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PubMed code 8360886

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM50044862
PNG
(2-(2-Benzyl-5-cyano-4-oxo-pentanoylamino)-3-phenyl...)
Show SMILES OC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)CC#N)Cc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c23-12-11-19(25)15-18(13-16-7-3-1-4-8-16)21(26)24-20(22(27)28)14-17-9-5-2-6-10-17/h1-10,18,20H,11,13-15H2,(H,24,26)(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
PubMed
 1.40E+4n/an/an/an/an/an/an/an/a



Salk Biotechnology/Industrial Associates

Curated by ChEMBL


Assay Description
Inhibition constant determined for neutral endopeptidase (NEP)

J Med Chem 36: 2408-11 (1993)


BindingDB Entry DOI: 10.7270/Q26D5S2X
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))		BDBM50044861
PNG
(2-[2-(2-Cyano-acetylamino)-3-phenyl-propionylamino...)
Show SMILES OC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)CC#N
Show InChI InChI=1S/C21H21N3O4/c22-12-11-19(25)23-17(13-15-7-3-1-4-8-15)20(26)24-18(21(27)28)14-16-9-5-2-6-10-16/h1-10,17-18H,11,13-14H2,(H,23,25)(H,24,26)(H,27,28)
PDB

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UniProtKB/SwissProt

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DrugBank
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.70E+4n/an/an/an/an/an/an/an/a



Salk Biotechnology/Industrial Associates

Curated by ChEMBL


Assay Description
Inhibition constant determined for Neutral endopeptidase (NEP)

J Med Chem 36: 2408-11 (1993)


BindingDB Entry DOI: 10.7270/Q26D5S2X
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)		BDBM50044861
PNG
(2-[2-(2-Cyano-acetylamino)-3-phenyl-propionylamino...)
Show SMILES OC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)CC#N
Show InChI InChI=1S/C21H21N3O4/c22-12-11-19(25)23-17(13-15-7-3-1-4-8-15)20(26)24-18(21(27)28)14-16-9-5-2-6-10-16/h1-10,17-18H,11,13-14H2,(H,23,25)(H,24,26)(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 6.50E+4n/an/an/an/an/an/an/an/a



Salk Biotechnology/Industrial Associates

Curated by ChEMBL


Assay Description
Inhibition constant determined for Angiotensin I converting enzyme

J Med Chem 36: 2408-11 (1993)


BindingDB Entry DOI: 10.7270/Q26D5S2X
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Rattus norvegicus)		BDBM50044862
PNG
(2-(2-Benzyl-5-cyano-4-oxo-pentanoylamino)-3-phenyl...)
Show SMILES OC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)CC#N)Cc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c23-12-11-19(25)15-18(13-16-7-3-1-4-8-16)21(26)24-20(22(27)28)14-17-9-5-2-6-10-17/h1-10,18,20H,11,13-15H2,(H,24,26)(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
>1.00E+7n/an/an/an/an/an/an/an/a



Salk Biotechnology/Industrial Associates

Curated by ChEMBL


Assay Description
Inhibition constant determined for angiotensin converting enzyme (ACE)

J Med Chem 36: 2408-11 (1993)


BindingDB Entry DOI: 10.7270/Q26D5S2X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%