-19-14-5-3-4-6-15(14)22-16/h3-6,9H,7-8,10H2,1-2H3,(H,18,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2273
PNG
(2-Pyridinone derivative 53 | 3-[2-(1,3-benzoxazol-...)
Show SMILES COCc1cc(CCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2O3/c1-11-13(10-21-2)9-12(17(20)18-11)7-8-16-19-14-5-3-4-6-15(14)22-16/h3-6,9H,7-8,10H2,1-2H3,(H,18,20)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2227
PNG
(2-Pyridinone derivative 7 | 3-[(quinolin-2-yl)meth...)
Show SMILES CCc1cc(CCc2ccc3ccccc3n2)c(=O)[nH]c1C
Show InChI InChI=1S/C19H20N2O/c1-3-14-12-16(19(22)20-13(14)2)9-11-17-10-8-15-6-4-5-7-18(15)21-17/h4-8,10,12H,3,9,11H2,1-2H3,(H,20,22)
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n/an/a 2.45E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2227
PNG
(2-Pyridinone derivative 7 | 3-[(quinolin-2-yl)meth...)
Show SMILES CCc1cc(CCc2ccc3ccccc3n2)c(=O)[nH]c1C
Show InChI InChI=1S/C19H20N2O/c1-3-14-12-16(19(22)20-13(14)2)9-11-17-10-8-15-6-4-5-7-18(15)21-17/h4-8,10,12H,3,9,11H2,1-2H3,(H,20,22)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50407109
PNG
(CHEMBL175037 | CHEMBL176587)
Show SMILES CCc1cc(C=Cc2nc3ccccc3o2)c(=O)[nH]c1C |w:6.6|
Show InChI InChI=1S/C17H16N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-10H,3H2,1-2H3,(H,18,20)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2263
PNG
(2-Pyridinone derivative 43 | 3-[(Z)-2-(1,3-benzoxa...)
Show SMILES CCc1cc(\C=C/c2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H16N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-10H,3H2,1-2H3,(H,18,20)/b9-8-
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2272
PNG
(2-Pyridinone derivative 52 | 3-[2-(1,3-benzoxazol-...)
Show SMILES Cc1[nH]c(=O)c(CCc2nc3ccccc3o2)cc1CO
Show InChI InChI=1S/C16H16N2O3/c1-10-12(9-19)8-11(16(20)17-10)6-7-15-18-13-4-2-3-5-14(13)21-15/h2-5,8,19H,6-7,9H2,1H3,(H,17,20)
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Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2272
PNG
(2-Pyridinone derivative 52 | 3-[2-(1,3-benzoxazol-...)
Show SMILES Cc1[nH]c(=O)c(CCc2nc3ccccc3o2)cc1CO
Show InChI InChI=1S/C16H16N2O3/c1-10-12(9-19)8-11(16(20)17-10)6-7-15-18-13-4-2-3-5-14(13)21-15/h2-5,8,19H,6-7,9H2,1H3,(H,17,20)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM1066
PNG
(2-[2-(5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-...)
Show SMILES CCc1cc(CCN2C(=O)c3ccccc3C2=O)c(=O)[nH]c1C
Show InChI InChI=1S/C18H18N2O3/c1-3-12-10-13(16(21)19-11(12)2)8-9-20-17(22)14-6-4-5-7-15(14)18(20)23/h4-7,10H,3,8-9H2,1-2H3,(H,19,21)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1066
PNG
(2-[2-(5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-...)
Show SMILES CCc1cc(CCN2C(=O)c3ccccc3C2=O)c(=O)[nH]c1C
Show InChI InChI=1S/C18H18N2O3/c1-3-12-10-13(16(21)19-11(12)2)8-9-20-17(22)14-6-4-5-7-15(14)18(20)23/h4-7,10H,3,8-9H2,1-2H3,(H,19,21)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50407135
PNG
(CHEMBL172773)
Show SMILES CCc1cc(CCC(=O)Nc2ccccc2O)c(=O)[nH]c1C
Show InChI InChI=1S/C17H20N2O3/c1-3-12-10-13(17(22)18-11(12)2)8-9-16(21)19-14-6-4-5-7-15(14)20/h4-7,10,20H,3,8-9H2,1-2H3,(H,18,22)(H,19,21)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2262
PNG
(2-Pyridinone derivative 42 | 3-[(E)-2-(1,3-benzoxa...)
Show SMILES CCc1cc(\C=C\c2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H16N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-10H,3H2,1-2H3,(H,18,20)/b9-8+
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n/an/a 5.90E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50407109
PNG
(CHEMBL175037 | CHEMBL176587)
Show SMILES CCc1cc(C=Cc2nc3ccccc3o2)c(=O)[nH]c1C |w:6.6|
Show InChI InChI=1S/C17H16N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-10H,3H2,1-2H3,(H,18,20)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2225
PNG
(2-Pyridinone derivative 5 | 3-[2-(naphth-2-yl)ethy...)
Show SMILES CCc1cc(CCc2ccc3ccccc3c2)c(=O)[nH]c1C
Show InChI InChI=1S/C20H21NO/c1-3-16-13-19(20(22)21-14(16)2)11-9-15-8-10-17-6-4-5-7-18(17)12-15/h4-8,10,12-13H,3,9,11H2,1-2H3,(H,21,22)
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n/an/a 8.40E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2225
PNG
(2-Pyridinone derivative 5 | 3-[2-(naphth-2-yl)ethy...)
Show SMILES CCc1cc(CCc2ccc3ccccc3c2)c(=O)[nH]c1C
Show InChI InChI=1S/C20H21NO/c1-3-16-13-19(20(22)21-14(16)2)11-9-15-8-10-17-6-4-5-7-18(17)12-15/h4-8,10,12-13H,3,9,11H2,1-2H3,(H,21,22)
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n/an/a 8.40E+3n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2233
PNG
(2-Pyridinone derivative 13 | 3-[2-(Furo[3,2-c]pyri...)
Show SMILES CCc1cc(CCc2cc3cnccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2O2/c1-3-12-8-13(17(20)19-11(12)2)4-5-15-9-14-10-18-7-6-16(14)21-15/h6-10H,3-5H2,1-2H3,(H,19,20)
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n/an/a 1.35E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2233
PNG
(2-Pyridinone derivative 13 | 3-[2-(Furo[3,2-c]pyri...)
Show SMILES CCc1cc(CCc2cc3cnccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2O2/c1-3-12-8-13(17(20)19-11(12)2)4-5-15-9-14-10-18-7-6-16(14)21-15/h6-10H,3-5H2,1-2H3,(H,19,20)
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n/an/a 1.35E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2265
PNG
(2-Pyridinone derivative 45 | 3-[3-(1,3-benzoxazol-...)
Show SMILES CCc1cc(CCCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-3-13-11-14(18(21)19-12(13)2)7-6-10-17-20-15-8-4-5-9-16(15)22-17/h4-5,8-9,11H,3,6-7,10H2,1-2H3,(H,19,21)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2265
PNG
(2-Pyridinone derivative 45 | 3-[3-(1,3-benzoxazol-...)
Show SMILES CCc1cc(CCCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-3-13-11-14(18(21)19-12(13)2)7-6-10-17-20-15-8-4-5-9-16(15)22-17/h4-5,8-9,11H,3,6-7,10H2,1-2H3,(H,19,21)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2271
PNG
(2-Pyridinone derivative 51 | 3-[2-(Benzoxazol-2-yl...)
Show SMILES Cc1[nH]c(=O)c(CCc2nc3ccccc3o2)cc1C(N)=O
Show InChI InChI=1S/C16H15N3O3/c1-9-11(15(17)20)8-10(16(21)18-9)6-7-14-19-12-4-2-3-5-13(12)22-14/h2-5,8H,6-7H2,1H3,(H2,17,20)(H,18,21)
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n/an/a 4.15E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2271
PNG
(2-Pyridinone derivative 51 | 3-[2-(Benzoxazol-2-yl...)
Show SMILES Cc1[nH]c(=O)c(CCc2nc3ccccc3o2)cc1C(N)=O
Show InChI InChI=1S/C16H15N3O3/c1-9-11(15(17)20)8-10(16(21)18-9)6-7-14-19-12-4-2-3-5-13(12)22-14/h2-5,8H,6-7H2,1H3,(H2,17,20)(H,18,21)
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n/an/a 4.15E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2264
PNG
(2-Pyridinone derivative 44 | 3-(1,3-benzoxazol-2-y...)
Show SMILES CCc1cc(Cc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16N2O2/c1-3-11-8-12(16(19)17-10(11)2)9-15-18-13-6-4-5-7-14(13)20-15/h4-8H,3,9H2,1-2H3,(H,17,19)
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n/an/a 4.50E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2264
PNG
(2-Pyridinone derivative 44 | 3-(1,3-benzoxazol-2-y...)
Show SMILES CCc1cc(Cc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16N2O2/c1-3-11-8-12(16(19)17-10(11)2)9-15-18-13-6-4-5-7-14(13)20-15/h4-8H,3,9H2,1-2H3,(H,17,19)
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n/an/a 4.50E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2224
PNG
(2-Pyridinone derivative 4 | 3-(2-Phenylethyl)-5-et...)
Show SMILES CCc1cc(CCc2ccccc2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H19NO/c1-3-14-11-15(16(18)17-12(14)2)10-9-13-7-5-4-6-8-13/h4-8,11H,3,9-10H2,1-2H3,(H,17,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2224
PNG
(2-Pyridinone derivative 4 | 3-(2-Phenylethyl)-5-et...)
Show SMILES CCc1cc(CCc2ccccc2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H19NO/c1-3-14-11-15(16(18)17-12(14)2)10-9-13-7-5-4-6-8-13/h4-8,11H,3,9-10H2,1-2H3,(H,17,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50407097
PNG
(CHEMBL367850)
Show SMILES CCC1C=C(CCc2nc3ccccc3o2)C(N)N=C1C |c:20,t:3|
Show InChI InChI=1S/C17H21N3O/c1-3-12-10-13(17(18)19-11(12)2)8-9-16-20-14-6-4-5-7-15(14)21-16/h4-7,10,12,17H,3,8-9,18H2,1-2H3
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n/an/a 1.00E+5n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2254
PNG
(2-Pyridinone derivative 34 | 3-[2-(1,3-benzoxazol-...)
Show SMILES CCc1cc(CCc2nc3ccccc3o2)c(N)nc1C
Show InChI InChI=1S/C17H19N3O/c1-3-12-10-13(17(18)19-11(12)2)8-9-16-20-14-6-4-5-7-15(14)21-16/h4-7,10H,3,8-9H2,1-2H3,(H2,18,19)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM2226
PNG
(2-Pyridinone derivative 6 | 3-[2-(Pyridin-2-yl)eth...)
Show SMILES CCc1cc(CCc2ccccn2)c(=O)[nH]c1C
Show InChI InChI=1S/C15H18N2O/c1-3-12-10-13(15(18)17-11(12)2)7-8-14-6-4-5-9-16-14/h4-6,9-10H,3,7-8H2,1-2H3,(H,17,18)
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n/an/a 2.60E+5n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2226
PNG
(2-Pyridinone derivative 6 | 3-[2-(Pyridin-2-yl)eth...)
Show SMILES CCc1cc(CCc2ccccn2)c(=O)[nH]c1C
Show InChI InChI=1S/C15H18N2O/c1-3-12-10-13(15(18)17-11(12)2)7-8-14-6-4-5-9-16-14/h4-6,9-10H,3,7-8H2,1-2H3,(H,17,18)
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n/an/a 2.60E+5n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50407106
PNG
(CHEMBL173868)
Show SMILES CCc1cc(CCC(=O)Nc2c(O)cc(Cl)cc2Cl)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18Cl2N2O3/c1-3-10-6-11(17(24)20-9(10)2)4-5-15(23)21-16-13(19)7-12(18)8-14(16)22/h6-8,22H,3-5H2,1-2H3,(H,20,24)(H,21,23)
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n/an/a>3.00E+5n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase


(Human immunodeficiency virus 1)
BDBM50407113
PNG
(CHEMBL173280)
Show SMILES CCc1cc(NCC(=O)Nc2c(O)cc(Cl)cc2Cl)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17Cl2N3O3/c1-3-9-4-12(16(24)20-8(9)2)19-7-14(23)21-15-11(18)5-10(17)6-13(15)22/h4-6,19,22H,3,7H2,1-2H3,(H,20,24)(H,21,23)
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n/an/a>3.00E+5n/an/an/an/an/an/a



Merck Reserch Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)


J Med Chem 36: 953-66 (1993)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%