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PubMed code 7752185

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034722
PNG
((Z)-Octadec-9-enoic acid (1,2-diphenyl-ethyl)-amid...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NC(Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H47NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-22-27-32(34)33-31(30-25-20-17-21-26-30)28-29-23-18-16-19-24-29/h9-10,16-21,23-26,31H,2-8,11-15,22,27-28H2,1H3,(H,33,34)/b10-9-
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n/an/a 150n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034738
PNG
(3-(Decyl-dimethyl-silanyl)-N-(1-phenyl-2-p-tolyl-e...)
Show SMILES CCCCCCCCCC[Si](C)(C)CCC(=O)NC(Cc1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C30H47NOSi/c1-5-6-7-8-9-10-11-15-23-33(3,4)24-22-30(32)31-29(28-16-13-12-14-17-28)25-27-20-18-26(2)19-21-27/h12-14,16-21,29H,5-11,15,22-25H2,1-4H3,(H,31,32)
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n/an/a 300n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034719
PNG
(CHEMBL289558 | N-[2-(4-Acetylamino-phenyl)-1-pheny...)
Show SMILES CC(=O)Nc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C30H28N2O2/c1-22(33)31-27-19-17-23(18-20-27)21-28(24-11-5-2-6-12-24)32-30(34)29(25-13-7-3-8-14-25)26-15-9-4-10-16-26/h2-20,28-29H,21H2,1H3,(H,31,33)(H,32,34)
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n/an/a 350n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034741
PNG
(CHEMBL41186 | N-[2-(4-Methanesulfonylamino-phenyl)...)
Show SMILES CS(=O)(=O)Nc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H28N2O3S/c1-35(33,34)31-26-19-17-22(18-20-26)21-27(23-11-5-2-6-12-23)30-29(32)28(24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-20,27-28,31H,21H2,1H3,(H,30,32)
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n/an/a 360n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034739
PNG
((Z)-Octadec-9-enoic acid [2-(4-amino-phenyl)-1-phe...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NC(Cc1ccc(N)cc1)c1ccccc1
Show InChI InChI=1S/C32H48N2O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-32(35)34-31(29-20-17-16-18-21-29)27-28-23-25-30(33)26-24-28/h9-10,16-18,20-21,23-26,31H,2-8,11-15,19,22,27,33H2,1H3,(H,34,35)/b10-9-
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n/an/a 360n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034737
PNG
(CHEMBL40318 | N-(1,2-Diphenyl-ethyl)-2,2-diphenyl-...)
Show SMILES O=C(NC(Cc1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H25NO/c30-28(27(24-17-9-3-10-18-24)25-19-11-4-12-20-25)29-26(23-15-7-2-8-16-23)21-22-13-5-1-6-14-22/h1-20,26-27H,21H2,(H,29,30)
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034720
PNG
(CHEMBL41350 | N-[2-(3,4-Dimethoxy-phenyl)-1-phenyl...)
Show SMILES COc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1OC
Show InChI InChI=1S/C30H29NO3/c1-33-27-19-18-22(21-28(27)34-2)20-26(23-12-6-3-7-13-23)31-30(32)29(24-14-8-4-9-15-24)25-16-10-5-11-17-25/h3-19,21,26,29H,20H2,1-2H3,(H,31,32)
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034725
PNG
(CHEMBL441971 | N-[2-(4-Hydroxy-phenyl)-1-phenyl-et...)
Show SMILES Oc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C28H25NO2/c30-25-18-16-21(17-19-25)20-26(22-10-4-1-5-11-22)29-28(31)27(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-19,26-27,30H,20H2,(H,29,31)
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n/an/a 800n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50028868
PNG
(CHEMBL41233 | N-[2-(4-Amino-phenyl)-1-phenyl-ethyl...)
Show SMILES Nc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C28H26N2O/c29-25-18-16-21(17-19-25)20-26(22-10-4-1-5-11-22)30-28(31)27(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-19,26-27H,20,29H2,(H,30,31)
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n/an/a 900n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034732
PNG
(CHEMBL296077 | N-[1-(4-Hydroxy-phenyl)-2-phenyl-et...)
Show SMILES Oc1ccc(cc1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H25NO2/c30-25-18-16-22(17-19-25)26(20-21-10-4-1-5-11-21)29-28(31)27(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-19,26-27,30H,20H2,(H,29,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034723
PNG
(CHEMBL418627 | N-[1-(3-Methoxy-phenyl)-2-phenyl-et...)
Show SMILES COc1cccc(c1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H27NO2/c1-32-26-19-11-18-25(21-26)27(20-22-12-5-2-6-13-22)30-29(31)28(23-14-7-3-8-15-23)24-16-9-4-10-17-24/h2-19,21,27-28H,20H2,1H3,(H,30,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034716
PNG
(CHEMBL42979 | N-[1-(4-Methoxy-phenyl)-2-phenyl-eth...)
Show SMILES COc1ccc(cc1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H27NO2/c1-32-26-19-17-23(18-20-26)27(21-22-11-5-2-6-12-22)30-29(31)28(24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-20,27-28H,21H2,1H3,(H,30,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034740
PNG
(CHEMBL41351 | N-[2-(4-Methoxy-phenyl)-1-phenyl-eth...)
Show SMILES COc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H27NO2/c1-32-26-19-17-22(18-20-26)21-27(23-11-5-2-6-12-23)30-29(31)28(24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-20,27-28H,21H2,1H3,(H,30,31)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034731
PNG
(2,2-Diphenyl-N-(1-phenyl-2-pyridin-4-yl-ethyl)-ace...)
Show SMILES O=C(NC(Cc1ccncc1)c1ccccc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O/c30-27(26(23-12-6-2-7-13-23)24-14-8-3-9-15-24)29-25(22-10-4-1-5-11-22)20-21-16-18-28-19-17-21/h1-19,25-26H,20H2,(H,29,30)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034721
PNG
(CHEMBL42230 | N-[1-(2-Methoxy-phenyl)-2-phenyl-eth...)
Show SMILES COc1ccccc1C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H27NO2/c1-32-27-20-12-11-19-25(27)26(21-22-13-5-2-6-14-22)30-29(31)28(23-15-7-3-8-16-23)24-17-9-4-10-18-24/h2-20,26,28H,21H2,1H3,(H,30,31)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50028868
PNG
(CHEMBL41233 | N-[2-(4-Amino-phenyl)-1-phenyl-ethyl...)
Show SMILES Nc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C28H26N2O/c29-25-18-16-21(17-19-25)20-26(22-10-4-1-5-11-22)30-28(31)27(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-19,26-27H,20,29H2,(H,30,31)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034734
PNG
(2,2-Diphenyl-N-(2-phenyl-1-pyridin-4-yl-ethyl)-ace...)
Show SMILES O=C(NC(Cc1ccccc1)c1ccncc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O/c30-27(26(23-12-6-2-7-13-23)24-14-8-3-9-15-24)29-25(22-16-18-28-19-17-22)20-21-10-4-1-5-11-21/h1-19,25-26H,20H2,(H,29,30)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034742
PNG
(CHEMBL289997 | N-[2-(4-Methoxy-phenyl)-1-(3-methox...)
Show SMILES COc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2cccc(OC)c2)cc1
Show InChI InChI=1S/C30H29NO3/c1-33-26-18-16-22(17-19-26)20-28(25-14-9-15-27(21-25)34-2)31-30(32)29(23-10-5-3-6-11-23)24-12-7-4-8-13-24/h3-19,21,28-29H,20H2,1-2H3,(H,31,32)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034726
PNG
(CHEMBL42303 | N-[1-(4-Amino-phenyl)-2-phenyl-ethyl...)
Show SMILES Nc1ccc(cc1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H26N2O/c29-25-18-16-22(17-19-25)26(20-21-10-4-1-5-11-21)30-28(31)27(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-19,26-27H,20,29H2,(H,30,31)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50022279
PNG
(3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)...)
Show SMILES CCCCCCCN(Cc1ccc(CC(C)(C)C)cc1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C26H36F2N2O/c1-5-6-7-8-9-16-30(25(31)29-24-15-14-22(27)17-23(24)28)19-21-12-10-20(11-13-21)18-26(2,3)4/h10-15,17H,5-9,16,18-19H2,1-4H3,(H,29,31)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034730
PNG
(CHEMBL44043 | N-(2-Imidazol-1-yl-1-phenyl-ethyl)-2...)
Show SMILES O=C(NC(Cn1ccnc1)c1ccccc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H23N3O/c29-25(24(21-12-6-2-7-13-21)22-14-8-3-9-15-22)27-23(18-28-17-16-26-19-28)20-10-4-1-5-11-20/h1-17,19,23-24H,18H2,(H,27,29)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034733
PNG
(2,2-Diphenyl-N-(2-phenyl-1-pyridin-3-yl-ethyl)-ace...)
Show SMILES O=C(NC(Cc1ccccc1)c1cccnc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O/c30-27(26(22-13-6-2-7-14-22)23-15-8-3-9-16-23)29-25(24-17-10-18-28-20-24)19-21-11-4-1-5-12-21/h1-18,20,25-26H,19H2,(H,29,30)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034729
PNG
(CHEMBL44349 | N-[2-(1-Heptyl-1H-imidazol-2-yl)-1-p...)
Show SMILES CCCCCCCn1ccnc1CC(NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H37N3O/c1-2-3-4-5-15-23-35-24-22-33-30(35)25-29(26-16-9-6-10-17-26)34-32(36)31(27-18-11-7-12-19-27)28-20-13-8-14-21-28/h6-14,16-22,24,29,31H,2-5,15,23,25H2,1H3,(H,34,36)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034714
PNG
(2,2-Diphenyl-N-{1-phenyl-2-[1-(2-trimethylsilanyl-...)
Show SMILES C[Si](C)(C)CCOCn1ccnc1CC(NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H37N3O2Si/c1-37(2,3)22-21-36-24-34-20-19-32-29(34)23-28(25-13-7-4-8-14-25)33-31(35)30(26-15-9-5-10-16-26)27-17-11-6-12-18-27/h4-20,28,30H,21-24H2,1-3H3,(H,33,35)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034727
PNG
(CHEMBL41208 | N-[2-(3-Amino-phenyl)-1-phenyl-ethyl...)
Show SMILES Nc1cccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)c1
Show InChI InChI=1S/C28H26N2O/c29-25-18-10-11-21(19-25)20-26(22-12-4-1-5-13-22)30-28(31)27(23-14-6-2-7-15-23)24-16-8-3-9-17-24/h1-19,26-27H,20,29H2,(H,30,31)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50005944
PNG
(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Show SMILES CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
Show InChI InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034717
PNG
(CHEMBL43805 | N-[2-(1H-Imidazol-2-yl)-1-phenyl-eth...)
Show SMILES O=C(NC(Cc1ncc[nH]1)c1ccccc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H23N3O/c29-25(24(20-12-6-2-7-13-20)21-14-8-3-9-15-21)28-22(18-23-26-16-17-27-23)19-10-4-1-5-11-19/h1-17,22,24H,18H2,(H,26,27)(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034728
PNG
(4-(1-Diphenylacetylamino-2-phenyl-ethyl)-benzoic a...)
Show SMILES OC(=O)c1ccc(cc1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H25NO3/c31-28(27(23-12-6-2-7-13-23)24-14-8-3-9-15-24)30-26(20-21-10-4-1-5-11-21)22-16-18-25(19-17-22)29(32)33/h1-19,26-27H,20H2,(H,30,31)(H,32,33)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034718
PNG
(CHEMBL295584 | N-[1-(1H-Imidazol-2-yl)-2-phenyl-et...)
Show SMILES O=C(NC(Cc1ccccc1)c1ncc[nH]1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H23N3O/c29-25(23(20-12-6-2-7-13-20)21-14-8-3-9-15-21)28-22(24-26-16-17-27-24)18-19-10-4-1-5-11-19/h1-17,22-23H,18H2,(H,26,27)(H,28,29)
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034735
PNG
(CHEMBL446610 | N-[1-(1-Oxy-pyridin-4-yl)-2-phenyl-...)
Show SMILES [O-][n+]1ccc(cc1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H24N2O2/c30-27(26(23-12-6-2-7-13-23)24-14-8-3-9-15-24)28-25(20-21-10-4-1-5-11-21)22-16-18-29(31)19-17-22/h1-19,25-26H,20H2,(H,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034724
PNG
(4-(2-Diphenylacetylamino-2-phenyl-ethyl)-benzoic a...)
Show SMILES OC(=O)c1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H25NO3/c31-28(27(23-12-6-2-7-13-23)24-14-8-3-9-15-24)30-26(22-10-4-1-5-11-22)20-21-16-18-25(19-17-21)29(32)33/h1-19,26-27H,20H2,(H,30,31)(H,32,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034715
PNG
(4-(2-Diphenylacetylamino-2-phenyl-ethyl)-benzoic a...)
Show SMILES COC(=O)c1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C30H27NO3/c1-34-30(33)26-19-17-22(18-20-26)21-27(23-11-5-2-6-12-23)31-29(32)28(24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-20,27-28H,21H2,1H3,(H,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034736
PNG
(2,2-Diphenyl-N-{2-phenyl-1-[1-(2-trimethylsilanyl-...)
Show SMILES C[Si](C)(C)CCOCn1ccnc1C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H37N3O2Si/c1-37(2,3)22-21-36-24-34-20-19-32-30(34)28(23-25-13-7-4-8-14-25)33-31(35)29(26-15-9-5-10-16-26)27-17-11-6-12-18-27/h4-20,28-29H,21-24H2,1-3H3,(H,33,35)
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034743
PNG
(CHEMBL40354 | N-[1,2-Bis-(4-methoxy-phenyl)-ethyl]...)
Show SMILES COc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccc(OC)cc2)cc1
Show InChI InChI=1S/C30H29NO3/c1-33-26-17-13-22(14-18-26)21-28(23-15-19-27(34-2)20-16-23)31-30(32)29(24-9-5-3-6-10-24)25-11-7-4-8-12-25/h3-20,28-29H,21H2,1-2H3,(H,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay

J Med Chem 38: 1600-7 (1995)


BindingDB Entry DOI: 10.7270/Q26T0KN9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%