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PubMed code 7908696

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453625
PNG
(CHEMBL2110229)
Show SMILES C[C@@H](N(C)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-22(25)24(30)27(4)18(3)23(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22,28H,8,11-12,15,25H2,1-4H3,(H,26,29)/t18-,22+/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036787
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(R)-1...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C23H31N3O3/c1-15-12-19(27)13-16(2)20(15)14-21(24)23(29)26-17(3)22(28)25-11-7-10-18-8-5-4-6-9-18/h4-6,8-9,12-13,17,21,27H,7,10-11,14,24H2,1-3H3,(H,25,28)(H,26,29)/t17-,21?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036787
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(R)-1...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C23H31N3O3/c1-15-12-19(27)13-16(2)20(15)14-21(24)23(29)26-17(3)22(28)25-11-7-10-18-8-5-4-6-9-18/h4-6,8-9,12-13,17,21,27H,7,10-11,14,24H2,1-3H3,(H,25,28)(H,26,29)/t17-,21?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453625
PNG
(CHEMBL2110229)
Show SMILES C[C@@H](N(C)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-22(25)24(30)27(4)18(3)23(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22,28H,8,11-12,15,25H2,1-4H3,(H,26,29)/t18-,22+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453616
PNG
(CHEMBL2110337)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(OCc2ccccc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H37N3O3/c1-21-17-26(36-20-25-13-8-5-9-14-25)18-22(2)27(21)19-28(31)30(35)33-23(3)29(34)32-16-10-15-24-11-6-4-7-12-24/h4-9,11-14,17-18,23,28H,10,15-16,19-20,31H2,1-3H3,(H,32,34)(H,33,35)/t23-,28+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036790
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-2-methyl...)
Show SMILES C[C@@H](NC(=O)C(C)(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-24(4,25)23(30)27-18(3)22(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,28H,8,11-12,15,25H2,1-4H3,(H,26,29)(H,27,30)/t18-,24?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036790
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-2-methyl...)
Show SMILES C[C@@H](NC(=O)C(C)(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-24(4,25)23(30)27-18(3)22(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,28H,8,11-12,15,25H2,1-4H3,(H,26,29)(H,27,30)/t18-,24?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036806
PNG
(2-Amino-3-[2,6-dimethyl-4-(4-nitro-benzyloxy)-phen...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(cc2)[N+]([O-])=O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H36N4O5/c1-20-16-26(39-19-24-11-13-25(14-12-24)34(37)38)17-21(2)27(20)18-28(31)30(36)33-22(3)29(35)32-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,31H2,1-3H3,(H,32,35)(H,33,36)/t22-,28?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453616
PNG
(CHEMBL2110337)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(OCc2ccccc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H37N3O3/c1-21-17-26(36-20-25-13-8-5-9-14-25)18-22(2)27(21)19-28(31)30(35)33-23(3)29(34)32-16-10-15-24-11-6-4-7-12-24/h4-9,11-14,17-18,23,28H,10,15-16,19-20,31H2,1-3H3,(H,32,34)(H,33,35)/t23-,28+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453625
PNG
(CHEMBL2110229)
Show SMILES C[C@@H](N(C)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-22(25)24(30)27(4)18(3)23(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22,28H,8,11-12,15,25H2,1-4H3,(H,26,29)/t18-,22+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453625
PNG
(CHEMBL2110229)
Show SMILES C[C@@H](N(C)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-22(25)24(30)27(4)18(3)23(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22,28H,8,11-12,15,25H2,1-4H3,(H,26,29)/t18-,22+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036787
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(R)-1...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C23H31N3O3/c1-15-12-19(27)13-16(2)20(15)14-21(24)23(29)26-17(3)22(28)25-11-7-10-18-8-5-4-6-9-18/h4-6,8-9,12-13,17,21,27H,7,10-11,14,24H2,1-3H3,(H,25,28)(H,26,29)/t17-,21?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036793
PNG
(2-Amino-3-[4-(4-fluoro-benzyloxy)-2,6-dimethyl-phe...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(F)cc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H36FN3O3/c1-20-16-26(37-19-24-11-13-25(31)14-12-24)17-21(2)27(20)18-28(32)30(36)34-22(3)29(35)33-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,32H2,1-3H3,(H,33,35)(H,34,36)/t22-,28?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036787
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(R)-1...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C23H31N3O3/c1-15-12-19(27)13-16(2)20(15)14-21(24)23(29)26-17(3)22(28)25-11-7-10-18-8-5-4-6-9-18/h4-6,8-9,12-13,17,21,27H,7,10-11,14,24H2,1-3H3,(H,25,28)(H,26,29)/t17-,21?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036805
PNG
(4-(4-{2-Amino-2-[(R)-1-(3-phenyl-propylcarbamoyl)-...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(cc2)C(O)=O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C31H37N3O5/c1-20-16-26(39-19-24-11-13-25(14-12-24)31(37)38)17-21(2)27(20)18-28(32)30(36)34-22(3)29(35)33-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,32H2,1-3H3,(H,33,35)(H,34,36)(H,37,38)/t22-,28?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036793
PNG
(2-Amino-3-[4-(4-fluoro-benzyloxy)-2,6-dimethyl-phe...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(F)cc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H36FN3O3/c1-20-16-26(37-19-24-11-13-25(31)14-12-24)17-21(2)27(20)18-28(32)30(36)34-22(3)29(35)33-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,32H2,1-3H3,(H,33,35)(H,34,36)/t22-,28?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036802
PNG
((S)-2-Amino-N-cyclopropylmethyl-3-(4-hydroxy-2,6-d...)
Show SMILES C[C@@H](N(CC1CC1)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C27H37N3O3/c1-18-14-23(31)15-19(2)24(18)16-25(28)27(33)30(17-22-11-12-22)20(3)26(32)29-13-7-10-21-8-5-4-6-9-21/h4-6,8-9,14-15,20,22,25,31H,7,10-13,16-17,28H2,1-3H3,(H,29,32)/t20-,25+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036802
PNG
((S)-2-Amino-N-cyclopropylmethyl-3-(4-hydroxy-2,6-d...)
Show SMILES C[C@@H](N(CC1CC1)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C27H37N3O3/c1-18-14-23(31)15-19(2)24(18)16-25(28)27(33)30(17-22-11-12-22)20(3)26(32)29-13-7-10-21-8-5-4-6-9-21/h4-6,8-9,14-15,20,22,25,31H,7,10-13,16-17,28H2,1-3H3,(H,29,32)/t20-,25+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036797
PNG
(2-Amino-3-[4-(4-cyano-benzyloxy)-2,6-dimethyl-phen...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(cc2)C#N)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C31H36N4O3/c1-21-16-27(38-20-26-13-11-25(19-32)12-14-26)17-22(2)28(21)18-29(33)31(37)35-23(3)30(36)34-15-7-10-24-8-5-4-6-9-24/h4-6,8-9,11-14,16-17,23,29H,7,10,15,18,20,33H2,1-3H3,(H,34,36)(H,35,37)/t23-,29?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453629
PNG
(CHEMBL170594)
Show SMILES COc1cc(C)c(C[C@H](N)C(=O)N[C@H](C)C(=O)NCCCc2ccccc2)c(C)c1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(30-4)14-17(2)21(16)15-22(25)24(29)27-18(3)23(28)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22H,8,11-12,15,25H2,1-4H3,(H,26,28)(H,27,29)/t18-,22+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453628
PNG
(CHEMBL2110227)
Show SMILES C[C@@H](NC(=O)[C@H](N)Cc1c(C)cc(OCc2ccccc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H37N3O3/c1-21-17-26(36-20-25-13-8-5-9-14-25)18-22(2)27(21)19-28(31)30(35)33-23(3)29(34)32-16-10-15-24-11-6-4-7-12-24/h4-9,11-14,17-18,23,28H,10,15-16,19-20,31H2,1-3H3,(H,32,34)(H,33,35)/t23-,28-/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against mu opioid receptor by the displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453616
PNG
(CHEMBL2110337)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(OCc2ccccc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H37N3O3/c1-21-17-26(36-20-25-13-8-5-9-14-25)18-22(2)27(21)19-28(31)30(35)33-23(3)29(34)32-16-10-15-24-11-6-4-7-12-24/h4-9,11-14,17-18,23,28H,10,15-16,19-20,31H2,1-3H3,(H,32,34)(H,33,35)/t23-,28+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453629
PNG
(CHEMBL170594)
Show SMILES COc1cc(C)c(C[C@H](N)C(=O)N[C@H](C)C(=O)NCCCc2ccccc2)c(C)c1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(30-4)14-17(2)21(16)15-22(25)24(29)27-18(3)23(28)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22H,8,11-12,15,25H2,1-4H3,(H,26,28)(H,27,29)/t18-,22+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Affinity for mu opioid receptor was measured by displacement of tritiated DAMGO from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036790
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-2-methyl...)
Show SMILES C[C@@H](NC(=O)C(C)(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-24(4,25)23(30)27-18(3)22(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,28H,8,11-12,15,25H2,1-4H3,(H,26,29)(H,27,30)/t18-,24?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036790
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-2-methyl...)
Show SMILES C[C@@H](NC(=O)C(C)(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-24(4,25)23(30)27-18(3)22(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,28H,8,11-12,15,25H2,1-4H3,(H,26,29)(H,27,30)/t18-,24?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036806
PNG
(2-Amino-3-[2,6-dimethyl-4-(4-nitro-benzyloxy)-phen...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(cc2)[N+]([O-])=O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H36N4O5/c1-20-16-26(39-19-24-11-13-25(14-12-24)34(37)38)17-21(2)27(20)18-28(31)30(36)33-22(3)29(35)32-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,31H2,1-3H3,(H,32,35)(H,33,36)/t22-,28?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453616
PNG
(CHEMBL2110337)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(OCc2ccccc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H37N3O3/c1-21-17-26(36-20-25-13-8-5-9-14-25)18-22(2)27(21)19-28(31)30(35)33-23(3)29(34)32-16-10-15-24-11-6-4-7-12-24/h4-9,11-14,17-18,23,28H,10,15-16,19-20,31H2,1-3H3,(H,32,34)(H,33,35)/t23-,28+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036787
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(R)-1...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C23H31N3O3/c1-15-12-19(27)13-16(2)20(15)14-21(24)23(29)26-17(3)22(28)25-11-7-10-18-8-5-4-6-9-18/h4-6,8-9,12-13,17,21,27H,7,10-11,14,24H2,1-3H3,(H,25,28)(H,26,29)/t17-,21?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453625
PNG
(CHEMBL2110229)
Show SMILES C[C@@H](N(C)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-22(25)24(30)27(4)18(3)23(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22,28H,8,11-12,15,25H2,1-4H3,(H,26,29)/t18-,22+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036793
PNG
(2-Amino-3-[4-(4-fluoro-benzyloxy)-2,6-dimethyl-phe...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(F)cc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H36FN3O3/c1-20-16-26(37-19-24-11-13-25(31)14-12-24)17-21(2)27(20)18-28(32)30(36)34-22(3)29(35)33-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,32H2,1-3H3,(H,33,35)(H,34,36)/t22-,28?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036793
PNG
(2-Amino-3-[4-(4-fluoro-benzyloxy)-2,6-dimethyl-phe...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(F)cc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H36FN3O3/c1-20-16-26(37-19-24-11-13-25(31)14-12-24)17-21(2)27(20)18-28(32)30(36)34-22(3)29(35)33-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,32H2,1-3H3,(H,33,35)(H,34,36)/t22-,28?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036802
PNG
((S)-2-Amino-N-cyclopropylmethyl-3-(4-hydroxy-2,6-d...)
Show SMILES C[C@@H](N(CC1CC1)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C27H37N3O3/c1-18-14-23(31)15-19(2)24(18)16-25(28)27(33)30(17-22-11-12-22)20(3)26(32)29-13-7-10-21-8-5-4-6-9-21/h4-6,8-9,14-15,20,22,25,31H,7,10-13,16-17,28H2,1-3H3,(H,29,32)/t20-,25+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036802
PNG
((S)-2-Amino-N-cyclopropylmethyl-3-(4-hydroxy-2,6-d...)
Show SMILES C[C@@H](N(CC1CC1)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C27H37N3O3/c1-18-14-23(31)15-19(2)24(18)16-25(28)27(33)30(17-22-11-12-22)20(3)26(32)29-13-7-10-21-8-5-4-6-9-21/h4-6,8-9,14-15,20,22,25,31H,7,10-13,16-17,28H2,1-3H3,(H,29,32)/t20-,25+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036794
PNG
(3-(4-Allyloxy-2,6-dimethyl-phenyl)-2-amino-N-[(R)-...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCC=C)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C26H35N3O3/c1-5-14-32-22-15-18(2)23(19(3)16-22)17-24(27)26(31)29-20(4)25(30)28-13-9-12-21-10-7-6-8-11-21/h5-8,10-11,15-16,20,24H,1,9,12-14,17,27H2,2-4H3,(H,28,30)(H,29,31)/t20-,24?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036805
PNG
(4-(4-{2-Amino-2-[(R)-1-(3-phenyl-propylcarbamoyl)-...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(cc2)C(O)=O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C31H37N3O5/c1-20-16-26(39-19-24-11-13-25(14-12-24)31(37)38)17-21(2)27(20)18-28(32)30(36)34-22(3)29(35)33-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,32H2,1-3H3,(H,33,35)(H,34,36)(H,37,38)/t22-,28?/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453629
PNG
(CHEMBL170594)
Show SMILES COc1cc(C)c(C[C@H](N)C(=O)N[C@H](C)C(=O)NCCCc2ccccc2)c(C)c1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(30-4)14-17(2)21(16)15-22(25)24(29)27-18(3)23(28)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22H,8,11-12,15,25H2,1-4H3,(H,26,28)(H,27,29)/t18-,22+/m1/s1
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Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036802
PNG
((S)-2-Amino-N-cyclopropylmethyl-3-(4-hydroxy-2,6-d...)
Show SMILES C[C@@H](N(CC1CC1)C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C27H37N3O3/c1-18-14-23(31)15-19(2)24(18)16-25(28)27(33)30(17-22-11-12-22)20(3)26(32)29-13-7-10-21-8-5-4-6-9-21/h4-6,8-9,14-15,20,22,25,31H,7,10-13,16-17,28H2,1-3H3,(H,29,32)/t20-,25+/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036797
PNG
(2-Amino-3-[4-(4-cyano-benzyloxy)-2,6-dimethyl-phen...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(cc2)C#N)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C31H36N4O3/c1-21-16-27(38-20-26-13-11-25(19-32)12-14-26)17-22(2)28(21)18-29(33)31(37)35-23(3)30(36)34-15-7-10-24-8-5-4-6-9-24/h4-6,8-9,11-14,16-17,23,29H,7,10,15,18,20,33H2,1-3H3,(H,34,36)(H,35,37)/t23-,29?/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Displacement of [3H]-DSLET from rat brain membrane delta opioid receptor

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036790
PNG
(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-2-methyl...)
Show SMILES C[C@@H](NC(=O)C(C)(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(28)14-17(2)21(16)15-24(4,25)23(30)27-18(3)22(29)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,28H,8,11-12,15,25H2,1-4H3,(H,26,29)(H,27,30)/t18-,24?/m1/s1
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n/an/a 1.38E+3n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453628
PNG
(CHEMBL2110227)
Show SMILES C[C@@H](NC(=O)[C@H](N)Cc1c(C)cc(OCc2ccccc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H37N3O3/c1-21-17-26(36-20-25-13-8-5-9-14-25)18-22(2)27(21)19-28(31)30(35)33-23(3)29(34)32-16-10-15-24-11-6-4-7-12-24/h4-9,11-14,17-18,23,28H,10,15-16,19-20,31H2,1-3H3,(H,32,34)(H,33,35)/t23-,28-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453629
PNG
(CHEMBL170594)
Show SMILES COc1cc(C)c(C[C@H](N)C(=O)N[C@H](C)C(=O)NCCCc2ccccc2)c(C)c1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(30-4)14-17(2)21(16)15-22(25)24(29)27-18(3)23(28)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22H,8,11-12,15,25H2,1-4H3,(H,26,28)(H,27,29)/t18-,22+/m1/s1
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n/an/a 2.09E+3n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453616
PNG
(CHEMBL2110337)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(OCc2ccccc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H37N3O3/c1-21-17-26(36-20-25-13-8-5-9-14-25)18-22(2)27(21)19-28(31)30(35)33-23(3)29(34)32-16-10-15-24-11-6-4-7-12-24/h4-9,11-14,17-18,23,28H,10,15-16,19-20,31H2,1-3H3,(H,32,34)(H,33,35)/t23-,28+/m1/s1
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n/an/a 2.52E+3n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50036793
PNG
(2-Amino-3-[4-(4-fluoro-benzyloxy)-2,6-dimethyl-phe...)
Show SMILES C[C@@H](NC(=O)C(N)Cc1c(C)cc(OCc2ccc(F)cc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H36FN3O3/c1-20-16-26(37-19-24-11-13-25(31)14-12-24)17-21(2)27(20)18-28(32)30(36)34-22(3)29(35)33-15-7-10-23-8-5-4-6-9-23/h4-6,8-9,11-14,16-17,22,28H,7,10,15,18-19,32H2,1-3H3,(H,33,35)(H,34,36)/t22-,28?/m1/s1
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n/an/a 1.08E+4n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453628
PNG
(CHEMBL2110227)
Show SMILES C[C@@H](NC(=O)[C@H](N)Cc1c(C)cc(OCc2ccccc2)cc1C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C30H37N3O3/c1-21-17-26(36-20-25-13-8-5-9-14-25)18-22(2)27(21)19-28(31)30(35)33-23(3)29(34)32-16-10-15-24-11-6-4-7-12-24/h4-9,11-14,17-18,23,28H,10,15-16,19-20,31H2,1-3H3,(H,32,34)(H,33,35)/t23-,28-/m1/s1
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n/an/a 1.75E+4n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453629
PNG
(CHEMBL170594)
Show SMILES COc1cc(C)c(C[C@H](N)C(=O)N[C@H](C)C(=O)NCCCc2ccccc2)c(C)c1
Show InChI InChI=1S/C24H33N3O3/c1-16-13-20(30-4)14-17(2)21(16)15-22(25)24(29)27-18(3)23(28)26-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-14,18,22H,8,11-12,15,25H2,1-4H3,(H,26,28)(H,27,29)/t18-,22+/m1/s1
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n/an/a 1.98E+4n/an/an/an/an/an/a



Searle

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranes

J Med Chem 37: 888-96 (1994)


BindingDB Entry DOI: 10.7270/Q27H1HN2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%