Affinity Data by PubMed id=8863812

PubMed code 8863812

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
State University of New York Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM50054213 (3-(1-Carboxymethyl-1H-imidazol-4-yl)-2-{4-[(2,4-di...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
State University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM50054215 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
State University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human))	BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
State University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM50054214 (2-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-amin...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
State University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human))	BDBM50054215 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
State University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human))	BDBM50054213 (3-(1-Carboxymethyl-1H-imidazol-4-yl)-2-{4-[(2,4-di...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
State University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human))	BDBM50054214 (2-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-amin...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
State University of New York Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%