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PubMed code 8388468

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50228246
PNG
(Indolidan)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C1=NNC(=O)CC1 |t:14|
Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-7-8(3-4-11(9)15-13(14)19)10-5-6-12(18)17-16-10/h3-4,7H,5-6H2,1-2H3,(H,15,19)(H,17,18)
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n/an/a 80n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 300n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045018
PNG
(2-(2-Pentyloxy-phenyl)-3H-imidazo[4,5-c]pyridine; ...)
Show SMILES CCCCCOc1ccccc1-c1nc2ccncc2[nH]1
Show InChI InChI=1S/C17H19N3O/c1-2-3-6-11-21-16-8-5-4-7-13(16)17-19-14-9-10-18-12-15(14)20-17/h4-5,7-10,12H,2-3,6,11H2,1H3,(H,19,20)
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n/an/a 1.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045012
PNG
(2-(2-Pentyloxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Show SMILES CCCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C17H19N3O/c1-2-3-6-12-21-15-10-5-4-8-13(15)16-19-14-9-7-11-18-17(14)20-16/h4-5,7-11H,2-3,6,12H2,1H3,(H,18,19,20)
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n/an/a 1.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045013
PNG
(2-(2-Butoxy-phenyl)-3H-imidazo[4,5-b]pyridine | CH...)
Show SMILES CCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C16H17N3O/c1-2-3-11-20-14-9-5-4-7-12(14)15-18-13-8-6-10-17-16(13)19-15/h4-10H,2-3,11H2,1H3,(H,17,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045017
PNG
(2-[2-(3-Chloro-propoxy)-phenyl]-3H-imidazo[4,5-b]p...)
Show SMILES ClCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C15H14ClN3O/c16-8-4-10-20-13-7-2-1-5-11(13)14-18-12-6-3-9-17-15(12)19-14/h1-3,5-7,9H,4,8,10H2,(H,17,18,19)
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n/an/a 2.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045016
PNG
(2-(2-Isobutoxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Show SMILES CC(C)COc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C16H17N3O/c1-11(2)10-20-14-8-4-3-6-12(14)15-18-13-7-5-9-17-16(13)19-15/h3-9,11H,10H2,1-2H3,(H,17,18,19)
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n/an/a 3.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045016
PNG
(2-(2-Isobutoxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Show SMILES CC(C)COc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C16H17N3O/c1-11(2)10-20-14-8-4-3-6-12(14)15-18-13-7-5-9-17-16(13)19-15/h3-9,11H,10H2,1-2H3,(H,17,18,19)
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n/an/a 3.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045015
PNG
(2-(2-Benzyloxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Show SMILES C(Oc1ccccc1-c1nc2ncccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-2-7-14(8-3-1)13-23-17-11-5-4-9-15(17)18-21-16-10-6-12-20-19(16)22-18/h1-12H,13H2,(H,20,21,22)
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n/an/a 4.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045009
PNG
(2-(2-Hexyloxy-phenyl)-3H-imidazo[4,5-b]pyridine | ...)
Show SMILES CCCCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C18H21N3O/c1-2-3-4-7-13-22-16-11-6-5-9-14(16)17-20-15-10-8-12-19-18(15)21-17/h5-6,8-12H,2-4,7,13H2,1H3,(H,19,20,21)
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n/an/a 4.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045013
PNG
(2-(2-Butoxy-phenyl)-3H-imidazo[4,5-b]pyridine | CH...)
Show SMILES CCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C16H17N3O/c1-2-3-11-20-14-9-5-4-7-12(14)15-18-13-8-6-10-17-16(13)19-15/h4-10H,2-3,11H2,1H3,(H,17,18,19)
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n/an/a 6.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045026
PNG
(2-(2-Propoxy-phenyl)-3H-imidazo[4,5-b]pyridine | C...)
Show SMILES CCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C15H15N3O/c1-2-10-19-13-8-4-3-6-11(13)14-17-12-7-5-9-16-15(12)18-14/h3-9H,2,10H2,1H3,(H,16,17,18)
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n/an/a 6.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045012
PNG
(2-(2-Pentyloxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Show SMILES CCCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C17H19N3O/c1-2-3-6-12-21-15-10-5-4-8-13(15)16-19-14-9-7-11-18-17(14)20-16/h4-5,7-11H,2-3,6,12H2,1H3,(H,18,19,20)
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n/an/a 6.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045014
PNG
(2-(2-Cyclopropylmethoxy-phenyl)-3H-imidazo[4,5-b]p...)
Show SMILES C(Oc1ccccc1-c1nc2ncccc2[nH]1)C1CC1
Show InChI InChI=1S/C16H15N3O/c1-2-6-14(20-10-11-7-8-11)12(4-1)15-18-13-5-3-9-17-16(13)19-15/h1-6,9,11H,7-8,10H2,(H,17,18,19)
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n/an/a 6.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a 6.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045015
PNG
(2-(2-Benzyloxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Show SMILES C(Oc1ccccc1-c1nc2ncccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-2-7-14(8-3-1)13-23-17-11-5-4-9-15(17)18-21-16-10-6-12-20-19(16)22-18/h1-12H,13H2,(H,20,21,22)
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n/an/a 8.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045017
PNG
(2-[2-(3-Chloro-propoxy)-phenyl]-3H-imidazo[4,5-b]p...)
Show SMILES ClCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C15H14ClN3O/c16-8-4-10-20-13-7-2-1-5-11(13)14-18-12-6-3-9-17-15(12)19-14/h1-3,5-7,9H,4,8,10H2,(H,17,18,19)
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n/an/a 9.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045026
PNG
(2-(2-Propoxy-phenyl)-3H-imidazo[4,5-b]pyridine | C...)
Show SMILES CCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C15H15N3O/c1-2-10-19-13-8-4-3-6-11(13)14-17-12-7-5-9-16-15(12)18-14/h3-9H,2,10H2,1H3,(H,16,17,18)
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n/an/a 1.10E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045021
PNG
(2-(2-Cyclopentyloxy-phenyl)-3H-imidazo[4,5-b]pyrid...)
Show SMILES C1CCC(C1)Oc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C17H17N3O/c1-2-7-12(6-1)21-15-10-4-3-8-13(15)16-19-14-9-5-11-18-17(14)20-16/h3-5,8-12H,1-2,6-7H2,(H,18,19,20)
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n/an/a 1.50E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045009
PNG
(2-(2-Hexyloxy-phenyl)-3H-imidazo[4,5-b]pyridine | ...)
Show SMILES CCCCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C18H21N3O/c1-2-3-4-7-13-22-16-11-6-5-9-14(16)17-20-15-10-8-12-19-18(15)21-17/h5-6,8-12H,2-4,7,13H2,1H3,(H,19,20,21)
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n/an/a 1.60E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045024
PNG
(2-(2-Ethoxy-phenyl)-3H-imidazo[4,5-b]pyridine | CH...)
Show SMILES CCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C14H13N3O/c1-2-18-12-8-4-3-6-10(12)13-16-11-7-5-9-15-14(11)17-13/h3-9H,2H2,1H3,(H,15,16,17)
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n/an/a 1.80E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045021
PNG
(2-(2-Cyclopentyloxy-phenyl)-3H-imidazo[4,5-b]pyrid...)
Show SMILES C1CCC(C1)Oc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C17H17N3O/c1-2-7-12(6-1)21-15-10-4-3-8-13(15)16-19-14-9-5-11-18-17(14)20-16/h3-5,8-12H,1-2,6-7H2,(H,18,19,20)
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n/an/a 1.90E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50000056
PNG
((sulmazole)2-(4-Methanesulfinyl-2-methoxy-phenyl)-...)
Show SMILES COc1cc(ccc1-c1nc2ncccc2[nH]1)S(C)=O
Show InChI InChI=1S/C14H13N3O2S/c1-19-12-8-9(20(2)18)5-6-10(12)13-16-11-4-3-7-15-14(11)17-13/h3-8H,1-2H3,(H,15,16,17)
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n/an/a 2.10E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045008
PNG
(2-(2-Propylsulfanyl-phenyl)-3H-imidazo[4,5-b]pyrid...)
Show SMILES CCCSc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C15H15N3S/c1-2-10-19-13-8-4-3-6-11(13)14-17-12-7-5-9-16-15(12)18-14/h3-9H,2,10H2,1H3,(H,16,17,18)
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n/an/a 2.40E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045011
PNG
(3-[2-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenoxy]-prop...)
Show SMILES OCCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C15H15N3O2/c19-9-4-10-20-13-7-2-1-5-11(13)14-17-12-6-3-8-16-15(12)18-14/h1-3,5-8,19H,4,9-10H2,(H,16,17,18)
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n/an/a 2.40E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045019
PNG
(CHEMBL32093 | [2-(3H-Imidazo[4,5-b]pyridin-2-yl)-p...)
Show SMILES CCCNc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C15H16N4/c1-2-9-16-12-7-4-3-6-11(12)14-18-13-8-5-10-17-15(13)19-14/h3-8,10,16H,2,9H2,1H3,(H,17,18,19)
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n/an/a 2.60E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045028
PNG
(2-(2-Propoxy-phenyl)-imidazo[1,2-a]pyrimidine | CH...)
Show SMILES CCCOc1ccccc1-c1cn2cccnc2n1
Show InChI InChI=1S/C15H15N3O/c1-2-10-19-14-7-4-3-6-12(14)13-11-18-9-5-8-16-15(18)17-13/h3-9,11H,2,10H2,1H3
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n/an/a 3.30E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045027
PNG
(2-(2-Methoxy-phenyl)-3H-imidazo[4,5-b]pyridine; hy...)
Show SMILES COc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C13H11N3O/c1-17-11-7-3-2-5-9(11)12-15-10-6-4-8-14-13(10)16-12/h2-8H,1H3,(H,14,15,16)
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n/an/a 3.40E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50045014
PNG
(2-(2-Cyclopropylmethoxy-phenyl)-3H-imidazo[4,5-b]p...)
Show SMILES C(Oc1ccccc1-c1nc2ncccc2[nH]1)C1CC1
Show InChI InChI=1S/C16H15N3O/c1-2-6-14(20-10-11-7-8-11)12(4-1)15-18-13-5-3-9-17-16(13)19-15/h1-6,9,11H,7-8,10H2,(H,17,18,19)
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n/an/a 3.70E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-IV isolated from guinea pig ventricle.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045007
PNG
(2-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenol | CHEMBL2...)
Show SMILES Oc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C12H9N3O/c16-10-6-2-1-4-8(10)11-14-9-5-3-7-13-12(9)15-11/h1-7,16H,(H,13,14,15)
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n/an/a 3.70E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045023
PNG
(Acetic acid 2-(3H-imidazo[4,5-b]pyridin-2-yl)-phen...)
Show SMILES CC(=O)Oc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C14H11N3O2/c1-9(18)19-12-7-3-2-5-10(12)13-16-11-6-4-8-15-14(11)17-13/h2-8H,1H3,(H,15,16,17)
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n/an/a 4.00E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045025
PNG
(2-(2-Methoxy-phenyl)-3H-imidazo[4,5-c]pyridine; hy...)
Show SMILES COc1ccccc1-c1nc2ccncc2[nH]1
Show InChI InChI=1S/C13H11N3O/c1-17-12-5-3-2-4-9(12)13-15-10-6-7-14-8-11(10)16-13/h2-8H,1H3,(H,15,16)
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n/an/a 4.20E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50045010
PNG
(2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[...)
Show SMILES COc1cc(ccc1-c1nc2cnccc2[nH]1)[S+](C)[O-]
Show InChI InChI=1S/C14H13N3O2S/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14/h3-8H,1-2H3,(H,16,17)
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n/an/a 4.20E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045010
PNG
(2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[...)
Show SMILES COc1cc(ccc1-c1nc2cnccc2[nH]1)[S+](C)[O-]
Show InChI InChI=1S/C14H13N3O2S/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14/h3-8H,1-2H3,(H,16,17)
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n/an/a 5.80E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50045022
PNG
(2-[2-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenoxy]-etha...)
Show SMILES OCCOc1ccccc1-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C14H13N3O2/c18-8-9-19-12-6-2-1-4-10(12)13-16-11-5-3-7-15-14(11)17-13/h1-7,18H,8-9H2,(H,15,16,17)
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n/an/a 6.40E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000056
PNG
((sulmazole)2-(4-Methanesulfinyl-2-methoxy-phenyl)-...)
Show SMILES COc1cc(ccc1-c1nc2ncccc2[nH]1)S(C)=O
Show InChI InChI=1S/C14H13N3O2S/c1-19-12-8-9(20(2)18)5-6-10(12)13-16-11-4-3-7-15-14(11)17-13/h3-8H,1-2H3,(H,15,16,17)
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n/an/a 1.50E+5n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricle

J Med Chem 36: 1387-92 (1993)


BindingDB Entry DOI: 10.7270/Q2JW8FHP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%