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PubMed code 7932545

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50037218
PNG
(1-((3S,4R)-3-Biphenyl-4-ylmethyl-4-hydroxy-chroman...)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)C1(CCCC1)C(O)=O
Show InChI InChI=1S/C28H28O4/c29-26-22(16-19-8-10-21(11-9-19)20-6-2-1-3-7-20)18-32-25-17-23(12-13-24(25)26)28(27(30)31)14-4-5-15-28/h1-3,6-13,17,22,26,29H,4-5,14-16,18H2,(H,30,31)/t22-,26+/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Tested for binding activity against [3H]-LTB4 to whole human neutrophil with halh maximal inhibition

J Med Chem 37: 3197-9 (1994)


BindingDB Entry DOI: 10.7270/Q298862K
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50037218
PNG
(1-((3S,4R)-3-Biphenyl-4-ylmethyl-4-hydroxy-chroman...)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)C1(CCCC1)C(O)=O
Show InChI InChI=1S/C28H28O4/c29-26-22(16-19-8-10-21(11-9-19)20-6-2-1-3-7-20)18-32-25-17-23(12-13-24(25)26)28(27(30)31)14-4-5-15-28/h1-3,6-13,17,22,26,29H,4-5,14-16,18H2,(H,30,31)/t22-,26+/m0/s1
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n/an/a 9.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane

J Med Chem 37: 3197-9 (1994)


BindingDB Entry DOI: 10.7270/Q298862K
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Mus musculus)		BDBM50037218
PNG
(1-((3S,4R)-3-Biphenyl-4-ylmethyl-4-hydroxy-chroman...)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)C1(CCCC1)C(O)=O
Show InChI InChI=1S/C28H28O4/c29-26-22(16-19-8-10-21(11-9-19)20-6-2-1-3-7-20)18-32-25-17-23(12-13-24(25)26)28(27(30)31)14-4-5-15-28/h1-3,6-13,17,22,26,29H,4-5,14-16,18H2,(H,30,31)/t22-,26+/m0/s1
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PubMed
n/an/a 30.3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptor

J Med Chem 37: 3197-9 (1994)


BindingDB Entry DOI: 10.7270/Q298862K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%