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PubMed code 8667360

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5171
PNG
((2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol...)
Show SMILES Oc1ccc(cc1O)C(=O)C(=C\c1c[nH]c2ccccc12)\C#N
Show InChI InChI=1S/C18H12N2O3/c19-9-12(18(23)11-5-6-16(21)17(22)8-11)7-13-10-20-15-4-2-1-3-14(13)15/h1-8,10,20-22H/b12-7+
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n/an/a 1.00E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5183
PNG
(2-Chloro-3-phenyl-6,7-dimethoxyquinoline | 2-chlor...)
Show SMILES COc1cc2cc(c(Cl)nc2cc1OC)-c1ccccc1
Show InChI InChI=1S/C17H14ClNO2/c1-20-15-9-12-8-13(11-6-4-3-5-7-11)17(18)19-14(12)10-16(15)21-2/h3-10H,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5176
PNG
((2E)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide | Ind...)
Show SMILES NC(=O)C(=C\c1c[nH]c2ccccc12)\C#N
Show InChI InChI=1S/C12H9N3O/c13-6-8(12(14)16)5-9-7-15-11-4-2-1-3-10(9)11/h1-5,7,15H,(H2,14,16)/b8-5+
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n/an/a 6.50E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5173
PNG
((2E)-2-cyano-3-(1H-indol-3-yl)prop-2-enethioamide ...)
Show SMILES NC(=S)C(=C\c1c[nH]c2ccccc12)\C#N
Show InChI InChI=1S/C12H9N3S/c13-6-8(12(14)16)5-9-7-15-11-4-2-1-3-10(9)11/h1-5,7,15H,(H2,14,16)/b8-5+
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n/an/a 6.50E+3n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4304
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O
Show InChI InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5169
PNG
((2E)-2-cyano-3-(1H-indol-5-yl)-N-(1-phenylethyl)pr...)
Show SMILES CC(NC(=O)C(=C\c1ccc2[nH]ccc2c1)\C#N)c1ccccc1
Show InChI InChI=1S/C20H17N3O/c1-14(16-5-3-2-4-6-16)23-20(24)18(13-21)12-15-7-8-19-17(11-15)9-10-22-19/h2-12,14,22H,1H3,(H,23,24)/b18-12+
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n/an/a 1.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4304
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O
Show InChI InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
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n/an/a 1.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5170
PNG
((2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol...)
Show SMILES Oc1ccc(cc1O)C(=O)C(=C\c1ccc2[nH]ccc2c1)\C#N
Show InChI InChI=1S/C18H12N2O3/c19-10-14(18(23)13-2-4-16(21)17(22)9-13)8-11-1-3-15-12(7-11)5-6-20-15/h1-9,20-22H/b14-8+
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5187
PNG
(2-(quinolin-4-ylmethylidene)propanedinitrile | 4-Q...)
Show SMILES N#C\[#6](=[#6]\c1ccnc2ccccc12)C#N
Show InChI InChI=1S/C13H7N3/c14-8-10(9-15)7-11-5-6-16-13-4-2-1-3-12(11)13/h1-7H
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n/an/a 1.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5170
PNG
((2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol...)
Show SMILES Oc1ccc(cc1O)C(=O)C(=C\c1ccc2[nH]ccc2c1)\C#N
Show InChI InChI=1S/C18H12N2O3/c19-10-14(18(23)13-2-4-16(21)17(22)9-13)8-11-1-3-15-12(7-11)5-6-20-15/h1-9,20-22H/b14-8+
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n/an/a 1.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5187
PNG
(2-(quinolin-4-ylmethylidene)propanedinitrile | 4-Q...)
Show SMILES N#C\[#6](=[#6]\c1ccnc2ccccc12)C#N
Show InChI InChI=1S/C13H7N3/c14-8-10(9-15)7-11-5-6-16-13-4-2-1-3-12(11)13/h1-7H
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n/an/a 1.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5175
PNG
((2E)-2-benzoyl-3-(1H-indol-3-yl)prop-2-enenitrile ...)
Show SMILES O=C(\C(=C\c1c[nH]c2ccccc12)C#N)c1ccccc1
Show InChI InChI=1S/C18H12N2O/c19-11-14(18(21)13-6-2-1-3-7-13)10-15-12-20-17-9-5-4-8-16(15)17/h1-10,12,20H/b14-10+
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n/an/a 2.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5174
PNG
((3Z)-2-amino-3-(1H-indol-3-ylmethylidene)prop-1-en...)
Show SMILES N=C(C(C#N)C#N)C(=Cc1c[nH]c2ccccc12)C#N |w:8.8|
Show InChI InChI=1S/C15H9N5/c16-6-10(15(19)12(7-17)8-18)5-11-9-20-14-4-2-1-3-13(11)14/h1-5,9,12,19-20H
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n/an/a 2.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5179
PNG
(2-chloro-6-methoxy-3-phenylquinoline | Quinoline-C...)
Show SMILES COc1ccc2nc(Cl)c(cc2c1)-c1ccccc1
Show InChI InChI=1S/C16H12ClNO/c1-19-13-7-8-15-12(9-13)10-14(16(17)18-15)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5182
PNG
(2-chloro-5,8-dimethoxy-3-phenylquinoline | Quinoli...)
Show SMILES COc1ccc(OC)c2nc(Cl)c(cc12)-c1ccccc1
Show InChI InChI=1S/C17H14ClNO2/c1-20-14-8-9-15(21-2)16-13(14)10-12(17(18)19-16)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5184
PNG
(2,3-Diphenyl-6,7-dimethoxyquinoline | 6,7-dimethox...)
Show SMILES COc1cc2cc(-c3ccccc3)c(nc2cc1OC)-c1ccccc1
Show InChI InChI=1S/C23H19NO2/c1-25-21-14-18-13-19(16-9-5-3-6-10-16)23(17-11-7-4-8-12-17)24-20(18)15-22(21)26-2/h3-15H,1-2H3
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n/an/a>3.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5179
PNG
(2-chloro-6-methoxy-3-phenylquinoline | Quinoline-C...)
Show SMILES COc1ccc2nc(Cl)c(cc2c1)-c1ccccc1
Show InChI InChI=1S/C16H12ClNO/c1-19-13-7-8-15-12(9-13)10-14(16(17)18-15)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a>3.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5181
PNG
(2-chloro-5,6,7-trimethoxy-3-phenylquinoline | Quin...)
Show SMILES COc1cc2nc(Cl)c(cc2c(OC)c1OC)-c1ccccc1
Show InChI InChI=1S/C18H16ClNO3/c1-21-15-10-14-13(16(22-2)17(15)23-3)9-12(18(19)20-14)11-7-5-4-6-8-11/h4-10H,1-3H3
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n/an/a>3.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5181
PNG
(2-chloro-5,6,7-trimethoxy-3-phenylquinoline | Quin...)
Show SMILES COc1cc2nc(Cl)c(cc2c(OC)c1OC)-c1ccccc1
Show InChI InChI=1S/C18H16ClNO3/c1-21-15-10-14-13(16(22-2)17(15)23-3)9-12(18(19)20-14)11-7-5-4-6-8-11/h4-10H,1-3H3
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5185
PNG
((2-(p-Nitrophenyl)-3-carbomethoxy-6,7-dimethoxyqui...)
Show SMILES COC(=O)c1cc2cc(OC)c(OC)cc2nc1-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H16N2O6/c1-25-16-9-12-8-14(19(22)27-3)18(20-15(12)10-17(16)26-2)11-4-6-13(7-5-11)21(23)24/h4-10H,1-3H3
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n/an/a>3.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5184
PNG
(2,3-Diphenyl-6,7-dimethoxyquinoline | 6,7-dimethox...)
Show SMILES COc1cc2cc(-c3ccccc3)c(nc2cc1OC)-c1ccccc1
Show InChI InChI=1S/C23H19NO2/c1-25-21-14-18-13-19(16-9-5-3-6-10-16)23(17-11-7-4-8-12-17)24-20(18)15-22(21)26-2/h3-15H,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5180
PNG
(6-chloro-7-phenyl-2H-[1,3]dioxolo[4,5-g]quinoline ...)
Show SMILES Clc1nc2cc3OCOc3cc2cc1-c1ccccc1
Show InChI InChI=1S/C16H10ClNO2/c17-16-12(10-4-2-1-3-5-10)6-11-7-14-15(20-9-19-14)8-13(11)18-16/h1-8H,9H2
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5182
PNG
(2-chloro-5,8-dimethoxy-3-phenylquinoline | Quinoli...)
Show SMILES COc1ccc(OC)c2nc(Cl)c(cc12)-c1ccccc1
Show InChI InChI=1S/C17H14ClNO2/c1-20-14-8-9-15(21-2)16-13(14)10-12(17(18)19-16)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a>3.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5186
PNG
(2-phenyl-N-(quinolin-3-yl)acetamide | Quinoline-Co...)
Show SMILES O=C(Cc1ccccc1)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H14N2O/c20-17(10-13-6-2-1-3-7-13)19-15-11-14-8-4-5-9-16(14)18-12-15/h1-9,11-12H,10H2,(H,19,20)
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n/an/a>3.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5171
PNG
((2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol...)
Show SMILES Oc1ccc(cc1O)C(=O)C(=C\c1c[nH]c2ccccc12)\C#N
Show InChI InChI=1S/C18H12N2O3/c19-9-12(18(23)11-5-6-16(21)17(22)8-11)7-13-10-20-15-4-2-1-3-14(13)15/h1-8,10,20-22H/b12-7+
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5180
PNG
(6-chloro-7-phenyl-2H-[1,3]dioxolo[4,5-g]quinoline ...)
Show SMILES Clc1nc2cc3OCOc3cc2cc1-c1ccccc1
Show InChI InChI=1S/C16H10ClNO2/c17-16-12(10-4-2-1-3-5-10)6-11-7-14-15(20-9-19-14)8-13(11)18-16/h1-8H,9H2
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n/an/a>3.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5183
PNG
(2-Chloro-3-phenyl-6,7-dimethoxyquinoline | 2-chlor...)
Show SMILES COc1cc2cc(c(Cl)nc2cc1OC)-c1ccccc1
Show InChI InChI=1S/C17H14ClNO2/c1-20-15-9-12-8-13(11-6-4-3-5-7-11)17(18)19-14(12)10-16(15)21-2/h3-10H,1-2H3
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n/an/a>3.00E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5185
PNG
((2-(p-Nitrophenyl)-3-carbomethoxy-6,7-dimethoxyqui...)
Show SMILES COC(=O)c1cc2cc(OC)c(OC)cc2nc1-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H16N2O6/c1-25-16-9-12-8-14(19(22)27-3)18(20-15(12)10-17(16)26-2)11-4-6-13(7-5-11)21(23)24/h4-10H,1-3H3
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5186
PNG
(2-phenyl-N-(quinolin-3-yl)acetamide | Quinoline-Co...)
Show SMILES O=C(Cc1ccccc1)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H14N2O/c20-17(10-13-6-2-1-3-7-13)19-15-11-14-8-4-5-9-16(14)18-12-15/h1-9,11-12H,10H2,(H,19,20)
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5176
PNG
((2E)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide | Ind...)
Show SMILES NC(=O)C(=C\c1c[nH]c2ccccc12)\C#N
Show InChI InChI=1S/C12H9N3O/c13-6-8(12(14)16)5-9-7-15-11-4-2-1-3-10(9)11/h1-5,7,15H,(H2,14,16)/b8-5+
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n/an/a 6.50E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5173
PNG
((2E)-2-cyano-3-(1H-indol-3-yl)prop-2-enethioamide ...)
Show SMILES NC(=S)C(=C\c1c[nH]c2ccccc12)\C#N
Show InChI InChI=1S/C12H9N3S/c13-6-8(12(14)16)5-9-7-15-11-4-2-1-3-10(9)11/h1-5,7,15H,(H2,14,16)/b8-5+
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n/an/a 6.50E+4n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5189
PNG
((2E)-2-cyano-3-(naphthalen-1-yl)prop-2-enamide | n...)
Show SMILES NC(=O)C(=C\c1cccc2ccccc12)\C#N
Show InChI InChI=1S/C14H10N2O/c15-9-12(14(16)17)8-11-6-3-5-10-4-1-2-7-13(10)11/h1-8H,(H2,16,17)/b12-8+
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4277
PNG
((3Z)-2-amino-3-(1H-indol-5-ylmethylidene)prop-1-en...)
Show SMILES N=C(C(C#N)C#N)C(=Cc1ccc2[nH]ccc2c1)C#N |w:8.8|
Show InChI InChI=1S/C15H9N5/c16-7-12(15(19)13(8-17)9-18)6-10-1-2-14-11(5-10)3-4-20-14/h1-6,13,19-20H
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5188
PNG
(2-(naphthalen-1-ylmethylidene)propanedinitrile | n...)
Show SMILES N#C\[#6](=[#6]\c1cccc2ccccc12)C#N
Show InChI InChI=1S/C14H8N2/c15-9-11(10-16)8-13-6-3-5-12-4-1-2-7-14(12)13/h1-8H
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5172
PNG
(2-(1H-indol-3-ylmethylidene)propanedinitrile | Ind...)
Show SMILES N#CC(=Cc1c[nH]c2ccccc12)C#N |(2.53,2.99,;1.76,4.33,;.99,5.66,;-.55,5.66,;-1.64,4.57,;-.73,3.32,;-1.64,2.08,;-3.1,2.55,;-4.32,1.78,;-5.65,2.55,;-5.65,4.1,;-4.32,4.87,;-3.1,4.1,;1.76,6.99,;2.53,8.33,)|
Show InChI InChI=1S/C12H7N3/c13-6-9(7-14)5-10-8-15-12-4-2-1-3-11(10)12/h1-5,8,15H
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n/an/a>1.00E+5n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4277
PNG
((3Z)-2-amino-3-(1H-indol-5-ylmethylidene)prop-1-en...)
Show SMILES N=C(C(C#N)C#N)C(=Cc1ccc2[nH]ccc2c1)C#N |w:8.8|
Show InChI InChI=1S/C15H9N5/c16-7-12(15(19)13(8-17)9-18)6-10-1-2-14-11(5-10)3-4-20-14/h1-6,13,19-20H
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5178
PNG
((2E)-2-(1,3-benzothiazol-2-yl)-3-(1H-indol-3-yl)pr...)
Show SMILES N#C\C(=C/c1c[nH]c2ccccc12)c1nc2ccccc2s1
Show InChI InChI=1S/C18H11N3S/c19-10-12(18-21-16-7-3-4-8-17(16)22-18)9-13-11-20-15-6-2-1-5-14(13)15/h1-9,11,20H/b12-9+
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5177
PNG
(3-amino-5-[(1Z)-1-cyano-2-(1H-indol-3-yl)eth-1-en-...)
Show SMILES Nc1[nH]nc(C(=Cc2c[nH]c3ccccc23)C#N)c1C#N |w:6.6|
Show InChI InChI=1S/C15H10N6/c16-6-9(14-12(7-17)15(18)21-20-14)5-10-8-19-13-4-2-1-3-11(10)13/h1-5,8,19H,(H3,18,20,21)
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5177
PNG
(3-amino-5-[(1Z)-1-cyano-2-(1H-indol-3-yl)eth-1-en-...)
Show SMILES Nc1[nH]nc(C(=Cc2c[nH]c3ccccc23)C#N)c1C#N |w:6.6|
Show InChI InChI=1S/C15H10N6/c16-6-9(14-12(7-17)15(18)21-20-14)5-10-8-19-13-4-2-1-3-11(10)13/h1-5,8,19H,(H3,18,20,21)
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5189
PNG
((2E)-2-cyano-3-(naphthalen-1-yl)prop-2-enamide | n...)
Show SMILES NC(=O)C(=C\c1cccc2ccccc12)\C#N
Show InChI InChI=1S/C14H10N2O/c15-9-12(14(16)17)8-11-6-3-5-10-4-1-2-7-13(10)11/h1-8H,(H2,16,17)/b12-8+
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5188
PNG
(2-(naphthalen-1-ylmethylidene)propanedinitrile | n...)
Show SMILES N#C\[#6](=[#6]\c1cccc2ccccc12)C#N
Show InChI InChI=1S/C14H8N2/c15-9-11(10-16)8-13-6-3-5-12-4-1-2-7-14(12)13/h1-8H
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5172
PNG
(2-(1H-indol-3-ylmethylidene)propanedinitrile | Ind...)
Show SMILES N#CC(=Cc1c[nH]c2ccccc12)C#N |(2.53,2.99,;1.76,4.33,;.99,5.66,;-.55,5.66,;-1.64,4.57,;-.73,3.32,;-1.64,2.08,;-3.1,2.55,;-4.32,1.78,;-5.65,2.55,;-5.65,4.1,;-4.32,4.87,;-3.1,4.1,;1.76,6.99,;2.53,8.33,)|
Show InChI InChI=1S/C12H7N3/c13-6-9(7-14)5-10-8-15-12-4-2-1-3-11(10)12/h1-5,8,15H
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Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5178
PNG
((2E)-2-(1,3-benzothiazol-2-yl)-3-(1H-indol-3-yl)pr...)
Show SMILES N#C\C(=C/c1c[nH]c2ccccc12)c1nc2ccccc2s1
Show InChI InChI=1S/C18H11N3S/c19-10-12(18-21-16-7-3-4-8-17(16)22-18)9-13-11-20-15-6-2-1-5-14(13)15/h1-9,11,20H/b12-9+
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UniChem
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5175
PNG
((2E)-2-benzoyl-3-(1H-indol-3-yl)prop-2-enenitrile ...)
Show SMILES O=C(\C(=C\c1c[nH]c2ccccc12)C#N)c1ccccc1
Show InChI InChI=1S/C18H12N2O/c19-11-14(18(21)13-6-2-1-3-7-13)10-15-12-20-17-9-5-4-8-16(15)17/h1-10,12,20H/b14-10+
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UniChem
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n/an/a 3.00E+5n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM5169
PNG
((2E)-2-cyano-3-(1H-indol-5-yl)-N-(1-phenylethyl)pr...)
Show SMILES CC(NC(=O)C(=C\c1ccc2[nH]ccc2c1)\C#N)c1ccccc1
Show InChI InChI=1S/C20H17N3O/c1-14(16-5-3-2-4-6-16)23-20(24)18(13-21)12-15-7-8-19-17(11-15)9-10-22-19/h2-12,14,22H,1H3,(H,23,24)/b18-12+
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n/an/a>3.00E+5n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5174
PNG
((3Z)-2-amino-3-(1H-indol-3-ylmethylidene)prop-1-en...)
Show SMILES N=C(C(C#N)C#N)C(=Cc1c[nH]c2ccccc12)C#N |w:8.8|
Show InChI InChI=1S/C15H9N5/c16-6-10(15(19)12(7-17)8-18)5-11-9-20-14-4-2-1-3-13(11)14/h1-5,9,12,19-20H
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UniProtKB/SwissProt

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UniChem
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n/an/a>3.00E+5n/an/an/an/a7.54



Hebrew University of Jerusalem



Assay Description
The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...


J Med Chem 39: 2170-7 (1996)


Article DOI: 10.1021/jm950727b
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%