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PubMed code 8101877

Compile data set for download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040237
PNG
(2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Sc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 0.880n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50010594
PNG
(2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 1.80n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 2n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 3.30n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 3.80n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040241
PNG
(3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2ccccc12 |t:8|
Show InChI InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
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 3.80n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040243
PNG
(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Sc2ccccc12 |t:8|
Show InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-7-6-13(19)12-15(17)20-18/h2-7,12H,8-11H2,1H3
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 4.10n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040237
PNG
(2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Sc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
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 4.40n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040243
PNG
(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Sc2ccccc12 |t:8|
Show InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-7-6-13(19)12-15(17)20-18/h2-7,12H,8-11H2,1H3
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 5.60n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040250
PNG
(8-Chloro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C17H18ClN5/c1-22-7-9-23(10-8-22)17-13-11-12(18)4-5-14(13)20-16-15(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 6.20n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50010594
PNG
(2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 13n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040237
PNG
(2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Sc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
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 14n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50010594
PNG
(2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 21n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 23n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040241
PNG
(3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2ccccc12 |t:8|
Show InChI InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
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 25n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 25n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50010594
PNG
(2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 28n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040244
PNG
(11-(4-Methyl-piperazin-1-yl)-5H-benzo[b]pyrido[4,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccncc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-8-10-22(11-9-21)17-13-12-18-7-6-14(13)19-15-4-2-3-5-16(15)20-17/h2-7,12,19H,8-11H2,1H3
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 29n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040243
PNG
(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Sc2ccccc12 |t:8|
Show InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-7-6-13(19)12-15(17)20-18/h2-7,12H,8-11H2,1H3
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 30n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 35n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 45n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040238
PNG
(9-Chloro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2cc(Cl)ccc12 |t:8|
Show InChI InChI=1S/C17H18ClN5/c1-22-7-9-23(10-8-22)17-13-5-4-12(18)11-15(13)20-16-14(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 48n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040245
PNG
(8-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(C)cc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-13-5-6-15-14(12-13)18(23-10-8-22(2)9-11-23)21-16-4-3-7-19-17(16)20-15/h3-7,12H,8-11H2,1-2H3,(H,19,20)
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 48n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 61n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040250
PNG
(8-Chloro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C17H18ClN5/c1-22-7-9-23(10-8-22)17-13-11-12(18)4-5-14(13)20-16-15(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 65n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 76n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040245
PNG
(8-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(C)cc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-13-5-6-15-14(12-13)18(23-10-8-22(2)9-11-23)21-16-4-3-7-19-17(16)20-15/h3-7,12H,8-11H2,1-2H3,(H,19,20)
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 94n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50017538
PNG
(5-(4-Methyl-piperazin-1-yl)-11H-benzo[b]pyrido[2,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ncccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-9-11-22(12-10-21)17-13-5-4-8-18-16(13)19-14-6-2-3-7-15(14)20-17/h2-8H,9-12H2,1H3,(H,18,19)
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 103n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040246
PNG
(3-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(C)cnc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-13-11-16-17(19-12-13)20-15-6-4-3-5-14(15)18(21-16)23-9-7-22(2)8-10-23/h3-6,11-12H,7-10H2,1-2H3,(H,19,20)
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 103n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 115n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040250
PNG
(8-Chloro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C17H18ClN5/c1-22-7-9-23(10-8-22)17-13-11-12(18)4-5-14(13)20-16-15(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 118n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040248
PNG
(8-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(F)cc12 |t:8|
Show InChI InChI=1S/C17H18FN5/c1-22-7-9-23(10-8-22)17-13-11-12(18)4-5-14(13)20-16-15(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 124n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040249
PNG
(6-(4-Methyl-piperazin-1-yl)-11H-benzo[e]pyrido[3,2...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-9-11-22(12-10-21)17-13-5-2-3-6-14(13)19-16-15(20-17)7-4-8-18-16/h2-8H,9-12H2,1H3,(H,18,19)
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 124n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040241
PNG
(3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2ccccc12 |t:8|
Show InChI InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
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 133n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040237
PNG
(2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Sc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
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 136n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040241
PNG
(3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2ccccc12 |t:8|
Show InChI InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
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 141n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040236
PNG
(11-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2N(C)c2ccccc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-21-10-12-23(13-11-21)17-14-6-3-4-8-16(14)22(2)18-15(20-17)7-5-9-19-18/h3-9H,10-13H2,1-2H3
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 175n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040238
PNG
(9-Chloro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2cc(Cl)ccc12 |t:8|
Show InChI InChI=1S/C17H18ClN5/c1-22-7-9-23(10-8-22)17-13-5-4-12(18)11-15(13)20-16-14(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 214n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040243
PNG
(8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Sc2ccccc12 |t:8|
Show InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-7-6-13(19)12-15(17)20-18/h2-7,12H,8-11H2,1H3
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 240n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040246
PNG
(3-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(C)cnc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-13-11-16-17(19-12-13)20-15-6-4-3-5-14(15)18(21-16)23-9-7-22(2)8-10-23/h3-6,11-12H,7-10H2,1-2H3,(H,19,20)
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 297n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040244
PNG
(11-(4-Methyl-piperazin-1-yl)-5H-benzo[b]pyrido[4,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccncc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-8-10-22(11-9-21)17-13-12-18-7-6-14(13)19-15-4-2-3-5-16(15)20-17/h2-7,12,19H,8-11H2,1H3
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 302n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017538
PNG
(5-(4-Methyl-piperazin-1-yl)-11H-benzo[b]pyrido[2,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ncccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-9-11-22(12-10-21)17-13-5-4-8-18-16(13)19-14-6-2-3-7-15(14)20-17/h2-8H,9-12H2,1H3,(H,18,19)
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 303n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040247
PNG
(6-(4-Methyl-piperazin-1-yl)-benzo[e]pyrido[3,2-b][...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2N(C=O)c2ccccc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-9-11-22(12-10-21)17-14-5-2-3-7-16(14)23(13-24)18-15(20-17)6-4-8-19-18/h2-8,13H,9-12H2,1H3
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 311n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040238
PNG
(9-Chloro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2cc(Cl)ccc12 |t:8|
Show InChI InChI=1S/C17H18ClN5/c1-22-7-9-23(10-8-22)17-13-5-4-12(18)11-15(13)20-16-14(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 366n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040245
PNG
(8-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(C)cc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-13-5-6-15-14(12-13)18(23-10-8-22(2)9-11-23)21-16-4-3-7-19-17(16)20-15/h3-7,12H,8-11H2,1-2H3,(H,19,20)
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 398n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040248
PNG
(8-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(F)cc12 |t:8|
Show InChI InChI=1S/C17H18FN5/c1-22-7-9-23(10-8-22)17-13-11-12(18)4-5-14(13)20-16-15(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 415n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040239
PNG
(10-(4-Methyl-piperazin-1-yl)-5H-2,5,11-triaza-dibe...)
Show SMILES CN1CCN(CC1)C1=Nc2cnccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-8-10-22(11-9-21)17-13-4-2-3-5-14(13)19-15-6-7-18-12-16(15)20-17/h2-7,12,19H,8-11H2,1H3
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 430n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040244
PNG
(11-(4-Methyl-piperazin-1-yl)-5H-benzo[b]pyrido[4,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccncc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-8-10-22(11-9-21)17-13-12-18-7-6-14(13)19-15-4-2-3-5-16(15)20-17/h2-7,12,19H,8-11H2,1H3
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 442n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040246
PNG
(3-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(C)cnc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-13-11-16-17(19-12-13)20-15-6-4-3-5-14(15)18(21-16)23-9-7-22(2)8-10-23/h3-6,11-12H,7-10H2,1-2H3,(H,19,20)
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 523n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040245
PNG
(8-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(C)cc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-13-5-6-15-14(12-13)18(23-10-8-22(2)9-11-23)21-16-4-3-7-19-17(16)20-15/h3-7,12H,8-11H2,1-2H3,(H,19,20)
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 530n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040249
PNG
(6-(4-Methyl-piperazin-1-yl)-11H-benzo[e]pyrido[3,2...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-9-11-22(12-10-21)17-13-5-2-3-6-14(13)19-16-15(20-17)7-4-8-18-16/h2-8H,9-12H2,1H3,(H,18,19)
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 665n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040248
PNG
(8-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(F)cc12 |t:8|
Show InChI InChI=1S/C17H18FN5/c1-22-7-9-23(10-8-22)17-13-11-12(18)4-5-14(13)20-16-15(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 677n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50017538
PNG
(5-(4-Methyl-piperazin-1-yl)-11H-benzo[b]pyrido[2,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ncccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-9-11-22(12-10-21)17-13-5-4-8-18-16(13)19-14-6-2-3-7-15(14)20-17/h2-8H,9-12H2,1H3,(H,18,19)
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 726n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040239
PNG
(10-(4-Methyl-piperazin-1-yl)-5H-2,5,11-triaza-dibe...)
Show SMILES CN1CCN(CC1)C1=Nc2cnccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-8-10-22(11-9-21)17-13-4-2-3-5-14(13)19-15-6-7-18-12-16(15)20-17/h2-7,12,19H,8-11H2,1H3
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 837n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040238
PNG
(9-Chloro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2cc(Cl)ccc12 |t:8|
Show InChI InChI=1S/C17H18ClN5/c1-22-7-9-23(10-8-22)17-13-5-4-12(18)11-15(13)20-16-14(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 1.02E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040246
PNG
(3-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(C)cnc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-13-11-16-17(19-12-13)20-15-6-4-3-5-14(15)18(21-16)23-9-7-22(2)8-10-23/h3-6,11-12H,7-10H2,1-2H3,(H,19,20)
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 1.14E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040248
PNG
(8-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(F)cc12 |t:8|
Show InChI InChI=1S/C17H18FN5/c1-22-7-9-23(10-8-22)17-13-11-12(18)4-5-14(13)20-16-15(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 1.55E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040247
PNG
(6-(4-Methyl-piperazin-1-yl)-benzo[e]pyrido[3,2-b][...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2N(C=O)c2ccccc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-9-11-22(12-10-21)17-14-5-2-3-7-16(14)23(13-24)18-15(20-17)6-4-8-19-18/h2-8,13H,9-12H2,1H3
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 1.87E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017538
PNG
(5-(4-Methyl-piperazin-1-yl)-11H-benzo[b]pyrido[2,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ncccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-9-11-22(12-10-21)17-13-5-4-8-18-16(13)19-14-6-2-3-7-15(14)20-17/h2-8H,9-12H2,1H3,(H,18,19)
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 1.97E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040242
PNG
(11-(4-Methyl-piperazin-1-yl)-benzo[b]pyrido[4,3-e]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2N(C=O)c2ccncc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-8-10-22(11-9-21)18-14-12-19-7-6-16(14)23(13-24)17-5-3-2-4-15(17)20-18/h2-7,12-13H,8-11H2,1H3
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 2.05E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040250
PNG
(8-Chloro-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]p...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccc(Cl)cc12 |t:8|
Show InChI InChI=1S/C17H18ClN5/c1-22-7-9-23(10-8-22)17-13-11-12(18)4-5-14(13)20-16-15(21-17)3-2-6-19-16/h2-6,11H,7-10H2,1H3,(H,19,20)
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 2.14E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040249
PNG
(6-(4-Methyl-piperazin-1-yl)-11H-benzo[e]pyrido[3,2...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-9-11-22(12-10-21)17-13-5-2-3-6-14(13)19-16-15(20-17)7-4-8-18-16/h2-8H,9-12H2,1H3,(H,18,19)
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 2.40E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040236
PNG
(11-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2N(C)c2ccccc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-21-10-12-23(13-11-21)17-14-6-3-4-8-16(14)22(2)18-15(20-17)7-5-9-19-18/h3-9H,10-13H2,1-2H3
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 2.90E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040242
PNG
(11-(4-Methyl-piperazin-1-yl)-benzo[b]pyrido[4,3-e]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2N(C=O)c2ccncc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-8-10-22(11-9-21)18-14-12-19-7-6-16(14)23(13-24)17-5-3-2-4-15(17)20-18/h2-7,12-13H,8-11H2,1H3
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 3.02E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040244
PNG
(11-(4-Methyl-piperazin-1-yl)-5H-benzo[b]pyrido[4,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2ccncc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-8-10-22(11-9-21)17-13-12-18-7-6-14(13)19-15-4-2-3-5-16(15)20-17/h2-7,12,19H,8-11H2,1H3
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 3.26E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040240
PNG
(5-(4-Methyl-piperazin-1-yl)-benzo[b]pyrido[2,3-e][...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2N(C=O)c2ncccc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-9-11-22(12-10-21)18-14-5-4-8-19-17(14)23(13-24)16-7-3-2-6-15(16)20-18/h2-8,13H,9-12H2,1H3
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 3.42E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50040242
PNG
(11-(4-Methyl-piperazin-1-yl)-benzo[b]pyrido[4,3-e]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2N(C=O)c2ccncc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-8-10-22(11-9-21)18-14-12-19-7-6-16(14)23(13-24)17-5-3-2-4-15(17)20-18/h2-7,12-13H,8-11H2,1H3
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 3.45E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040249
PNG
(6-(4-Methyl-piperazin-1-yl)-11H-benzo[e]pyrido[3,2...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-9-11-22(12-10-21)17-13-5-2-3-6-14(13)19-16-15(20-17)7-4-8-18-16/h2-8H,9-12H2,1H3,(H,18,19)
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 3.65E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040239
PNG
(10-(4-Methyl-piperazin-1-yl)-5H-2,5,11-triaza-dibe...)
Show SMILES CN1CCN(CC1)C1=Nc2cnccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-8-10-22(11-9-21)17-13-4-2-3-5-14(13)19-15-6-7-18-12-16(15)20-17/h2-7,12,19H,8-11H2,1H3
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 3.97E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040236
PNG
(11-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2N(C)c2ccccc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-21-10-12-23(13-11-21)17-14-6-3-4-8-16(14)22(2)18-15(20-17)7-5-9-19-18/h3-9H,10-13H2,1-2H3
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 6.02E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50040240
PNG
(5-(4-Methyl-piperazin-1-yl)-benzo[b]pyrido[2,3-e][...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2N(C=O)c2ncccc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-9-11-22(12-10-21)18-14-5-4-8-19-17(14)23(13-24)16-7-3-2-6-15(16)20-18/h2-8,13H,9-12H2,1H3
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 7.12E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 7.47E+3n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040239
PNG
(10-(4-Methyl-piperazin-1-yl)-5H-2,5,11-triaza-dibe...)
Show SMILES CN1CCN(CC1)C1=Nc2cnccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C17H19N5/c1-21-8-10-22(11-9-21)17-13-4-2-3-5-14(13)19-15-6-7-18-12-16(15)20-17/h2-7,12,19H,8-11H2,1H3
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 1.35E+4n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040242
PNG
(11-(4-Methyl-piperazin-1-yl)-benzo[b]pyrido[4,3-e]...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2N(C=O)c2ccncc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-8-10-22(11-9-21)18-14-12-19-7-6-16(14)23(13-24)17-5-3-2-4-15(17)20-18/h2-7,12-13H,8-11H2,1H3
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 2.39E+4n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040236
PNG
(11-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2N(C)c2ccccc12 |t:8|
Show InChI InChI=1S/C18H21N5/c1-21-10-12-23(13-11-21)17-14-6-3-4-8-16(14)22(2)18-15(20-17)7-5-9-19-18/h3-9H,10-13H2,1-2H3
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 2.71E+4n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040240
PNG
(5-(4-Methyl-piperazin-1-yl)-benzo[b]pyrido[2,3-e][...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2N(C=O)c2ncccc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-9-11-22(12-10-21)18-14-5-4-8-19-17(14)23(13-24)16-7-3-2-6-15(16)20-18/h2-8,13H,9-12H2,1H3
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 3.02E+4n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50040247
PNG
(6-(4-Methyl-piperazin-1-yl)-benzo[e]pyrido[3,2-b][...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2N(C=O)c2ccccc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-9-11-22(12-10-21)17-14-5-2-3-7-16(14)23(13-24)18-15(20-17)6-4-8-19-18/h2-8,13H,9-12H2,1H3
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 4.79E+4n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040247
PNG
(6-(4-Methyl-piperazin-1-yl)-benzo[e]pyrido[3,2-b][...)
Show SMILES CN1CCN(CC1)C1=Nc2cccnc2N(C=O)c2ccccc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-9-11-22(12-10-21)17-14-5-2-3-7-16(14)23(13-24)18-15(20-17)6-4-8-19-18/h2-8,13H,9-12H2,1H3
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 1.00E+5n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50040240
PNG
(5-(4-Methyl-piperazin-1-yl)-benzo[b]pyrido[2,3-e][...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2N(C=O)c2ncccc12 |t:8|
Show InChI InChI=1S/C18H19N5O/c1-21-9-11-22(12-10-21)18-14-5-4-8-19-17(14)23(13-24)16-7-3-2-6-15(16)20-18/h2-8,13H,9-12H2,1H3
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 1.00E+5n/an/an/an/an/an/an/an/a



University of Liège

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.

J Med Chem 36: 2107-14 (1993)


BindingDB Entry DOI: 10.7270/Q22B8X37
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%