Affinity Data by PubMed id=7752206

PubMed code 7752206

Found 20 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034949 (2-Amino-6-(3,5-dichloro-phenylamino)-3H-pyrimidin-...) Show SMILES Nc1nc(Nc2cc(Cl)cc(Cl)c2)cc(=O)[nH]1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034950 (2-Amino-6-(3,4-dichloro-phenylamino)-3H-pyrimidin-...) Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)cc(=O)[nH]1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034955 (CHEMBL53605 \| N2-(3,4-Dichloro-phenyl)-9H-purine...) Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50013091 (2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034947 (2-(3,5-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034963 (CHEMBL51501 \| N2-(3,5-Dichloro-phenyl)-9H-purine...) Show SMILES Nc1nc(Nc2cc(Cl)cc(Cl)c2)nc2nc[nH]c12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50028342 (6-(3,4-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...) Show SMILES Clc1ccc(Nc2cc(=O)[nH]c(=O)[nH]2)cc1Cl Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034952 (6-(3,5-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...) Show SMILES Clc1cc(Cl)cc(Nc2cc(=O)[nH]c(=O)[nH]2)c1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034961 (6-Chloro-N4-(3,4-dichloro-phenyl)-pyrimidine-2,4...) Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034955 (CHEMBL53605 \| N2-(3,4-Dichloro-phenyl)-9H-purine...) Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50013091 (2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50013091 (2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50013091 (2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50034955 (CHEMBL53605 \| N2-(3,4-Dichloro-phenyl)-9H-purine...) Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against coupled primase-DNA polymerase I assay				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50034955 (CHEMBL53605 \| N2-(3,4-Dichloro-phenyl)-9H-purine...) Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against coupled primase-DNA polymerase I assay				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50034961 (6-Chloro-N4-(3,4-dichloro-phenyl)-pyrimidine-2,4...) Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTP				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50034955 (CHEMBL53605 \| N2-(3,4-Dichloro-phenyl)-9H-purine...) Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTP				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50013091 (2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTP				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50034961 (6-Chloro-N4-(3,4-dichloro-phenyl)-pyrimidine-2,4...) Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50034961 (6-Chloro-N4-(3,4-dichloro-phenyl)-pyrimidine-2,4...) Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
Stanford University Medical School Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%