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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM767 (4-Cyano-N-[3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 0.800 | -51.4 | n/a | n/a | n/a | n/a | n/a | 5.0 | 22 |
Upjohn | Assay Description HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K... | J Med Chem 38: 4968-71 (1995) Article DOI: 10.1021/jm00026a002 BindingDB Entry DOI: 10.7270/Q2ZP449D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM763 (Cyclooctylpyranonesulfonamide deriv. 8b | N-{3-[(S...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 3 | -48.2 | n/a | n/a | n/a | n/a | n/a | 5.0 | 22 |
Upjohn | Assay Description HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K... | J Med Chem 38: 4968-71 (1995) Article DOI: 10.1021/jm00026a002 BindingDB Entry DOI: 10.7270/Q2ZP449D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM766 (Cyclooctylpyranonesulfonamide deriv. 8e | N-{3-[cy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3 | -48.2 | n/a | n/a | n/a | n/a | n/a | 5.0 | 22 |
Upjohn | Assay Description HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K... | J Med Chem 38: 4968-71 (1995) Article DOI: 10.1021/jm00026a002 BindingDB Entry DOI: 10.7270/Q2ZP449D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM765 (Cyclooctylpyranonesulfonamide deriv. 8d | N-{3-[cy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5 | -46.9 | n/a | n/a | n/a | n/a | n/a | 5.0 | 22 |
Upjohn | Assay Description HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K... | J Med Chem 38: 4968-71 (1995) Article DOI: 10.1021/jm00026a002 BindingDB Entry DOI: 10.7270/Q2ZP449D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM764 (Cyclooctylpyranonesulfonamide deriv. 8c | N-{3-[cy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 9 | -45.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 22 |
Upjohn | Assay Description HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K... | J Med Chem 38: 4968-71 (1995) Article DOI: 10.1021/jm00026a002 BindingDB Entry DOI: 10.7270/Q2ZP449D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
