Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034435 (5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity of the compound towards ET1 receptor was determined in A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (RAT) | BDBM50034435 (5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Selectivity for the ET-A receptor over ETB receptor was observed in rat cerebellar membranes | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034435 (5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034435 (5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Antagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034452 (4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034465 (CHEMBL30199 | N-[5-(3,4-Dimethyl-isoxazol-5-ylsulf...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034437 (5-Dimethylaminomethyl-naphthalene-1-sulfonic acid ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034450 (5-Amino-naphthalene-1-sulfonic acid (3,4-dimethyl-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034410 (5-Isopropenyl-naphthalene-1-sulfonic acid (3,4-dim...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034462 (5-Methoxy-naphthalene-1-sulfonic acid (3,4-dimethy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034418 (5-Hydroxy-naphthalene-1-sulfonic acid (3,4-dimethy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Antagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery rings | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034461 (CHEMBL282961 | N-(3,4-Dimethyl-isoxazol-5-yl)-4-hy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034468 (4-Benzylamino-N-(3,4-dimethyl-isoxazol-5-yl)-benze...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034441 (5-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-naphthalen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034446 (CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034440 (CHEMBL286682 | N-(3,4-Dimethyl-isoxazol-5-yl)-4-pr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50034474 (4-Amino-N-(3-methyl-isoxazol-5-yl)-benzenesulfonam...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50044084 (4-Cyano-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50036288 (4-Dimethylamino-N-(3,4-dimethyl-isoxazol-5-yl)-ben...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 8.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells | J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB | |||||||||||
More data for this Ligand-Target Pair |