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PubMed code 7830265

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035540
PNG
(5-(4-tert-Butyl-phenyl)-2,3-dihydro-imidazo[2,1-a]...)
Show SMILES CC(C)(C)c1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:11,20|
Show InChI InChI=1S/C21H22N2/c1-21(2,3)17-10-8-15(9-11-17)19-14-16-6-4-5-7-18(16)20-22-12-13-23(19)20/h4-11,14H,12-13H2,1-3H3
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n/an/a 900n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035570
PNG
(5-(4-Thiomorpholin-4-ylmethyl-phenyl)-2,3-dihydro-...)
Show SMILES C(N1CCSCC1)c1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:15,24|
Show InChI InChI=1S/C22H23N3S/c1-2-4-20-19(3-1)15-21(25-10-9-23-22(20)25)18-7-5-17(6-8-18)16-24-11-13-26-14-12-24/h1-8,15H,9-14,16H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035557
PNG
(5-[4-(2-Methyl-piperidin-1-ylmethyl)-phenyl]-2,3-d...)
Show SMILES CC1CCCCN1Cc1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:16,25|
Show InChI InChI=1S/C24H27N3/c1-18-6-4-5-14-26(18)17-19-9-11-20(12-10-19)23-16-21-7-2-3-8-22(21)24-25-13-15-27(23)24/h2-3,7-12,16,18H,4-6,13-15,17H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035548
PNG
(5-(4-tert-Butyl-phenyl)-8-chloro-2,3-dihydro-imida...)
Show SMILES CC(C)(C)c1ccc(cc1)C1=Cc2cc(Cl)ccc2C2=NCCN12 |t:11,21|
Show InChI InChI=1S/C21H21ClN2/c1-21(2,3)16-6-4-14(5-7-16)19-13-15-12-17(22)8-9-18(15)20-23-10-11-24(19)20/h4-9,12-13H,10-11H2,1-3H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035556
PNG
(5-(4-Morpholin-4-ylmethyl-phenyl)-2,3-dihydro-imid...)
Show SMILES C(N1CCOCC1)c1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:15,24|
Show InChI InChI=1S/C22H23N3O/c1-2-4-20-19(3-1)15-21(25-10-9-23-22(20)25)18-7-5-17(6-8-18)16-24-11-13-26-14-12-24/h1-8,15H,9-14,16H2
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n/an/a 2.80E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035560
PNG
(5-Biphenyl-4-yl-2,3-dihydro-imidazo[2,1-a]isoquino...)
Show SMILES C1CN2C(=N1)c1ccccc1C=C2c1ccc(cc1)-c1ccccc1 |c:3,13|
Show InChI InChI=1S/C23H18N2/c1-2-6-17(7-3-1)18-10-12-19(13-11-18)22-16-20-8-4-5-9-21(20)23-24-14-15-25(22)23/h1-13,16H,14-15H2
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n/an/a 3.40E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035539
PNG
(5-(3-tert-Butyl-phenyl)-2,3-dihydro-imidazo[2,1-a]...)
Show SMILES CC(C)(C)c1cccc(c1)C1=Cc2ccccc2C2=NCCN12 |t:11,20|
Show InChI InChI=1S/C21H22N2/c1-21(2,3)17-9-6-8-16(13-17)19-14-15-7-4-5-10-18(15)20-22-11-12-23(19)20/h4-10,13-14H,11-12H2,1-3H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035547
PNG
(5-(3-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Show SMILES Clc1cccc(c1)C1=Cc2ccccc2C2=NCCN12 |t:8,17|
Show InChI InChI=1S/C17H13ClN2/c18-14-6-3-5-13(10-14)16-11-12-4-1-2-7-15(12)17-19-8-9-20(16)17/h1-7,10-11H,8-9H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035555
PNG
(5-p-Tolyl-2,3-dihydro-imidazo[2,1-a]isoquinoline |...)
Show SMILES Cc1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:8,17|
Show InChI InChI=1S/C18H16N2/c1-13-6-8-14(9-7-13)17-12-15-4-2-3-5-16(15)18-19-10-11-20(17)18/h2-9,12H,10-11H2,1H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035558
PNG
(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Show SMILES Fc1ccccc1C1=Cc2ccccc2C2=NCCN12 |t:8,17|
Show InChI InChI=1S/C17H13FN2/c18-15-8-4-3-7-14(15)16-11-12-5-1-2-6-13(12)17-19-9-10-20(16)17/h1-8,11H,9-10H2
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n/an/a 5.70E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035550
PNG
(5-(4-Ethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoqu...)
Show SMILES CCc1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:9,18|
Show InChI InChI=1S/C19H18N2/c1-2-14-7-9-15(10-8-14)18-13-16-5-3-4-6-17(16)19-20-11-12-21(18)19/h3-10,13H,2,11-12H2,1H3
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n/an/a 6.30E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Compound were tested for the inhibition of [3H]-PAF binding to human platelets.


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035569
PNG
(5-(4-Trimethylsilanyl-phenyl)-2,3-dihydro-imidazo[...)
Show SMILES C[Si](C)(C)c1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:11,20|
Show InChI InChI=1S/C20H22N2Si/c1-23(2,3)17-10-8-15(9-11-17)19-14-16-6-4-5-7-18(16)20-21-12-13-22(19)20/h4-11,14H,12-13H2,1-3H3
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n/an/a 6.50E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035568
PNG
(4-(2,3-Dihydro-imidazo[2,1-a]isoquinolin-5-yl)-phe...)
Show SMILES Oc1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:8,17|
Show InChI InChI=1S/C17H14N2O/c20-14-7-5-12(6-8-14)16-11-13-3-1-2-4-15(13)17-18-9-10-19(16)17/h1-8,11,20H,9-10H2
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n/an/a 7.20E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035554
PNG
(5-(4-Piperidin-1-ylmethyl-phenyl)-2,3-dihydro-imid...)
Show SMILES C(N1CCCCC1)c1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:15,24|
Show InChI InChI=1S/C23H25N3/c1-4-13-25(14-5-1)17-18-8-10-19(11-9-18)22-16-20-6-2-3-7-21(20)23-24-12-15-26(22)23/h2-3,6-11,16H,1,4-5,12-15,17H2
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n/an/a 7.50E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035553
PNG
(5-(2-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Show SMILES Clc1ccccc1C1=Cc2ccccc2C2=NCCN12 |t:8,17|
Show InChI InChI=1S/C17H13ClN2/c18-15-8-4-3-7-14(15)16-11-12-5-1-2-6-13(12)17-19-9-10-20(16)17/h1-8,11H,9-10H2
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n/an/a 8.10E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035542
PNG
(CHEMBL80647 | Diallyl-[4-(2,3-dihydro-imidazo[2,1-...)
Show SMILES C=CCN(CC=C)Cc1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:15,24|
Show InChI InChI=1S/C24H25N3/c1-3-14-26(15-4-2)18-19-9-11-20(12-10-19)23-17-21-7-5-6-8-22(21)24-25-13-16-27(23)24/h3-12,17H,1-2,13-16,18H2
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n/an/a 9.20E+3n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035544
PNG
(5-Phenyl-2,3-dihydro-imidazo[2,1-a]isoquinoline | ...)
Show SMILES C1CN2C(=N1)c1ccccc1C=C2c1ccccc1 |c:3,13|
Show InChI InChI=1S/C17H14N2/c1-2-6-13(7-3-1)16-12-14-8-4-5-9-15(14)17-18-10-11-19(16)17/h1-9,12H,10-11H2
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n/an/a 1.12E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035559
PNG
(CHEMBL80774 | Dicyclohexyl-[4-(2,3-dihydro-imidazo...)
Show SMILES C(N(C1CCCCC1)C1CCCCC1)c1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:23,32|
Show InChI InChI=1S/C30H37N3/c1-3-10-26(11-4-1)33(27-12-5-2-6-13-27)22-23-15-17-24(18-16-23)29-21-25-9-7-8-14-28(25)30-31-19-20-32(29)30/h7-9,14-18,21,26-27H,1-6,10-13,19-20,22H2
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n/an/a 1.31E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035564
PNG
(5-(4-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Show SMILES Fc1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:8,17|
Show InChI InChI=1S/C17H13FN2/c18-14-7-5-12(6-8-14)16-11-13-3-1-2-4-15(13)17-19-9-10-20(16)17/h1-8,11H,9-10H2
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n/an/a 1.42E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Compound were tested for the inhibition of [3H]-PAF binding to human platelets.


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035566
PNG
(5-Thiophen-2-yl-2,3-dihydro-imidazo[2,1-a]isoquino...)
Show SMILES C1CN2C(=N1)c1ccccc1C=C2c1cccs1 |c:3,13|
Show InChI InChI=1S/C15H12N2S/c1-2-5-12-11(4-1)10-13(14-6-3-9-18-14)17-8-7-16-15(12)17/h1-6,9-10H,7-8H2
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n/an/a 1.52E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035565
PNG
(5-(3,4-Dichloro-phenyl)-2,3-dihydro-imidazo[2,1-a]...)
Show SMILES Clc1ccc(cc1Cl)C1=Cc2ccccc2C2=NCCN12 |t:9,18|
Show InChI InChI=1S/C17H12Cl2N2/c18-14-6-5-12(9-15(14)19)16-10-11-3-1-2-4-13(11)17-20-7-8-21(16)17/h1-6,9-10H,7-8H2
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n/an/a 1.70E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035543
PNG
(5-Benzo[1,3]dioxol-5-yl-2,3-dihydro-imidazo[2,1-a]...)
Show SMILES C1Oc2ccc(cc2O1)C1=Cc2ccccc2C2=NCCN12 |t:11,20|
Show InChI InChI=1S/C18H14N2O2/c1-2-4-14-12(3-1)9-15(20-8-7-19-18(14)20)13-5-6-16-17(10-13)22-11-21-16/h1-6,9-10H,7-8,11H2
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n/an/a 1.90E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035552
PNG
(5-(3-Trifluoromethyl-phenyl)-2,3-dihydro-imidazo[2...)
Show SMILES FC(F)(F)c1cccc(c1)C1=Cc2ccccc2C2=NCCN12 |t:11,20|
Show InChI InChI=1S/C18H13F3N2/c19-18(20,21)14-6-3-5-13(10-14)16-11-12-4-1-2-7-15(12)17-22-8-9-23(16)17/h1-7,10-11H,8-9H2
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n/an/a 1.92E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Compound were tested for the inhibition of [3H]-PAF binding to human platelets.


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035562
PNG
(5-(3,4-Dimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-a...)
Show SMILES COc1ccc(cc1OC)C1=Cc2ccccc2C2=NCCN12 |t:11,20|
Show InChI InChI=1S/C19H18N2O2/c1-22-17-8-7-14(12-18(17)23-2)16-11-13-5-3-4-6-15(13)19-20-9-10-21(16)19/h3-8,11-12H,9-10H2,1-2H3
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n/an/a 2.20E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035549
PNG
(5-(4-tert-Butyl-phenyl)-9-methyl-2,3-dihydro-imida...)
Show SMILES Cc1ccc2C=C(N3CCN=C3c2c1)c1ccc(cc1)C(C)(C)C |c:5,10|
Show InChI InChI=1S/C22H24N2/c1-15-5-6-17-14-20(24-12-11-23-21(24)19(17)13-15)16-7-9-18(10-8-16)22(2,3)4/h5-10,13-14H,11-12H2,1-4H3
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n/an/a 3.18E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035563
PNG
(5-(4-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Show SMILES Clc1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:8,17|
Show InChI InChI=1S/C17H13ClN2/c18-14-7-5-12(6-8-14)16-11-13-3-1-2-4-15(13)17-19-9-10-20(16)17/h1-8,11H,9-10H2
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n/an/a 3.72E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035546
PNG
(5-(4-tert-Butyl-phenyl)-9-chloro-2,3-dihydro-imida...)
Show SMILES CC(C)(C)c1ccc(cc1)C1=Cc2ccc(Cl)cc2C2=NCCN12 |t:11,21|
Show InChI InChI=1S/C21H21ClN2/c1-21(2,3)16-7-4-14(5-8-16)19-12-15-6-9-17(22)13-18(15)20-23-10-11-24(19)20/h4-9,12-13H,10-11H2,1-3H3
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n/an/a 4.04E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035537
PNG
(5-Pyridin-4-yl-2,3-dihydro-imidazo[2,1-a]isoquinol...)
Show SMILES C1CN2C(=N1)c1ccccc1C=C2c1ccncc1 |c:3,13|
Show InChI InChI=1S/C16H13N3/c1-2-4-14-13(3-1)11-15(12-5-7-17-8-6-12)19-10-9-18-16(14)19/h1-8,11H,9-10H2
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n/an/a 4.79E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035541
PNG
(5-(4-Methoxy-phenyl)-2,3-dihydro-imidazo[2,1-a]iso...)
Show SMILES COc1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:9,18|
Show InChI InChI=1S/C18H16N2O/c1-21-15-8-6-13(7-9-15)17-12-14-4-2-3-5-16(14)18-19-10-11-20(17)18/h2-9,12H,10-11H2,1H3
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n/an/a 5.50E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035545
PNG
(5-(4-Pyrrolidin-1-ylmethyl-phenyl)-2,3-dihydro-imi...)
Show SMILES C(N1CCCC1)c1ccc(cc1)C1=Cc2ccccc2C2=NCCN12 |t:14,23|
Show InChI InChI=1S/C22H23N3/c1-2-6-20-19(5-1)15-21(25-14-11-23-22(20)25)18-9-7-17(8-10-18)16-24-12-3-4-13-24/h1-2,5-10,15H,3-4,11-14,16H2
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n/an/a 5.94E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035551
PNG
(5-(2,4-Dichloro-phenyl)-2,3-dihydro-imidazo[2,1-a]...)
Show SMILES Clc1ccc(C2=Cc3ccccc3C3=NCCN23)c(Cl)c1 |t:5,14|
Show InChI InChI=1S/C17H12Cl2N2/c18-12-5-6-14(15(19)10-12)16-9-11-3-1-2-4-13(11)17-20-7-8-21(16)17/h1-6,9-10H,7-8H2
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n/an/a 8.20E+4n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035567
PNG
(5-Pyridin-3-yl-2,3-dihydro-imidazo[2,1-a]isoquinol...)
Show SMILES C1CN2C(=N1)c1ccccc1C=C2c1cccnc1 |c:3,13|
Show InChI InChI=1S/C16H13N3/c1-2-6-14-12(4-1)10-15(13-5-3-7-17-11-13)19-9-8-18-16(14)19/h1-7,10-11H,8-9H2
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n/an/a 1.00E+5n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035538
PNG
(5-Furan-2-yl-2,3-dihydro-imidazo[2,1-a]isoquinolin...)
Show SMILES C1CN2C(=N1)c1ccccc1C=C2c1ccco1 |c:3,13|
Show InChI InChI=1S/C15H12N2O/c1-2-5-12-11(4-1)10-13(14-6-3-9-18-14)17-8-7-16-15(12)17/h1-6,9-10H,7-8H2
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n/an/a 1.00E+5n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50035561
PNG
(5-(3,4,5-Trimethoxy-phenyl)-2,3-dihydro-imidazo[2,...)
Show SMILES COc1cc(cc(OC)c1OC)C1=Cc2ccccc2C2=NCCN12 |t:13,22|
Show InChI InChI=1S/C20H20N2O3/c1-23-17-11-14(12-18(24-2)19(17)25-3)16-10-13-6-4-5-7-15(13)20-21-8-9-22(16)20/h4-7,10-12H,8-9H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sandoz Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to human platelet activating factor receptor


J Med Chem 38: 234-40 (1995)


BindingDB Entry DOI: 10.7270/Q27M06Z1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%