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PubMed code 8648610

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50028866
PNG
(CHEMBL297271 | N-[(1S,2R)-2-(4-Hydroxy-phenyl)-ind...)
Show SMILES Oc1ccc(cc1)[C@H]1Cc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H25NO2/c31-24-17-15-20(16-18-24)26-19-23-13-7-8-14-25(23)28(26)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,26-28,31H,19H2,(H,30,32)/t26-,28-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes at 10 microM

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050744
PNG
(CHEMBL367428 | N-[2-(4-Hydroxy-phenyl)-indan-1-yl]...)
Show SMILES Oc1ccc(cc1)C1Cc2ccccc2C1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H25NO2/c31-24-17-15-20(16-18-24)26-19-23-13-7-8-14-25(23)28(26)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,26-28,31H,19H2,(H,30,32)
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n/an/a 100n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes at 10 microM

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50028866
PNG
(CHEMBL297271 | N-[(1S,2R)-2-(4-Hydroxy-phenyl)-ind...)
Show SMILES Oc1ccc(cc1)[C@H]1Cc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H25NO2/c31-24-17-15-20(16-18-24)26-19-23-13-7-8-14-25(23)28(26)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,26-28,31H,19H2,(H,30,32)/t26-,28-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050727
PNG
(CHEMBL49165 | N-[(1S,2R)-2-(4-Methoxy-phenyl)-cycl...)
Show SMILES COc1ccc(cc1)[C@H]1CCCC[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29NO2/c1-30-23-18-16-20(17-19-23)24-14-8-9-15-25(24)28-27(29)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-7,10-13,16-19,24-26H,8-9,14-15H2,1H3,(H,28,29)/t24-,25+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050747
PNG
(CHEMBL296683 | N-[(1R,2R)-2-(4-Hydroxy-phenyl)-ind...)
Show SMILES Oc1ccc(cc1)[C@H]1Cc2ccccc2[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H25NO2/c31-24-17-15-20(16-18-24)26-19-23-13-7-8-14-25(23)28(26)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,26-28,31H,19H2,(H,30,32)/t26-,28+/m1/s1
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n/an/a 230n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050728
PNG
(CHEMBL47558 | N-[(5R,6R)-6-(4-Hydroxy-phenyl)-6,7,...)
Show SMILES Oc1ccc(cc1)[C@H]1CCCc2ccccc2[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H29NO2/c33-26-20-18-23(19-21-26)28-17-9-15-22-10-7-8-16-27(22)30(28)32-31(34)29(24-11-3-1-4-12-24)25-13-5-2-6-14-25/h1-8,10-14,16,18-21,28-30,33H,9,15,17H2,(H,32,34)/t28-,30+/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050733
PNG
(CHEMBL45650 | N-[(1S,2R)-2-(4-Hydroxy-phenyl)-1,2,...)
Show SMILES Oc1ccc(cc1)[C@H]1CCc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-25-18-15-22(16-19-25)27-20-17-21-9-7-8-14-26(21)29(27)31-30(33)28(23-10-3-1-4-11-23)24-12-5-2-6-13-24/h1-16,18-19,27-29,32H,17,20H2,(H,31,33)/t27-,29-/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050739
PNG
(CHEMBL297378 | N-[(1R,2R)-2-(4-Hydroxy-phenyl)-7-m...)
Show SMILES COc1ccc2CC[C@@H]([C@@H](NC(=O)C(c3ccccc3)c3ccccc3)c2c1)c1ccc(O)cc1
Show InChI InChI=1S/C31H29NO3/c1-35-26-18-14-22-15-19-27(21-12-16-25(33)17-13-21)30(28(22)20-26)32-31(34)29(23-8-4-2-5-9-23)24-10-6-3-7-11-24/h2-14,16-18,20,27,29-30,33H,15,19H2,1H3,(H,32,34)/t27-,30-/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050734
PNG
(CHEMBL46234 | N-[(1S,2R)-2-(4-Hydroxy-phenyl)-cycl...)
Show SMILES Oc1ccc(cc1)[C@H]1CCCC[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H27NO2/c28-22-17-15-19(16-18-22)23-13-7-8-14-24(23)27-26(29)25(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-6,9-12,15-18,23-25,28H,7-8,13-14H2,(H,27,29)/t23-,24+/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050725
PNG
(CHEMBL298239 | N-[(1R,2R)-2-(3-Hydroxy-phenyl)-1,2...)
Show SMILES Oc1cccc(c1)[C@H]1CCc2ccccc2[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-25-16-9-15-24(20-25)27-19-18-21-10-7-8-17-26(21)29(27)31-30(33)28(22-11-3-1-4-12-22)23-13-5-2-6-14-23/h1-17,20,27-29,32H,18-19H2,(H,31,33)/t27-,29+/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050741
PNG
(CHEMBL296219 | N-[(1S,2R)-2-(4-Amino-phenyl)-1,2,3...)
Show SMILES Nc1ccc(cc1)[C@H]1CCc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H28N2O/c31-25-18-15-22(16-19-25)27-20-17-21-9-7-8-14-26(21)29(27)32-30(33)28(23-10-3-1-4-11-23)24-12-5-2-6-13-24/h1-16,18-19,27-29H,17,20,31H2,(H,32,33)/t27-,29-/m1/s1
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n/an/a 700n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050726
PNG
(CHEMBL296772 | N-[(1R,2R)-2-(4-Hydroxy-phenyl)-1,2...)
Show SMILES Oc1ccc(cc1)[C@H]1CCc2ccccc2[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-25-18-15-22(16-19-25)27-20-17-21-9-7-8-14-26(21)29(27)31-30(33)28(23-10-3-1-4-11-23)24-12-5-2-6-13-24/h1-16,18-19,27-29,32H,17,20H2,(H,31,33)/t27-,29+/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034725
PNG
(CHEMBL441971 | N-[2-(4-Hydroxy-phenyl)-1-phenyl-et...)
Show SMILES Oc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C28H25NO2/c30-25-18-16-21(17-19-25)20-26(22-10-4-1-5-11-22)29-28(31)27(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-19,26-27,30H,20H2,(H,29,31)
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n/an/a 800n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050746
PNG
(CHEMBL48002 | N-((1S,2R)-6-Hydroxy-2-phenyl-1,2,3,...)
Show SMILES Oc1ccc2[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)[C@H](CCc2c1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-25-17-19-27-24(20-25)16-18-26(21-10-4-1-5-11-21)29(27)31-30(33)28(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,17,19-20,26,28-29,32H,16,18H2,(H,31,33)/t26-,29+/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050735
PNG
(CHEMBL295655 | N-((1R,2R)-6-Hydroxy-2-phenyl-1,2,3...)
Show SMILES Oc1ccc2[C@H](NC(=O)C(c3ccccc3)c3ccccc3)[C@H](CCc2c1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-25-17-19-27-24(20-25)16-18-26(21-10-4-1-5-11-21)29(27)31-30(33)28(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,17,19-20,26,28-29,32H,16,18H2,(H,31,33)/t26-,29-/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050736
PNG
(2,2-Diphenyl-N-((1S,2R)-2-pyridin-4-yl-1,2,3,4-tet...)
Show SMILES O=C(N[C@H]1[C@H](CCc2ccccc12)c1ccncc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H26N2O/c32-29(27(23-10-3-1-4-11-23)24-12-5-2-6-13-24)31-28-25-14-8-7-9-21(25)15-16-26(28)22-17-19-30-20-18-22/h1-14,17-20,26-28H,15-16H2,(H,31,32)/t26-,28-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034732
PNG
(CHEMBL296077 | N-[1-(4-Hydroxy-phenyl)-2-phenyl-et...)
Show SMILES Oc1ccc(cc1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H25NO2/c30-25-18-16-22(17-19-25)26(20-21-10-4-1-5-11-21)29-28(31)27(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-19,26-27,30H,20H2,(H,29,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050740
PNG
(CHEMBL48107 | N-((1R,2R)-7-Hydroxy-2-phenyl-1,2,3,...)
Show SMILES Oc1ccc2CC[C@@H]([C@@H](NC(=O)C(c3ccccc3)c3ccccc3)c2c1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-25-18-16-22-17-19-26(21-10-4-1-5-11-21)29(27(22)20-25)31-30(33)28(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-16,18,20,26,28-29,32H,17,19H2,(H,31,33)/t26-,29-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050738
PNG
(CHEMBL45580 | N-[(3R,4R)-3-(4-Hydroxy-phenyl)-chro...)
Show SMILES Oc1ccc(cc1)[C@H]1COc2ccccc2[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H25NO3/c31-23-17-15-20(16-18-23)25-19-33-26-14-8-7-13-24(26)28(25)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,25,27-28,31H,19H2,(H,30,32)/t25-,28+/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050737
PNG
(CHEMBL412439 | N-((1S,2R)-5-Hydroxy-2-phenyl-1,2,3...)
Show SMILES Oc1cccc2[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)[C@H](CCc12)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-27-18-10-17-26-25(27)20-19-24(21-11-4-1-5-12-21)29(26)31-30(33)28(22-13-6-2-7-14-22)23-15-8-3-9-16-23/h1-18,24,28-29,32H,19-20H2,(H,31,33)/t24-,29+/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050729
PNG
(CHEMBL45544 | N-[(1R,2R)-2-(3-Methoxy-phenyl)-1,2,...)
Show SMILES COc1cccc(c1)[C@H]1CCc2ccccc2[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H29NO2/c1-34-26-17-10-16-25(21-26)28-20-19-22-11-8-9-18-27(22)30(28)32-31(33)29(23-12-4-2-5-13-23)24-14-6-3-7-15-24/h2-18,21,28-30H,19-20H2,1H3,(H,32,33)/t28-,30+/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034716
PNG
(CHEMBL42979 | N-[1-(4-Methoxy-phenyl)-2-phenyl-eth...)
Show SMILES COc1ccc(cc1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H27NO2/c1-32-26-19-17-23(18-20-26)27(21-22-11-5-2-6-12-22)30-29(31)28(24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-20,27-28H,21H2,1H3,(H,30,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034723
PNG
(CHEMBL418627 | N-[1-(3-Methoxy-phenyl)-2-phenyl-et...)
Show SMILES COc1cccc(c1)C(Cc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H27NO2/c1-32-26-19-11-18-25(21-26)27(20-22-12-5-2-6-13-22)30-29(31)28(23-14-7-3-8-15-23)24-16-9-4-10-17-24/h2-19,21,27-28H,20H2,1H3,(H,30,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes at 10 microM

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034740
PNG
(CHEMBL41351 | N-[2-(4-Methoxy-phenyl)-1-phenyl-eth...)
Show SMILES COc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H27NO2/c1-32-26-19-17-22(18-20-26)21-27(23-11-5-2-6-12-23)30-29(31)28(24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-20,27-28H,21H2,1H3,(H,30,31)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050723
PNG
(CHEMBL45495 | N-[(1S,2R)-2-(3-Hydroxy-phenyl)-1,2,...)
Show SMILES Oc1cccc(c1)[C@H]1CCc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-25-16-9-15-24(20-25)27-19-18-21-10-7-8-17-26(21)29(27)31-30(33)28(22-11-3-1-4-12-22)23-13-5-2-6-14-23/h1-17,20,27-29,32H,18-19H2,(H,31,33)/t27-,29-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050745
PNG
(CHEMBL45994 | N-[(1S,2R)-2-(3-Methoxy-phenyl)-1,2,...)
Show SMILES COc1cccc(c1)[C@H]1CCc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H29NO2/c1-34-26-17-10-16-25(21-26)28-20-19-22-11-8-9-18-27(22)30(28)32-31(33)29(23-12-4-2-5-13-23)24-14-6-3-7-15-24/h2-18,21,28-30H,19-20H2,1H3,(H,32,33)/t28-,30-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050742
PNG
(CHEMBL46346 | N-((1S,2R)-7-Hydroxy-2-phenyl-1,2,3,...)
Show SMILES Oc1ccc2CC[C@@H]([C@H](NC(=O)C(c3ccccc3)c3ccccc3)c2c1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-25-18-16-22-17-19-26(21-10-4-1-5-11-21)29(27(22)20-25)31-30(33)28(23-12-6-2-7-13-23)24-14-8-3-9-15-24/h1-16,18,20,26,28-29,32H,17,19H2,(H,31,33)/t26-,29+/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50034742
PNG
(CHEMBL289997 | N-[2-(4-Methoxy-phenyl)-1-(3-methox...)
Show SMILES COc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2cccc(OC)c2)cc1
Show InChI InChI=1S/C30H29NO3/c1-33-26-18-16-22(17-19-26)20-28(25-14-9-15-27(21-25)34-2)31-30(32)29(23-10-5-3-6-11-23)24-12-7-4-8-13-24/h3-19,21,28-29H,20H2,1-2H3,(H,31,32)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes at 10 microM

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050732
PNG
(CHEMBL297899 | N-[(3R,4S)-3-(4-Hydroxy-phenyl)-chr...)
Show SMILES Oc1ccc(cc1)[C@H]1COc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H25NO3/c31-23-17-15-20(16-18-23)25-19-33-26-14-8-7-13-24(26)28(25)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,25,27-28,31H,19H2,(H,30,32)/t25-,28-/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050730
PNG
(CHEMBL297678 | N-[(1S,2R)-2-(2-Hydroxy-phenyl)-1,2...)
Show SMILES Oc1ccccc1[C@H]1CCc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-27-18-10-9-17-25(27)26-20-19-21-11-7-8-16-24(21)29(26)31-30(33)28(22-12-3-1-4-13-22)23-14-5-2-6-15-23/h1-18,26,28-29,32H,19-20H2,(H,31,33)/t26-,29-/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050724
PNG
(CHEMBL45617 | N-[(1R,2R)-2-(4-Methoxy-phenyl)-cycl...)
Show SMILES COc1ccc(cc1)[C@H]1CCCC[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29NO2/c1-30-23-18-16-20(17-19-23)24-14-8-9-15-25(24)28-27(29)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-7,10-13,16-19,24-26H,8-9,14-15H2,1H3,(H,28,29)/t24-,25-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050749
PNG
(CHEMBL45674 | N-[(1R,2R)-2-(4-Hydroxy-phenyl)-cycl...)
Show SMILES Oc1ccc(cc1)[C@H]1CCCC[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H27NO2/c28-22-17-15-19(16-18-22)23-13-7-8-14-24(23)27-26(29)25(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-6,9-12,15-18,23-25,28H,7-8,13-14H2,(H,27,29)/t23-,24-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050748
PNG
(CHEMBL47672 | N-[(1S,2R)-7-Hydroxy-2-(4-hydroxy-ph...)
Show SMILES Oc1ccc(cc1)[C@H]1CCc2ccc(O)cc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H27NO3/c32-24-15-11-20(12-16-24)26-18-14-21-13-17-25(33)19-27(21)29(26)31-30(34)28(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-13,15-17,19,26,28-29,32-33H,14,18H2,(H,31,34)/t26-,29+/m1/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050743
PNG
(CHEMBL47474 | N-[(1R,2R)-2-(2-Hydroxy-phenyl)-1,2,...)
Show SMILES Oc1ccccc1[C@H]1CCc2ccccc2[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H27NO2/c32-27-18-10-9-17-25(27)26-20-19-21-11-7-8-16-24(21)29(26)31-30(33)28(22-12-3-1-4-13-22)23-14-5-2-6-15-23/h1-18,26,28-29,32H,19-20H2,(H,31,33)/t26-,29+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against acyl-coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes.

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Rattus norvegicus)		BDBM50050731
PNG
(CHEMBL289839 | N-[(1R,2S)-2-(4-Hydroxy-phenyl)-ind...)
Show SMILES Oc1ccc(cc1)[C@@H]1Cc2ccccc2[C@@H]1NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H25NO2/c31-24-17-15-20(16-18-24)26-19-23-13-7-8-14-25(23)28(26)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,26-28,31H,19H2,(H,30,32)/t26-,28-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes at 10 microM

J Med Chem 39: 1704-19 (1996)


Article DOI: 10.1021/jm950833d
BindingDB Entry DOI: 10.7270/Q2QN65V7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%